Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :3A

    
• • ·Table of Contents

    Pagina :6A

    
• • ·Editorial Board

    Pagina :27A

    

• Reader services

  • ·Information for Readers

    Pagina :28A

    
  • ·News & Notes

    Pagina :30A

    Mappa Mappa
  • ·CME Activities Calendar

    Pagina :34A

    Mappa Mappa

• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :1-2

    Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson

    Mappa Mappa  

• Reviews and feature articles

  • ·Asthma across the ages: Knowledge gaps in childhood asthma

    Pagina :3-13

    Stanley J. Szefler, James F. Chmiel, Anne M. Fitzpatrick, George Giacoia, Thomas P. Green, Daniel J. Jackson, Heber C. Nielsen, Wanda Phipatanakul, Hengameh H. Raissy

    Riassunto Riassunto Mappa Mappa  
  • ·Asthma across the ages: Knowledge gaps in childhood asthma

    Pagina :14-15

    
  • ·Pharmacogenetics: Implications of race and ethnicity on defining genetic profiles for personalized medicine

    Pagina :16-26

    Victor E. Ortega, Deborah A. Meyers

    Riassunto Riassunto Mappa Mappa  
  • ·Researching asthma across the ages: Insights from the National Heart, Lung, and Blood Institute’s Asthma Network

    Pagina :27-33

    Michael D. Cabana, Susan J. Kunselman, Sharmilee M. Nyenhuis, Michael E. Wechsler

    Riassunto Riassunto Mappa Mappa
  • ·Designing clinical trials to address the needs of childhood and adult asthma: The National Heart, Lung, and Blood Institute's AsthmaNet

    Pagina :34

    E. Rand Sutherland, William W. Busse, National Heart, Lung, and Blood Institute's AsthmaNet ?

    Riassunto Riassunto Mappa Mappa
  • ·Combination corticosteroid/?-agonist inhaler as reliever therapy: A solution for intermittent and mild asthma?

    Pagina :39-41

    Richard Beasley, Mark Weatherall, Philippa Shirtcliffe, Robert Hancox, Helen K. Reddel

    Riassunto Riassunto
  • ·Differences in asthma genetics between Chinese and other populations

    Pagina :42-48

    Ting F. Leung, Fanny W.S. Ko, Hing Y. Sy, Stephen K.W. Tsui, Gary W.K. Wong

    Riassunto Riassunto Mappa Mappa  
  • ·Advances in adult asthma diagnosis and treatment in 2013

    Pagina :49-56

    Andrea J. Apter

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors' choice

    Pagina :57-58

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

    Mappa Mappa  

• Asthma and lower airway disease

  • ·Parental psychological distress during pregnancy and wheezing in preschool children: The Generation R Study

    Pagina :59

    Mònica Guxens, Agnes M.M. Sonnenschein–van der Voort, Henning Tiemeier, Albert Hofman, Jordi Sunyer, Johan C. de Jongste, Vincent W.V. Jaddoe, Liesbeth Duijts

    Riassunto Riassunto Mappa Mappa  
  • ·Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes

    Pagina :68

    Marjan Kerkhof, H. Marike Boezen, Raquel Granell, Alet H. Wijga, Bert Brunekreef, Henriëtte A. Smit, Johan C. de Jongste, Carel Thijs, Monique Mommers, John Penders, John Henderson, Gerard H. Koppelman, Dirkje S. Postma

    Riassunto Riassunto Mappa Mappa  
  • ·A simulation model of building intervention impacts on indoor environmental quality, pediatric asthma, and costs

    Pagina :77-84

    Maria Patricia Fabian, Gary Adamkiewicz, Natasha Kay Stout, Megan Sandel, Jonathan Ian Levy

    Riassunto Riassunto Mappa Mappa   
  • ·Neonatal health of infants born to mothers with asthma

    Pagina :85

    Pauline Mendola, Tuija I. Männistö, Kira Leishear, Uma M. Reddy, Zhen Chen, S. Katherine Laughon

    Riassunto Riassunto Mappa Mappa  
  • ·Validation and psychometric properties of the Asthma Control Questionnaire among children

    Pagina :91

    Jessica M. Nguyen, Janet T. Holbrook, Christine Y. Wei, Lynn B. Gerald, W. Gerald Teague, Robert A. Wise, American Lung Association Asthma Clinical Research Centers

    Riassunto Riassunto Mappa Mappa  
  • ·Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis

    Pagina :98

    Grazyna Bochenek, Joanna Kuschill-Dziurda, Krystyna Szafraniec, Hanna Plutecka, Andrzej Szczeklik, Ewa Nizankowska-Mogilnicka

    Riassunto Riassunto Mappa Mappa  
  • ·Can an airway challenge test predict respiratory diseases? A population-based international study

    Pagina :104

    Alessandro Marcon, Isa Cerveri, Matthias Wjst, Josep Antó, Joachim Heinrich, Christer Janson, Deborah Jarvis, Bénédicte Leynaert, Nicole Probst-Hensch, Cecilie Svanes, Kjell Toren, Peter Burney, Roberto de Marco

    Riassunto Riassunto Mappa Mappa  
  • ·A simple asthma prediction tool for preschool children with wheeze or cough

    Pagina :111

    Anina M. Pescatore, Cristian M. Dogaru, Lutz Duembgen, Michael Silverman, Erol A. Gaillard, Ben D. Spycher, Claudia E. Kuehni

    Riassunto Riassunto Mappa Mappa  
  • ·Predicting the future for recurrent respiratory symptoms in young children: Applying a dash of science to the art of medicine

    Pagina :119-120

    Stephen Turner

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Efficacy of a short course of specific immunotherapy in patients with allergic rhinoconjunctivitis to ragweed pollen

    Pagina :121

    Piyush Patel, Tom Holdich, Karl J. Fischer von Weikersthal-Drachenberg, Birgit Huber

    Riassunto Riassunto Mappa Mappa  
  • ·Grass tablet sublingual immunotherapy downregulates the T_H2 cytokine response followed by regulatory T-cell generation

    Pagina :130

    Abel Suárez-Fueyo, Tania Ramos, Agustín Galán, Lucia Jimeno, Peter A. Wurtzen, Alicia Marin, Consolación de Frutos, Carlos Blanco, Ana C. Carrera, Domingo Barber, Rosa Varona

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and skin disease

  • ·Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression

    Pagina :139

    Atsushi Otsuka, Hiromi Doi, Gyohei Egawa, Akiko Maekawa, Tomoko Fujita, Satoshi Nakamizo, Chisa Nakashima, Saeko Nakajima, Takeshi Watanabe, Yoshiki Miyachi, Shuh Narumiya, Kenji Kabashima

    Riassunto Riassunto Mappa Mappa  
  • ·Cord serum 25-hydroxyvitamin D and risk of early childhood transient wheezing and atopic dermatitis

    Pagina :147-153

    Nour Baïz, Patricia Dargent-Molina, John D. Wark, Jean-Claude Souberbielle, Isabella Annesi-Maesano, EDEN Mother-Child Cohort Study Group

    Riassunto Riassunto Mappa Mappa  
  • ·Vitamin D status at birth: An important and potentially modifiable determinant of atopic disease in childhood?

    Pagina :154-155

    Leonard B. Bacharier

    

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Allergen reference doses for precautionary labeling (VITAL 2.0): Clinical implications

    Pagina :156-164

    Katrina J. Allen, Benjamin C. Remington, Joseph L. Baumert, Rene W.R. Crevel, Geert F. Houben, Simon Brooke-Taylor, Astrid G. Kruizinga, Steve L. Taylor

    Riassunto Riassunto Mappa Mappa   
  • ·Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases

    Pagina :165

    Randi J. Bertelsen, Anne Lise Brantsæter, Maria C. Magnus, Margaretha Haugen, Ronny Myhre, Bo Jacobsson, Matthew P. Longnecker, Helle M. Meltzer, Stephanie J. London

    Riassunto Riassunto Mappa Mappa  

• Immune deficiencies, infection, and systemic immune disorders

  • ·High-content cytometry and transcriptomic biomarker profiling of human B-cell activation

    Pagina :172

    Christian Hennig, Claudia Ilginus, Kaan Boztug, Julia Skokowa, Laszlo Marodi, Anna Szaflarska, Mareike Sass, Claudio Pignata, Sara Sebnem Kilic, Isabel Caragol, Ulrich Baumann, Christoph Klein, Karl Welte, Gesine Hansen

    Riassunto Riassunto Mappa Mappa  
  • ·Intravenous immunoglobulin induces a functional silencing program similar to anergy in human B cells

    Pagina :181

    Jean-François Séïté, Carole Goutsmedt, Pierre Youinou, Jacques-Olivier Pers, Sophie Hillion

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·CD11a polymorphisms regulate T_H2 cell homing and T_H2-related disease

    Pagina :189

    John M. Knight, Seung-Hyo Lee, Luz Roberts, C. Wayne Smith, Scott T. Weiss, Farrah Kheradmand, David B. Corry

    Riassunto Riassunto Mappa Mappa  
  • ·The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell–driven immune responses in the setting of allergic asthma

    Pagina :198

    Caroline Übel, Nina Sopel, Anna Graser, Kai Hildner, Cornelia Reinhardt, Theodor Zimmermann, Ralf Joachim Rieker, Anja Maier, Markus F. Neurath, Kenneth M. Murphy, Susetta Finotto

    Riassunto Riassunto Mappa Mappa  
  • ·Identification of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease

    Pagina :207

    Kirandeep K. Chana, Peter S. Fenwick, Andrew G. Nicholson, Peter J. Barnes, Louise E. Donnelly

    Riassunto Riassunto Mappa Mappa  
  • ·T cell–derived microvesicles induce mast cell production of IL-24: Relevance to inflammatory skin diseases

    Pagina :217

    Irit Shefler, Metsada Pasmanik-Chor, Dvora Kidron, Yoseph A. Mekori, Alon Y. Hershko

    Riassunto Riassunto Mappa Mappa  
  • ·Prenatal alcohol exposure and childhood atopic disease: A Mendelian randomization approach

    Pagina :225

    Seif O. Shaheen, Clare Rutterford, Luisa Zuccolo, Susan M. Ring, George Davey Smith, John W. Holloway, A. John Henderson

    Riassunto Riassunto Mappa Mappa
  • ·Real-time differential tracking of human neutrophil and eosinophil migration in vivo

    Pagina :233

    Joanna J. Lukawska, Lefteris Livieratos, Barbara M. Sawyer, Tak Lee, Michael O'Doherty, Philip J. Blower, Martin Kofi, James R. Ballinger, Christopher J. Corrigan, Gopinath Gnanasegaran, Ehsan Sharif-Paghaleh, Gregory E.D. Mullen

    Riassunto Riassunto Mappa Mappa   
  • ·Mice deficient in the St3gal3 gene product ?2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation

    Pagina :240

    Takumi Kiwamoto, Mary E. Brummet, Fan Wu, Mary G. Motari, David F. Smith, Ronald L. Schnaar, Zhou Zhu, Bruce S. Bochner

    Riassunto Riassunto Mappa Mappa  
  • ·Genome-wide association study of lung function phenotypes in a founder population

    Pagina :248

    Tsung-Chieh Yao, Gaixin Du, Lide Han, Ying Sun, Donglei Hu, James J. Yang, Rasika Mathias, Lindsey A. Roth, Nicholas Rafaels, Emma E. Thompson, Dagan A. Loisel, Rebecca Anderson, Celeste Eng, Maitane Arruabarrena Orbegozo, Melody Young, James M. Klocksieben, Elizabeth Anderson, Kathleen Shanovich, Lucille A. Lester, L. Keoki Williams, Kathleen C. Barnes, Esteban G. Burchard, Dan L. Nicolae, Mark Abney, Carole Ober

    Riassunto Riassunto Mappa Mappa  

• Letters to the Editor

  • ·Human bocavirus 1 may suppress rhinovirus-associated immune response in wheezing children

    Pagina :256

    Heikki Lukkarinen, Maria Söderlund-Venermo, Tytti Vuorinen, Tobias Allander, Klaus Hedman, Olli Simell, Olli Ruuskanen, Tuomas Jartti

     
  • ·Children with severe asthma have unique oxidative stress–associated metabolomic profiles

    Pagina :258

    Anne M. Fitzpatrick, Youngja Park, Lou Ann S. Brown, Dean P. Jones

     
  • ·Urinary metabolomic changes as a predictive biomarker of asthma exacerbation

    Pagina :261

    Claudia Chaves Loureiro, Iola F. Duarte, Joana Gomes, Joana Carrola, António S. Barros, Ana M. Gil, Jean Bousquet, Ana Todo Bom, Sílvia M. Rocha

     
  • ·Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction

    Pagina :263

    Arthur F. Gelb, Alfred Yamamoto, Thais Mauad, Jozef Kollin, Mark J. Schein, Jay A. Nadel

     
  • ·Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation

    Pagina :265-267

    Peter D. Arkwright, Philip Riley, Stephen M. Hughes, Hana Alachkar, Robert F. Wynn

     
  • ·Phenotypic differences between IgG₄⁺ and IgG₁⁺ B cells point to distinct regulation of the IgG₄ response

    Pagina :267

    Laura C. Lighaam, Ellen Vermeulen, Tamara den Bleker, Kimberley J. Meijlink, Rob C. Aalberse, Eleanor Barnes, Emma L. Culver, S. Marieke van Ham, Theo Rispens

     
  • ·Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting Fc?RI-mediated mast cell activation

    Pagina :270

    Kumi Izawa, Masamichi Isobe, Toshihiro Matsukawa, Shinichi Ito, Akie Maehara, Mariko Takahashi, Yoshinori Yamanishi, Ayako Kaitani, Toshihiko Oki, Ko Okumura, Toshio Kitamura, Jiro Kitaura

     
  • ·Replication study of genetic variants associated with chronic rhinosinusitis and nasal polyposis

    Pagina :273-275

    Viktor Henmyr, Griet Vandeplas, Christer Halldén, Torbjörn Säll, Heidi Olze, Claus Bachert, Lars Olaf Cardell

     
  • ·Suppressor of cytokine signaling 3 expression is diminished in sinonasal tissues from patients with chronic rhinosinusitis with nasal polyps

    Pagina :275

    Kathryn E. Hulse, Katrina Chaung, Sudarshan Seshadri, Lydia Suh, James E. Norton, Roderick G. Carter, Robert C. Kern, David B. Conley, Rakesh K. Chandra, Bruce K. Tan, Anju T. Peters, Leslie C. Grammer, Kathleen E. Harris, Troy R. Torgerson, Atsushi Kato, Robert P. Schleimer

     
  • ·Differential homeostatic dynamics of human regulatory T-cell subsets following neonatal thymectomy

    Pagina :277

    Alvin W.L. Schadenberg, Theo van den Broek, Marten A. Siemelink, Selma O. Algra, Petrus R. de Jong, Nicolaas J.G. Jansen, Berent J. Prakken, Femke van Wijk

     
  • ·South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin

    Pagina :280

    Fatemah Thawer-Esmail, Ivone Jakasa, Gail Todd, Yaran Wen, Sara J. Brown, Karin Kroboth, Linda E. Campbell, Grainne M. O'Regan, W.H. Irwin McLean, Alan D. Irvine, Sanja Kezic, Aileen Sandilands

     

• Correspondence

  • ·Major rabbit allergen Ory c 3: What could be its possible role as a sensitizing agent in real life?

    Pagina :283-284

    Gennaro Liccardi, Antonello Salzillo, Maria Russo, Giuseppe Esposito, Annabella Liccardi, Gennaro D'Amato

     
  • ·Reply

    Pagina :284-285

    Christiane Hilger, Stéphanie Kler, François Hentges

    

• Maintenance of Certification clinical management series

  • ·Evidence-based approach to aspirin desensitization in aspirin-exacerbated respiratory disease

    Pagina :286

    Katharine M. Woessner, Andrew A. White

    Mappa Mappa