Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A5

    
• • ·Table of Contents

    Pagina :A8

    
• • ·Editorial Board

    Pagina :A23

    

• Reader services

  • ·Information for Readers

    Pagina :A24

    
  • ·News & Notes

    Pagina :A26

    Mappa Mappa  
  • ·Continuing Medical Education Calendar

    Pagina :A29

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• Reviews and feature articles

  • ·Overview of the current status of gene therapy for primary immune deficiencies (PIDs)

    Pagina :229-233

    Caroline Y. Kuo, Donald B. Kohn

    Riassunto Riassunto  
  • ·Overview of the current status of gene therapy for primary immune deficiencies (PIDs)

    Pagina :234-235

    
  • ·Neonatal thymectomy in children—accelerating the immunologic clock?

    Pagina :236-243

    Angela Deya-Martinez, Aisling M. Flinn, Andrew R. Gennery

    Riassunto Riassunto Mappa Mappa  
  • ·Consensus report from the Food Allergy Research & Education (FARE) 2019 Oral Immunotherapy for Food Allergy Summit

    Pagina :244-249

    Amber N. Pepper, Amal Assa’ad, Michael Blaiss, Emily Brown, Sharon Chinthrajah, Christina Ciaccio, Mary Beth Fasano, Ruchi Gupta, Nurry Hong, David Lang, Todd Mahr, Erin Malawer, Anita Roach, Wayne Shreffler, Scott Sicherer, Kathleen Vickers, Brian P. Vickery, Richard Wasserman, Kimberley Yates, Thomas B. Casale

    Riassunto Riassunto Mappa Mappa

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :250-255

    Zuhair K. Ballas, Associate Editors of the JACI

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• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :256-257

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Gene therapy for X-linked severe combined immunodeficiency: Historical outcomes and current status

    Pagina :258-261

    Sung-Yun Pai, Adrian J. Thrasher

    Mappa Mappa  
  • ·Gene therapy for Wiskott-Aldrich syndrome: History, new vectors, future directions

    Pagina :262-265

    Francesca Ferrua, Francesco Marangoni, Alessandro Aiuti, Maria Grazia Roncarolo

    Mappa Mappa  
  • ·Cost considerations for clinicians prescribing biologic drugs: Who pays?

    Pagina :266-269

    Christopher Hvisdas, Patrick K. Gleeson, Andrea J. Apter

     
  • ·Targeting maternal immune function during pregnancy for asthma prevention in offspring: Harnessing the “farm effect”?

    Pagina :270-272

    Patrick G. Holt, Deborah H. Strickland, Adnan Custovic

    Mappa Mappa  
  • ·Active control of mucosal tolerance and inflammation by human IgA and IgG antibodies

    Pagina :273-275

    Willianne Hoepel, Korneliusz Golebski, Cornelis M. van Drunen, Jeroen den Dunnen

     

• Editorials

  • ·NK cells as a possible new player in atopic dermatitis

    Pagina :276-277

    Kenji Kabashima, Stephan Weidinger

     
  • ·ILC2s: Are they what we think they are?

    Pagina :280-282

    Kellen J. Cavagnero, Taylor A. Doherty

     
  • ·Birth control medications decrease asthma incidence

    Pagina :283-284

    Dawn C. Newcomb

     
  • ·Taking the red out of eosinophilic inflammation in COPD

    Pagina :278-279

    Robert K. Bush

    

• COVID-19

  • ·Molecular mechanisms and epidemiology of COVID-19 from an allergist’s perspective

    Pagina :285-299

    Koa Hosoki, Abhijit Chakraborty, Sanjiv Sur

    Riassunto Riassunto Mappa Mappa  
  • ·Risk and management of patients with mastocytosis and MCAS in the SARS-CoV-2 (COVID-19) pandemic: Expert opinions

    Pagina :300-306

    Peter Valent, Cem Akin, Patrizia Bonadonna, Knut Brockow, Marek Niedoszytko, Boguslaw Nedoszytko, Joseph H. Butterfield, Ivan Alvarez-Twose, Karl Sotlar, Juliana Schwaab, Mohamad Jawhar, Andreas Reiter, Mariana Castells, Wolfgang R. Sperr, Hanneke C. Kluin-Nelemans, Olivier Hermine, Jason Gotlib, Roberta Zanotti, Sigurd Broesby-Olsen, Hans-Peter Horny, Massimo Triggiani, Frank Siebenhaar, Alberto Orfao, Dean D. Metcalfe, Michel Arock, Karin Hartmann

    Riassunto Riassunto Mappa Mappa
  • ·Prevalence and characterization of asthma in hospitalized and nonhospitalized patients with COVID-19

    Pagina :307

    Krishan D. Chhiba, Gayatri B. Patel, Thanh Huyen T. Vu, Michael M. Chen, Amina Guo, Elizabeth Kudlaty, Quan Mai, Chen Yeh, Lutfiyya N. Muhammad, Kathleen E. Harris, Bruce S. Bochner, Leslie C. Grammer, Paul A. Greenberger, Ravi Kalhan, Fei Li Kuang, Carol A. Saltoun, Robert P. Schleimer, Whitney W. Stevens, Anju T. Peters

    Riassunto Riassunto Mappa Mappa  
  • ·Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype

    Pagina :315

    Matthew Camiolo, Marc Gauthier, Naftali Kaminski, Anuradha Ray, Sally E. Wenzel

    Riassunto Riassunto Mappa Mappa  
  • ·Successful use of methylprednisolone for treating severe COVID-19

    Pagina :325-327

    Jing Liu, Xiaobin Zheng, Yiying Huang, Hong Shan, Jin Huang

      
  • ·Association of asthma and its genetic predisposition with the risk of severe COVID-19

    Pagina :327

    Zhaozhong Zhu, Kohei Hasegawa, Baoshan Ma, Michimasa Fujiogi, Carlos A. Camargo, Liming Liang

     
  • ·Molecular pharmacology of ciclesonide against SARS-CoV-2

    Pagina :330-331

    Hirokazu Kimura, Hiromu Kurusu, Mitsuru Sada, Daisuke Kurai, Koichi Murakami, Wataru Kamitani, Haruyoshi Tomita, Kazuhiko Katayama, Akihide Ryo

     
  • ·COVID-19: Time to embrace MDI+ valved-holding chambers!

    Pagina :331

    Israel Amirav, Michael T. Newhouse

    
  • ·The bimodal SARS-CoV-2 outbreak in Italy as an effect of environmental and allergic causes

    Pagina :331-332

    Salvatore Chirumbolo, Geir Bjørklund

    
  • ·Reply

    Pagina :332-334

    Valentin Navel, Frédéric Chiambaretta, Frédéric Dutheil

     
  • ·Prevalence of comorbid asthma in COVID-19 patients

    Pagina :334-335

    Marcus W. Butler, Aoife O’Reilly, Eleanor M. Dunican, Patrick Mallon, Eoin R. Feeney, Michael P. Keane, Cormac McCarthy

    
  • ·Reply

    Pagina :335-336

    Lu Qin, Cong Zhang, Junqing Yue, Min Xie

    

• Rhinitis, sinusitis, and ocular allergy

  • ·Type 2 inflammation in chronic rhinosinusitis without nasal polyps: Another relevant endotype

    Pagina :337

    Tim Delemarre, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Hans Nauwynck, Claus Bachert, Elien Gevaert

    Riassunto Riassunto Mappa Mappa  

• Food allergy and gastrointestinal disease

  • ·Biomarkers of severity and threshold of allergic reactions during oral peanut challenges

    Pagina :344-355

    Alexandra F. Santos, George Du Toit, Colin O’Rourke, Natalia Becares, Natália Couto-Francisco, Suzana Radulovic, Ekaterina Khaleva, Monica Basting, Kristina M. Harris, David Larson, Peter Sayre, Marshall Plaut, Graham Roberts, Henry T. Bahnson, Gideon Lack

    Riassunto Riassunto Mappa Mappa   

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Midostaurin improves quality of life and mediator-related symptoms in advanced systemic mastocytosis

    Pagina :356

    Karin Hartmann, Jason Gotlib, Cem Akin, Olivier Hermine, Farrukh T. Awan, Elizabeth Hexner, Michael J. Mauro, Hans D. Menssen, Suman Redhu, Stefanie Knoll, Karl Sotlar, Tracy I. George, Hans-Peter Horny, Peter Valent, Andreas Reiter, Hanneke C. Kluin-Nelemans

    Riassunto Riassunto Mappa Mappa  

• Biologics and immunotherapy

  • ·An anti–IL-13 antibody reverses epithelial-mesenchymal transition biomarkers in eosinophilic esophagitis: Phase 2 trial results

    Pagina :367

    Peter H. Gann, Ryan J. Deaton, Nathan McMahon, Margaret H. Collins, Evan S. Dellon, Ikuo Hirano, Steven Ye Hua, Cristian Rodriguez, Sarah Harris

    Riassunto Riassunto Mappa Mappa  

• Mechanisms of allergy/immunology

  • ·Charcot-Leyden crystal protein/galectin-10 interacts with cationic ribonucleases and is required for eosinophil granulogenesis

    Pagina :377

    Milica M. Grozdanovic, Christine B. Doyle, Li Liu, Brian T. Maybruck, Mark A. Kwatia, Nethaji Thiyagarajan, K. Ravi Acharya, Steven J. Ackerman

    Riassunto Riassunto Mappa Mappa  
  • ·Optimal identification of human conventional and nonconventional (CRTH2^–IL7Rα^–) ILC2s using additional surface markers

    Pagina :390-405

    Sucai Liu, Kapil Sirohi, Mukesh Verma, Jerome McKay, Lidia Michalec, Anand Sripada, Tomas Danhorn, Donald Rollins, James Good, Magdalena M. Gorska, Richard J. Martin, Rafeul Alam

    Riassunto Riassunto Mappa Mappa   

• Translational and clinical immunology

  • ·Outcome of autoimmune cytopenia after hematopoietic cell transplantation in primary immunodeficiency

    Pagina :406-416

    Su Han Lum, Sabeena Selvarajah, Angela Deya-Martinez, Peter McNaughton, Ali Sobh, Sheila Waugh, Shirelle Burton-Fanning, Lisa Newton, Julie Gandy, Zohreh Nademi, Stephen Owens, Eleri Williams, Marieke Emonts, Terry Flood, Andrew Cant, Mario Abinun, Sophie Hambleton, Andrew R. Gennery, Mary Slatter

    Riassunto Riassunto Mappa Mappa   
  • ·Plasma protein profiling reflects T_H1-driven immune dysregulation in common variable immunodeficiency

    Pagina :417-428

    Jonas Hultberg, Jan Ernerudh, Marie Larsson, Åsa Nilsdotter-Augustinsson, Sofia Nyström

    Riassunto Riassunto Mappa Mappa   
  • ·Long-term follow-up of 168 patients with X-linked agammaglobulinemia reveals increased morbidity and mortality

    Pagina :429-437

    Vassilios Lougaris, Annarosa Soresina, Manuela Baronio, Davide Montin, Silvana Martino, Sara Signa, Stefano Volpi, Marco Zecca, Maddalena Marinoni, Lucia Augusta Baselli, Rosa Maria Dellepiane, Maria Carrabba, Giovanna Fabio, Maria Caterina Putti, Francesco Cinetto, Claudio Lunardi, Luisa Gazzurelli, Alessio Benvenuto, Patrizia Bertolini, Francesca Conti, Rita Consolini, Silvia Ricci, Chiara Azzari, Lucia Leonardi, Marzia Duse, Federica Pulvirenti, Cinzia Milito, Isabella Quinti, Caterina Cancrini, Andrea Finocchi, Viviana Moschese, Emilia Cirillo, Ludovica Crescenzi, Giuseppe Spadaro, Carolina Marasco, Angelo Vacca, Fabio Cardinale, Baldassare Martire, Antonino Trizzino, Maria Licciardello, Fausto Cossu, Gigliola Di Matteo, Raffaele Badolato, Simona Ferrari, Silvia Giliani, Andrea Pession, Alberto Ugazio, Claudio Pignata, Alessandro Plebani

    Riassunto Riassunto Mappa Mappa   

• Epidemiology and health care delivery

  • ·Hormonal contraceptives and onset of asthma in reproductive-age women: Population-based cohort study

    Pagina :438-446

    Bright I. Nwaru, Rebecca Pillinger, Holly Tibble, Syed A. Shah, Dermot Ryan, Hilary Critchley, David Price, Catherine M. Hawrylowicz, Colin R. Simpson, Ireneous N. Soyiri, Francis Appiagyei, Aziz Sheikh

    Riassunto Riassunto Mappa Mappa   

• Letters to the Editor

  • ·HSCT provides effective treatment for lymphoproliferative disorders in children with primary immunodeficiency

    Pagina :447-450

    Giulia Prunotto, Ugonna T. Offor, Sujith Samarasinghe, Robert Wynn, Ajay Vora, Ben Carpenter, Claire Gowdy, Kieran McHugh, Kevin P. Windebank, Attilio Maria Rovelli, Mary A. Slatter, Andrew R. Gennery, Paul Veys, Chris M. Bacon, Simon Bomken, Giovanna Lucchini

      
  • ·Glycolipid-mediated basophil activation in alpha-gal allergy

    Pagina :450-452

    Onyinye I. Iweala, Shailesh K. Choudhary, Claire T. Addison, Cole J. Batty, Camille M. Kapita, Claire Amelio, Alexander J. Schuyler, Shenglou Deng, Eric M. Bachelder, Kristy M. Ainslie, Paul B. Savage, Patrick J. Brennan, Scott P. Commins

      
  • ·Anti-Saccharomyces cerevisiae IgG and IgA antibodies are associated with systemic inflammation and advanced disease in hidradenitis suppurativa

    Pagina :452

    Florence Assan, Jeremy Gottlieb, Florence Tubach, Said Lebbah, Nicolas Guigue, Geoffroy Hickman, Emeline Pape, Marine Madrange, Emmanuel Delaporte, Boualem Sendid, François Aubin, Francis Derouin, Stéphane Bretagne, Pascal Richette, Asma Smahi, Emilie Sbidian, Hervé Bachelez

     

• Correspondence

  • ·Multiomic approaches to study B cells: Sequencing, cytometry, imaging, and beyond

    Pagina :456-457

    John-Paul Oliveria

     
  • ·Reply

    Pagina :457-458

    Ilka Hoof, Mohamed H. Shamji, Peter S. Andersen

    
  • ·Anti–Saccharomyces cervisiae antibodies in hidradenitis suppurativa: More than a gut feeling

    Pagina :458

    John W. Frew

    
  • ·Reply

    Pagina :458-459

    Hervé Bachelez, Florence Assan

    
  • ·Cephalosporin allergens: Is the cephalosporoyl and R1 side-chain focus too narrow?

    Pagina :459-460

    Brian A. Baldo

    
  • ·Reply

    Pagina :460-461

    Maria I. Montañez, Angela Martín-Serrano, Cristobalina Mayorga, Esther Barrionuevo, Natalia Pérez, Antonino Romano, Esther Moreno, Adriana Ariza, Ezequiel Pérez-Inestrosa, Maria J. Torres

    
  • ·Anti–Saccharomyces cerevisiae antibodies could reflect distinct phenotypes in hidradenitis suppurativa

    Pagina :461

    Kelsey R. van Straalen

    
  • ·Reply

    Pagina :461-462

    Florence Assan, Hervé Bachelez

    
  • ·The clinical relevance of the clinical cytological grading in patients with chronic rhinosinusitis with nasal polyps

    Pagina :462-463

    Matteo Gelardi, Michele Cassano, Giorgio Ciprandi

     
  • ·Reply

    Pagina :463-464

    Joaquim Mullol, Franklin Mariño, Meritxell Valls, Isam Alobid, Concepció Marin

    

• Corrigenda

  • ·Corrigenda

    Pagina :465

    
  • ·Corrigendum

    Pagina :465