Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :5A

    
• • ·Table of Contents

    Pagina :7A

    
• • ·Editorial Board

    Pagina :28A

    

• Reader services

  • ·Information for Readers

    Pagina :29A

    
  • ·News & Notes

    Pagina :30A

    Mappa Mappa  
  • ·CME Activities Calendar

    Pagina :36A

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :1-2

    Marc E. Rothenberg, Jean Bousquet

    Mappa Mappa  

• Reviews and feature articles

  • ·The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

    Pagina :3-13

    Christina E. West, Harald Renz, Maria C. Jenmalm, Anita L. Kozyrskyj, Katrina J. Allen, Peter Vuillermin, Susan L. Prescott

    Riassunto Riassunto Mappa Mappa  
  • ·The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies

    Pagina :14

    
  • ·Update on epigenetics in allergic disease

    Pagina :15-24

    Hani Harb, Harald Renz

    Riassunto Riassunto Mappa Mappa  
  • ·The microbiome in asthma

    Pagina :25-30

    Yvonne J. Huang, Homer A. Boushey

    Riassunto Riassunto Mappa Mappa  
  • ·Systems biology of asthma and allergic diseases: A multiscale approach

    Pagina :31-42

    Supinda Bunyavanich, Eric E. Schadt

    Riassunto Riassunto Mappa Mappa  
  • ·Making it big in allergy

    Pagina :43-45

    Leah C. Kottyan, Matthew T. Weirauch, Marc E. Rothenberg

    
  • ·Advances in adult asthma diagnosis and treatment in 2014

    Pagina :46-53

    Andrea J. Apter

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors' Choice

    Pagina :54-55

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

    Mappa Mappa  

• Asthma and lower airway disease

  • ·Consumption of unprocessed cow's milk protects infants from common respiratory infections

    Pagina :56

    Georg Loss, Martin Depner, Laurien H. Ulfman, R.J. Joost van Neerven, Alexander J. Hose, Jon Genuneit, Anne M. Karvonen, Anne Hyvärinen, Vincent Kaulek, Caroline Roduit, Juliane Weber, Roger Lauener, Petra Ina Pfefferle, Juha Pekkanen, Outi Vaarala, Jean-Charles Dalphin, Josef Riedler, Charlotte Braun-Fahrländer, Erika von Mutius, Markus J. Ege, PASTURE study group ?

    Riassunto Riassunto Mappa Mappa  
  • ·Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease

    Pagina :63

    Michael A. Ghebre, Mona Bafadhel, Dhananjay Desai, Suzanne E. Cohen, Paul Newbold, Laura Rapley, Jo Woods, Paul Rugman, Ian D. Pavord, Chris Newby, Paul R. Burton, Richard D. May, Chris E. Brightling

    Riassunto Riassunto Mappa Mappa  
  • ·Comparison of US emergency department acute asthma care quality: 1997-2001 and 2011-2012

    Pagina :73

    Kohei Hasegawa, Ashley F. Sullivan, Yusuke Tsugawa, Stuart J. Turner, Susan Massaro, Sunday Clark, Chu-Lin Tsai, Carlos A. Camargo, MARC-36 Investigators ?

    Riassunto Riassunto Mappa Mappa  
  • ·Identification of novel immune phenotypes for allergic and nonallergic childhood asthma

    Pagina :81-91

    Diana Raedler, Nikolaus Ballenberger, Elisabeth Klucker, Andreas Böck, Ragna Otto, Olivia Prazeres da Costa, Otto Holst, Thomas Illig, Thorsten Buch, Erika von Mutius, Bianca Schaub

    Riassunto Riassunto Mappa Mappa   
  • ·Phenotypic and genotypic association of epithelial IL1RL1 to human T_H2-like asthma

    Pagina :92

    Russell S. Traister, Crystal E. Uvalle, Gregory A. Hawkins, Deborah A. Meyers, Eugene R. Bleecker, Sally E. Wenzel

    Riassunto Riassunto Mappa Mappa  
  • ·Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases

    Pagina :100

    Shannon L. Russell, Matthew J. Gold, Lisa A. Reynolds, Benjamin P. Willing, Pedro Dimitriu, Lisa Thorson, Stephen A. Redpath, Georgia Perona-Wright, Marie-Renée Blanchet, William W. Mohn, B. Brett Finlay, Kelly M. McNagny

    Riassunto Riassunto Mappa Mappa  
  • ·Indoor fungal diversity and asthma: A meta-analysis and systematic review of risk factors

    Pagina :110-122

    Richard A. Sharpe, Nick Bearman, Christopher R. Thornton, Kerryn Husk, Nicholas J. Osborne

    Riassunto Riassunto Mappa Mappa   
  • ·Risk of congenital malformations for asthmatic pregnant women using a long-acting ?₂-agonist and inhaled corticosteroid combination versus higher-dose inhaled corticosteroid monotherapy

    Pagina :123

    Sherif Eltonsy, Amelie Forget, Marie-France Beauchesne, Lucie Blais

    Riassunto Riassunto Mappa Mappa  
  • ·Perception versus reality: The saga of inhaled asthma controller medication and fetal risk

    Pagina :131-132

    Joshua A. Steinberg

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Total transcriptome, proteome, and allergome of Johnson grass pollen, which is important for allergic rhinitis in subtropical regions

    Pagina :133-142

    Bradley C. Campbell, Edward K. Gilding, Victoria Timbrell, Preethi Guru, Dorothy Loo, Danila Zennaro, Adriano Mari, Graham Solley, Michelle M. Hill, Ian D. Godwin, Janet M. Davies

    Riassunto Riassunto Mappa Mappa   
  • ·Identifying the heterogeneity of young adult rhinitis through cluster analysis in the Isle of Wight birth cohort

    Pagina :143

    Ramesh J. Kurukulaaratchy, Hongmei Zhang, Veeresh Patil, Abid Raza, Wilfried Karmaus, Susan Ewart, S. Hasan Arshad

    Riassunto Riassunto Mappa Mappa  
  • ·Defining phenotypes in rhinitis: A step toward personalized medicine

    Pagina :151-152

    Pedro Giavina-Bianchi

    

• Atopic dermatitis and skin disease

  • ·Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection

    Pagina :153-163

    Hitokazu Esaki, David A. Ewald, Benjamin Ungar, Mariya Rozenblit, Xiuzhong Zheng, Hui Xu, Yeriel D. Estrada, Xiangyu Peng, Hiroshi Mitsui, Thomas Litman, Mayte Suárez-Fariñas, James G. Krueger, Emma Guttman-Yassky

    Riassunto Riassunto Mappa Mappa   
  • ·Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

    Pagina :164

    Helen A. Brough, Andrew H. Liu, Scott Sicherer, Kerry Makinson, Abdel Douiri, Sara J. Brown, Alick C. Stephens, W.H. Irwin McLean, Victor Turcanu, Robert A. Wood, Stacie M. Jones, Wesley Burks, Peter Dawson, Donald Stablein, Hugh Sampson, Gideon Lack

    Riassunto Riassunto Mappa Mappa  

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Influence of early-life exposures on food sensitization and food allergy in an inner-city birth cohort

    Pagina :171

    Emily C. McGowan, Gordon R. Bloomberg, Peter J. Gergen, Cynthia M. Visness, Katy F. Jaffee, Megan Sandel, George O'Connor, Meyer Kattan, James Gern, Robert A. Wood

    Riassunto Riassunto Mappa Mappa  
  • ·Distinct parameters of the basophil activation test reflect the severity and threshold of allergic reactions to peanut

    Pagina :179-186

    Alexandra F. Santos, George Du Toit, Abdel Douiri, Suzana Radulovic, Alick Stephens, Victor Turcanu, Gideon Lack

    Riassunto Riassunto Mappa Mappa   
  • ·Transcriptome analysis of proton pump inhibitor–responsive esophageal eosinophilia reveals proton pump inhibitor–reversible allergic inflammation

    Pagina :187

    Ting Wen, Evan S. Dellon, Fouad J. Moawad, Glenn T. Furuta, Seema S. Aceves, Marc E. Rothenberg

    Riassunto Riassunto Mappa Mappa  

• Immune deficiencies, infection, and systemic immune disorders

  • ·Classification of common variable immunodeficiencies using flow cytometry and a memory B-cell functionality assay

    Pagina :198

    Amelia L. Rösel, Carmen Scheibenbogen, Ulrike Schliesser, André Sollwedel, Bodo Hoffmeister, Leif Hanitsch, Horst von Bernuth, Renate Krüger, Klaus Warnatz, Hans-Dieter Volk, Sybill Thomas

    Riassunto Riassunto Mappa Mappa  
  • ·T-cell receptor diversity is selectively skewed in T-cell populations of patients with Wiskott-Aldrich syndrome

    Pagina :209

    Junfeng Wu, Dawei Liu, Wenwei Tu, Wenxia Song, Xiaodong Zhao

    Riassunto Riassunto Mappa Mappa  
  • ·Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like disorder caused by loss-of-function mutations in LRBA

    Pagina :217

    Louis-Marie Charbonnier, Erin Janssen, Janet Chou, Toshiro K. Ohsumi, Sevgi Keles, Joyce T. Hsu, Michel J. Massaad, Maria Garcia-Lloret, Rima Hanna-Wakim, Ghassan Dbaibo, Abdullah A. Alangari, Abdulrahman Alsultan, Daifulah Al-Zahrani, Raif S. Geha, Talal A. Chatila

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·Genetic ancestry influences asthma susceptibility and lung function among Latinos

    Pagina :228-235

    Maria Pino-Yanes, Neeta Thakur, Christopher R. Gignoux, Joshua M. Galanter, Lindsey A. Roth, Celeste Eng, Katherine K. Nishimura, Sam S. Oh, Hita Vora, Scott Huntsman, Elizabeth A. Nguyen, Donglei Hu, Katherine A. Drake, David V. Conti, Andres Moreno-Estrada, Karla Sandoval, Cheryl A. Winkler, Luisa N. Borrell, Fred Lurmann, Talat S. Islam, Adam Davis, Harold J. Farber, Kelley Meade, Pedro C. Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A. Lenoir, Jean G. Ford, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Shannon M. Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Carlos D. Bustamante, L. Keoki Williams, Frank D. Gilliland, W. James Gauderman, Rajesh Kumar, Dara G. Torgerson, Esteban G. Burchard

    Riassunto Riassunto Mappa Mappa   
  • ·Dynamic transcriptional and epigenomic reprogramming from pediatric nasal epithelial cells to induced pluripotent stem cells

    Pagina :236-244

    Hong Ji, Xue Zhang, Sunghee Oh, Christopher N. Mayhew, Ashley Ulm, Hari K. Somineni, Mark Ericksen, James M. Wells, Gurjit K. Khurana Hershey

    Riassunto Riassunto Mappa Mappa   
  • ·Prostaglandin D₂: A dominant mediator of aspirin-exacerbated respiratory disease

    Pagina :245-252

    Katherine N. Cahill, Jillian C. Bensko, Joshua A. Boyce, Tanya M. Laidlaw

    Riassunto Riassunto Mappa Mappa  
  • ·HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping

    Pagina :253

    Jean-Louis Guéant, Antonino Romano, Jose-Antonio Cornejo-Garcia, Abderrahim Oussalah, Celine Chery, Natalia Blanca-López, Rosa-Maria Guéant-Rodriguez, Francesco Gaeta, Pierre Rouyer, Thomas Josse, Gabriella Canto, F. David Carmona, Lara Bossini-Castillo, Javier Martin, Jose-Julio Laguna, Javier Fernandez, Francisco Feo, David A. Ostrov, Pablo C. Plasencia, Cristobalina Mayorga, Maria-Jose Torres, Miguel Blanca

    Riassunto Riassunto Mappa Mappa  

• Letters to the Editor

  • ·Gut immune reconstitution in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome after hematopoietic stem cell transplantation

    Pagina :260

    Eleonora Gambineri, Sara Ciullini Mannurita, Helen Robertson, Marina Vignoli, Beate Haugk, Paolo Lionetti, Sophie Hambleton, Dawn Barge, Andrew R. Gennery, Mary Slatter, Zohreh Nademi, Terence J. Flood, Anthony Jackson, Mario Abinun, Andrew J. Cant

     
  • ·Recognizing mastocytosis in patients with anaphylaxis: Value of KIT D816V mutation analysis of peripheral blood

    Pagina :262-264

    Sigurd Broesby-Olsen, Athamaica Ruiz Oropeza, Carsten Bindslev-Jensen, Hanne Vestergaard, Michael Boe Møller, Frank Siebenhaar, Thomas Kristensen, Charlotte G. Mortz, Mastocytosis Centre Odense University Hospital (MastOUH) and Odense Research Centre for Anaphylaxis

    
  • ·B-cell linear epitopes mapping of antigen-5 allergen from Polybia paulista wasp venom

    Pagina :264

    José Roberto Aparecido dos Santos-Pinto, Lucilene Delazari dos Santos, Helen Andrade Arcuri, Anally Ribeiro da Silva Menegasso, Paloma Napoleão Pêgo, Keity Souza Santos, Fábio Morato Castro, Jorge Elias Kalil, Salvatore Giovanni De-Simone, Mario Sergio Palma

     
  • ·Bacterial metabolites of diet-derived lignans and isoflavones inversely associate with asthma and wheezing

    Pagina :267

    Juan-Carlos Cardet, Christina B. Johns, Jessica H. Savage

     
  • ·Casein-related anaphylaxis after use of an Everlast kickboxing glove

    Pagina :269-271

    Robert G. Hamilton, David I. Scheer, Rebecca Gruchalla, N. Franklin Adkinson, Hugh A. Sampson

     
  • ·Impaired receptor editing and heterozygous RAG2 mutation in a patient with systemic lupus erythematosus and erosive arthritis

    Pagina :272-273

    Jolan E. Walter, Mindy S. Lo, Katalin Kis-Toth, Irit Tirosh, Francesco Frugoni, Yu Nee Lee, Krisztian Csomos, Karin Chen, Shiv Pillai, Jonathan Dunham, George C. Tsokos, Eline T. Luning Prak, Luigi D. Notarangelo

    
  • ·Food allergy in patients with primary immunodeficiency diseases: Prevalence within the US Immunodeficiency Network (USIDNET)

    Pagina :273-275

    Karen S. Tuano, Jordan S. Orange, Kathleen Sullivan, Charlotte Cunningham-Rundles, Francisco A. Bonilla, Carla M. Davis

     
  • ·Environmental lead exposure and increased risk for total and allergen-specific IgE in US adults

    Pagina :275

    Kyoung-Bok Min, Jin-Young Min

     
  • ·Metagenomic heterogeneity explains dual immune effects of endotoxins

    Pagina :277-280

    Susanne Brix, Carsten Eriksen, Jeppe Madura Larsen, Hans Bisgaard

     
  • ·Whole-exome sequencing in patients with ichthyosis reveals modifiers associated with increased IgE levels and allergic sensitizations

    Pagina :280

    Dimitra Kiritsi, Manthoula Valari, Paola Fortugno, Ingrid Hausser, Lilia Lykopoulou, Giovanna Zambruno, Judith Fischer, Leena Bruckner-Tuderman, Thilo Jakob, Cristina Has

     
  • ·Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency

    Pagina :283

    Lien Van Eyck, Michael S. Hershfield, Diana Pombal, Susan J. Kelly, Nancy J. Ganson, Leen Moens, Glynis Frans, Heidi Schaballie, Gert De Hertogh, James Dooley, Xavier Bossuyt, Carine Wouters, Adrian Liston, Isabelle Meyts

     

• Correspondence

  • ·Clinical relevance of house dust mite immunotherapy

    Pagina :288

    Brian Lipworth

    
  • ·Reply

    Pagina :288-289

    Karl-Christian Bergmann, Pascal Demoly, Kathy Abiteboul, Robert K. Zeldin

    
  • ·EXCELS study results do not rule out potential cancer risk with omalizumab

    Pagina :289

    Jie Li, Margie Goulding, Sally Seymour, Peter Starke

    
  • ·Reply

    Pagina :289-290

    Aidan Long, Kenneth Rothman, Hubert Chen, Gillis Carrigan, Stanley Szefler, EXCELS study authors

    
  • ·?₂-Agonist therapy may contribute to the air pollution and IL-6–associated risk of developing severe asthma with dual-positive T_H2/T_H17 cells

    Pagina :290-291

    Sergio E. Chiarella, G.R. Scott Budinger, Gökhan M. Mutlu

    
  • ·Reply

    Pagina :291

    Rafeul Alam

    
  • ·When are serum specific IgE levels positive?

    Pagina :291-292

    Guglielmo Scala, Stefano Miceli Sopo

    
  • ·Reply

    Pagina :292-293

    Salvatore Tripodi, Carlo Caffarelli, Giovanna Stringari, Arianna Dondi, Riccardo Asero, Paolo Maria Matricardi

    
  • ·Knowledge of the literature is crucial for meta-analyses

    Pagina :293-294

    Danilo Di Bona, Antonella Plaia, Gabriele Di Lorenzo

    
  • ·Facilitated dissociation of IgE versus cell replacement

    Pagina :294-295

    Donald MacGlashan