Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :3A

    
• • ·Table of Contents

    Pagina :6A

    
• • ·Editorial Board

    Pagina :24A

    

• Reader services

  • ·Information for Readers

    Pagina :26A

    
  • ·News & Notes

    Pagina :28A

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  • ·CME Activities Calendar

    Pagina :32A

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :289-290

    Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson

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• Reviews and feature articles

  • ·Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

    Pagina :291

    Scott H. Sicherer, Hugh A. Sampson

    Riassunto Riassunto Mappa Mappa  
  • ·Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

    Pagina :308

    
  • ·Food allergy: Insights into etiology, prevention, and treatment provided by murine models

    Pagina :309-317

    Michiko K. Oyoshi, Hans C. Oettgen, Talal A. Chatila, Raif S. Geha, Paul J. Bryce

    Riassunto Riassunto Mappa Mappa  
  • ·State of the art on food allergen immunotherapy: Oral, sublingual, and epicutaneous

    Pagina :318-323

    Stacie M. Jones, A. Wesley Burks, Christophe Dupont

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  • ·Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2013

    Pagina :324-334

    Scott H. Sicherer, Donald Y.M. Leung

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  • ·Primary Immune Deficiency Treatment Consortium (PIDTC) report

    Pagina :335

    Linda M. Griffith, Morton J. Cowan, Luigi D. Notarangelo, Donald B. Kohn, Jennifer M. Puck, Sung-Yun Pai, Barbara Ballard, Sarah C. Bauer, Jack J.H. Bleesing, Marcia Boyle, Amy Brower, Rebecca H. Buckley, Mirjam van der Burg, Lauri M. Burroughs, Fabio Candotti, Andrew J. Cant, Talal Chatila, Charlotte Cunningham-Rundles, Mary C. Dinauer, Christopher C. Dvorak, Alexandra H. Filipovich, Thomas A. Fleisher, Hubert Bobby Gaspar, Tayfun Gungor, Elie Haddad, Emily Hovermale, Faith Huang, Alan Hurley, Mary Hurley, Sumathi Iyengar, Elizabeth M. Kang, Brent R. Logan, Janel R. Long-Boyle, Harry L. Malech, Sean A. McGhee, Fred Modell, Vicki Modell, Hans D. Ochs, Richard J. O'Reilly, Robertson Parkman, David J. Rawlings, John M. Routes, William T. Shearer, Trudy N. Small, Heather Smith, Kathleen E. Sullivan, Paul Szabolcs, Adrian Thrasher, Troy R. Torgerson, Paul Veys, Kenneth Weinberg, Juan Carlos Zuniga-Pflucker, workshop participants

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• The Editors' choice

  • ·The Editors' Choice

    Pagina :348-349

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

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• Asthma and lower airway disease

  • ·Predictors of asthma control and lung function responsiveness to step 3 therapy in children with uncontrolled asthma

    Pagina :350-356

    Nathan Rabinovitch, David T. Mauger, Nichole Reisdorph, Ronina Covar, Jonathan Malka, Robert F. Lemanske, Wayne J. Morgan, Theresa W. Guilbert, Robert S. Zeiger, Leonard B. Bacharier, Stanley J. Szefler

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  • ·Prematurity, atopy, and childhood asthma in Puerto Ricans

    Pagina :357

    Christian Rosas-Salazar, Sima K. Ramratnam, John M. Brehm, Yueh-Ying Han, Nadia Boutaoui, Erick Forno, Edna Acosta-Pérez, María Alvarez, Angel Colón-Semidey, Glorisa Canino, Juan C. Celedón

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  • ·Childhood asthma clusters and response to therapy in clinical trials

    Pagina :363

    Timothy S. Chang, Robert F. Lemanske, David T. Mauger, Anne M. Fitzpatrick, Christine A. Sorkness, Stanley J. Szefler, Ronald E. Gangnon, C. David Page, Daniel J. Jackson, Childhood Asthma Research and Education (CARE) Network Investigators

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  • ·A genome-wide association study of bronchodilator response in Latinos implicates rare variants

    Pagina :370

    Katherine A. Drake, Dara G. Torgerson, Christopher R. Gignoux, Joshua M. Galanter, Lindsey A. Roth, Scott Huntsman, Celeste Eng, Sam S. Oh, Sook Wah Yee, Lawrence Lin, Carlos D. Bustamante, Andrés Moreno-Estrada, Karla Sandoval, Adam Davis, Luisa N. Borrell, Harold J. Farber, Rajesh Kumar, Pedro C. Avila, Emerita Brigino-Buenaventura, Rocio Chapela, Jean G. Ford, Michael A. LeNoir, Fred Lurmann, Kelley Meade, Denise Serebrisky, Shannon Thyne, William Rodríguez-Cintrón, Saunak Sen, José R. Rodríguez-Santana, Ryan D. Hernandez, Kathleen M. Giacomini, Esteban G. Burchard

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  • ·Prostaglandin E₂ suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells

    Pagina :379

    Zbigniew Zas?ona, Katsuhide Okunishi, Emilie Bourdonnay, Racquel Domingo-Gonzalez, Bethany B. Moore, Nicholas W. Lukacs, David M. Aronoff, Marc Peters-Golden

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  • ·Measures of gene expression in sputum cells can identify T_H2-high and T_H2-low subtypes of asthma

    Pagina :388

    Michael C. Peters, Zesemayat K. Mekonnen, Shaopeng Yuan, Nirav R. Bhakta, Prescott G. Woodruff, John V. Fahy

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  • ·Asthma phenotyping: T_H2-high, T_H2-low, and beyond

    Pagina :395-396

    Peter J. Sterk, René Lutter

    
  • ·Validation studies of asthma patient-reported outcomes: “We want more!”

    Pagina :397-398

    Christine A. Sorkness

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Associations between serum folate and vitamin D levels and incident mouse sensitization in adults

    Pagina :399-404

    Corinne A. Keet, Wayne G. Shreffler, Roger D. Peng, William Matsui, Elizabeth C. Matsui

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  • ·Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial

    Pagina :405-413

    Raakel Luoto, Olli Ruuskanen, Matti Waris, Marko Kalliomäki, Seppo Salminen, Erika Isolauri

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  • ·Efficacy of the oral chemoattractant receptor homologous molecule on T_H2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis

    Pagina :414

    Norbert Krug, Abhya Gupta, Philipp Badorrek, Ruediger Koenen, Meike Mueller, Anna Pivovarova, James Hilbert, Kristiane Wetzel, Jens M. Hohlfeld, Chester Wood

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  • ·The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps

    Pagina :420

    Yi Wei, Wentong Xia, Xingling Ye, Yunping Fan, Jianbo Shi, Weiping Wen, Pingchang Yang, Huabin Li, Nasal Health Group, China (NHGC)

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• Atopic dermatitis and skin disease

  • ·Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: A systematic review

    Pagina :429-438

    Evelien Roekevisch, Phyllis Ira Spuls, Denise Kuester, Jacqueline Limpens, Jochen Schmitt

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  • ·Transcutaneous yellow fever vaccination of subjects with or without atopic dermatitis

    Pagina :439-447

    Mark K. Slifka, Donald Y.M. Leung, Erika Hammarlund, Hans-Peter Raué, Eric L. Simpson, Susan Tofte, Shahana Baig-Lewis, Gloria David, Henry Lynn, Rob Woolson, Tissa Hata, Henry Milgrom, Jon Hanifin

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  • ·A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

    Pagina :448

    Ferda Cevikbas, Xidao Wang, Tasuku Akiyama, Cordula Kempkes, Terhi Savinko, Attila Antal, Gabriela Kukova, Timo Buhl, Akihiko Ikoma, Joerg Buddenkotte, Vassili Soumelis, Micha Feld, Harri Alenius, Stacey R. Dillon, Earl Carstens, Bernhard Homey, Allan Basbaum, Martin Steinhoff

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• Food, drug, insect sting allergy, and anaphylaxis

  • ·Anaphylaxis in America: The prevalence and characteristics of anaphylaxis in the United States

    Pagina :461-467

    Robert A. Wood, Carlos A. Camargo, Philip Lieberman, Hugh A. Sampson, Lawrence B. Schwartz, Myron Zitt, Charlotte Collins, Michael Tringale, Marilyn Wilkinson, John Boyle, F. Estelle R. Simons

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  • ·Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy

    Pagina :468

    Brian P. Vickery, Amy M. Scurlock, Michael Kulis, Pamela H. Steele, Janet Kamilaris, Jelena P. Berglund, Caitlin Burk, Anne Hiegel, Suzanna Carlisle, Lynn Christie, Tamara T. Perry, Robbie D. Pesek, Saira Sheikh, Yamini Virkud, P. Brian Smith, Mohamed H. Shamji, Stephen R. Durham, Stacie M. Jones, A. Wesley Burks

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  • ·Population response to change in infant feeding guidelines for allergy prevention

    Pagina :476-484

    Dean Tey, Katrina J. Allen, Rachel L. Peters, Jennifer J. Koplin, Mimi L.K. Tang, Lyle C. Gurrin, Anne-Louise Ponsonby, Adrian J. Lowe, Melissa Wake, Shyamali C. Dharmage, HealthNuts study investigators

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  • ·The natural history and clinical predictors of egg allergy in the first 2 years of life: A prospective, population-based cohort study

    Pagina :485

    Rachel L. Peters, Shyamali C. Dharmage, Lyle C. Gurrin, Jennifer J. Koplin, Anne-Louise Ponsonby, Adrian J. Lowe, Mimi L.K. Tang, Dean Tey, Marnie Robinson, David Hill, Helen Czech, Leone Thiele, Nicholas J. Osborne, Katrina J. Allen, HealthNuts study

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  • ·The natural history of egg allergy in an observational cohort

    Pagina :492

    Scott H. Sicherer, Robert A. Wood, Brian P. Vickery, Stacie M. Jones, Andrew H. Liu, David M. Fleischer, Peter Dawson, Lloyd Mayer, A. Wesley Burks, Alexander Grishin, Donald Stablein, Hugh A. Sampson

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  • ·Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

    Pagina :500

    Aleena Syed, Marco A. Garcia, Shu-Chen Lyu, Robert Bucayu, Arunima Kohli, Satoru Ishida, Jelena P. Berglund, Mindy Tsai, Holden Maecker, Gerri O’Riordan, Stephen J. Galli, Kari C. Nadeau

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  • ·Diet and food allergy development during infancy: Birth cohort study findings using prospective food diary data

    Pagina :511-519

    Kate E.C. Grimshaw, Joe Maskell, Erin M. Oliver, Ruth C.G. Morris, Keith D. Foote, E.N. Clare Mills, Barrie M. Margetts, Graham Roberts

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  • ·Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM

    Pagina :520

    Iván Álvarez-Twose, Roberta Zanotti, David González-de-Olano, Patrizia Bonadonna, Arantza Vega, Almudena Matito, Laura Sánchez-Muñoz, José Mário Morgado, Omar Perbellini, Andrés García-Montero, Giovanna De Matteis, Cristina Teodósio, Maurizio Rossini, María Jara-Acevedo, Donatella Schena, Andrea Mayado, Alberto Zamò, Manuela Mollejo, Paula Sánchez-López, Nieves Cabañes, Alberto Orfao, Luis Escribano, Spanish Network on Mastocytosis (REMA) and theItalian Network on Mastocytosis (RIMA), Italian Network on Mastocytosis (RIMA)

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• Immune deficiencies, infection, and systemic immune disorders

  • ·Targeted next-generation sequencing: A novel diagnostic tool for primary immunodeficiencies

    Pagina :529

    Isaac J. Nijman, Joris M. van Montfrans, Marlous Hoogstraat, Marianne L. Boes, Lisette van de Corput, Ellen D. Renner, Patrick van Zon, Stef van Lieshout, Martin G. Elferink, Mirjam van der Burg, Clementien L. Vermont, Bert van der Zwaag, Esther Janson, Edwin Cuppen, Johannes K. Ploos van Amstel, Marielle E. van Gijn

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  • ·Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency

    Pagina :535-542

    Paul J. Maglione, Huaibin M. Ko, Mary B. Beasley, James A. Strauchen, Charlotte Cunningham-Rundles

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• Mechanisms of allergy and clinical immunology

  • ·Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers

    Pagina :543

    Gunda Herberth, Mario Bauer, Michaela Gasch, Denise Hinz, Stefan Röder, Sven Olek, Tibor Kohajda, Ulrike Rolle-Kampczyk, Martin von Bergen, Ulrich Sack, Michael Borte, Irina Lehmann, Lifestyle and Environmental Factors and Their Influence on Newborns Allergy Risk study group

    Riassunto Riassunto Mappa Mappa  
  • ·Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood

    Pagina :551

    Anna Lluis, Martin Depner, Beatrice Gaugler, Philippe Saas, Vera Isabel Casaca, Diana Raedler, Sven Michel, Jorg Tost, Jing Liu, Jon Genuneit, Petra Pfefferle, Marjut Roponen, Juliane Weber, Charlotte Braun-Fahrländer, Josef Riedler, Roger Lauener, Dominique Angèle Vuitton, Jean-Charles Dalphin, Juha Pekkanen, Erika von Mutius, Bianca Schaub

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  • ·Neuronal chemorepellent Semaphorin 3E inhibits human airway smooth muscle cell proliferation and migration

    Pagina :560

    Hesam Movassagh, Lianyu Shan, Andrew J. Halayko, Michael Roth, Michael Tamm, Jamila Chakir, Abdelilah S. Gounni

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  • ·Circadian regulation of allergic reactions by the mast cell clock in mice

    Pagina :568

    Yuki Nakamura, Nobuhiro Nakano, Kayoko Ishimaru, Mutsuko Hara, Takako Ikegami, Yu Tahara, Ryohei Katoh, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Chiharu Nishiyama, Atsuhito Nakao

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• Letters to the Editor

  • ·Prevalence and characteristics of eosinophilic esophagitis in 2 ethnically distinct pediatric populations

    Pagina :576-577

    Rupinder K. Gill, Awni Al-Subu, Yoram Elitsur, Raavi Gupta, William R. Treem, Simon Rabinowitz, Steven M. Schwarz

     
  • ·Correlation of increased PARP14 and CCL26 expression in biopsies from children with eosinophilic esophagitis

    Pagina :577

    Purna Krishnamurthy, Joseph D. Sherrill, Kalyan Parashette, Shreevrat Goenka, Marc E. Rothenberg, Sandeep Gupta, Mark H. Kaplan

     
  • ·Childhood-to-adolescence evolution of IgE antibodies to pollens and plant foods in the BAMSE cohort

    Pagina :580

    Magnus Wickman, Anna Asarnoj, Henrike Tillander, Niklas Andersson, Anna Bergström, Inger Kull, Erik Melén, Göran Pershagen, Staffan Ahlstedt, Gunnar Lilja, Marianne van Hage, MeDALL consortium

     
  • ·Access to health care and food in children with food allergy

    Pagina :582

    Christina B. Johns, Jessica H. Savage

     
  • ·Specific IgE reactivity to Tri a 36 in children with wheat food allergy

    Pagina :585-587

    Alexandra Baar, Sandra Pahr, Claudia Constantin, Stavroula Giavi, Alkisti Manoussaki, Nikolaos G. Papadopoulos, Christof Ebner, Adriano Mari, Susanne Vrtala, Rudolf Valenta

      
  • ·GLCCI1 rs37973 does not influence treatment response to inhaled corticosteroids in white subjects with asthma

    Pagina :587-589

    Louise Hosking, Eugene Bleecker, Soumitra Ghosh, Astrid Yeo, Loretta Jacques, Michael Mosteller, Deborah Meyers

     
  • ·New childhood and adult reference intervals for total IgE

    Pagina :589-591

    Thomas B. Martins, Michael E. Bandhauer, Ashley M. Bunker, William L. Roberts, Harry R. Hill

    
  • ·A novel mutation in IFN-? receptor 1 presenting as multisystem Mycobacterium intracellulare infection

    Pagina :591-592

    David M. Rose, Jane Atkins, Steven M. Holland, Anthony J. Infante

    
  • ·Premature immune senescence during HIV-1 vertical infection relates with response to influenza vaccination

    Pagina :592

    Alberto Cagigi, Stefano Rinaldi, Angela Di Martino, Emma Concetta Manno, Paola Zangari, Angela Aquilani, Nicola Cotugno, Luciana Nicolosi, Alberto Villani, Stefania Bernardi, Isabella Donatelli, Savita Pahwa, Paolo Rossi, Paolo Palma

     
  • ·Infantile eczema: Prognosis and risk of asthma and rhinitis in preadolescence

    Pagina :594

    Natalia Ballardini, Anna Bergström, Maria Böhme, Marianne van Hage, Eva Hallner, Emma Johansson, Cilla Söderhäll, Inger Kull, Magnus Wickman, Carl-Fredrik Wahlgren

     
  • ·Survey on retransplantation criteria for patients with severe combined immunodeficiency

    Pagina :597-599

    Elie Haddad, Zoulfia Allakhverdi, Linda M. Griffith, Morton J. Cowan, Luigi D. Notarangelo

     

• Correspondence

  • ·A beneficial effect of rituximab on autoimmune thrombotic thrombocytopenic purpura: Just a B-cell depletion?

    Pagina :600

    Jae Il Shin, Michael Eisenhut

    
  • ·Reply

    Pagina :600-601

    Hidemi Toyoda, Eiichi Azuma

    
  • ·Is cooked whole egg really less allergenic than pasteurized raw whole egg powder?

    Pagina :601

    Mauro Calvani, Valentina Giorgio, Stefano Miceli Sopo

    
  • ·Reply

    Pagina :601-602

    Debra J. Palmer, Jessica Metcalfe, Maria Makrides, Susan L. Prescott

    

• Maintenance of Certification clinical management series

  • ·Infection-induced wheezing in young children

    Pagina :603

    Avraham Beigelman, Leonard B. Bacharier

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  • ·Correction

    Pagina :604

    
  • ·Correction

    Pagina :604