Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :5A

    
• • ·Table of Contents

    Pagina :8A

    
• • ·Editorial Board

    Pagina :30A

    

• Reader services

  • ·Information for Readers

    Pagina :31A

    
  • ·News & Notes

    Pagina :32A

    Mappa Mappa
  • ·CME Activities Calendar

    Pagina :42A

    Mappa Mappa

• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :587-588

    Marc E. Rothenberg, Jean Bousquet

    Mappa Mappa  

• Reviews and feature articles

  • ·The alpha-gal story: Lessons learned from connecting the dots

    Pagina :589-596

    John W. Steinke, Thomas A.E. Platts-Mills, Scott P. Commins

    Riassunto Riassunto Mappa Mappa  
  • ·The alpha-gal story: Lessons learned from connecting the dots

    Pagina :597

    
  • ·Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

    Pagina :598-608

    Bruce S. Bochner, Nives Zimmermann

    Riassunto Riassunto Mappa Mappa  
  • ·Glycans and glycan-binding proteins in immune regulation: A concise introduction to glycobiology for the allergist

    Pagina :609-615

    Ronald L. Schnaar

    Riassunto Riassunto Mappa Mappa  
  • ·Allergy to furry animals: New insights, diagnostic approaches, and challenges

    Pagina :616-625

    Jon R. Konradsen, Takao Fujisawa, Marianne van Hage, Gunilla Hedlin, Christiane Hilger, Jörg Kleine-Tebbe, Elizabeth C. Matsui, Graham Roberts, Eva Rönmark, Thomas A.E. Platts-Mills

    Riassunto Riassunto Mappa Mappa  
  • ·The 3 major types of innate and adaptive cell-mediated effector immunity

    Pagina :626-635

    Francesco Annunziato, Chiara Romagnani, Sergio Romagnani

    Riassunto Riassunto Mappa Mappa  
  • ·Environmental exposure chambers in allergen immunotherapy trials: Current status and clinical validation needs

    Pagina :636-643

    Karen Rösner-Friese, Susanne Kaul, Stefan Vieths, Oliver Pfaar

    Riassunto Riassunto Mappa Mappa
  • ·Advances in pediatric asthma in 2014: Moving toward a population health perspective

    Pagina :644-652

    Stanley J. Szefler

    Riassunto Riassunto Mappa Mappa

• The Editors' choice

  • ·The Editors' Choice

    Pagina :653-654

    Donald Y.M. Leung, Stanley J. Szefler, Associate Editors of the JACI

    Mappa Mappa  

• Asthma and lower airway disease

  • ·Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic

    Pagina :655-662

    Corinne A. Keet, Meredith C. McCormack, Craig E. Pollack, Roger D. Peng, Emily McGowan, Elizabeth C. Matsui

    Riassunto Riassunto Mappa Mappa   
  • ·Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma

    Pagina :663

    Euan R. Tovey, Sacha Stelzer-Braid, Brett G. Toelle, Brian G. Oliver, Helen K. Reddel, Christiana M. Willenborg, Yvonne Belessis, Frances L. Garden, Adam Jaffe, Roxanne Strachan, Darryl Eyles, William D. Rawlinson, Guy B. Marks

    Riassunto Riassunto Mappa Mappa  
  • ·Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma

    Pagina :670

    Jantina C. de Groot, Eric N.H. van Roon, Huib Storm, Nic J.G.M. Veeger, Aeilko H. Zwinderman, Pieter S. Hiemstra, Elisabeth H.D. Bel, Anneke ten Brinke

    Riassunto Riassunto Mappa Mappa  
  • ·Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature

    Pagina :676

    Jessica P. Rajan, Nathan E. Wineinger, Donald D. Stevenson, Andrew A. White

    Riassunto Riassunto Mappa Mappa  
  • ·Symptom- and fraction of exhaled nitric oxide–driven strategies for asthma control: A cluster-randomized trial in primary care

    Pagina :682

    Persijn J. Honkoop, Rik J.B. Loijmans, Evelien H. Termeer, Jiska B. Snoeck-Stroband, Wilbert B. van den Hout, Moira J. Bakker, Willem J.J. Assendelft, Gerben ter Riet, Peter J. Sterk, Tjard R.J. Schermer, Jacob K. Sont, Asthma Control Cost-Utility Randomized Trial Evaluation (ACCURATE) Study Group

    Riassunto Riassunto Mappa Mappa  
  • ·Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode

    Pagina :691

    Tuomas Jartti, Riitta Nieminen, Tytti Vuorinen, Pasi Lehtinen, Tero Vahlberg, James Gern, Carlos A. Camargo, Olli Ruuskanen

    Riassunto Riassunto Mappa Mappa  
  • ·Fraction of exhaled nitric oxide measurements and asthma control: Are the numbers starting to add up?

    Pagina :689

    Louise Fleming, Andrew Bush

    
  • ·Prednisone for acute virus-associated wheeze in children: Panacea or one more brick in the wall?

    Pagina :699-700

    W. Gerald Teague

    

• Rhinitis, sinusitis, and upper airway disease

  • ·Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma

    Pagina :701

    American Lung Association–Asthma Clinical Research Centers' Writing Committee:, Anne E. Dixon, Mario Castro, Rubin I. Cohen, Lynn B. Gerald, Janet T. Holbrook, Charles G. Irvin, Shyam Mohapatra, Stephen P. Peters, Sobharani Rayapudi, Elizabeth A. Sugar, Robert A. Wise

    Riassunto Riassunto Mappa Mappa   
  • ·Will a nasal corticosteroid improve control for patients with step 3 or higher persistent asthma?

    Pagina :710-711

    Paul A. Greenberger

    

• Atopic dermatitis and skin disease

  • ·Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin

    Pagina :712-720

    Joel Correa da Rosa, Dana Malajian, Avner Shemer, Mariya Rozenblit, Nikhil Dhingra, Tali Czarnowicki, Saakshi Khattri, Benjamin Ungar, Robert Finney, Hui Xu, Xiuzhong Zheng, Yeriel D. Estrada, Xiangyu Peng, Mayte Suárez-Fariñas, James G. Krueger, Emma Guttman-Yassky

    Riassunto Riassunto Mappa Mappa   
  • ·Eczema and cardiovascular risk factors in 2 US adult population studies

    Pagina :721

    Jonathan I. Silverberg, Philip Greenland

    Riassunto Riassunto Mappa Mappa

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production

    Pagina :729

    Valerie Hox, Avanti Desai, Geethani Bandara, Alasdair M. Gilfillan, Dean D. Metcalfe, Ana Olivera

    Riassunto Riassunto Mappa Mappa  
  • ·Administration of a probiotic with peanut oral immunotherapy: A randomized trial

    Pagina :737

    Mimi L.K. Tang, Anne-Louise Ponsonby, Francesca Orsini, Dean Tey, Marnie Robinson, Ee Lyn Su, Paul Licciardi, Wesley Burks, Susan Donath

    Riassunto Riassunto Mappa Mappa  
  • ·Adverse reactions associated with oral and parenteral use of cephalosporins: A retrospective population-based analysis

    Pagina :745

    Eric Macy, Richard Contreras

    Riassunto Riassunto Mappa Mappa

• Immune deficiencies, infection, and systemic immune disorders

  • ·Defective B-cell proliferation and maintenance of long-term memory in patients with chronic granulomatous disease

    Pagina :753

    Nicola Cotugno, Andrea Finocchi, Alberto Cagigi, Gigliola Di Matteo, Maria Chiriaco, Silvia Di Cesare, Paolo Rossi, Alessandro Aiuti, Paolo Palma, Iyadh Douagi

    Riassunto Riassunto Mappa Mappa  
  • ·IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome

    Pagina :762-770

    Omar Niss, Allyson Sholl, Jack J. Bleesing, David A. Hildeman

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy and clinical immunology

  • ·IL-10–overexpressing B cells regulate innate and adaptive immune responses

    Pagina :771

    Barbara Stanic, Willem van de Veen, Oliver F. Wirz, Beate Rückert, Hideaki Morita, Stefan Söllner, Cezmi A. Akdis, Mübeccel Akdis

    Riassunto Riassunto Mappa Mappa  
  • ·Thymic stromal lymphopoietin signaling in CD4⁺ T cells is required for T_H2 memory

    Pagina :781

    Qun Wang, Jianguang Du, Jingjing Zhu, Xiaowei Yang, Baohua Zhou

    Riassunto Riassunto Mappa Mappa  
  • ·Diminished reliability of tryptase as risk indicator of mastocytosis in older overweight subjects

    Pagina :792-798

    Byrthe J.P.R. Vos, Eveline van der Veer, Pieter C. van Voorst Vader, André B. Mulder, Sicco van der Heide, Suzanne Arends, Johanna C. Kluin-Nelemans, Jan G.R. de Monchy, Jasper J. van Doormaal, Joanne N.G. Oude Elberink

    Riassunto Riassunto Mappa Mappa  
  • ·Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells

    Pagina :799

    Yi Jia, Huifeng Yu, Steve M. Fernandes, Yadong Wei, Anabel Gonzalez-Gil, Mary G. Motari, Katarina Vajn, Whitney W. Stevens, Anju T. Peters, Bruce S. Bochner, Robert C. Kern, Robert P. Schleimer, Ronald L. Schnaar

    Riassunto Riassunto Mappa Mappa  

• Letters to the Editor

  • ·Staphylococcus aureus colonization is associated with wheeze and asthma among US children and young adults

    Pagina :811

    Meghan F. Davis, Roger D. Peng, Meredith C. McCormack, Elizabeth C. Matsui

     
  • ·Postmenopausal hormone therapy and asthma-related hospital admission

    Pagina :813

    Klaus Bønnelykke, Ole Raaschou-Nielsen, Anne Tjønneland, Charlotte Suppli Ulrik, Hans Bisgaard, Zorana Jovanovic Andersen

     
  • ·Patients with positive skin test results to penicillin should not undergo penicillin or amoxicillin challenge

    Pagina :816-817

    Miguel A. Park, Roland Solensky, David A. Khan, Mariana C. Castells, Eric M. Macy, David M. Lang

    
  • ·Long-term consequences of Hodgkin lymphoma therapy on T-cell lymphopoiesis

    Pagina :818

    Isabelle Pellier, Gilles Renier, Josué Rakotonjanahary, Marie Audrain, Elsa Berardi, Martine Gardembas, Aline Clavert, Marie Pierre Moles, Stéphanie Proust-Houdemont, Yves Reguerre, Emilie De Carli, Martine Georgin-Mege, Erwan Garo, Simon Blanchard, Charline Miot, Capucine Picard, Yves Delneste, Alain Fischer, Aline Tanguy-Schmidt, Pascale Jeannin

     
  • ·Peripheral airways dysfunction in obesity reflects increased bronchomotor tone

    Pagina :820-822

    Alpa G. Desai, Alkis Togias, Clyde Schechter, Beth Fisher, Aimee Parow, Gwen Skloot

     
  • ·High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma

    Pagina :822

    Stephen J. Fowler, Gaël Tavernier, Robert Niven

     
  • ·Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33

    Pagina :824

    Paul E. Pfeffer, Yin-Huai Chen, Grzegorz Woszczek, Nick C. Matthews, Elfy Chevretton, Atul Gupta, Sejal Saglani, Andrew Bush, Chris Corrigan, David J. Cousins, Catherine M. Hawrylowicz

     
  • ·Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE

    Pagina :827

    Ho-Sung Yu, Mi-Jin Kang, Ji-Won Kwon, So-Yeon Lee, Eun Lee, Song-I. Yang, Young-Ho Jung, Kyungmo Hong, Young-Joon Kim, Seung-Hwa Lee, Ha-Jung Kim, Hyung Young Kim, Ju-Hee Seo, Byoung-Ju Kim, Hyo-Bin Kim, Soo-Jong Hong

     
  • ·Anaphylaxis in America: A national physician survey

    Pagina :830-833

    Ashley M. Altman, Carlos A. Camargo, F. Estelle R. Simons, Philip Lieberman, Hugh A. Sampson, Lawrence B. Schwartz, F. Myron Zitt, Charlotte Collins, Michael Tringale, Marilyn Wilkinson, Robert A. Wood

     
  • ·Increasing rate of hospitalizations for food-induced anaphylaxis in Italian children: An analysis of the Italian Ministry of Health database

    Pagina :833

    Rita Nocerino, Ludovica Leone, Linda Cosenza, Roberto Berni Canani

     

• Correspondence

  • ·Reduced granulocyte counts in sputum may reflect aggravated disease

    Pagina :836

    Carl Persson, Lena Uller

    
  • ·Reply

    Pagina :836-837

    Maria M. Aleman, Katherine Mills, Martha Almond, Krista Todoric, Hongtao Zhang, Haibo Zhou, David B. Peden, Michelle L. Hernandez

    
  • ·Occupational asthma is a cause of adult-onset asthma with poor prognosis

    Pagina :837

    P. Sherwood Burge, Vicky C. Moore, Alastair S. Robertson

    
  • ·Reply

    Pagina :837-838

    Guus A. Westerhof, Elisabeth H. Bel