Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reviews and feature articles

  • ·Cell-by-cell deciphering of T cells in allergic inflammation

    Pagina :1143-1148

    Ting Wen, Marc E. Rothenberg

    Riassunto Riassunto  
  • ·Cell-by-cell deciphering of T cells in allergic inflammation

    Pagina :1149

    
  • ·Single-cell analysis to understand the diversity of immune cell types that drive disease pathogenesis

    Pagina :1150-1153

    Grégory Seumois, Pandurangan Vijayanand

    Riassunto Riassunto  

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :1154-1155

    Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :1156-1157

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia

    Pagina :1158-1160

    Nora A. Barrett, Alex K. Shalek

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• Editorials

  • ·The Journal of Allergy and Clinical Immunology: 90 years strong

    Pagina :1161-1162

    Zuhair K. Ballas

    
  • ·Landmark papers in our journal: Articles I to III of the series describing the discovery of IgE by the Ishizakas

    Pagina :1163-1165

    Hirohisa Saito, Harald Renz

     
  • ·The ?-adrenergic theory of bronchial asthma: 50 years later

    Pagina :1166-1168

    Blanca Camoretti-Mercado, Richard F. Lockey

     
  • ·Asthma and psoriasis: What do they have in common? IL-17A!

    Pagina :1169-1171

    William W. Busse

     
  • ·Targeting histone deacetylases to restore epithelial barrier integrity: A new option for personalized medicine in patients with allergic airway disorders?

    Pagina :1172-1174

    Steve N. Georas

     
  • ·Counteracting lipids orchestrate type 2 immunity

    Pagina :1175-1176

    Kilian Eyerich

     
  • ·Blocking antibodies in immunotherapy: Quality versus quantity

    Pagina :1177-1179

    Donald MacGlashan

     

• Asthma and lower airway disease

  • ·Symptoms and perception of airway obstruction in asthmatic patients: Clinical implications for use of reliever medications

    Pagina :1180-1186

    Peter J. Barnes, Stanley J. Szefler, Helen K. Reddel, Bradley E. Chipps

    Riassunto Riassunto Mappa Mappa   
  • ·Distinct nasal airway bacterial microbiotas differentially relate to exacerbation in pediatric patients with asthma

    Pagina :1187-1197

    Kathryn McCauley, Juliana Durack, Ricardo Valladares, Douglas W. Fadrosh, Din L. Lin, Agustin Calatroni, Petra K. LeBeau, Hoang T. Tran, Kei E. Fujimura, Brandon LaMere, Geil Merana, Kole Lynch, Robyn T. Cohen, Jacqueline Pongracic, Gurjit K. Khurana Hershey, Carolyn M. Kercsmar, Michelle Gill, Andrew H. Liu, Haejin Kim, Meyer Kattan, Stephen J. Teach, Alkis Togias, Homer A. Boushey, James E. Gern, Daniel J. Jackson, Susan V. Lynch, National Institute of Allergy and Infectious Diseases–sponsored Inner-City Asthma Consortium

    Riassunto Riassunto Mappa Mappa   
  • ·IL-17–high asthma with features of a psoriasis immunophenotype

    Pagina :1198-1213

    Jörgen Östling, Marleen van Geest, James P.R. Schofield, Zala Jevnikar, Susan Wilson, Jonathan Ward, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Sven-Erik Dahlen, Stephen J. Fowler, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Ana R. Sousa, Yike Guo, Ian M. Adcock, Peter Howarth, Kian Fan Chung, Jeanette Bigler, Peter J. Sterk, Paul J. Skipp, Ratko Djukanovi?, Outi Vaarala, U-BIOPRED Study Group, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, K.F. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powell, G. Praticò, M. Puig N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Antonios Aliprantis, David Allen, Kjell Alving, P. Badorrek, David Balgoma, S. Ballereau, Clair Barber, Manohara Kanangana Batuwitage, A. Bautmans, A. Bedding, A.F. Behndig, Jorge Beleta, A. Berglind, A. Berton, Grazyna Bochenek, Armin Braun, D. Campagna, Leon Carayannopoulos, C. Casaulta, Romanas Chaleckis, B. Dahlén, imothy Davison, Jorge De Alba, Inge De Lepeleire, Tamara Dekker, Ingrid Delin, P. Dennison, Annemiek Dijkhuis, Paul Dodson, Aleksandra Draper, K. Dyson, Jessica Edwards, L. El Hadjam, Rosalia Emma, Magnus Ericsson, C. Faulenbach, Breda Flood, G. Galffy, Hector Gallart, D. Garissi, J. Gent, M. Gerhardsson de Verdier, D. Gibeon, Cristina Gomez, Kerry Gove, Neil Gozzard, E. Guillmant-Farry, E. Henriksson, Lorraine Hewitt, U. Hoda, Richard Hu, Sile Hu, X. Hu, E. Jeyasingham, K. Johnson, N. Jullian, Juliette Kamphuis, Erika J. Kennington, Dyson Kerry, G. Kerry, M. Klüglich, Hugo Knobel, Johan Kolmert, J.R. Konradsen, Maxim Kots, Kosmas Kretsos, L. Krueger, Scott Kuo, Maciej Kupczyk, Bart Lambrecht, A.-S. Lantz, Christopher Larminie, L.X. Larsson, P. Latzin, N. Lazarinis, N. Lemonnier, Saeeda Lone-Latif, L.A. Lowe, Alexander Manta, Lisa Marouzet, Jane Martin, Caroline Mathon, L. McEvoy, Sally Meah, A. Menzies-Gow, Leanne Metcalf, Maria Mikus, Philip Monk, Shama Naz, K. Nething, Ben Nicholas, U. Nihlén, Peter Nilsson, R. Niven, B. Nordlund, S. Nsubuga, Antonio Pacino, Susanna Palkonen, J. Pellet, Giorgio Pennazza, Anne Petrén, Sandy Pink, C. Pison, Anthony Postle, Malayka Rahman-Amin, Lara Ravanetti, Emma Ray, Stacey Reinke, Leanne Reynolds, K. Riemann, Martine Robberechts, J.P. Rocha, C. Rossios, Kirsty Russell, Michael Rutgers, G. Santini, Marco Santoninco, M. Saqi, Corinna Schoelch, James P.R. Schofield, S. Scott, N. Sehgal, Marcus Sjödin, Barbara Smids, Caroline Smith, Jessica Smith, Katherine M. Smith, P. Söderman, A. Sogbessan, F. Spycher, Doroteya Staykova, S. Stephan, J. Stokholm, K. Strandberg, M. Sunther, M. Szentkereszty, L. Tamasi, K. Tariq, John-Olof Thörngren, Jonathan Thorsen, S. Valente, Marianne van de Pol, C.M. van Drunen, Jonathan Van Eyll, Jenny Versnel, Anton Vink, C. von Garnier, A. Vyas, Frans Wald, Samantha Walker, Jonathan Ward, Kristiane Wetzel, Coen Wiegman, Siân Williams, Xian Yang, Elizabeth Yeyasingham, W. Yu Amgen, W. Zetterquist, Z. Zolkipli, A.H. Zwinderman

    Riassunto Riassunto Mappa Mappa   
  • ·Associations between fungal and bacterial microbiota of airways and asthma endotypes

    Pagina :1214

    Anukriti Sharma, Bharathi Laxman, Edward T. Naureckas, D. Kyle Hogarth, Anne I. Sperling, Julian Solway, Carole Ober, Jack A. Gilbert, Steven R. White

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• Rhinitis, sinusitis, and ocular allergy

  • ·15-Lipoxygenase 1 in nasal polyps promotes CCL26/eotaxin 3 expression through extracellular signal-regulated kinase activation

    Pagina :1228

    Zhipeng Li, Ming Zeng, Yanhan Deng, Jinming Zhao, Xiuxia Zhou, John B. Trudeau, Ezequiel Goldschmidt, John A. Moore, Hongwei Chu, Weitian Zhang, Shankai Yin, Zheng Liu, Y. Peter Di, Stella E. Lee, Sally E. Wenzel

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  • ·Blocking histone deacetylase activity as a novel target for epithelial barrier defects in patients with allergic rhinitis

    Pagina :1242

    Brecht Steelant, Paulina Wawrzyniak, Katleen Martens, Anne-Charlotte Jonckheere, Benoit Pugin, Rik Schrijvers, Dominique M. Bullens, Jeroen A. Vanoirbeek, Krzysztof Krawczyk, Anita Dreher, Cezmi A. Akdis, Peter W. Hellings

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  • ·Cross-talk between T_H2 and T_H17 pathways in patients with chronic rhinosinusitis with nasal polyps

    Pagina :1254-1264

    Min Wang, Nan Zhang, Ming Zheng, Ying Li, Lingling Meng, Yu Ruan, Jinbo Han, Na Zhao, Xiangdong Wang, Luo Zhang, Claus Bachert

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• Atopic dermatitis and inflammatory skin disease

  • ·Prostaglandin E₂ (PGE₂)–EP2 signaling negatively regulates murine atopic dermatitis–like skin inflammation by suppressing thymic stromal lymphopoietin expression

    Pagina :1265

    Yu Sawada, Tetsuya Honda, Satoshi Nakamizo, Saeko Nakajima, Yumi Nonomura, Atsushi Otsuka, Gyohei Egawa, Tomohiro Yoshimoto, Motonobu Nakamura, Shuh Narumiya, Kenji Kabashima

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  • ·Crisaborole and atopic dermatitis skin biomarkers: An intrapatient randomized trial

    Pagina :1274-1289

    Robert Bissonnette, Ana B. Pavel, Aisleen Diaz, John L. Werth, Chuanbo Zang, Ivana Vranic, Vivek S. Purohit, Michael A. Zielinski, Bonnie Vlahos, Yeriel D. Estrada, Etienne Saint-Cyr Proulx, William C. Ports, Emma Guttman-Yassky

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• Food allergy and gastrointestinal disease

  • ·Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens

    Pagina :1290-1309

    Joost Westerhout, Joseph L. Baumert, W. Marty Blom, Katrina J. Allen, Barbara Ballmer-Weber, René W.R. Crevel, Anthony E.J. Dubois, Montserrat Fernández-Rivas, Matthew J. Greenhawt, Jonathan O'B. Hourihane, Jennifer J. Koplin, Astrid G. Kruizinga, Thuy-My Le, Hugh A. Sampson, Wayne G. Shreffler, Paul J. Turner, Steve L. Taylor, Geert F. Houben, Benjamin C. Remington

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  • ·Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy

    Pagina :1310

    Sarita U. Patil, Johanna Steinbrecher, Agustin Calatroni, Neal Smith, Alex Ma, Bert Ruiter, Yamini Virkud, Michael Schneider, Wayne G. Shreffler

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  • ·Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization

    Pagina :1320

    Edwin H. Kim, Luanna Yang, Ping Ye, Rishu Guo, Quefeng Li, Michael D. Kulis, A. Wesley Burks

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  • ·Earlier ingestion of peanut after changes to infant feeding guidelines: The EarlyNuts study

    Pagina :1327

    Victoria X. Soriano, Rachel L. Peters, Anne-Louise Ponsonby, Shyamali C. Dharmage, Kirsten P. Perrett, Michael J. Field, Andrew Knox, Dean Tey, Sasha Odoi, Grace Gell, Beatriz Camesella Perez, Katrina J. Allen, Lyle C. Gurrin, Jennifer J. Koplin

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• Biologics and immunotherapy

  • ·Long-term safety and pharmacodynamics of mepolizumab in children with severe asthma with an eosinophilic phenotype

    Pagina :1336

    Atul Gupta, Masanori Ikeda, Bob Geng, Jay Azmi, Robert G. Price, Eric S. Bradford, Steven W. Yancey, Jonathan Steinfeld

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• Mechanisms of allergy/immunology

  • ·Percutaneous sensitization is limited by in situ inhibition of cutaneous dendritic cell migration through skin-resident regulatory T cells

    Pagina :1343

    Sho Hanakawa, Akihiko Kitoh, Rintaro Shibuya, Teruki Dainichi, Takashi Nomura, Tetsuya Honda, Gyohei Egawa, Atsushi Otsuka, Saeko Nakajima, Mitsugu Fujita, Kenji Kabashima

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  • ·HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy

    Pagina :1354-1363

    Emiko Noguchi, Masato Akiyama, Akiko Yagami, Tomomitsu Hirota, Yukinori Okada, Zenichiro Kato, Reiko Kishikawa, Yuma Fukutomi, Michihiro Hide, Eishin Morita, Michiko Aihara, Makiko Hiragun, Yuko Chinuki, Takahiro Okabe, Akiko Ito, Atsuko Adachi, Atsushi Fukunaga, Yumiko Kubota, Toshiyuki Aoki, Youko Aoki, Kazue Nishioka, Tetsuya Adachi, Nobuo Kanazawa, Hitoshi Miyazawa, Hiroyuki Sakai, Takehito Kozuka, Hideo Kitamura, Hideo Hashizume, Chiharu Kanegane, Koji Masuda, Kumiya Sugiyama, Reiko Tokuda, Junichi Furuta, Ikkou Higashimoto, Atsuko Kato, Mariko Seishima, Akihiko Tajiri, Atsuko Tomura, Hiroko Taniguchi, Hiroto Kojima, Hidenori Tanaka, Aiko Sakai, Wataru Morii, Masashi Nakamura, Yoichiro Kamatani, Atsushi Takahashi, Michiaki Kubo, Mayumi Tamari, Hirohisa Saito, Kayoko Matsunaga

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  • ·Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy

    Pagina :1364-1376

    Helka Göös, Christopher L. Fogarty, Biswajyoti Sahu, Vincent Plagnol, Kristiina Rajamäki, Katariina Nurmi, Xiaonan Liu, Elisabet Einarsdottir, Annukka Jouppila, Tom Pettersson, Helena Vihinen, Kaarel Krjutskov, Päivi Saavalainen, Asko Järvinen, Mari Muurinen, Dario Greco, Giovanni Scala, James Curtis, Dan Nordström, Robert Flaumenhaft, Outi Vaarala, Panu E. Kovanen, Salla Keskitalo, Annamari Ranki, Juha Kere, Markku Lehto, Luigi D. Notarangelo, Sergey Nejentsev, Kari K. Eklund, Markku Varjosalo, Jussi Taipale, Mikko R.J. Seppänen

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  • ·Dedicator of cytokinesis protein 2 couples with lymphoid enhancer–binding factor 1 to regulate expression of CD21 and B-cell differentiation

    Pagina :1377

    Yukai Jing, Danqing Kang, Luyao Liu, Huang Huang, Anwei Chen, Lu Yang, Panpan Jiang, Na Li, Heather Miller, Zheng Liu, Xiaofei Zhu, Jun Yang, Xiaochuan Wang, Jinqiao Sun, Zhiping Liu, Wanli Liu, Xinyuan Zhou, Chaohong Liu

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• Translational and clinical immunology

  • ·T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children

    Pagina :1391

    Cara L. Hrusch, Michelle M. Stein, Justyna Gozdz, Mark Holbreich, Erika von Mutius, Donata Vercelli, Carole Ober, Anne I. Sperling

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• Environmental and occupational disease

  • ·Indoor bacterial microbiota and development of asthma by 10.5 years of age

    Pagina :1402-1410

    Anne M. Karvonen, Pirkka V. Kirjavainen, Martin Täubel, Balamuralikrishna Jayaprakash, Rachel I. Adams, Joanne E. Sordillo, Diane R. Gold, Anne Hyvärinen, Sami Remes, Erika von Mutius, Juha Pekkanen

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• Letters to the Editor

  • ·Immunoinflammatory responses to febrile lower respiratory infections in infants display uniquely complex/intense transcriptomic profiles

    Pagina :1411-1413

    Anya C. Jones, Denise Anderson, Sally Galbraith, Emmanuelle Fantino, Diana Gutierrez Cardenas, James F. Read, Michael Serralha, Barbara J. Holt, Deborah H. Strickland, Peter D. Sly, Anthony Bosco, Patrick G. Holt

      
  • ·Single-cell transcriptomics reveal polyclonal memory T-cell responses in skin with positive abacavir patch test results

    Pagina :1413

    Alec James Redwood, Francois Rwandamuriye, Abha Chopra, Shay Leary, Ramesh Ram, Wyatt McDonnell, Katherine Konvinse, Katie White, Rebecca Pavlos, David M. Koelle, Simon Mallal, Elizabeth J. Phillips

     
  • ·De novo generation of a functional human thymus from induced pluripotent stem cells

    Pagina :1416

    Amiet R. Chhatta, Martijn Cordes, Maaike A.J. Hanegraaf, Sandra Vloemans, Tom Cupedo, Jan J. Cornelissen, Francoise Carlotti, Daniela Salvatori, Karin Pike-Overzet, Willem E. Fibbe, Rob C. Hoeben, Harald M.M. Mikkers, Frank J.T. Staal

     
  • ·Hedgehog signaling promotes T_H2 differentiation in naive human CD4 T cells

    Pagina :1419

    Diana C. Yánez, Ching-In Lau, Mira Manilal Chawda, Susan Ross, Anna L. Furmanski, Tessa Crompton

     
  • ·Early-onset airway damage in early-career elite athletes: A risk factor for exercise-induced bronchoconstriction

    Pagina :1423

    Anne-Charlotte Jonckheere, Sven Seys, Ellen Dilissen, An-Sofie Schelpe, Sarah Van der Eycken, Steffie Corthout, Tulasi Verhalle, Janne Goossens, Vincent Vanbelle, Sven Aertgeerts, Thierry Troosters, Koen Peers, Lieven Dupont, Dominique Bullens

     
  • ·Novel pendrin inhibitor attenuates airway hyperresponsiveness and mucin expression in experimental murine asthma

    Pagina :1425

    Jinhong Park, Hyun Jae Lee, Doona Song, Mia Gi, Sungwoo Jo, Dong-kyu Jeon, Yohan Seo, Bomin Kim, Ho Lee, Wan Namkung, Gyoonhee Han, Jae Young Choi

     
  • ·Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics

    Pagina :1428

    Jaime M. Cyphert-Daly, Zhonghui Yang, Jennifer L. Ingram, Robert M. Tighe, Loretta G. Que

     
  • ·Unconventional ST2- and CD127-negative lung ILC2 populations are induced by the fungal allergen Alternaria alternata

    Pagina :1432

    Kellen J. Cavagnero, Jana H. Badrani, Luay H. Naji, Michael B. Amadeo, Veranca S. Shah, Suzanna Gasparian, Alexa Pham, Alice W. Wang, Grégory Seumois, Michael Croft, David H. Broide, Taylor A. Doherty

     
  • ·Prevalence and characteristics of adult shellfish allergy in the United States

    Pagina :1435

    Christopher M. Warren, Ozge N. Aktas, Ruchi S. Gupta, Carla M. Davis

     
  • ·Functional evaluation of the pathological significance of MEFV variants using induced pluripotent stem cell–derived macrophages

    Pagina :1438

    Takeshi Shiba, Takayuki Tanaka, Hiroaki Ida, Misa Watanabe, Haruna Nakaseko, Mitsujiro Osawa, Hirofumi Shibata, Kazushi Izawa, Takahiro Yasumi, Yuri Kawasaki, Megumu K. Saito, Junko Takita, Toshio Heike, Ryuta Nishikomori

     
  • ·Recurrent inflammatory disease caused by a heterozygous mutation in CD48

    Pagina :1441

    Benjamin Volkmer, Raquel Planas, Emanuel Gossweiler, Anna Lünemann, Lennart Opitz, Andrea Mauracher, Ursina Nüesch, Tenzin Gayden, Daniela Kaiser, Barbara Drexel, Claudia Dumrese, Nada Jabado, Stefano Vavassori, Jana Pachlopnik Schmid

     
  • ·Early-life antibiotic exposure and childhood food allergy: A systematic review

    Pagina :1445-1448

    Stejara A. Netea, Nicole L. Messina, Nigel Curtis

     
  • ·Detection of KIT D816V mutation in patients with severe anaphylaxis and normal basal tryptase—first data from the Anaphylaxis Registry (NORA)

    Pagina :1448

    Sabine Dölle-Bierke, Frank Siebenhaar, Thomas Burmeister, Margitta Worm

     
  • ·A comprehensive characterization of chronic norovirus infection in immunodeficient hosts

    Pagina :1450-1453

    Li-An K. Brown, Christopher Ruis, Ian Clark, Sunando Roy, Julianne R. Brown, Adriana S. Albuquerque, Smita Y. Patel, Joanne Miller, Mohammed Yousuf Karim, Samir Dervisevic, Jennifer Moore, Charlotte A. Williams, Juliana Cudini, Fernando Moreira, Penny Neild, Suranjith L. Seneviratne, Sarita Workman, Christos Toumpanakis, Claire Atkinson, Siobhan O. Burns, Judith Breuer, David M. Lowe

      

• Correspondence

  • ·Does maternal IgG protect infants from allergen-specific IgE sensitization?

    Pagina :1454-1455

    Rob C. Aalberse, Ulrike Gehring, Marjan Tewis, Theo Rispens

     
  • ·Reply

    Pagina :1455-1456

    Sabine Flicker, Musa Khaitov, Rudolf Valenta

    

• Corrigenda

  • ·Corrigenda

    Pagina :1456

    
  • ·Corrigenda

    Pagina :1456

    

• Reader services

  • ·Information for Readers

    Pagina :A36

    
  • ·News & Notes

    Pagina :A38

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  • ·Continuing Medical Education Calendar

    Pagina :A47

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