Sommario

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reviews and feature articles

  • ·Mechanisms that define transient versus persistent food allergy

    Pagina :453-457

    M. Cecilia Berin

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  • ·Treatment of urticarial vasculitis: A systematic review

    Pagina :458-466

    Pavel Kolkhir, Maria Grakhova, Hanna Bonnekoh, Karoline Krause, Marcus Maurer

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  • ·Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: A systematic review

    Pagina :467-485

    Petra Zimmermann, Nicole Messina, William W. Mohn, B. Brett Finlay, Nigel Curtis

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  • ·The Consortium for Food Allergy Research (CoFAR): The first generation

    Pagina :486-493

    Hugh A. Sampson, M. Cecilia Berin, Marshall Plaut, Scott H. Sicherer, Stacie Jones, A. Wesley Burks, Robert Lindblad, Donald Y.M. Leung, Robert A. Wood

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  • ·Evaluating primary end points in peanut immunotherapy clinical trials

    Pagina :494-506

    Pablo Rodríguez del Río, Carmelo Escudero, Silvia Sánchez-García, María Dolores Ibáñez, Brian P. Vickery

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  • ·Lessons learned from the study of human inborn errors of innate immunity

    Pagina :507-527

    Giorgia Bucciol, Leen Moens, Barbara Bosch, Xavier Bossuyt, Jean-Laurent Casanova, Anne Puel, Isabelle Meyts

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  • ·Flow cytometry: Surface markers and beyond

    Pagina :528-537

    Ottavia M. Delmonte, Thomas A. Fleisher

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• The Editors' choice

  • ·The Editors' Choice

    Pagina :538-539

    Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :540-541

    Marc E. Rothenberg, Jean Bousquet

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• Beyond the frontiers

  • ·Lab-on-a-chip technologies for diagnosis and monitoring of airway inflammation

    Pagina :542-544

    Mehdi Javanmard

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• Paradigms and perspectives

  • ·Prevention of food allergy: Beyond peanut

    Pagina :545-547

    J. Andrew Bird, Christopher Parrish, Kiran Patel, Jennifer A. Shih, Brian P. Vickery

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• Editorials

  • ·A personal perspective on mentoring

    Pagina :548-549

    Dean D. Metcalfe

    
  • ·School-based interventions: Where do we go from here?

    Pagina :550-551

    Jean-Marie Bruzzese, Meyer Kattan

     
  • ·Tipping the balance: A biased nanobody antagonist of CCR3 with potential for the treatment of eosinophilic inflammation

    Pagina :552-553

    James E. Pease, Timothy J. Williams

     
  • ·What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy?

    Pagina :554-556

    Katrina J. Allen, Jennifer J. Koplin

     
  • ·Identification of novel allergic diathesis genes: Are we closer to novel therapeutic targets?

    Pagina :557-559

    Michelle Daya, Kathleen C. Barnes

     
  • ·Awaiting allograft antigen: For rejection or tolerance?

    Pagina :560-562

    Tomoaki Ando, Toshiaki Kawakami

     
  • ·Staphylococcus aureus, epithelial disruption, and nasal polyps: Are we one step ahead in combatting this foe?

    Pagina :563-564

    Mahboobeh Mahdavinia, Pete S. Batra

     

• Asthma and lower airway disease

  • ·A natural killer T-cell subset that protects against airway hyperreactivity

    Pagina :565

    Ya-Ting Chuang, Krystle Leung, Ya-Jen Chang, Rosemarie H. DeKruyff, Paul B. Savage, Richard Cruse, Christophe Benoit, Dirk Elewaut, Nicole Baumgarth, Dale T. Umetsu

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  • ·Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

    Pagina :577-590

    Zala Jevnikar, Jörgen Östling, Elisabeth Ax, Jenny Calvén, Kristofer Thörn, Elisabeth Israelsson, Lisa Öberg, Akul Singhania, Laurie C.K. Lau, Susan J. Wilson, Jonathan A. Ward, Anoop Chauhan, Ana R. Sousa, Bertrand De Meulder, Matthew J. Loza, Frédéric Baribaud, Peter J. Sterk, Kian Fan Chung, Kai Sun, Yike Guo, Ian M. Adcock, Debbie Payne, Barbro Dahlen, Pascal Chanez, Dominick E. Shaw, Norbert Krug, Jens M. Hohlfeld, Thomas Sandström, Ratko Djukanovic, Anna James, Timothy S.C. Hinks, Peter H. Howarth, Outi Vaarala, Marleen van Geest, Henric Olsson

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• Rhinitis, sinusitis, and ocular allergy

  • ·Staphylococcus aureus impairs sinonasal epithelial repair: Effects in patients with chronic rhinosinusitis with nasal polyps and control subjects

    Pagina :591

    Fabiana C.P. Valera, Manon Ruffin, Damien Adam, Émilie Maillé, Badr Ibrahim, Julie Berube, Simon Rousseau, Emmanuelle Brochiero, Martin Y. Desrosiers

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• Atopic dermatitis and inflammatory skin disease

  • ·Ichthyosis molecular fingerprinting shows profound T_H17 skewing and a unique barrier genomic signature

    Pagina :604-618

    Kunal Malik, Helen He, Thy Nhat Huynh, Gary Tran, Kelly Mueller, Kristina Doytcheva, Yael Renert-Yuval, Tali Czarnowicki, Shai Magidi, Margaret Chou, Yeriel D. Estrada, Huei-Chi Wen, Xiangyu Peng, Hui Xu, Xiuzhong Zheng, James G. Krueger, Amy S. Paller, Emma Guttman-Yassky

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  • ·IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice

    Pagina :619

    Juan Manuel Leyva-Castillo, Juhan Yoon, Raif S. Geha

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  • ·T cell–intrinsic prostaglandin E₂-EP2/EP4 signaling is critical in pathogenic T_H17 cell–driven inflammation

    Pagina :631-643

    Jinju Lee, Tomohiro Aoki, Dean Thumkeo, Ratklao Siriwach, Chengcan Yao, Shuh Narumiya

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• Food allergy and gastrointestinal disease

  • ·Patterns of tree nut sensitization and allergy in the first 6 years of life in a population-based cohort

    Pagina :644

    Vicki McWilliam, Rachel Peters, Mimi L.K. Tang, Shyamali Dharmage, Anne-Louise Ponsonby, Lyle Gurrin, Kirsten Perrett, Jennifer Koplin, Katrina J. Allen, HealthNuts investigators ‡ TerenceDwyerAdrianLoweMelissaWakeColinRobertson, Terence Dwyer, Adrian Lowe, Melissa Wake, Colin Robertson

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  • ·Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy

    Pagina :651

    Anna Nowak-W?grzyn, Robert A. Wood, Kari C. Nadeau, Jacqueline A. Pongracic, Alice K. Henning, Robert W. Lindblad, Kirsten Beyer, Hugh A. Sampson

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  • ·Rural and urban food allergy prevalence from the South African Food Allergy (SAFFA) study

    Pagina :662

    Maresa Botha, Wisdom Basera, Heidi E. Facey-Thomas, Ben Gaunt, Claudia L. Gray, Jordache Ramjith, Alexandra Watkins, Michael E. Levin

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• Biologics and immunotherapy

  • ·Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness

    Pagina :669

    Milica Grozdanovic, Kimberly G. Laffey, Hazem Abdelkarim, Ben Hitchinson, Anantha Harijith, Hyung-Geon Moon, Gye Young Park, Lee K. Rousslang, Joanne C. Masterson, Glenn T. Furuta, Nadya I. Tarasova, Vadim Gaponenko, Steven J. Ackerman

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• Mechanisms of allergy/immunology

  • ·Profilin-mediated food-induced allergic reactions are associated with oral epithelial remodeling

    Pagina :681

    Domenico Rosace, Cristina Gomez-Casado, Paloma Fernandez, Marina Perez-Gordo, María del Carmen Dominguez, Angel Vega, María Teresa Belver, Tania Ramos, Francisco Vega, Guadalupe Marco, Manuel de Pedro, Leticia Sanchez, María de las Mercedes Arnas, Marcela Santaolalla, Miguel Ángel Saez, Sara Benedé, Montserrat Fernandez-Rivas, Carlos Blanco, Maria Isabel Alvarado, María M. Escribese, Domingo Barber

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  • ·Eleven loci with new reproducible genetic associations with allergic disease risk

    Pagina :691-699

    Manuel A.R. Ferreira, Judith M. Vonk, Hansjörg Baurecht, Ingo Marenholz, Chao Tian, Joshua D. Hoffman, Quinta Helmer, Annika Tillander, Vilhelmina Ullemar, Yi Lu, Franz Rüschendorf, 23andMe Research Team f, SHARE study ?, David A. Hinds, Norbert Hübner, Stephan Weidinger, Patrik K.E. Magnusson, Eric Jorgenson, Young-Ae Lee, Dorret I. Boomsma, Robert Karlsson, Catarina Almqvist, Gerard H. Koppelman, Lavinia Paternoster

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  • ·CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy

    Pagina :700

    Olatz Zenarruzabeitia, Joana Vitallé, Iñigo Terrén, Ane Orrantia, Itziar Astigarraga, Leire Dopazo, Carlos Gonzalez, Laura Santos-Díez, Carlos Tutau, Pedro M. Gamboa, Agurtzane Bilbao, Francisco Borrego

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  • ·Severe combined immunodeficiency in stimulator of interferon genes (STING) V154M/wild-type mice

    Pagina :712

    Delphine Bouis, Peggy Kirstetter, Florent Arbogast, Delphine Lamon, Virginia Delgado, Sophie Jung, Claudine Ebel, Hugues Jacobs, Anne-Marie Knapp, Nadia Jeremiah, Alexandre Belot, Thierry Martin, Yanick J. Crow, Isabelle André-Schmutz, Anne-Sophie Korganow, Frédéric Rieux-Laucat, Pauline Soulas-Sprauel

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• Translational and clinical immunology

  • ·Recombination activity of human recombination-activating gene 2 (RAG2) mutations and correlation with clinical phenotype

    Pagina :726-735

    Irit Tirosh, Yasuhiro Yamazaki, Francesco Frugoni, Francesca A. Ververs, Eric J. Allenspach, Yu Zhang, Siobhan Burns, Waleed Al-Herz, Lenora Noroski, Jolan E. Walter, Andrew R. Gennery, Mirjam van der Burg, Luigi D. Notarangelo, Yu Nee Lee

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  • ·Identification of galectin-3 as an autoantigen in patients with IgG₄-related disease

    Pagina :736

    Cory A. Perugino, Sultan B. AlSalem, Hamid Mattoo, Emanuel Della-Torre, Vinay Mahajan, Gayathri Ganesh, Hugues Allard-Chamard, Zachary Wallace, Sydney B. Montesi, Johannes Kreuzer, Wilhelm Haas, John H. Stone, Shiv Pillai

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• Epidemiology and health care delivery

  • ·Building Bridges for Asthma Care: Reducing school absence for inner-city children with health disparities

    Pagina :746

    Stanley J. Szefler, Michelle M. Cloutier, Miguel Villarreal, Jessica P. Hollenbach, Melanie Gleason, Christy Haas-Howard, Carol Vinick, Agustin Calatroni, Lisa Cicutto, Marty White, Shann Williams, Meghan McGinn, Christine Langton, Donna Shocks, Herman Mitchell, David A. Stempel

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  • ·School-supervised use of a once-daily inhaled corticosteroid regimen: A cluster randomized trial

    Pagina :755-764

    Joe K. Gerald, Julia M. Fisher, Mark A. Brown, Conrad J. Clemens, Melissa A. Moore, Scott C. Carvajal, Donna Bryson, Nikki Stefan, Dean Billheimer, Lynn B. Gerald

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• Letters to the Editor

  • ·Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection

    Pagina :765

    Liyana Ahmad, Bayarchimeg Mashbat, Corwin Leung, Charlotte Brookes, Samar Hamad, Sina Krokowski, Avinash R. Shenoy, Lazaro Lorenzo, Michael Levin, Peter O'Hare, Shen-Ying Zhang, Jean-Laurent Casanova, Serge Mostowy, Vanessa Sancho-Shimizu

     
  • ·Increased surface expression of NOTCH on memory T cells in peripheral blood from patients with asthma

    Pagina :769

    Irma Tindemans, Heleen Vroman, Melanie Lukkes, Menno van Nimwegen, Marjolein J.W. de Bruijn, Bobby W.S. Li, Alex Kleinjan, Geertje M. de Boer, Gerdien A. Tramper-Stranders, Mirjam Kool, Gert-Jan Braunstahl, Rudi W. Hendriks

     
  • ·Maintained thymic output of conventional and regulatory T cells during human pregnancy

    Pagina :771

    Sandra Hellberg, Ratnesh B. Mehta, Anna Forsberg, Göran Berg, Jan Brynhildsen, Ola Winqvist, Maria C. Jenmalm, Jan Ernerudh

     
  • ·Intestinal dysbiosis in inflammatory bowel disease associated with primary immunodeficiency

    Pagina :775

    Harry Sokol, Nizar Mahlaoui, Claire Aguilar, Perrine Bach, Olivier Join-Lambert, Aurélie Garraffo, Philippe Seksik, François Danion, Sarah Jegou, Marjolene Straube, Christelle Lenoir, Bénédicte Neven, Despina Moshous, Stéphane Blanche, Bénédicte Pigneur, Olivier Goulet, Frank Ruemmele, Felipe Suarez, Laurent Beaugerie, Stéphanie Pannier, Françoise Mazingue, Olivier Lortholary, Lionel Galicier, Capucine Picard, Geneviève de Saint Basile, Sylvain Latour, Alain Fischer

     
  • ·Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma

    Pagina :778

    Yapei Huang, Yan Xie, Haihong Jiang, Peter W. Abel, Reynold A. Panettieri, Thomas B. Casale, Yaping Tu

     
  • ·EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease

    Pagina :782

    David C. Thomas, Louis-Marie Charbonnier, Andrea Schejtman, Hasan Aldhekri, Eve L. Coomber, Elizabeth R. Dufficy, Anne E. Beenken, James C. Lee, Simon Clare, Anneliese O. Speak, Adrian J. Thrasher, Giorgia Santilli, Hamoud Al-Mousa, Fowzan S. Alkuraya, Talal A. Chatila, Kenneth G.C. Smith

     
  • ·CSF3R/CD114 mediates infection-dependent transition to severe asthma

    Pagina :785

    Hao Wang, Meaghan FitzPatrick, Nicholas J. Wilson, Desiree Anthony, Patrick C. Reading, Catherine Satzke, Eileen M. Dunne, Paul V. Licciardi, Huei Jiunn Seow, Kristy Nichol, Ian M. Adcock, Kian Fan Chung, Gary P. Anderson, Ross Vlahos, Peter Wark, Steven Bozinovski

     
  • ·Real-life treatment of cholinergic urticaria with omalizumab

    Pagina :788

    Sabine Altrichter, Mati Chuamanochan, Henriette Knoth, Aida Asady, Tatevik Ohanyan, Martin Metz, Marcus Maurer

     
  • ·Identification of bee venom Api m 1 IgE epitopes and characterization of corresponding mimotopes

    Pagina :791

    Abida Zahirovi?, Ana Koren, Peter Kopa?, Borut Štrukelj, Peter Korošec, Mojca Lunder

     
  • ·Imatinib stimulates prostaglandin E₂ and attenuates cytokine release via EP4 receptor activation

    Pagina :794

    Thomas Bärnthaler, Katharina Jandl, Heinz Sill, Barbara Uhl, Yannick Schreiber, Magdalena Grill, Dominique Thomas, Rudolf Schicho, Gunther Marsche, Saša Frank, Akos Heinemann, Rufina Schuligoi

     
  • ·Human primary immunodeficiency caused by expression of a kinase-dead p110? mutant

    Pagina :797

    Sarah Beaussant Cohen, Wayne Bainter, Jared L. Johnson, Ting-Yu Lin, Jenny C.Y. Wong, Jacqueline G. Wallace, Jennifer Jones, Sonia Qureshi, Fatima Mir, Farah Qamar, Lewis C. Cantley, Raif S. Geha, Janet Chou

     
  • ·Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease

    Pagina :799

    Katherine N. Cahill, Katherine Murphy, Joseph Singer, Elliot Israel, Joshua A. Boyce, Tanya M. Laidlaw

     
  • ·Validation of the maximum symptom day among children with asthma

    Pagina :803

    Tianshi David Wu, Matthew Perzanowski, Roger D. Peng, Robert A. Wise, Susan Balcer-Whaley, Michelle Newman, Amparito Cunningham, Wanda Phipatanakul, Elizabeth C. Matsui, Meredith C. McCormack

     
  • ·Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

    Pagina :805-807

    Heleen Scheerens, Ashley Smith, Olga Li, Lee Honigberg, Jeffrey M. Harris, Gabriele Holtappels, Claus Bachert

      
  • ·Oral exposure to mite allergens: Sensitizer or tolerogenic?

    Pagina :808

    Mario Sánchez-Borges, Arnaldo Capriles-Hullet

    
  • ·Reply

    Pagina :808-809

    Patricia Macchiaverni, Nour Baiz, Akila Rekima, Isabella Annesi-Maesano, Valerie Verhasselt

    
  • ·Early-onset generalized pustular psoriasis is representative of autoinflammatory keratinization diseases

    Pagina :809-810

    Masashi Akiyama

    
  • ·Reply

    Pagina :810-811

    Alexander A. Navarini, Catherine H. Smith, Jonathan N. Barker, Francesca Capon

    
  • ·Corrigendum

    Pagina :811

     

• Reader services

  • ·Information for Readers

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  • ·News & Notes

    Pagina :A38

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  • ·Continuing Medical Education Calendar

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