Sommario

• Editorial

  • ·What Is Reasonable and Necessary for Alzheimer Patients from Randomized Clinical Trials to Clinical Practice?

    Pagina :331-332

    Lefkos T. Middleton, J. Touchon, B. Vellas

    

• Viewpoint

  • ·«Compounded Interest» in Alzheimer’s Disease: Do New Amyloid-Targeting Treatments Justify Their Use

    Pagina :333-335

    Cristina Sampaio

     
  • ·Balancing the Conflicting Goals for Treatment of Alzheimer’s Disease with Monoclonal Antibodies

    Pagina :336-338

    David R. Scrase, N. Budhwar

    Riassunto Riassunto
  • ·Clinicians’ Perspectives on How Disease Modifying Drugs for Alzheimer’s Disease Impact Specialty Care

    Pagina :339-341

    Serge Gauthier, Z. Ismail, Z. Goodarzi, K.P. Ng, P. Rosa-Neto

    Riassunto Riassunto Mappa Mappa
  • ·When It Comes to Lecanemab (and Donanemab), How Might We Think about ‘Reasonable and Necessary’?

    Pagina :342-343

    Lon S. Schneider

    

• Point of View

  • ·What Is Reasonable and Necessary for People Living with AD after the FDA Approves a Treatment?

    Pagina :344-345

    Rachelle S. Doody, S. Skerjanec

    

• Viewpoint

  • ·Defining FDA Approved Treatments as Reasonable and Necessary: Perspectives of Individuals Living with Alzheimer’s Disease and Care Partners

    Pagina :346-348

    M.C. Carrillo, M. Moreno

    Mappa Mappa
  • ·Amyloid-targeting New Therapies for Alzheimer’s Disease: A Health Economics Perspective

    Pagina :349-352

    L. Jönsson, Anders Wimo

    Mappa Mappa  

• Editorial

  • ·Clinical Implementation of Lecanemab: Challenges, Questions and Solutions

    Pagina :353-355

    Takeshi Iwatsubo

    
  • ·Appropriate Use Recommendations for Lecanemab

    Pagina :356

    Michael S. Rafii

    
  • ·Lecanemab: Appropriate Use Recommendations — A Commentary from a European Perspective

    Pagina :357-358

    Lutz Frölich, F. Jessen

    
  • ·Implications of Emerging Uses of Genetic Testing for Alzheimer’s Disease

    Pagina :359-361

    Drew Blasco, J.S. Roberts

    Mappa Mappa

• Review

  • ·Lecanemab: Appropriate Use Recommendations

    Pagina :362-377

    J. Cummings, L. Apostolova, G.D. Rabinovici, A. Atri, P. Aisen, S. Greenberg, S. Hendrix, D. Selkoe, M. Weiner, R.C. Petersen, S. Salloway, For the Alzheimer’s Disease and Related Disorders Therapeutics Work Group

    Riassunto Riassunto Mappa Mappa  

• Commentary

  • ·Clinical Efficacy in Individual Patients Treated with Lecanemab

    Pagina :378-379

    Serge Gauthier, J. Therriault, P. Rosa-Neto

     

• Editorial

  • ·Expanding the ATN Framework to Further Personalize Therapies

    Pagina :380

    S. Gauthier, Pedro Rosa-Neto

    

• Special Article

  • ·Adding the Topographical Information from Tau-PET to the A/T/(N) Framework: Steps Towards Staging AD in Vivo

    Pagina :381-386

    J. Therriault, S. Gauthier, Pedro Rosa-Neto

    Riassunto Riassunto Mappa Mappa  

• Review

  • ·White Matter Hyperintensity as a Vascular Contribution to the AT(N) Framework

    Pagina :387-400

    Kok Pin Ng, J.Y. Shen, H.J. Chiew, A.S.L. Ng, N. Kandiah, P. Rosa-Neto, S. Gauthier

    Riassunto Riassunto Mappa Mappa  
  • ·Neuroinflammation Biomarkers in the AT(N) Framework Across the Alzheimer’s Disease Continuum

    Pagina :401-417

    A. Bieger, A. Rocha, B. Bellaver, L. Machado, L. Da Ros, W.V. Borelli, J. Therriault, A.C. Macedo, T.A. Pascoal, S. Gauthier, P. Rosa-Neto, Eduardo R. Zimmer

    Riassunto Riassunto Mappa Mappa  

• CTAD Task Force Paper

  • ·Can We Use Blood Biomarkers as Entry Criteria and for Monitoring Drug Treatment Effects in Clinical Trials? A Report from the EU/US CTAD Task Force

    Pagina :418-425

    D. Angioni, O. Hansson, R.J. Bateman, C. Rabe, M. Toloue, J.B. Braunstein, S. Agus, J.R. Sims, T. Bittner, M.C. Carrillo, H. Fillit, C.L. Masters, S. Salloway, P. Aisen, M. Weiner, B. Vellas, S. Gauthier, EU/US/CTAD Task force, Susan Abushakra, Mohammad Afshar, John Alam, Alicia Algeciras-Schimnich, Sandrine Andrieu, Clive Ballard, Amos Baruch, Richard Batrla, Monika Baudler, Joanne Bell, Sasha Bozeat, Dawn Brooks, Tricia Brooks, Szofia Bullain, Jan Burmeister, Min Cho, Emily Collins, Gavin Cook, Jeffrey Cummings, Chris Dague, Susan De Santi, Rachelle Doody, Billy Dunn, Michael Egan, Sven Eriksson, Rianne Esquivel, Tom Fagan, Phyllis Ferrell, Michela Gallagher, Anna-Kaija Grönblad, Avis Hains, Harald Hampel, Nanco Hefting, Suzanne Hendrix, Carole Ho, Helen Hu, Zahinoor Ismail, Daryl Jones, Gene Kinney, Paul Kinnon, Ricky Kurzman, Lars Lannfelt, John Lawson, Nathalie LeBastard, Valérie Legrand, Nicole Lewandowski, Carine Lim, Costantine Lyketsos, Donna Masterman, Ming Lu, Mark Mintun, José Luis Molinuevo, Cecilia Monteiro, Bradford Navia, Tomas Odergren, Gunilla Osswald, Lewis Penny, Michael Pontecorvo, Anton Porsteinsson, Rema Raman, Gesine Respondek, Larisa Reyderman, Sharon Rogers, Paul Rosenberg, Sharon Rosenzweig-Lipson, Mark Roskey, Rubel Carrie, Ziad Saad, Rachel Schindler, Dennis Selkoe, Melanie Shulman, Kaycee Sink, Lisa Sipe, Daniel Skovronsky, Elizabeth Somers, Maria Soto, Johannes Streffer, Pedro Such, Joyce Suhy, Jacques Touchon, Manu Vandijck, Anne White, David Wilson, Wagner Zago, Jin Zhou

    Riassunto Riassunto Mappa Mappa

• Review

  • ·Diagnostic Biomarkers of Amyloid and Tau Pathology in Alzheimer’s Disease: An Overview of Tests for Clinical Practice in the United States and Europe

    Pagina :426-442

    Leonardo Iaccarino, S.C. Burnham, G. Dell’Agnello, S.A. Dowsett, S. Epelbaum

    Riassunto Riassunto Mappa Mappa   
  • ·Adult Renal Dysfunction and Risk of Dementia or Cognitive Decline: Brain-Kidney Axis Hypothesis Based on a Systematic Review and Meta-Analysis

    Pagina :443-452

    H.-C. Chi, Y. Liu, C.-C. Tan, Y.-C. Zhang, L. Tan, Wei Xu

    Riassunto Riassunto Mappa Mappa   

• Original Research

  • ·Outreach, Screening, and Randomization of APOE ε4 Carriers into an Alzheimer’s Prevention Trial: A global Perspective from the API Generation Program

    Pagina :453-463

    T. Walsh, L. Duff, M. -E. Riviere, P.N. Tariot, K. Doak, M. Smith, B. Borowsky, C. Lopez Lopez, P.C. Arratia, F. Liu, I. Scholten, D. Gordon, J. Arbuckle, A. Graf, M. Quinn, J. Ricart, Jessica Langbaum

    Riassunto Riassunto Mappa Mappa  
  • ·Combined Evidence for a Long-Term, Clinical Slowing Effect of Multinutrient Intervention in Prodromal Alzheimer’s Disease: Post-Hoc Analysis of 3-Year Data from the LipiDiDiet Trial

    Pagina :464-470

    Suzanne B. Hendrix, H. Soininen, A. Solomon, P.J. Visser, A.M.J. van Hees, D.S. Counotte, J. Nicodemus-Johnson, S.P. Dickson, K. Blennow, M. Kivipelto, T. Hartmann, LipiDiDiet clinical study group

    Riassunto Riassunto Mappa Mappa  
  • ·Cohort Effects in Alzheimer’s Disease Trials: An Empirical Assessment Utilizing Data from the Alzheimer’s Disease Cooperative Study

    Pagina :471-477

    Adam I. Birnbaum, J.D. Grill, D.L. Gillen

    Riassunto Riassunto Mappa Mappa   
  • ·Validation of the CogDrisk Instrument as Predictive of Dementia in Four General Community-Dwelling Populations

    Pagina :478-487

    S. Kootar, M.H. Huque, R. Eramudugolla, D. Rizzuto, M.C. Carlson, M.C. Odden, O.L. Lopez, C. Qiu, L. Fratiglioni, S.D. Han, D.A. Bennett, R. Peters, Kaarin J. Anstey

    Riassunto Riassunto Mappa Mappa  
  • ·Usefulness of Community Pharmacy for Early Detection of Cognitive Impairment in Older People Using the IQ-CODE Questionnaire

    Pagina :488-496

    L.F. Agüera Ortiz, G. García-Ribas, F. Jordano Luna, M.C. Porras Álvarez, N. Sánchez Marcos, Begoña Soler López, Grupo de estudio NEURAXCARE

    Riassunto Riassunto Mappa Mappa  
  • ·Physical Activity Is Associated with Slower Cognitive Decline in Older Adults with Type 2 Diabetes

    Pagina :497-502

    Yaacov Rabinowitz, R. Ravona-Springer, A. Heymann, E. Moshier, Y. Berman, J. Schwartz, M. Sano, D. Aisenberg, M. Schnaider-Beeri

    Riassunto Riassunto Mappa Mappa   
  • ·Pushing through the Barriers: Peer Advice to Increase Physical Activity and Reduce Dementia Risk from Participants in a Massive Open Online Alzheimer’s Focused Course

    Pagina :503-512

    M.R. Abela, H. Maxwell, A. Bindoff, J. Alty, M. Farrow, K. Lawler

    Riassunto Riassunto Mappa Mappa  
  • ·Association of Circulating Caprylic Acid with Risk of Mild Cognitive Impairment and Alzheimer’s Disease in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Cohort

    Pagina :513-522

    L. Fan, X. Zhu, A.R. Borenstein, X. Huang, M.J. Shrubsole, L.L. Dugan, Qi Dai

    Riassunto Riassunto Mappa Mappa   
  • ·Association between Neuropsychological Performance and CSF Profile in Subjective Cognitive Decline: Towards the Diagnosis of Preclinical AD

    Pagina :523-529

    E. Chipi, G. Bellomo, N. Salvadori, C. Montanucci, L. Gaetani, F. Paolini Paoletti, Lucilla Parnetti

    Riassunto Riassunto Mappa Mappa   
  • ·Reproductive Markers in Alzheimer’s Disease Progression: The Framingham Heart Study

    Pagina :530-535

    Huitong Ding, Y. Li, T.F.A. Ang, Y. Liu, S. Devine, R. Au, P.M. Doraiswamy, Chunyu Liu

    Riassunto Riassunto Mappa Mappa   
  • ·A Genetic Validation of the Neurodegeneration Biomarkers Tau-A and Tau-C - A Mendelian Randomization Study

    Pagina :536-542

    T.M. Axelsen, C. Bager, A. Bihlet, M.A. Karsdal, K. Henriksen, M.H.E. Tang

    Riassunto Riassunto Mappa Mappa  
  • ·Association between Longitudinal Cerebrospinal Fluid Alzheimer’s Biomarkers and the Lifestyle for Brain Health (LIBRA) Index: Findings from the European Prevention of Alzheimer’s Dementia Cohort Study (EPAD LCS)

    Pagina :543-550

    Tyler S. Saunders, M. Protsiv, N.D. Jenkins, A. Solomon, K. Blennow, C. Ritchie, G. Muniz-Terrera

    Riassunto Riassunto Mappa Mappa  
  • ·Understanding Online Registry Facilitators and Barriers Experienced by Black Brain Health Registry Participants: The Community Engaged Digital Alzheimer’s Research (CEDAR) Study

    Pagina :551-561

    Miriam T. Ashford, D. Zhu, J. Bride, E. McLean, A. Aaronson, C. Conti, C. Cypress, P. Griffin, R. Ross, T. Duncan, X. Deng, A. Ulbricht, J. Fockler, M.R. Camacho, D. Flenniken, D. Truran, S.R. Mackin, C. Hill, M.W. Weiner, D. Byrd, R.W. Turner, H. Cham, M. Rivera Mindt, R.L. Nosheny

    Riassunto Riassunto Mappa Mappa  
  • ·Subjective Cognitive Complaints: Comparing the Relation between Self-Reported Versus Informant-Reported Subjective Cognitive Complaints and Cognitive Performances in Cognitively Unimpaired, Mild Cognitive Impairment and Populations with Dementia

    Pagina :562-570

    S.-W. Peng, C.-Y. Wang, S.-Y. Lin, Y.-L. Lee, Y.-C. Lin, Y.-J. Lin, Pei-Ning Wang

    Riassunto Riassunto Mappa Mappa   
  • ·Chinese Preclinical Alzheimer’s Disease Study (C-PAS): Design and Challenge from PET Acceptance

    Pagina :571-580

    L. Cui, L. Huang, F.-F. Pan, Y. Wang, Q. Huang, Y.-H. Guan, C-Y.Z. Lo, Y.-H. Guo, Agnes Suiyin Chan, Fang Xie, Qihao Guo

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  • ·Neuroprotective Effects of IVIG against Alzheimer’s Disease via Regulation of Antigen Processing and Presentation by MHC Class I Molecules in 3xTg-AD Mice

    Pagina :581-594

    Z. Fei, B. Pan, R. Pei, S. Ye, Z. Wang, L. Ma, R. Zhang, C. Li, Xi Du, Haijun Cao

    Riassunto Riassunto Mappa Mappa   

• Brief Report

  • ·‘Time Saved’ As a Demonstration of Clinical Meaningfulness and Illustrated Using the Donanemab TRAILBLAZER-ALZ Study Findings

    Pagina :595-599

    S.P. Dickson, Alette M. Wessels, S.A. Dowsett, C. Mallinckrodt, J.D. Sparks, S. Chatterjee, S. Hendrix

    Riassunto Riassunto Mappa Mappa  
  • ·Ten Years after the National Alzheimer’s Plan: Dementia Remains a Hidden Syndrome in France

    Pagina :600-606

    J.-F. Dartigues, J.A. Avila-Funes, L. Letenneur, C. Meillon, C. Helmer, H. Amieva, Karine Pérès

    Riassunto Riassunto Mappa Mappa  

• Brief Communication

  • ·Associations between Participant Characteristics and Participant Feedback about an Unsupervised Online Cognitive Assessment in a Research Registry

    Pagina :607-614

    Miriam T. Ashford, J. Eichenbaum, C. Jin, J. Neuhaus, A. Aaronson, A. Ulbricht, M.R. Camacho, J. Fockler, D. Flenniken, D. Truran, R.S. Mackin, P. Maruff, M.W. Weiner, R.L. Nosheny

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