Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :5A

    
• • ·Table of Contents

    Pagina :8A

    
• • ·Editorial Board

    Pagina :26A

    

• Reader services

  • ·Information for Readers

    Pagina :27A

    
  • ·News & Notes

    Pagina :32A

    Mappa Mappa  
  • ·CME Activities Calendar

    Pagina :35A

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :297-298

    Marc E. Rothenberg, Jean Bousquet

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• Reviews and feature articles

  • ·Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care

    Pagina :299-310

    Merritt L. Fajt, Sally E. Wenzel

    Riassunto Riassunto Mappa Mappa   
  • ·Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care

    Pagina :311

    
  • ·The future of biologics: Applications for food allergy

    Pagina :312-323

    Rebecca N. Bauer, Monali Manohar, Anne Marie Singh, David C. Jay, Kari C. Nadeau

    Riassunto Riassunto Mappa Mappa  
  • ·The translational revolution and use of biologics in patients with inflammatory skin diseases

    Pagina :324-336

    Shinji Noda, James G. Krueger, Emma Guttman-Yassky

    Riassunto Riassunto Mappa Mappa  
  • ·The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria

    Pagina :337

    Tse Wen Chang, Christina Chen, Chien-Jen Lin, Martin Metz, Martin K. Church, Marcus Maurer

    Riassunto Riassunto Mappa Mappa  
  • ·Worms as therapeutic agents for allergy and asthma: Understanding why benefits in animal studies have not translated into clinical success

    Pagina :343-353

    Holly Evans, Edward Mitre

    Riassunto Riassunto Mappa Mappa
  • ·Targeted therapy for allergic diseases: At the intersection of cutting-edge science and clinical practice

    Pagina :354-356

    Mark Boguniewicz, Donald Y.M. Leung

    
  • ·Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2014

    Pagina :357-367

    Scott H. Sicherer, Donald Y.M. Leung

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• The Editors' choice

  • ·The Editors' Choice

    Pagina :368-369

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

    Mappa Mappa  

• Asthma and lower airway disease

  • ·Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy

    Pagina :370

    Mireia Gascon, Maribel Casas, Eva Morales, Damaskini Valvi, Ana Ballesteros-Gómez, Noelia Luque, Soledad Rubio, Núria Monfort, Rosa Ventura, David Martínez, Jordi Sunyer, Martine Vrijheid

    Riassunto Riassunto Mappa Mappa  
  • ·IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers

    Pagina :379-385

    Michelle L. Hernandez, Katherine Mills, Martha Almond, Krista Todoric, Maria M. Aleman, Hongtao Zhang, Haibo Zhou, David B. Peden

    Riassunto Riassunto Mappa Mappa  
  • ·IL-27 and type 2 immunity in asthmatic patients: Association with severity, CXCL9, and signal transducer and activator of transcription signaling

    Pagina :386

    Min Xie, Anthony T. Mustovich, Yi Jiang, John B. Trudeau, Anuradha Ray, Prabir Ray, Haizhen Hu, Fernando Holguin, Bruce Freeman, Sally E. Wenzel

    Riassunto Riassunto Mappa Mappa  
  • ·D prostanoid receptor 2 (chemoattractant receptor–homologous molecule expressed on T_H2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells

    Pagina :395

    Sally E. Stinson, Yassine Amrani, Christopher E. Brightling

    Riassunto Riassunto Mappa Mappa  
  • ·The Xolair Pregnancy Registry (EXPECT): The safety of omalizumab use during pregnancy

    Pagina :407-412

    Jennifer Namazy, Michael D. Cabana, Angela E. Scheuerle, John M. Thorp, Hubert Chen, Gillis Carrigan, Yan Wang, Joachim Veith, Elizabeth B. Andrews

    Riassunto Riassunto Mappa Mappa
  • ·Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease

    Pagina :413

    Jessy S. Deshane, David T. Redden, Meiqin Zeng, Marion L. Spell, Jaroslaw W. Zmijewski, John T. Anderson, Rohit J. Deshane, Amit Gaggar, Gene P. Siegal, Edward Abraham, Mark T. Dransfield, David D. Chaplin

    Riassunto Riassunto Mappa Mappa  
  • ·DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency

    Pagina :425-440

    Mohamed A. Ghonim, Kusma Pyakurel, Jihang Ju, Paulo C. Rodriguez, Matthew R. Lammi, Christian Davis, Mohammad Q. Abughazleh, Moselhy S. Mansy, Amarjit S. Naura, A. Hamid Boulares

    Riassunto Riassunto Mappa Mappa  
  • ·Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children

    Pagina :441-448

    Joanne E. Sordillo, Christina V. Scirica, Sheryl L. Rifas-Shiman, Matthew W. Gillman, Supinda Bunyavanich, Carlos A. Camargo, Scott T. Weiss, Diane R. Gold, Augusto A. Litonjua

    Riassunto Riassunto Mappa Mappa
  • ·Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge

    Pagina :451

    Katsuyuki Takeda, Yoshiki Shiraishi, Shigeru Ashino, Junyan Han, Yi Jia, Meiqin Wang, Nancy A. Lee, James J. Lee, Erwin W. Gelfand

    Riassunto Riassunto Mappa Mappa  
  • ·Acetaminophen and childhood asthma: Pill-popping at our peril?

    Pagina :449-450

    Seif O. Shaheen

    
  • ·A survivor: The eosinophil as a regulator in asthma

    Pagina :461-462

    Dorothy S. Cheung, Mitchell H. Grayson

     

• Rhinitis, sinusitis, and upper airway disease

  • ·Association between climate factors, pollen counts, and childhood hay fever prevalence in the United States

    Pagina :463

    Jonathan I. Silverberg, Marc Braunstein, Mary Lee-Wong

    Riassunto Riassunto Mappa Mappa  
  • ·Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps

    Pagina :470-476

    Javier Milara, Teresa Peiró, Miquel Armengot, Soledad Frias, Anselm Morell, Adela Serrano, Julio Cortijo

    Riassunto Riassunto Mappa Mappa   

• Atopic dermatitis and skin disease

  • ·Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice

    Pagina :477

    James J. Lee, Cheryl A. Protheroe, Huijun Luo, Sergei I. Ochkur, Gregory D. Scott, Katie R. Zellner, Randall J. Raish, Mark V. Dahl, Miriam L. Vega, Olivia Conley, Rachel M. Condjella, Jake A. Kloeber, Joseph L. Neely, Yash S. Patel, Patty Maizer, Andrew Mazzolini, Allison D. Fryer, Noah W. Jacoby, David B. Jacoby, Nancy A. Lee

    Riassunto Riassunto Mappa Mappa  
  • ·Eosinophils and itch: Partners in crime or strange bedfellows?

    Pagina :488-490

    Kristin M. Leiferman

     

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Ramipril and metoprolol intake aggravate human and murine anaphylaxis: Evidence for direct mast cell priming

    Pagina :491-499

    Maria Nassiri, Magda Babina, Sabine Dölle, Günter Edenharter, Franziska Ruëff, Margitta Worm

    Riassunto Riassunto Mappa Mappa  
  • ·Intravenous anti–IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis

    Pagina :500-507

    Marc E. Rothenberg, Ting Wen, Allison Greenberg, Oral Alpan, Benjamin Enav, Ikuo Hirano, Kari Nadeau, Sergio Kaiser, Thomas Peters, Antonio Perez, Ieuan Jones, Jonathan P. Arm, Robert M. Strieter, Ronald Sabo, Kulasiri A. Gunawardena

    Riassunto Riassunto Mappa Mappa   
  • ·Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease

    Pagina :508

    John Croese, Paul Giacomin, Severine Navarro, Andrew Clouston, Leisa McCann, Annette Dougall, Ivana Ferreira, Atik Susianto, Peter O'Rourke, Mariko Howlett, James McCarthy, Christian Engwerda, Dianne Jones, Alex Loukas

    Riassunto Riassunto Mappa Mappa   

• Immune deficiencies, infection, and systemic immune disorders

  • ·Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease

    Pagina :517

    Ruby F. Fernandez-Boyanapalli, S. Courtney Frasch, Stacey M. Thomas, Kenneth C. Malcolm, Michael Nicks, Ronald J. Harbeck, Claudia V. Jakubzick, Raphael Nemenoff, Peter M. Henson, Steven M. Holland, Donna L. Bratton

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·RhoA signaling through platelet P2Y₁ receptor controls leukocyte recruitment in allergic mice

    Pagina :528

    Richard T. Amison, Stefania Momi, Abigail Morris, Giorgia Manni, Sandra Keir, Paolo Gresele, Clive P. Page, Simon C. Pitchford

    Riassunto Riassunto Mappa Mappa  
  • ·The draft genome, transcriptome, and microbiome of Dermatophagoides farinae reveal a broad spectrum of dust mite allergens

    Pagina :539-548

    Ting-Fung Chan, Kun-Mei Ji, Aldrin Kay-Yuen Yim, Xiao-Yu Liu, Jun-Wei Zhou, Rui-Qi Li, Kevin Yi Yang, Jing Li, Meng Li, Patrick Tik-Wan Law, Yu-Lan Wu, Ze-Lang Cai, Hao Qin, Ying Bao, Ross Ka-Kit Leung, Patrick Kwok-Shing Ng, Ju Zou, Xiao-Jun Zhong, Pi-Xin Ran, Nan-Shan Zhong, Zhi-Gang Liu, Stephen Kwok-Wing Tsui

    Riassunto Riassunto Mappa Mappa   
  • ·Studies of house dust mites can now fully embrace the “-omics” era

    Pagina :549-550

    Geoffrey A. Stewart

    

• Letters to the Editor

  • ·Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation

    Pagina :551

    Eleanor Higgins, Tariq Al Shehri, Maeve A. McAleer, Niall Conlon, Conleth Feighery, Desa Lilic, Alan D. Irvine

     
  • ·Humanized anti–IFN-? (HuZAF) in the treatment of psoriasis

    Pagina :553

    Jamie L. Harden, Leanne M. Johnson-Huang, Maria Francesca Chamian, Edmund Lee, Tillman Pearce, Craig L. Leonardi, Asifa Haider, Michelle A. Lowes, James G. Krueger

     
  • ·Genetic variants of inducible costimulator are associated with allergic asthma susceptibility

    Pagina :556

    Anand Kumar Andiappan, Sriram Narayanan, Rachel A. Myers, Bernett Lee, Maartje A. Nieuwenhuis, Alessandra Nardin, Choon-Sik Park, Hyoung Doo Shin, Jeong-Hyun Kim, Harm-Jan Westra, Lude Franke, Tonu Esko, Andres Metspalu, Yik-Ying Teo, Seang Mei Saw, Chiea Chuen Khor, Jianjun Liu, Gerard H. Koppelman, Dirkje S. Postma, Michael Poidinger, John E. Connolly, De Yun Wang, Olaf Rotzschke, Maria A. Curotto de Lafaille, Fook Tim Chew

     
  • ·Mutation of TNFRSF13B in a child with 22q11 deletion syndrome associated with granulomatous lymphoproliferation

    Pagina :559-561

    Michael W. Mather, Hannah Hayhurst, Chris M. Bacon, Theresa S. Cole, Qiang Pan-Hammarström, Siraj Misbah, Andrew R. Gennery

     
  • ·Myeloid lineage–restricted somatic mosaicism of NLRP3 mutations in patients with variant Schnitzler syndrome

    Pagina :561

    Heleen D. de Koning, Mariëlle E. van Gijn, Monique Stoffels, Johanna Jongekrijg, Patrick L.J.M. Zeeuwen, Martin G. Elferink, Isaac J. Nijman, Patrick A.M. Jansen, Kornelia Neveling, Jos W.M. van der Meer, Joost Schalkwijk, Anna Simon

     
  • ·The coreceptor programmed death 1 inhibits T-cell adhesion by regulating Rap1

    Pagina :564

    Inbar Azoulay-Alfaguter, Marianne Strazza, Ariel Pedoeem, Adam Mor

     
  • ·Tolerance and immunity after sequential lung and bone marrow transplantation from an unrelated cadaveric donor

    Pagina :567

    Paul Szabolcs, Rebecca H. Buckley, Robert Duane Davis, Jerelyn Moffet, Judith Voynow, Jeyaraj Antony, Xiaohua Chen, Gregory D. Sempowski, David W. Zaas

     
  • ·Hereditary angioedema: Molecular and clinical differences among European populations

    Pagina :570

    Matthaios Speletas, Agnes Szilagyi, Fotis Psarros, Dimitru Moldovan, Markus Magerl, Maria Kompoti, Evangelia Gramoustianou, Andras Bors, Eniko Mihaly, Attila Tordai, Antigoni Avramouli, Lilian Varga, Marcus Maurer, Henriette Farkas, Anastasios E. Germenis

     
  • ·Associations between the 17q21 region and allergic rhinitis in 5 birth cohorts

    Pagina :573

    Elaine Fuertes, Cilla Söderhäll, Nathalie Acevedo, Allan Becker, Michael Brauer, Moira Chan-Yeung, F. Nicole Dijk, Joachim Heinrich, Johan de Jongste, Gerard H. Koppelman, Dirkje S. Postma, Juha Kere, Anita L. Kozyrskyj, Göran Pershagen, Andrew Sandford, Marie Standl, Carla M.T. Tiesler, Melanie Waldenberger, Marit Westman, Christopher Carlsten, Erik Melén

     
  • ·Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second-generation Asians suggest genetic regulation of eosinophilia

    Pagina :576-579

    Mahboobeh Mahdavinia, Lydia A. Suh, Roderick G. Carter, Whitney W. Stevens, James E. Norton, Atsushi Kato, Bruce K. Tan, Robert C. Kern, David B. Conley, Rakesh Chandra, Jennifer Lavin, Anju T. Peters, Leslie C. Grammer, Robert P. Schleimer

     
  • ·Effect of ingested H₁ antihistamines on methacholine challenge

    Pagina :579-580

    Donald W. Cockcroft, Beth E. Davis, Yeonju Roh, Joe-Ann Lourens

     
  • ·Changes in peanut allergy prevalence in different ethnic groups in 2 time periods

    Pagina :580-582

    Adam T. Fox, Hande Kaymakcalan, Michael Perkin, George du Toit, Gideon Lack

     

• Correspondence

  • ·Understanding food allergen thresholds requires careful analysis of the available clinical data

    Pagina :583-584

    Steve L. Taylor, Geert F. Houben, Joseph L. Baumert, Rene R.W.R. Crevel, Katrina J. Allen, Anthony E.J. Dubois, Andre C. Knulst, Benjamin C. Remington, Astrid G. Kruizinga, W. Marty Blom, Simon Brooke-Taylor

    
  • ·Reply

    Pagina :584-585

    Stefano Luccioli, Ernest Kwegyir-Afful