Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :3A

    
• • ·Table of Contents

    Pagina :6A

    
• • ·Editorial Board

    Pagina :28A

    

• Reader services

  • ·Information for Readers

    Pagina :29A

    
  • ·News & Notes

    Pagina :38A

    Mappa Mappa  
  • ·CME Activities Calendar

    Pagina :42A

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• Reviews and feature articles

  • ·A Special Thank-You to Our Reviewers

    Pagina :754-759

    
  • ·Targeted strategies directed at the molecular defect: Toward precision medicine for select primary immunodeficiency disorders

    Pagina :715-723

    Luigi D. Notarangelo, Thomas A. Fleisher

    Riassunto Riassunto Mappa Mappa  
  • ·Targeted strategies directed at the molecular defect: Toward precision medicine for select primary immunodeficiency disorders

    Pagina :724-725

    
  • ·New frontiers in the therapy of primary immunodeficiency: From gene addition to gene editing

    Pagina :726-732

    Donald B. Kohn, Caroline Y. Kuo

    Riassunto Riassunto Mappa Mappa  
  • ·Treatment of infants identified as having severe combined immunodeficiency by means of newborn screening

    Pagina :733-742

    Morna J. Dorsey, Christopher C. Dvorak, Morton J. Cowan, Jennifer M. Puck

    Riassunto Riassunto Mappa Mappa  
  • ·Immune defects caused by mutations in the ubiquitin system

    Pagina :743-753

    Amos Etzioni, Aaron Ciechanover, Eli Pikarsky

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors' Choice

    Pagina :760-761

    Cezmi A. Akdis, Zuhair K. Ballas, Associate Editors of the JACI

    Mappa Mappa  

• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :762-763

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Aspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease

    Pagina :764-766

    Katherine N. Cahill, Joshua A. Boyce

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• Editorials

  • ·Childhood obesity and asthma: To BMI or not to BMI?

    Pagina :767-768

    Erick Forno

    
  • ·It's a lot of work to be nonallergic

    Pagina :769-770

    Alessandro Sette, Véronique Schulten

    

• Asthma and lower airway disease

  • ·Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction

    Pagina :771

    Imran Satia, Nikolaos Tsamandouras, Kimberley Holt, Huda Badri, Mark Woodhead, Kayode Ogungbenro, Timothy W. Felton, Paul M. O'Byrne, Stephen J. Fowler, Jaclyn A. Smith

    Riassunto Riassunto Mappa Mappa  
  • ·Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle

    Pagina :780-789

    Philip J. Austin, Eleni Tsitsiou, Charlotte Boardman, Simon W. Jones, Mark A. Lindsay, Ian M. Adcock, Kian Fan Chung, Mark M. Perry

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  • ·Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development

    Pagina :790-796

    Halie M. Anderson, Robert F. Lemanske, Joseph R. Arron, Cecile T.J. Holweg, Victoria Rajamanickam, Ronald E. Gangnon, James E. Gern, Daniel J. Jackson

    Riassunto Riassunto Mappa Mappa  
  • ·No evidence of large genetic effects on steroid response in asthma patients

    Pagina :797

    Michael Mosteller, Louise Hosking, Kay Murphy, Judong Shen, Kijoung Song, Matthew Nelson, Soumitra Ghosh

    Riassunto Riassunto Mappa Mappa  
  • ·Pathways linking health literacy, health beliefs, and cognition to medication adherence in older adults with asthma

    Pagina :804-809

    Tacara N. Soones, Jenny L. Lin, Michael S. Wolf, Rachel O'Conor, Melissa Martynenko, Juan P. Wisnivesky, Alex D. Federman

    Riassunto Riassunto Mappa Mappa  
  • ·Body fat mass distribution and interrupter resistance, fractional exhaled nitric oxide, and asthma at school-age

    Pagina :810

    Herman T. den Dekker, Karen P.I. Ros, Johan C. de Jongste, Irwin K. Reiss, Vincent W. Jaddoe, Liesbeth Duijts

    Riassunto Riassunto Mappa Mappa  
  • ·Automated identification of an aspirin-exacerbated respiratory disease cohort

    Pagina :819

    Katherine N. Cahill, Christina B. Johns, Jing Cui, Paige Wickner, David W. Bates, Tanya M. Laidlaw, Patrick E. Beeler

    Riassunto Riassunto Mappa Mappa  
  • ·Bacterial microbiota of the upper respiratory tract and childhood asthma

    Pagina :826

    Martin Depner, Markus J. Ege, Michael J. Cox, Sarah Dwyer, Alan W. Walker, Lena T. Birzele, Jon Genuneit, Elisabeth Horak, Charlotte Braun-Fahrländer, Hanna Danielewicz, Raina M. Maier, Miriam F. Moffatt, William O. Cookson, Dick Heederik, Erika von Mutius, Antje Legatzki

    Riassunto Riassunto Mappa Mappa  
  • ·The impact of a history of asthma on long-term outcomes of people with newly diagnosed chronic obstructive pulmonary disease: A population study

    Pagina :835-843

    Tetyana Kendzerska, Teresa M. To, Shawn D. Aaron, M. Diane Lougheed, Mohsen Sadatsafavi, J. Mark FitzGerald, Andrea S. Gershon, Canadian Respiratory Research Network

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• Rhinitis, sinusitis, and upper airway disease

  • ·Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge

    Pagina :844-854

    Sunil K. Ahuja, Muthu Saravanan Manoharan, Nathan L. Harper, Fabio Jimenez, Benjamin D. Hobson, Hernan Martinez, Puraskar Ingale, Ya-Guang Liu, Andrew Carrillo, Zheng Lou, Dean L. Kellog, Seema S. Ahuja, Cynthia G. Rather, Robert E. Esch, Daniel A. Ramirez, Robert A. Clark, Kari Nadeau, Charles P. Andrews, Robert L. Jacobs, Weijing He

    Riassunto Riassunto Mappa Mappa   
  • ·MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps

    Pagina :855

    Javier Milara, Anselm Morell, Beatriz Ballester, Miguel Armengot, Esteban Morcillo, Julio Cortijo

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and skin disease

  • ·Bullous pemphigoid outcome is associated with CXCL10-induced matrix metalloproteinase 9 secretion from monocytes and neutrophils but not lymphocytes

    Pagina :863

    Meriem Riani, Sébastien Le Jan, Julie Plée, Anne Durlach, Richard Le Naour, Guy Haegeman, Philippe Bernard, Frank Antonicelli

    Riassunto Riassunto Mappa Mappa  

• Food, drug, insect sting allergy, and anaphylaxis

  • ·Omalizumab facilitates rapid oral desensitization for peanut allergy

    Pagina :873

    Andrew J. MacGinnitie, Rima Rachid, Hana Gragg, Sara V. Little, Paul Lakin, Antonella Cianferoni, Jennifer Heimall, Melanie Makhija, Rachel Robison, R. Sharon Chinthrajah, John Lee, Jennifer Lebovidge, Tina Dominguez, Courtney Rooney, Megan Ott Lewis, Jennifer Koss, Elizabeth Burke-Roberts, Kimberly Chin, Tanya Logvinenko, Jacqueline A. Pongracic, Dale T. Umetsu, Jonathan Spergel, Kari C. Nadeau, Lynda C. Schneider

    Riassunto Riassunto Mappa Mappa  
  • ·Novel baseline predictors of adverse events during oral immunotherapy in children with peanut allergy

    Pagina :882

    Yamini V. Virkud, A. Wesley Burks, Pamela H. Steele, Lloyd J. Edwards, Jelena P. Berglund, Stacie M. Jones, Amy M. Scurlock, Tamara T. Perry, Robert D. Pesek, Brian P. Vickery

    Riassunto Riassunto Mappa Mappa  
  • ·Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis

    Pagina :889

    Kaori Mukai, Nicolas Gaudenzio, Sheena Gupta, Nora Vivanco, Sean C. Bendall, Holden T. Maecker, Rebecca S. Chinthrajah, Mindy Tsai, Kari C. Nadeau, Stephen J. Galli

    Riassunto Riassunto Mappa Mappa  

• Immune deficiencies, infection, and systemic immune disorders

  • ·Human CD40 ligand deficiency dysregulates the macrophage transcriptome causing functional defects that are improved by exogenous IFN-?

    Pagina :900

    Otavio Cabral-Marques, Rodrigo Nalio Ramos, Lena F. Schimke, Taj Ali Khan, Eduardo Pinheiro Amaral, Caio César Barbosa Bomfim, Osvaldo Reis Junior, Tabata Takahashi França, Christina Arslanian, Joanna Darck Carola Correia Lima, Cristina Worm Weber, Janaíra Fernandes Ferreira, Fabiola Scancetti Tavares, Jing Sun, Maria Regina D'Imperio Lima, Marília Seelaender, Vera Lucia Garcia Calich, José Alexandre Marzagão Barbuto, Beatriz Tavares Costa-Carvalho, Gabriela Riemekasten, Gisela Seminario, Liliana Bezrodnik, Luigi Notarangelo, Troy R. Torgerson, Hans D. Ochs, Antonio Condino-Neto

    Riassunto Riassunto Mappa Mappa  
  • ·Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination

    Pagina :913-922

    María Belén Almejún, Bárbara Carolina Campos, Virginia Patiño, Miguel Galicchio, Marta Zelazko, Matías Oleastro, Pablo Oppezzo, Silvia Danielian

    Riassunto Riassunto Mappa Mappa  
  • ·?-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis

    Pagina :923

    Frank Kolbinger, Christian Loesche, Marie-Anne Valentin, Xiaoyu Jiang, Yi Cheng, Philip Jarvis, Thomas Peters, Claudio Calonder, Gerard Bruin, Florine Polus, Birgit Aigner, David M. Lee, Manfred Bodenlenz, Frank Sinner, Thomas Rudolf Pieber, Dhavalkumar D. Patel

    Riassunto Riassunto Mappa Mappa  
  • ·Dedicator of cytokinesis 8–deficient CD4⁺ T cells are biased to a T_H2 effector fate at the expense of T_H1 and T_H17 cells

    Pagina :933-949

    Stuart G. Tangye, Bethany Pillay, Katrina L. Randall, Danielle T. Avery, Tri Giang Phan, Paul Gray, John B. Ziegler, Joanne M. Smart, Jane Peake, Peter D. Arkwright, Sophie Hambleton, Jordan Orange, Christopher C. Goodnow, Gulbu Uzel, Jean-Laurent Casanova, Saul Oswaldo Lugo Reyes, Alexandra F. Freeman, Helen C. Su, Cindy S. Ma

    Riassunto Riassunto Mappa Mappa   

• Mechanisms of allergy and clinical immunology

  • ·Pentraxin 3 deletion aggravates allergic inflammation through a T_H17-dominant phenotype and enhanced CD4 T-cell survival

    Pagina :950

    Jyoti Balhara, Lianyu Shan, Jingbo Zhang, Anik Muhuri, Andrew J. Halayko, Muhamad S. Almiski, Diana Doeing, John McConville, Martin M. Matzuk, Abdelilah S. Gounni

    Riassunto Riassunto Mappa Mappa  
  • ·Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production

    Pagina :964

    Laura Maggi, Gianni Montaini, Alessio Mazzoni, Beatrice Rossettini, Manuela Capone, Maria Caterina Rossi, Veronica Santarlasci, Francesco Liotta, Oliviero Rossi, Oreste Gallo, Raffaele De Palma, Enrico Maggi, Lorenzo Cosmi, Sergio Romagnani, Francesco Annunziato

    Riassunto Riassunto Mappa Mappa  
  • ·Airborne dust and high temperatures are risk factors for invasive bacterial disease

    Pagina :977

    Jean-François Jusot, Daniel R. Neill, Elaine M. Waters, Mathieu Bangert, Marisol Collins, Laura Bricio Moreno, Katiellou G. Lawan, Mouhaiminou Moussa Moussa, Emma Dearing, Dean B. Everett, Jean-Marc Collard, Aras Kadioglu

    Riassunto Riassunto Mappa Mappa  
  • ·Pharmacologic inhibition of Notch signaling suppresses food antigen–induced mucosal mast cell hyperplasia

    Pagina :987

    Asuka Honjo, Nobuhiro Nakano, Susumu Yamazaki, Mutsuko Hara, Koichiro Uchida, Jiro Kitaura, Chiharu Nishiyama, Hideo Yagita, Yoshikazu Ohtsuka, Hideoki Ogawa, Ko Okumura, Toshiaki Shimizu

    Riassunto Riassunto Mappa Mappa  
  • ·Defective natural killer cell activity in a mouse model of eczema herpeticum

    Pagina :997

    Yuko Kawakami, Tomoaki Ando, Jong-Rok Lee, Gisen Kim, Yu Kawakami, Tae Nakasaki, Manando Nakasaki, Kenji Matsumoto, Youn Soo Choi, Toshiaki Kawakami

    Riassunto Riassunto Mappa Mappa  
  • ·MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation

    Pagina :1007

    Kristina Johansson, Carina Malmhäll, Patricia Ramos-Ramírez, Madeleine Rådinger

    Riassunto Riassunto Mappa Mappa  
  • ·Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development

    Pagina :1017

    Majda Dzidic, Thomas R. Abrahamsson, Alejandro Artacho, Bengt Björkstén, Maria Carmen Collado, Alex Mira, Maria C. Jenmalm

    Riassunto Riassunto Mappa Mappa  

• Letters to the Editor

  • ·Antibody-encoding repertoires of bone marrow and peripheral blood—a focus on IgE

    Pagina :1026-1030

    Mattias Levin, Fredrik Levander, Robert Palmason, Lennart Greiff, Mats Ohlin

      
  • ·Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?

    Pagina :1030

    Ryenne N. Ogburn, Thomas A. Randall, Yingrong Xu, Julia H. Roberts, Betelihem Mebrahtu, Jaret M. Karnuta, S. Dean Rider, Grace E. Kissling, Robert E. London, Anna Pomés, Larry Arlian, Michael C. Fitzgerald, Geoffrey A. Mueller

     
  • ·Abnormal B-cell maturation in the bone marrow of patients with germline mutations in PIK3CD

    Pagina :1032

    Alina E. Dulau Florea, Raul C. Braylan, Kristian T. Schafernak, Kelli W. Williams, Janine Daub, Rakesh K. Goyal, Jennifer M. Puck, V. Koneti Rao, Stefania Pittaluga, Steven M. Holland, Gulbu Uzel, Katherine R. Calvo

     
  • ·Neutralizing capacity of monoclonal and polyclonal anti-natalizumab antibodies: The immune response to antibody therapeutics preferentially targets the antigen-binding site

    Pagina :1035

    Karin A. van Schie, Simone Kruithof, Pauline A. van Schouwenburg, Anke Vennegoor, Joep Killestein, Gertjan Wolbink, Theo Rispens

     
  • ·A pilot study to investigate the use of serum inhaled corticosteroid concentration as a potential marker of treatment adherence in severe asthma

    Pagina :1037

    Kate E. George, Dorothy M. Ryan, Brian Keevil, Robert Niven, Stephen J. Fowler

     
  • ·Hematopoietic stem cell transplantation corrects WIP deficiency

    Pagina :1039

    Hamoud Al-Mousa, Abbas Hawwari, Abdulaziz Al-Ghonaium, Bandar Al-Saud, Hasan Al-Dhekri, Saleh Al-Muhsen, Sahar Elshorbagi, Majed Dasouki, Lina El-Baik, Amal Alseraihy, Mouhab Ayas, Rand Arnaout

     
  • ·Outcome of patients with NEMO deficiency following allogeneic hematopoietic cell transplant

    Pagina :1040

    Shanmuganathan Chandrakasan, Rebecca A. Marsh, Gulbu Uzel, Steven M. Holland, Kara N. Shah, Jack Bleesing

    
  • ·Vedolizumab as a successful treatment of CTLA-4–associated autoimmune enterocolitis

    Pagina :1043

    Alexander A. Navarini, Petr Hruz, Christoph T. Berger, Tie Zheng Hou, Charlotte Schwab, Annemarie Gabrysch, Rebecca Higgins, Natalie Frede, Barbara-Christina Padberg Sgier, Olle Kämpe, Anne-Valérie Burgener, Florian Marquardsen, Fabian Baldin, Marc Bigler, Anne Kistner, Annaise Jauch, Olivier Bignucolo, Benedikt Meyer, Fabian Meienberg, Matthias Mehling, Lukas T. Jeker, Ingmar Heijnen, Thomas D. Daikeler, Jan-Olaf Gebbers, Bodo Grimbacher, David M. Sansom, Raphael Jeker, Christoph Hess, Mike Recher

     
  • ·Hematopoietic stem cell transplant in patients with activated PI3K delta syndrome

    Pagina :1046-1049

    Zohreh Nademi, Mary A. Slatter, Christopher C. Dvorak, Benedicte Neven, Alain Fischer, Felipe Suarez, Claire Booth, Kanchan Rao, Alexandra Laberko, Julia Rodina, Yves Bertrand, Sylwia Ko?tan, Robert D?bski, Terence Flood, Mario Abinun, Andrew R. Gennery, Sophie Hambleton, Stephan Ehl, Andrew J. Cant

    
  • ·B cells differentiate in human thymus and express AIRE

    Pagina :1049

    Vincent Gies, Aurélien Guffroy, François Danion, Philippe Billaud, Céline Keime, Jean-Daniel Fauny, Sandrine Susini, Anne Soley, Thierry Martin, Jean-Louis Pasquali, Frédéric Gros, Isabelle André-Schmutz, Pauline Soulas-Sprauel, Anne-Sophie Korganow

     
  • ·Minimally important differences and risk levels for the Composite Asthma Severity Index

    Pagina :1052-1055

    Rebecca Z. Krouse, Christine A. Sorkness, Jeremy J. Wildfire, Agustin Calatroni, Rebecca Gruchalla, Gurjit K. Khurana Hershey, Meyer Kattan, Andrew H. Liu, Melanie Makhija, Stephen J. Teach, Joseph B. West, Robert A. Wood, Edward M. Zoratti, Peter J. Gergen

     
  • ·Cardiac magnetic resonance imaging for the diagnosis and follow-up of Loeffler's endocarditis

    Pagina :1055-1057

    Grazia Casavecchia, Matteo Gravina, Michele Correale, Antonio Totaro, Luca Macarini, Matteo Di Biase, Natale Daniele Brunetti

      
  • ·Adult atopic dermatitis and the risk of type 2 diabetes

    Pagina :1057-1059

    Yuki M.F. Andersen, Alexander Egeberg, Gunnar H. Gislason, Lone Skov, Filip K. Knop, Jacob P. Thyssen

     
  • ·Serum autoreactivity predicts time to response to omalizumab therapy in chronic spontaneous urticaria

    Pagina :1059

    Janine Gericke, Martin Metz, Tatevik Ohanyan, Karsten Weller, Sabine Altrichter, Per Stahl Skov, Sidsel Falkencrone, Janko Brand, Arno Kromminga, Tomasz Hawro, Martin K. Church, Marcus Maurer

     
  • ·Large-scale gene expression profiling reveals distinct type 2 inflammatory patterns in chronic rhinosinusitis subtypes

    Pagina :1061

    Matthew A. Tyler, Chris B. Russell, Dirk E. Smith, James B. Rottman, Caroline J. Padro Dietz, Xuguang Hu, Martin J. Citardi, Samer Fakhri, Shervin Assassi, Amber Luong

     

• Correspondence

  • ·Multiplex platform technology and bioinformatics are essential for development of biomarkers in atopic dermatitis

    Pagina :1065

    Judith L. Thijs, Athula Herath, Marjolein S. de Bruin-Weller, DirkJan Hijnen

    
  • ·Reply

    Pagina :1065-1066

    Linda Krause, Nikola S. Mueller, Stefanie Eyerich

    
  • ·Comparing sensitivity of Hymenoptera allergen components on different diagnostic assay systems: Comparing apples and oranges?

    Pagina :1066-1067

    Thilo Jakob, Edzard Spillner

    
  • ·Reply

    Pagina :1067-1068

    Gunter J. Sturm, Christoph Schrautzer, Lisa Arzt, Werner Aberer

    

• Correction

  • ·Correction

    Pagina :1068-1069