Sommario

• • ·Dare we dream of the end of malaria?

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• • ·Cover artist for 2020

    Pagina :2

    Marco De Ambrogi

     
• • ·Early childhood diarrhoea: from data to interventions

    Pagina :2-3

    Karen H Keddy

    
• • ·Trends in the global burden of paediatric lower respiratory infections

    Pagina :4-5

    Carina King, Eric D McCollum

    
• • ·Turning influenza vaccinology on its head to reveal the stalk

    Pagina :5-7

    Sophie A Valkenburg, Benjamin J Cowling

    
• • ·Alternative hepatitis B vaccine strategies in healthy non-responders to a first standard vaccination scheme

    Pagina :7-8

    Paul Loubet, Odile Launay

     
• • ·Test-and-not-treat: importance for mass drug administration

    Pagina :8-10

    Jesica Herrick

     
• • ·What makes a score a winner?

    Pagina :10-11

    Jonathon R Campbell, Dick Menzies

     
• • ·Tuberculosis: an instrument of early mortality in life course

    Pagina :11-12

    Barbara Reis-Santos, Marli Souza Rocha

     
• • ·HTLV-1: the silent impact revealed

    Pagina :12-14

    Lucy B M Cook, Graham P Taylor

    
• • ·Is there a silver lining to the Zika virus epidemic in the Americas?

    Pagina :14-15

    Sylvia Becker-Dreps, Elizabeth M Stringer, Filemon Bucardo, Natalie M Bowman, Michael J Boivin

    
• • ·Viral emergence and immune interplay in flavivirus vaccines

    Pagina :15-17

    Carlo Fischer, Edmilson F de Oliveira-Filho, Jan Felix Drexler

     
• • ·Preparedness for emerging epidemic threats: a Lancet Infectious Diseases Commission

    Pagina :17-19

    Vernon J Lee, Ximena Aguilera, David Heymann, Annelies Wilder-Smith, Lancet Infectious Diseases Commission, Vernon J. Lee, Ximena Aguilera, David L. Heymann, Annelies Wilder-Smith, Daniel G. Bausch, Sylvie Briand, Christianne Bruschke, Eduardo H. Carmo, Sean Cleghorn, Lalit Dandona, Christl Donnelly, Ibrahima Socé Fall, Jane Halton, Richard Hatchett, Felicia Hong, Peter Horby, Chikwe Ihekweazu, Michael Jacobs, Kamran Khan, Yijun Lin, Gabriel Leung, Constance Low, Bethan F. McDonald, Ziad A. Memish, Ryan Morhard, Deborah HL Ng, John Nkengasong, Junxiong Pang, Stephen C. Redd, Karen Tan, Wen Qing Yeo

     
• • ·Doripenem for treating nosocomial pneumonia and ventilator-associated pneumonia

    Pagina :20

    Hung-Jen Tang, Chih-Cheng Lai

    
• • ·Doripenem for treating nosocomial pneumonia and ventilator-associated pneumonia – Authors’ reply

    Pagina :20-21

    Marin H Kollef, Álvaro Réa-Neto, Richard G Wunderink, Christopher J Bruno, Elizabeth G Rhee

    
• • ·Preventing paralytic polio caused by vaccine-derived poliovirus type 2

    Pagina :21-22

    Carlos Franco-Paredes, Jose I Santos-Preciado, Andres F Henao-Martinez, Alfonso J Rodriguez-Morales, Peter Carrasco

    
• • ·Tuberculosis test results using fresh versus biobanked urine samples with FujiLAM

    Pagina :22-23

    Tobias Broger, Monde Muyoyeta, Andrew D Kerkhoff, Claudia M Denkinger, Emmanuel Moreau

    
• • ·Measles outbreaks at mass gathering mostly occur at youth events

    Pagina :23

    Van Thuan Hoang, Philippe Gautret

     
• • ·Adaptive trials of new antimicrobials for infections with carbapenem-resistant, Gram-negative bacteria

    Pagina :24

    Milo Gatti, Maddalena Giannella, Luigia Scudeller, Pierluigi Viale

     
• • ·8-year M type surveillance of Streptococcus pyogenes in China

    Pagina :24-25

    Yuanhai You, Xiaomin Peng, Peng Yang, Quanyi Wang, Jianzhong Zhang

      
• • ·1 year after acute Zika virus infection in men

    Pagina :25-26

    Louis Bujan, Jean-Michel Mansuy, Safouane Hamdi, Christophe Pasquier, Guillaume Joguet

    
• • ·Multigenic architecture of piperaquine resistance trait in Plasmodium falciparum

    Pagina :26-27

    Miguel Silva, Carla Calçada, Miguel Teixeira, Maria Isabel Veiga, Pedro Eduardo Ferreira

     
• • ·Naegleria fowleri in Pakistan

    Pagina :27-28

    Mahwish Ali, Syed Babar Jamal, Syeda Mehpara Farhat

    
• • ·Correction to Lancet Infect Dis 2019; published online Oct 30. https://doi.org/10.1016/S1473-3099(19)30540-7

    Pagina :e1

    
• • ·Correction to Lancet Infect Dis 2019; published online Nov 18. https://doi.org/10.1016/S1473-3099(19)30552-3

    Pagina :e1

    
• • ·Correction to Lancet Infect Dis 2019; 19: 988–1000

    Pagina :e1

    
• • ·Nigeria’s widening tuberculosis gap

    Pagina :29

    Paul Adepoju

     
• • ·Highlights from ASTMH 2019

    Pagina :30

    Marco De Ambrogi

     
• • ·The pitfalls of sanitation work

    Pagina :31-32

    Talha Burki

     
• • ·Infectious disease surveillance update

    Pagina :32

    Ruth Zwizwai

    Mappa Mappa
• • ·Research brief

    Pagina :33

    Dara Mohammadi

    Mappa Mappa
• • ·You will learn anyway

    Pagina :34

    Jack Williamson

     
• • ·The HIV epidemic in China: the story of a silent plague

    Pagina :35

    Quintina Dawson

     
• • ·Stories of the 1918 influenza pandemic and its legacy

    Pagina :36

    Marta Gritti

     
• • ·Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017

    Pagina :37-59

    GBD 2017 Diarrhoeal Disease Collaborators, Christopher E Troeger, Ibrahim A. Khalil, Brigette F. Blacker, Molly H. Biehl, Samuel B. Albertson, Stephanie R M Zimsen, Puja C Rao, Degu Abate, Alireza Ahmadi, Mohamed Lemine Cheikh brahim Ahmed, Chalachew Genet Akal, Fares Alahdab, Noore Alam, Kefyalew Addis Alene, Vahid Alipour, Syed Mohamed Aljunid, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Saeed Amini, Nahla Hamed Anber, Mina Anjomshoa, Carl Abelardo T. Antonio, Jalal Arabloo, Olatunde Aremu, Hagos Tasew Atalay, Suleman Atique, Euripide F G A Avokpaho, Samah Awad, Ashish Awasthi, Alaa Badawi, Kalpana Balakrishnan, Joseph Adel Mattar Banoub, Aleksandra Barac, Quique Bassat, Neeraj Bedi, Derrick A. Bennett, Krittika Bhattacharyya, Zulfiqar A Bhutta, Ali Bijani, Josip Car, Félix Carvalho, Carlos A Castañeda-Orjuela, Devasahayam J Christopher, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Feleke Mekonnen Demeke, Aniruddha Deshpande, Shirin Djalalinia, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, Maysaa El Sayed Zaki, Aman Yesuf Endries, Eduarda Fernandes, Florian Fischer, Nancy Fullman, William M. Gardner, Birhanu Geta, Keyghobad Ghadiri, Giuseppe Gorini, Alessandra C Goulart, Yuming Guo, Gessessew Bugssa Hailu, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Hamid Yimam Hassen, Chi Linh Hoang, Mihaela Hostiuc, Zakir Hussain, Seyed Sina Naghibi Irvani, Spencer L. James, Ravi Prakash Jha, Jost B. Jonas, André Karch, Amir Kasaeian, Tesfaye Dessale Kassa, Nicholas J Kassebaum, Adane Teshome Kefale, Yousef Saleh Khader, Ejaz Ahmad Khan, Md Nuruzzaman Khan, Young-Ho Khang, Abdullah T Khoja, Ruth W Kimokoti, Adnan Kisa, Sezer Kisa, Niranjan Kissoon, Sonali Kochhar, Soewarta Kosen, Ai Koyanagi, Barthelemy Kuate Defo, G Anil Kumar, Dharmesh Kumar Lal, Cheru Tesema Leshargie, Shanshan Li, Rakesh Lodha, Erlyn Rachelle King Macarayan, Marek Majdan, Abdullah A. Mamun, Helena Manguerra, Addisu Melese, Ziad A Memish, Desalegn Tadese Mengistu, Tuomo J Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Erkin M Mirrakhimov, Babak Moazen, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Lorenzo Monasta, Catrin E Moore, Jonathan F. Mosser, Seyyed Meysam Mousavi, Srinivas Murthy, Ghulam Mustafa, Javad Nazari, Cuong Tat Nguyen, Long Hoang Nguyen, Muhammad Imran Nisar, Molly R Nixon, Felix Akpojene Ogbo, Anselm Okoro, Andrew T Olagunju, Tinuke O Olagunju, Mahesh P A, Smita Pakhale, Maarten J Postma, Mostafa Qorbani, Reginald Quansah, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Rajesh Kumar Rai, Mohammad Sadegh Rezai, Aziz Rezapour, Maria Jesus Rios-Blancas, Luca Ronfani, Katherine Rosettie, Dietrich Rothenbacher, Saeed Safari, Zikria Saleem, Evanson Zondani Sambala, Abdallah M. Samy, Milena M Santric Milicevic, Benn Sartorius, Monika Sawhney, Seyedmojtaba Seyedmousavi, Masood Ali Shaikh, Aziz Sheikh, Mika Shigematsu, David L Smith, Joan B Soriano, Chandrashekhar T Sreeramareddy, Jeffrey D Stanaway, Mu’awiyyah Babale Sufiyan, Teklay G E Teklu, Mohamad-Hani Temsah, Belay Tessema, Bach Xuan Tran, Khanh Bao Tran, Irfan Ullah, Rachel L Updike, Tommi Juhani Vasankari, Yousef Veisani, Fiseha Wadilo Wada, Yasir Waheed, Marcia Weaver, Kirsten E Wiens, Charles Shey Wiysonge, Ebrahim M Yimer, Naohiro Yonemoto, Zoubida Zaidi, Heather J Zar, Afshin Zarghi, Stephen S Lim, Theo Vos, Ali H Mokdad, Christopher J L Murray, Hmwe Hmwe Kyu, Simon I. Hay, Robert C Reiner

    Riassunto Riassunto Mappa Mappa   
• • ·Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years: an analysis for the Global Burden of Disease Study 2017

    Pagina :60-79

    GBD 2017 Lower Respiratory Infections Collaborators, Christopher E Troeger, Ibrahim A Khalil, Brigette F Blacker, Molly H Biehl, Samuel B Albertson, Stephanie R M Zimsen, Puja C Rao, Degu Abate, Amha Admasie, Alireza Ahmadi, Mohamed Lemine Cheikh Brahim Ahmed, Chalachew Genet Akal, Fares Alahdab, Noore Alam, Kefyalew Addis Alene, Vahid Alipour, Syed Mohamed Aljunid, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Saeed Amini, Mina Anjomshoa, Carl Abelardo T Antonio, Jalal Arabloo, Olatunde Aremu, Hagos Tasew Atalay, Suleman Atique, Euripide F G A Avokpaho, Samah Awad, Ashish Awasthi, Alaa Badawi, Kalpana Balakrishnan, Joseph Adel Mattar Banoub, Aleksandra Barac, Quique Bassat, Neeraj Bedi, Derrick A Bennett, Krittika Bhattacharyya, Zulfiqar A Bhutta, Ali Bijani, Corey B Bills, Josip Car, Félix Carvalho, Carlos A Castañeda-Orjuela, Kate Causey, Devasahayam J Christopher, Aaron J Cohen, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Feleke Mekonnen Demeke, Shirin Djalalinia, Manisha Dubey, Eleonora Dubljanin, Eyasu Ejeta Duken, Maysaa El Sayed Zaki, Aman Yesuf Endries, Eduarda Fernandes, Florian Fischer, Joseph Frostad, Nancy Fullman, William M Gardner, Birhanu Geta, Keyghobad Ghadiri, Giuseppe Gorini, Alessandra C Goulart, Yuming Guo, Gessessew Bugssa Hailu, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Samer Hamidi, Hamid Yimam Hassen, Chi Linh Hoang, Nobuyuki Horita, Mihaela Hostiuc, Zakir Hussain, Seyed Sina Naghibi Irvani, Spencer L James, Ravi Prakash Jha, Jost B Jonas, André Karch, Amir Kasaeian, Tesfaye Dessale Kassa, Nicholas J Kassebaum, Adane Teshome Kefale, Yousef Saleh Khader, Ejaz Ahmad Khan, Gulfaraz Khan, Md Nuruzzaman Khan, Young-Ho Khang, Abdullah T Khoja, Ruth W Kimokoti, Adnan Kisa, Sezer Kisa, Niranjan Kissoon, Luke D Knibbs, Sonali Kochhar, Soewarta Kosen, Parvaiz A Koul, Ai Koyanagi, Barthelemy Kuate Defo, G Anil Kumar, Dharmesh Kumar Lal, Cheru Tesema Leshargie, Sonia Lewycka, Shanshan Li, Rakesh Lodha, Erlyn Rachelle King Macarayan, Marek Majdan, Abdullah A Mamun, Helena Manguerra, Varshil Mehta, Addisu Melese, Ziad A Memish, Desalegn Tadese Mengistu, Tuomo J Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Erkin M Mirrakhimov, Babak Moazen, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Lorenzo Monasta, Catrin E Moore, Lidia Morawska, Jonathan F Mosser, Seyyed Meysam Mousavi, Srinivas Murthy, Ghulam Mustafa, Javad Nazari, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Long Hoang Nguyen, Son Hoang Nguyen, Katie R Nielsen, Muhammad Imran Nisar, Molly R Nixon, Felix Akpojene Ogbo, Anselm Okoro, Andrew T Olagunju, Tinuke O Olagunju, Eyal Oren, Justin R Ortiz, Mahesh P A, Smita Pakhale, Maarten J Postma, Mostafa Qorbani, Reginald Quansah, Alireza Rafiei, Fakher Rahim, Vafa Rahimi-Movaghar, Rajesh Kumar Rai, Marissa Bettay Reitsma, Mohammad Sadegh Rezai, Aziz Rezapour, Maria Jesus Rios-Blancas, Luca Ronfani, Dietrich Rothenbacher, Salvatore Rubino, Zikria Saleem, Evanson Zondani Sambala, Abdallah M Samy, Milena M Santric Milicevic, Rodrigo Sarmiento-Suárez, Benn Sartorius, Miloje Savic, Monika Sawhney, Sonia Saxena, Alyssa Sbarra, Seyedmojtaba Seyedmousavi, Masood Ali Shaikh, Aziz Sheikh, Mika Shigematsu, David L Smith, Chandrashekhar T Sreeramareddy, Jeffrey D Stanaway, Mu’awiyyah Babale Sufiyan, Mohamad-Hani Temsah, Belay Tessema, Bach Xuan Tran, Khanh Bao Tran, Afewerki Gebremeskel Tsadik, Irfan Ullah, Rachel L Updike, Tommi Juhani Vasankari, Yousef Veisani, Fiseha Wadilo Wada, Yasir Waheed, Katie Welgan, Kirsten E Wiens, Charles Shey Wiysonge, Ebrahim M Yimer, Naohiro Yonemoto, Zoubida Zaidi, Heather J Zar, Stephen S Lim, Theo Vos, Ali H Mokdad, Christopher J L Murray, Hmwe Hmwe Kyu, Simon I Hay, Robert C Reiner

    Riassunto Riassunto Mappa Mappa   
• • ·Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

    Pagina :80-91

    David I Bernstein, Jeffrey Guptill, Abdollah Naficy, Raffael Nachbagauer, Francesco Berlanda-Scorza, Jodi Feser, Patrick C Wilson, Alicia Solórzano, Marie Van der Wielen, Emmanuel B Walter, Randy A Albrecht, Kristen N Buschle, Yao-qing Chen, Carine Claeys, Michelle Dickey, Haley L Dugan, Megan E Ermler, Debra Freeman, Min Gao, Christopher Gast, Jenna J Guthmiller, Rong Hai, Carole Henry, Linda Yu-Ling Lan, Monica McNeal, Anna-Karin E Palm, Dustin G Shaw, Christopher T Stamper, Weina Sun, Victoria Sutton, Micah E Tepora, Rahnuma Wahid, Heather Wenzel, Teddy John Wohlbold, Bruce L Innis, Adolfo García-Sastre, Peter Palese, Florian Krammer

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• • ·Serological response to three alternative series of hepatitis B revaccination (Fendrix, Twinrix, and HBVaxPro-40) in healthy non-responders: a multicentre, open-label, randomised, controlled, superiority trial

    Pagina :92-101

    Stijn F H Raven, Christian J P A Hoebe, Ann C T M Vossen, Leo G Visser, Jeannine L A Hautvast, Anna H E Roukens, Jim E van Steenbergen

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• • ·Implications for annual retesting after a test-and-not-treat strategy for onchocerciasis elimination in areas co-endemic with Loa loa infection: an observational cohort study

    Pagina :102-109

    Sébastien DS Pion, Hugues Nana-Djeunga, Yannick Niamsi-Emalio, Cédric B Chesnais, Hugo Deléglise, Charles Mackenzie, Wilma Stolk, Daniel A Fletcher, Amy D Klion, Thomas B Nutman, Michel Boussinesq, Joseph Kamgno

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• • ·A household-level score to predict the risk of tuberculosis among contacts of patients with tuberculosis: a derivation and external validation prospective cohort study

    Pagina :110-122

    Matthew J Saunders, Tom Wingfield, Sumona Datta, Rosario Montoya, Eric Ramos, Matthew R Baldwin, Marco A Tovar, Benjamin E W Evans, Robert H Gilman, Carlton A Evans

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• • ·Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study

    Pagina :123-132

    Otavio T Ranzani, Laura C Rodrigues, Sidney Bombarda, Cátia M Minto, Eliseu A Waldman, Carlos R R Carvalho

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• • ·Association between HTLV-1 infection and adverse health outcomes: a systematic review and meta-analysis of epidemiological studies

    Pagina :133-143

    Gill Schierhout, Skye McGregor, Antoine Gessain, Lloyd Einsiedel, Marianne Martinello, John Kaldor

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• • ·Creutzfeldt-Jakob disease: a systematic review of global incidence, prevalence, infectivity, and incubation

    Pagina :e2

    Lesley Uttley, Christopher Carroll, Ruth Wong, David A Hilton, Matt Stevenson

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• • ·The public health crisis of underimmunisation: a global plan of action

    Pagina :e11

    Lawrence O Gostin, James G Hodge, Barry R Bloom, Ayman El-Mohandes, Jonathan Fielding, Peter Hotez, Ann Kurth, Heidi J Larson, Walter A Orenstein, Kenneth Rabin, Scott C Ratzan, Daniel Salmon

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• • ·WHO international standard for anti-rubella: learning from its application

    Pagina :e17

    Sarah L Kempster, Neil Almond, Wayne Dimech, Liliane Grangeot-Keros, Daniela Huzly, Joseph Icenogle, Haja Sittana El Mubarak, Mick N Mulders, C Micha Nübling

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• • ·PCR correction strategies for malaria drug trials: updates and clarifications

    Pagina :e20

    Ingrid Felger, Georges Snounou, Ian Hastings, Joerg J Moehrle, Hans-Peter Beck

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• • ·Brucellosis mimicking herpes simplex virus encephalitis

    Pagina :144

    Ashok K Pannu, Atul Saroch, Navneet Sharma, Vikas Bhatia