Sommario

• Point of View

  • ·Revisiting the Cholinergic Hypothesis in Alzheimer’s Disease: Emerging Evidence from Translational and Clinical Research

    Pagina :2-15

    Harald Hampel, M.-M. Mesulam, A.C. Cuello, A.S. Khachaturian, A. Vergallo, M.R. Farlow, P.J. Snyder, E. Giacobini, Z.S. Khachaturian, Cholinergic System Working Group, and for the Alzheimer Precision Medicine Initiative (APMI)

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• Original Research

  • ·Polygenic Risk Score Analysis of Alzheimer’s Disease in Cases without APOE4 or APOE2 Alleles

    Pagina :16-19

    V. Escott-Price, A. Myers, M. Huentelman, M. Shoai, John Hardy

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  • ·Designing Trials of Disease Modifying Agents for Early and Preclinical Alzheimer’s Disease Intervention: What Evidence is Meaningful to Patients, Providers, and Payers?

    Pagina :20-26

    Donna A. Messner, P. Rabins, A.C. Downing, M. Irizarry, N.L. Foster, J. Al Naber, O. Dabbous, H. Fillit, S. Gabler, R. Krakauer, D. Lotz, E. Payzant, L. Schneider, J. Tyrone, D. Van Amerongen, D. Wuest

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  • ·Pimavanserin in Alzheimer’s Disease Psychosis: Efficacy in Patients with More Pronounced Psychotic Symptoms

    Pagina :27-33

    Clive Ballard, J.M. Youakim, B. Coate, S. Stankovic

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  • ·Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer’s Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study

    Pagina :34-41

    V. Pérez-Grijalba, J. Romero, Pedro Pesini, L. Sarasa, I. Monleón, I. San-José, J. Arbizu, P. Martínez-Lage, J. Munuera, A. Ruiz, L. Tárraga, M. Boada, M. Sarasa, The AB255 Study Group

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  • ·Treatable Vascular Risk and Cognitive Performance in Persons Aged 35 Years or Older: Longitudinal Study of Six Years

    Pagina :42-49

    Marlise E.A. van Eersel, H. Joosten, R.T. Gansevoort, J.P.J. Slaets, G.J. Izaks

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  • ·Diet as a Risk Factor for Cognitive Decline in African Americans and Caucasians with a Parental History of Alzheimer’s Disease: A Cross-Sectional Pilot Study Dietary Patterns

    Pagina :50-55

    A.C. Nutaitis, S.D. Tharwani, M.C. Serra, F.C. Goldstein, L. Zhao, S.S. Sher, D.D. Verble, Whitney Wharton

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  • ·Increased Functional Connectivity After Listening to Favored Music in Adults With Alzheimer Dementia

    Pagina :56-62

    J.B. King, K.G. Jones, E. Goldberg, M. Rollins, K. MacNamee, C. Moffit, S.R. Naidu, M.A. Ferguson, E. Garcia-Leavitt, J. Amaro, K.R. Breitenbach, J.M. Watson, R.K. Gurgel, Jeffrey S. Anderson, N.L. Foster

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• Review

  • ·AADvac1, an Active Immunotherapy for Alzheimer’s Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development

    Pagina :63-69

    P. Novak, N. Zilka, M. Zilkova, B. Kovacech, R. Skrabana, M. Ondrus, L. Fialova, E. Kontsekova, M. Otto, M. Novak

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• Short Communication

  • ·Bifidobacterium Breve A1 Supplementation Improved Cognitive Decline in Older Adults with Mild Cognitive Impairment: An Open-Label, Single-Arm Study

    Pagina :70-75

    Yodai Kobayashi, T. Kinoshita, A. Matsumoto, K. Yoshino, I. Saito, J.-Z. Xiao

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