Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A9

    
• • ·Table of Contents

    Pagina :A11

    
• • ·Editorial Board

    Pagina :A32

    

• Reader services

  • ·Information for Readers

    Pagina :A34

    
  • ·News & Notes

    Pagina :A36

    Mappa Mappa
  • ·CME Calendar-AAAAI

    Pagina :A45

    

• Reviews and feature articles

  • ·What has been learned by cytokine targeting of asthma?

    Pagina :235-249

    William W. Busse, Ravi Viswanathan

    Riassunto Riassunto Mappa Mappa  
  • ·What has been learned by cytokine targeting of asthma?

    Pagina :250

    
  • ·Are blood cytokines reliable biomarkers of allergic disease diagnosis and treatment responses?

    Pagina :251-258

    Susanne Radonjic-Hoesli, Nikolay Pavlov, Hans-Uwe Simon, Dagmar Simon

    Riassunto Riassunto Mappa Mappa  
  • ·Epigenetic regulation of immune function in asthma

    Pagina :259-265

    Sunita Sharma, Ivana V. Yang, David A. Schwartz

    Riassunto Riassunto Mappa Mappa  
  • ·Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease

    Pagina :266-276

    Archana Shankar, Jaclyn W. McAlees, Ian P. Lewkowich

    Riassunto Riassunto Mappa Mappa  

• The Editors' choice

  • ·The Editors’ choice

    Pagina :277-281

    Mappa Mappa  

• News beyond our pages

  • ·News Beyond Our Pages

    Pagina :282-283

    Marc E. Rothenberg, Jean Bousquet

    Mappa Mappa  

• Paradigms and perspectives

  • ·What can we learn from treating atopic itch in dogs?

    Pagina :284-286

    Angelina Labib, Gil Yosipovitch, Thierry Olivry

    Mappa Mappa  
  • ·Chronic rhinosinusitis: Future treatments and unmet needs

    Pagina :287-290

    Sneha Giri, Alexander L. Schneider, Bruce K. Tan

    Mappa Mappa  
  • ·Eosinophilic gastrointestinal diseases make a name for themselves: A new consensus statement with updated nomenclature

    Pagina :291-293

    Benjamin L. Wright, Justin T. Schwartz, Melanie A. Ruffner, Glenn T. Furuta, Nirmala Gonsalves, Evan S. Dellon, Seema S. Aceves

     

• Editorials

  • ·Blood endotypic signature in atopic dermatitis: The challenge in personalized medicine

    Pagina :294-296

    Tom C. Chan, Chia-Yu Chu

     
  • ·Does shining a spotlight on XIAP deficiency bring the role of allogeneic HCT into better focus?

    Pagina :297-298

    Rebecca A. Marsh

    
  • ·A “LEAP” forward in understanding immune mechanisms of oral tolerance to peanut

    Pagina :299-301

    Timothy P. Moran, Michael D. Kulis

     

• COVID-19

  • ·Risk factors for SARS-CoV-2 infection and transmission in households with children with asthma and allergy: A prospective surveillance study

    Pagina :302-311

    Max A. Seibold, Camille M. Moore, Jamie L. Everman, Blake J.M. Williams, James D. Nolin, Ana Fairbanks-Mahnke, Elizabeth G. Plender, Bhavika B. Patel, Samuel J. Arbes, Leonard B. Bacharier, Casper G. Bendixsen, Agustin Calatroni, Carlos A. Camargo, William D. Dupont, Glenn T. Furuta, Tebeb Gebretsadik, Rebecca S. Gruchalla, Ruchi S. Gupta, Gurjit K. Khurana Hershey, Liza Bronner Murrison, Daniel J. Jackson, Christine C. Johnson, Meyer Kattan, Andrew H. Liu, Stephanie J. Lussier, George T. O’Connor, Katherine Rivera-Spoljaric, Wanda Phipatanakul, Marc E. Rothenberg, Christine M. Seroogy, Stephen J. Teach, Edward M. Zoratti, Alkis Togias, Patricia C. Fulkerson, Tina V. Hartert, HEROS study team

    Riassunto Riassunto Mappa Mappa   
  • ·Preexisting comorbidities shape the immune response associated with severe COVID-19

    Pagina :312-324

    Stefanie Kreutmair, Manuel Kauffmann, Susanne Unger, Florian Ingelfinger, Nicolás Gonzalo Núñez, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Ekaterina Friebel, Can Ulutekin, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P. Malek, Siri Göpel, Peter Rosenberger, Helene A. Häberle, Ikram Ayoub, Sally Al-Hajj, Manfred Claassen, Roland Liblau, Guillaume Martin-Blondel, Michael Bitzer, Antoine Roquilly, Burkhard Becher

    Riassunto Riassunto Mappa Mappa   

• Asthma and lower airway disease

  • ·Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma

    Pagina :325-336

    Kathleen Lee-Sarwar, Sandra Dedrick, Babak Momeni, Rachel S. Kelly, Robert S. Zeiger, George T. O’Connor, Megan T. Sandel, Leonard B. Bacharier, Avraham Beigelman, Nancy Laranjo, Diane R. Gold, Jessica Lasky-Su, Augusto A. Litonjua, Yang-Yu Liu, Scott T. Weiss

    Riassunto Riassunto Mappa Mappa   

• Rhinitis, sinusitis, and ocular allergy

  • ·IL-17A mediates pyroptosis via the ERK pathway and contributes to steroid resistance in CRSwNP

    Pagina :337-351

    Yue Li, Li-Hong Chang, Wei-Qiang Huang, Hong-Wei Bao, Xia Li, Xiao-Hong Chen, Hao-Tian Wu, Zhou-Zhou Yao, Zi-Zhen Huang, Samuel E. Weinberg, De-Yu Fang, Ya-Na Zhang, Ge-Hua Zhang

    Riassunto Riassunto Mappa Mappa   
  • ·Prognostic factors for polyp recurrence in chronic rhinosinusitis with nasal polyps

    Pagina :352

    Junqin Bai, Julia H. Huang, Caroline P.E. Price, Jacob M. Schauer, Lydia A. Suh, Regan Harmon, David B. Conley, Kevin C. Welch, Robert C. Kern, Stephanie Shintani-Smith, Anju T. Peters, Whitney W. Stevens, Atsushi Kato, Robert P. Schleimer, Bruce K. Tan

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and inflammatory skin disease

  • ·Transient receptor potential vanilloid 1 plays a major role in low temperature–mediated skin barrier dysfunction

    Pagina :362

    Byung Eui Kim, Jessica Hui-Beckman, Taras Lyubchenko, Clifton F. Hall, Sahand Fallahi, Amelia Brull, Elena Goleva, Donald Y.M. Leung

    Riassunto Riassunto Mappa Mappa  
  • ·Single-cell transcriptome profile of mouse skin undergoing antigen-driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions

    Pagina :373-384

    Juan Manuel Leyva-Castillo, Liang Sun, Shih-Ying Wu, Shira Rockowitz, Piotr Sliz, Raif S. Geha

    Riassunto Riassunto Mappa Mappa   
  • ·Blood transcriptome profiling identifies 2 candidate endotypes of atopic dermatitis

    Pagina :385-395

    Lena Möbus, Elke Rodriguez, Inken Harder, Nicole Boraczynski, Silke Szymczak, Matthias Hübenthal, Dora Stölzl, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger, Biomap and the TREATgermany study group

    Riassunto Riassunto Mappa Mappa   

• Food allergy and gastrointestinal disease

  • ·α-Gal present on both glycolipids and glycoproteins contributes to immune response in meat-allergic patients

    Pagina :396

    Neera Chakrapani, Jörg Fischer, Kyra Swiontek, Françoise Codreanu-Morel, Farah Hannachi, Martine Morisset, Clément Mugemana, Dmitry Bulaev, Simon Blank, Carsten Bindslev-Jensen, Tilo Biedermann, Markus Ollert, Christiane Hilger

    Riassunto Riassunto Mappa Mappa  

• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·Massive release of T_H2 cytokines induced a cytokine storm during a severe mast cell activation event in a patient with indolent systemic mastocytosis

    Pagina :406

    Thomas Boehm, Robin Ristl, Jakob Mühlbacher, Peter Valent, Markus Wahrmann, Bernd Jilma

    Riassunto Riassunto Mappa Mappa  

• Biologics and immunotherapy

  • ·Rapid and sustained effect of dupilumab on clinical and mechanistic outcomes in aspirin-exacerbated respiratory disease

    Pagina :415-424

    Kathleen M. Buchheit, Aaqib Sohail, Jonathan Hacker, Rie Maurer, Deborah Gakpo, Jillian C. Bensko, Faith Taliaferro, Jose Ordovas-Montanes, Tanya M. Laidlaw

    Riassunto Riassunto Mappa Mappa   

• Mechanisms of allergy/immunology

  • ·A mouse model of the LEAP study reveals a role for CTLA-4 in preventing peanut allergy induced by environmental peanut exposure

    Pagina :425

    James W. Krempski, Jyoti K. Lama, Koji Iijima, Takao Kobayashi, Mayumi Matsunaga, Hirohito Kita

    Riassunto Riassunto Mappa Mappa  

• Translational and clinical immunology

  • ·Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG₄-related disease and Kimura disease

    Pagina :440

    Ryusuke Munemura, Takashi Maehara, Yuka Murakami, Risako Koga, Ryuichi Aoyagi, Naoki Kaneko, Atsushi Doi, Cory A. Perugino, Emanuel Della-Torre, Takako Saeki, Yasuharu Sato, Hidetaka Yamamoto, Tamotsu Kiyoshima, John H. Stone, Shiv Pillai, Seiji Nakamura

    Riassunto Riassunto Mappa Mappa  
  • ·Phenotype, genotype, treatment, and survival outcomes in patients with X-linked inhibitor of apoptosis deficiency

    Pagina :456-466

    Linlin Yang, Claire Booth, Carsten Speckmann, Markus G. Seidel, Austen J.J. Worth, Gerhard Kindle, Arjan C. Lankester, Bodo Grimbacher, ESID Clinical and Registry Working Parties, Andrew R. Gennery, Mikko R.J. Seppanen, Emma C. Morris, Siobhan O. Burns, Anna Sediva, Benedicte Neven, Fabian Hauck, Klaus Warnatz, Malgorzata Pac, Maria Carrabba, Pere Palacin, Peter Jandus, Ann Gardulf, Nizar Mahlaoui, Martine Pergent, Catharina Schutz, Svetlana Sharapova, Lougaris Vassilios, Fabio Candotti, Stephano Volpi

    Riassunto Riassunto Mappa Mappa   
  • ·Studies on activation and regulation of the coagulation cascade in chronic rhinosinusitis with nasal polyps

    Pagina :467

    Ping-Ping Cao, Bao-Feng Wang, James E. Norton, Lydia A. Suh, Roderick G. Carter, Whitney W. Stevens, Anna G. Staudacher, Julia H. Huang, Kathryn E. Hulse, Anju T. Peters, Leslie C. Grammer, David B. Conley, Kevin C. Welch, Robert C. Kern, Zheng Liu, Jingying Ye, Robert P. Schleimer

    Riassunto Riassunto Mappa Mappa  

• Environmental and occupational disease

  • ·Acute air pollution exposure increases TET enzymes in human PBMCs

    Pagina :477

    Hang Li, Min Hyung Ryu, Juma Orach, Agnes Yuen, Kevin S.K. Lau, Chantane Yeung, Weiping Wen, Chris Carlsten

    Riassunto Riassunto Mappa Mappa  

• Correspondence

  • ·Is allergen absorption a key determinant of severity in food-induced reactions?

    Pagina :489

    Paul J. Turner

     
  • ·Reply

    Pagina :490

    Laura R. Hoyt, Adam Williams, Stephanie C. Eisenbarth

    

• Corrigenda

  • ·Corrigenda

    Pagina :491

     
  • ·Corrigendum

    Pagina :491