Sommario

• • ·UK cancer care threatened by government incompetence

    Pagina :1387

     
• • ·EZH2 inhibition for epithelioid sarcoma and follicular lymphoma

    Pagina :1388-1390

    Roman Groisberg, Vivek Subbiah

     
• • ·Implementing preoperative endocrine therapy in breast cancer

    Pagina :1390-1392

    Montserrat Muñoz, Aleix Prat

     
• • ·HER2DX: a tool that might inform treatment choices for HER2-positive breast cancer

    Pagina :1392-1393

    Sara A Hurvitz

     
• • ·The current state of adjuvant therapy of melanoma

    Pagina :1394-1395

    Ahmad A Tarhini

      
• • ·Angiogenesis inhibitors in neuroendocrine tumours: finally coming of age

    Pagina :1395-1397

    Pamela L Kunz

     
• • ·A roadmap for the early detection and diagnosis of cancer

    Pagina :1397-1399

    David Crosby, Nicole Lyons, Emma Greenwood, Samantha Harrison, Sara Hiom, Jodie Moffat, Talisia Quallo, Emlyn Samuel, Ian Walker, Early Detection and Diagnosis Roadmap Steering Group

     
• • ·How current assay approval policies are leading to unintended imprecision medicine

    Pagina :1399-1401

    Roberto Salgado, Andrew M Bellizzi, David Rimm, John M S Bartlett, Torsten Nielsen, Moch Holger, Anne-Vibeke Laenkholm, Cecily Quinn, Gábor Cserni, Isabela W Cunha, Isabel Alvarado-Cabrero, Ian Cree

    
• • ·Results from the PROPHYLOCHIP-PRODIGE 15 trial

    Pagina :e496

    Pieter J Tanis, Jurriaan B Tuynman, Ignace H J T de Hingh

    
• • ·Results from the PROPHYLOCHIP-PRODIGE 15 trial

    Pagina :e497

    Swapnil Patel, Diwakar Pandey, Avanish Saklani

    
• • ·Results from the PROPHYLOCHIP-PRODIGE 15 trial – Authors’ reply

    Pagina :e498

    Diane Goéré, Michel Ducreux

    
• • ·Residual disease after mastectomy

    Pagina :e499

    Nigel J Bundred, David Dodwell, James R Bundred, Ramsey I Cutress

    
• • ·Residual disease after mastectomy

    Pagina :e500

    Zhen-Yu Wu, Jing Han, Jin Sup Eom, Sei Hyun Ahn, BeomSeok Ko

    
• • ·Residual disease after mastectomy – Authors’ reply

    Pagina :e501

    Orit Kaidar-Person, Thorsten Kühn, Philip Poortmans

    
• • ·An imbalance in competing mortality favouring Debio 1143

    Pagina :e502

    Kaveh Zakeri, Yao Yu, Nancy Lee

    
• • ·An imbalance in competing mortality favouring Debio 1143 – Authors’ reply

    Pagina :e503

    Jean Bourhis, Xu-Shan Sun, Yungan Tao

    
• • ·Mammography screening for breast cancer—the UK Age trial

    Pagina :e504

    Katy J L Bell, Les Irwig, Brooke Nickel, Jolyn Hersch, Andrew Hayen, Alexandra Barratt

     
• • ·Mammography screening for breast cancer—the UK Age trial

    Pagina :e505

    Humaid O Al-Shamsi

    
• • ·Mammography screening for breast cancer—the UK Age trial

    Pagina :e506

    Ismail Jatoi

    
• • ·Mammography screening for breast cancer—the UK Age trial

    Pagina :e507

    Ritika Gera, Michael J Michell, Kefah Mokbel

    
• • ·Mammography screening for breast cancer—the UK Age trial

    Pagina :e508

    Steven A Narod

    
• • ·Mammography screening for breast cancer—the UK Age trial

    Pagina :e509

    Alberto Donzelli, Giulia Giudicatti, Donatella Sghedoni

    
• • ·Mammography screening for breast cancer—the UK Age trial – Authors’ reply

    Pagina :e510

    Stephen W Duffy, Peter D Sasieni

    
• • ·Recommendations for breast cancer screening

    Pagina :e511

    László Tabár, Peter B Dean

    
• • ·Recommendations for breast cancer screening

    Pagina :e512

    Martin J Yaffe, Paula B Gordon, Michael N Linver

    
• • ·Recommendations for breast cancer screening

    Pagina :e513

    Daniel B Kopans

    
• • ·Recommendations for breast cancer screening – Author’s reply

    Pagina :514

    Anthony B Miller

    
• • ·Dabrafenib plus trametinib in patients with BRAF^V600E-mutated biliary tract cancer

    Pagina :e515

    Rowan F van Golen, Tim J A Dekker

    
• • ·Dabrafenib plus trametinib in patients with BRAF^V600E-mutated biliary tract cancer – Authors’ reply

    Pagina :e516

    Vivek Subbiah, Ulrik Lassen, Eduard Gasal, Paul Burgess, Zev A Wainberg

    
• • ·Declines in health insurance among cancer survivors since the 2016 US elections

    Pagina :e517

    Haley A Moss, Xuesong Han, K Robin Yabroff, Junzo Chino, Fumiko Chino

     
• • ·Correction to Lancet Oncol 2017; 18: 347–56

    Pagina :e518

    
• • ·Correction to Lancet Oncol 2019; 20: 1370–85

    Pagina :e518

    
• • ·Correction to Lancet Oncol 2020; 21: 1378–86

    Pagina :e518

    
• • ·Burnout among cancer professionals during COVID-19

    Pagina :1402

    Talha Khan Burki

     
• • ·ESMO Virtual Congress 2020

    Pagina :1403-1404

    Katherine Gourd, Cheryl Lai, Cheryl Reeves

    Mappa Mappa  
• • ·New empowerment tool for all patients with cancer in Europe

    Pagina :1405

    Elizabeth Gourd

     
• • ·Tobacco Transformation Index under fire

    Pagina :1406

    Talha Khan Burki

     
• • ·Carcinogenicity of opium consumption

    Pagina :1407-1408

    IARC Monographs Vol 126 group, Saman Warnakulasuriya, Deirdre Cronin-Fenton, Jennifer Jinot, Farin Kamangar, Reza Malekzadeh, Nazir A Dar, Arash Etemadi, Paola Fortini, Deborah C Glass, Narges Khanjani, Ruri Kikura-Hanajiri, Nuria Malats, Akram Pourshams, Afarin Rahimi-Movaghar, David B Richardson, Vikash Sewram, Jennifer Girschik, Michelle C Turner, Eero Suonio, Yann Grosse, Lamia Benbrahim-Tallaa, Mahdi Sheikh, Bayan Hosseini, MengMeng Li, Heidi Mattock, Kathryn Z Guyton, Mary K Schubauer-Berigan

    
• • ·India–China border standoff raises concerns on drug supplies

    Pagina :1408-1409

    Dinesh C Sharma

     
• • ·Prof Theodor Billroth and Ferdinand II King Consort of Portugal: who owns the truth?

    Pagina :1410-1411

    Bartlomiej Szostakowski

     
• • ·Personal choice in The Farewell and Ordinary Love

    Pagina :1412

    Sophia Davis

     
• • ·Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial

    Pagina :1413-1422

    Mariano Provencio, Ernest Nadal, Amelia Insa, María Rosario García-Campelo, Joaquín Casal-Rubio, Manuel Dómine, Margarita Majem, Delvys Rodríguez-Abreu, Alex Martínez-Martí, Javier De Castro Carpeño, Manuel Cobo, Guillermo López Vivanco, Edel Del Barco, Reyes Bernabé Caro, Nuria Viñolas, Isidoro Barneto Aranda, Santiago Viteri, Eva Pereira, Ana Royuela, Marta Casarrubios, Clara Salas Antón, Edwin R Parra, Ignacio Wistuba, Virginia Calvo, Raquel Laza-Briviesca, Atocha Romero, Bartomeu Massuti, Alberto Cruz-Bermúdez

    Riassunto Riassunto Mappa Mappa   
• • ·Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study

    Pagina :1423-1432

    Mrinal Gounder, Patrick Schöffski, Robin L Jones, Mark Agulnik, Gregory M Cote, Victor M Villalobos, Steven Attia, Rashmi Chugh, Tom Wei-Wu Chen, Thierry Jahan, Elizabeth T Loggers, Abha Gupta, Antoine Italiano, George D Demetri, Ravin Ratan, Lara E Davis, Olivier Mir, Palma Dileo, Brian A Van Tine, Joseph G Pressey, Trupti Lingaraj, Anand Rajarethinam, Laura Sierra, Shefali Agarwal, Silvia Stacchiotti

    Riassunto Riassunto Mappa Mappa   
• • ·Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial

    Pagina :1433-1442

    Franck Morschhauser, Hervé Tilly, Aristeidis Chaidos, Pamela McKay, Tycel Phillips, Sarit Assouline, Connie Lee Batlevi, Phillip Campbell, Vincent Ribrag, Gandhi Laurent Damaj, Michael Dickinson, Wojciech Jurczak, Maciej Kazmierczak, Stephen Opat, John Radford, Anna Schmitt, Jay Yang, Jennifer Whalen, Shefali Agarwal, Deyaa Adib, Gilles Salles

    Riassunto Riassunto Mappa Mappa   
• • ·Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial

    Pagina :1443-1454

    Ian Smith, John Robertson, Lucy Kilburn, Maggie Wilcox, Abigail Evans, Chris Holcombe, Kieran Horgan, Cliona Kirwan, Elizabeth Mallon, Mark Sibbering, Anthony Skene, Raghavan Vidya, Maggie Cheang, Jane Banerji, James Morden, Kally Sidhu, Andrew Dodson, Judith M Bliss, Mitch Dowsett

    Riassunto Riassunto Mappa Mappa   
• • ·A multivariable prognostic score to guide systemic therapy in early-stage HER2-positive breast cancer: a retrospective study with an external evaluation

    Pagina :1455-1464

    Aleix Prat, Valentina Guarneri, Laia Paré, Gaia Griguolo, Tomás Pascual, Maria V Dieci, Núria Chic, Blanca González-Farré, Antonio Frassoldati, Esther Sanfeliu, Juan M Cejalvo, Montserrat Muñoz, Giancarlo Bisagni, Fara Brasó-Maristany, Loredana Urso, Maria Vidal, Alba A Brandes, Barbara Adamo, Antonino Musolino, Federica Miglietta, Benedetta Conte, Mafalda Oliveira, Cristina Saura, Sònia Pernas, Jesús Alarcón, Antonio Llombart-Cussac, Javier Cortés, Luis Manso, Rafael López, Eva Ciruelos, Francesco Schettini, Patricia Villagrasa, Lisa A Carey, Charles M Perou, Federico Piacentini, Roberto D’Amico, Enrico Tagliafico, Joel S Parker, Pierfranco Conte

    Riassunto Riassunto Mappa Mappa   
• • ·Adjuvant nivolumab versus ipilimumab in resected stage IIIB–C and stage IV melanoma (CheckMate 238): 4-year results from a multicentre, double-blind, randomised, controlled, phase 3 trial

    Pagina :1465-1477

    Paolo A Ascierto, Michele Del Vecchio, Mario Mandalá, Helen Gogas, Ana M Arance, Stephane Dalle, C Lance Cowey, Michael Schenker, Jean-Jacques Grob, Vanna Chiarion-Sileni, Iván Márquez-Rodas, Marcus O Butler, Michele Maio, Mark R Middleton, Luis de la Cruz-Merino, Petr Arenberger, Victoria Atkinson, Andrew Hill, Leslie A Fecher, Michael Millward, Nikhil I Khushalani, Paola Queirolo, Maurice Lobo, Veerle de Pril, John Loffredo, James Larkin, Jeffrey Weber

    Riassunto Riassunto Mappa Mappa   
• • ·Intermittent schedules of the oral RAF–MEK inhibitor CH5126766/VS-6766 in patients with RAS/RAF-mutant solid tumours and multiple myeloma: a single-centre, open-label, phase 1 dose-escalation and basket dose-expansion study

    Pagina :1478-1488

    Christina Guo, Maxime Chénard-Poirier, Desamparados Roda, Maria de Miguel, Samuel J Harris, Irene Moreno Candilejo, Priya Sriskandarajah, Wen Xu, Mariana Scaranti, Anastasia Constantinidou, Jenny King, Mona Parmar, Alison J Turner, Suzanne Carreira, Ruth Riisnaes, Laura Finneran, Emma Hall, Yuji Ishikawa, Kiyohiko Nakai, Nina Tunariu, Bristi Basu, Martin Kaiser, Juanita Suzanne Lopez, Anna Minchom, Johann S de Bono, Udai Banerji

    Riassunto Riassunto Mappa Mappa   
• • ·Surufatinib in advanced pancreatic neuroendocrine tumours (SANET-p): a randomised, double-blind, placebo-controlled, phase 3 study

    Pagina :1489-1499

    Jianming Xu, Lin Shen, Chunmei Bai, Wei Wang, Jie Li, Xianjun Yu, Zhiping Li, Enxiao Li, Xianglin Yuan, Yihebali Chi, Yongmei Yin, Wenhui Lou, Nong Xu, Yuxian Bai, Tao Zhang, Dianrong Xiu, Xiuwen Wang, Ying Yuan, Jia Chen, Shukui Qin, Ru Jia, Ming Lu, Yuejuan Cheng, Zhiwei Zhou, Jing Li, James He, Weiguo Su

    Riassunto Riassunto Mappa Mappa   
• • ·Surufatinib in advanced extrapancreatic neuroendocrine tumours (SANET-ep): a randomised, double-blind, placebo-controlled, phase 3 study

    Pagina :1500-1512

    Jianming Xu, Lin Shen, Zhiwei Zhou, Jie Li, Chunmei Bai, Yihebali Chi, Zhiping Li, Nong Xu, Enxiao Li, Tianshu Liu, Yuxian Bai, Ying Yuan, Xingya Li, Xiuwen Wang, Jia Chen, Jieer Ying, Xianjun Yu, Shukui Qin, Xianglin Yuan, Tao Zhang, Yanhong Deng, Dianrong Xiu, Ying Cheng, Min Tao, Ru Jia, Wei Wang, Jing Li, Songhua Fan, Mengye Peng, Weiguo Su

    Riassunto Riassunto Mappa Mappa   
• • ·Quality of life in patients with metastatic prostate cancer following treatment with cabazitaxel versus abiraterone or enzalutamide (CARD): an analysis of a randomised, multicentre, open-label, phase 4 study

    Pagina :1513-1525

    Karim Fizazi, Gero Kramer, Jean-Christophe Eymard, Cora N Sternberg, Johann de Bono, Daniel Castellano, Bertrand Tombal, Christian Wülfing, Michael Liontos, Joan Carles, Roberto Iacovelli, Bohuslav Melichar, Ásgerður Sverrisdóttir, Christine Theodore, Susan Feyerabend, Carole Helissey, Stéphane Oudard, Gaetano Facchini, Elizabeth M Poole, Ayse Ozatilgan, Christine Geffriaud-Ricouard, Samira Bensfia, Ronald de Wit

    Riassunto Riassunto Mappa Mappa   
• • ·Gamma knife radiosurgery for uveal melanomas and metastases: a systematic review and meta-analysis

    Pagina :1526-1536

    Tariq Parker, Grant Rigney, Justiss Kallos, S Tonya Stefko, Hideyuki Kano, Ajay Niranjan, Alexander L Green, Tipu Aziz, Pamela Rath, L Dade Lunsford

    Riassunto Riassunto Mappa Mappa   
• • ·Cancer and climate change

    Pagina :e519

    Robert A Hiatt, Naomi Beyeler

    Riassunto Riassunto Mappa Mappa  
• • ·Comprehensive guidance on the diagnosis and management of primary mesenchymal tumours of the thyroid gland

    Pagina :e528

    Sriram Gubbi, Shilpa Thakur, Shirisha Avadhanula, Katherine A Araque, Armando C Filie, Mark Raffeld, James Welch, Jaydira Del Rivero, Electron Kebebew, Kenneth D Burman, Leonard Wartofsky, Joanna Klubo-Gwiezdzinska

    Riassunto Riassunto Mappa Mappa   
• • ·Ocular surface squamous neoplasia in association with Crohn’s disease

    Pagina :e538

    Devjyoti Tripathy, Ruchi Mittal