Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A5

    
• • ·Table of Contents

    Pagina :A7

    
• • ·Editorial Board

    Pagina :A30

    

• Reader services

  • ·Information for Readers

    Pagina :A31

    
  • ·News & Notes

    Pagina :A32

    Mappa Mappa  
  • ·CME Calendar-AAAAI

    Pagina :A35

    

• Reviews and feature articles

  • ·Biologics in the treatment of asthma in children and adolescents

    Pagina :581-589

    Leonard B. Bacharier, Daniel J. Jackson

    Riassunto Riassunto Mappa Mappa  
  • ·Might biologics serve to interrupt the atopic march?

    Pagina :590-594

    Jonathan M. Spergel, George Du Toit, Carla M. Davis

    Riassunto Riassunto Mappa Mappa  
  • ·The role of biologics in pediatric food allergy and eosinophilic gastrointestinal disorders

    Pagina :595-606

    Sayantani B. Sindher, Suzanne Barshow, Jyothi Tirumalasetty, Stefania Arasi, Dan Atkins, Maureen Bauer, Philippe Bégin, Margaret H. Collins, Antoine Deschildre, Alfred D. Doyle, Alessandro Fiocchi, Glenn T. Furuta, Maria Garcia-Lloret, Maurizio Mennini, Marc E. Rothenberg, Jonathan M. Spergel, Julie Wang, Robert A. Wood, Benjamin L. Wright, Torsten Zuberbier, Andrew R. Chin, Andrew Long, Kari C. Nadeau, R. Sharon Chinthrajah

    Riassunto Riassunto Mappa Mappa  
  • ·Biologics and JAK inhibitors for the treatment of monogenic systemic autoinflammatory diseases in children

    Pagina :607-618

    Yan Du, Meng Liu, Peter A. Nigrovic, Fatma Dedeoglu, Pui Y. Lee

    Riassunto Riassunto Mappa Mappa   
  • ·25 Years of translational research in the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC)

    Pagina :619-633

    Hans Bisgaard, Bo Chawes, Jakob Stokholm, Marianne Mikkelsen, Ann-Marie Malby Schoos, Klaus Bønnelykke

    Riassunto Riassunto Mappa Mappa   
  • ·Neutrophils in host defense, healing, and hypersensitivity: Dynamic cells within a dynamic host

    Pagina :634-655

    Marie Siwicki, Paul Kubes

    Riassunto Riassunto Mappa Mappa  
  • ·Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee

    Pagina :656-670

    Allison J. Burbank, Michelle L. Hernandez, Akilah Jefferson, Tamara T. Perry, Wanda Phipatanakul, Jill Poole, Elizabeth C. Matsui

    Riassunto Riassunto Mappa Mappa  
  • ·In lasting tribute: Dr Hans Bisgaard, January 24, 1955, to September 8, 2022

    Pagina :671-672

    Klaus Bønnelykke, Bo Chawes, Jakob Stokholm, Nilofar V. Følsgaard, Ann-Marie M. Schoos, Marianne Mikkelsen

     

• The Editors' choice

  • ·The Editors’ Choice

    Pagina :673-678

    Mappa Mappa  

• News beyond our pages

  • ·News beyond our pages

    Pagina :679-680

    Marc E. Rothenberg, Jean Bousquet

    Mappa Mappa  

• Paradigms and perspectives

  • ·Biologics in the management of childhood atopic dermatitis

    Pagina :681-685

    Sneha Butala, Amy S. Paller

    Mappa Mappa  
  • ·Immunodeficiency secondary to biologics

    Pagina :686-690

    Roxane Labrosse, Elie Haddad

    Mappa Mappa  
  • ·Knowledge gaps and future opportunities for biologics in childhood allergic and immunologic disorders

    Pagina :691-693

    Cullen M. Dutmer, Andrew H. Liu

    Mappa Mappa  

• Editorials

  • ·In search of the Holy Grail in atopic dermatitis: Will dupilumab become the first disease-modifying atopic dermatitis drug?

    Pagina :694-696

    Thomas Bieber

     
  • ·Patients with CVID have their own “gut feeling” for viruses

    Pagina :697-699

    Raffaele De Palma

     

• Asthma and lower airway disease

  • ·Eosinophil depletion with benralizumab is associated with attenuated mannitol airway hyperresponsiveness in severe uncontrolled eosinophilic asthma

    Pagina :700

    Rory Chan, Chris RuiWen Kuo, Sunny Jabbal, Brian J. Lipworth

    Riassunto Riassunto Mappa Mappa  
  • ·The upper-airway microbiome as a biomarker of asthma exacerbations despite inhaled corticosteroid treatment

    Pagina :706-715

    Javier Perez-Garcia, Mario González-Carracedo, Antonio Espuela-Ortiz, José M. Hernández-Pérez, Ruperto González-Pérez, Olaia Sardón-Prado, Elena Martin-Gonzalez, Elena Mederos-Luis, Paloma Poza-Guedes, Paula Corcuera-Elosegui, Ariel Callero, Inmaculada Sánchez-Machín, Javier Korta-Murua, José A. Pérez-Pérez, Jesús Villar, Maria Pino-Yanes, Fabian Lorenzo-Diaz

    Riassunto Riassunto Mappa Mappa   
  • ·Indoor environmental exposures and obstructive lung disease phenotypes among children with asthma living in poor urban neighborhoods

    Pagina :716

    Torie Grant, Travis Lilley, Meredith C. McCormack, Paul J. Rathouz, Roger Peng, Corinne A. Keet, Ana Rule, Meghan Davis, Susan Balcer-Whaley, Michelle Newman, Elizabeth C. Matsui

    Riassunto Riassunto Mappa Mappa  

• Rhinitis, sinusitis, and ocular allergy

  • ·Chronic rhinosinusitis patients display an aberrant immune cell localization with enhanced S aureus biofilm metabolic activity and biomass

    Pagina :723

    Gohar Shaghayegh, Clare Cooksley, George Spyro Bouras, Beula Subashini Panchatcharam, Rejhan Idrizi, Metta Jana, Sarah Ellis, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde

    Riassunto Riassunto Mappa Mappa  

• Atopic dermatitis and inflammatory skin disease

  • ·IL-31–generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin

    Pagina :737

    Takashi Hashimoto, Hiroo Yokozeki, Hajime Karasuyama, Takahiro Satoh

    Riassunto Riassunto Mappa Mappa  

• Biologics and immunotherapy

  • ·Comparative efficacy of tezepelumab to mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis

    Pagina :747-755

    Tanawin Nopsopon, Grace Lassiter, Ming-Li Chen, G. Caleb Alexander, Corinne Keet, Hwanhee Hong, Ayobami Akenroye

    Riassunto Riassunto Mappa Mappa   
  • ·Attenuating the atopic march: Meta-analysis of the dupilumab atopic dermatitis database for incident allergic events

    Pagina :756-766

    Gregory P. Geba, Dateng Li, Meng Xu, Kusha Mohammadi, Richa Attre, Marius Ardeleanu, Bret Musser

    Riassunto Riassunto Mappa Mappa   

• Translational and clinical immunology

  • ·Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses

    Pagina :767-777

    Mari Kaarbø, Mingyi Yang, Johannes R. Hov, Kristian Holm, Mirta Mittelstedt Leal de Sousa, Magnhild E. Macpherson, Henrik M. Reims, Anne-Marte Bakken Kran, Bente Halvorsen, Tom H. Karlsen, Pål Aukrust, Knut E.A. Lundin, Børre Fevang, Magnar Bjørås, Silje Fjellgård Jørgensen

    Riassunto Riassunto Mappa Mappa   

• Brief reports

  • ·Do upper respiratory viruses contribute to racial and ethnic disparities in emergency department visits for asthma?

    Pagina :778

    Darlene Bhavnani, Matthew Wilkinson, Rebecca A. Zárate, Susan Balcer-Whaley, Daniel S.W. Katz, Paul J. Rathouz, Elizabeth C. Matsui

    Riassunto Riassunto Mappa Mappa  
  • ·Biallelic TLR4 deficiency in humans

    Pagina :783

    Melania Capitani, Ahmad A. Al-Shaibi, Sumeet Pandey, Lisa Gartner, Henry Taylor, Satanay Z. Hubrack, Nourhen Agrebi, Muneera Jassim Al-Mohannadi, Saad Al Kaabi, Thomas Vogl, Johannes Roth, Daniel Kotlarz, Christoph Klein, Adrian K. Charles, Vinayan Vijayakumar, Mohammed Yousuf Karim, Bruce George, Simon P. Travis, Mamoun Elawad, Bernice Lo, Holm H. Uhlig

    Riassunto Riassunto Mappa Mappa  
  • ·Human MD2 deficiency—an inborn error of immunity with pleiotropic features

    Pagina :791

    Yue Li, Ziqi Yu, Madlin Schenk, Irena Lagovsky, David Illig, Christoph Walz, Meino Rohlfs, Raffaele Conca, Aleixo M. Muise, Scott B. Snapper, Holm H. Uhlig, Ben Zion Garty, Christoph Klein, Daniel Kotlarz

    Riassunto Riassunto Mappa Mappa  
  • ·Untargeted serum metabolomic analysis reveals a role for purinergic signaling in FPIES

    Pagina :797-802

    Daniel Lozano-Ojalvo, Xin Chen, David Dunkin, Charuta Agashe, Mary Grace Baker, J. Andrew Bird, Elena Molina, Anna Nowak-Wegrzyn, M. Cecilia Berin

    Riassunto Riassunto Mappa Mappa   

• Correspondence

  • ·Accurate phenotyping of cross-reactive hypersensitivity is essential to shed light on the underlying mechanisms in NSAID-induced urticaria/angioedema

    Pagina :803

    José Antonio Cornejo-García, Rafael Núñez, María J. Torres, Inmaculada Doña

    
  • ·Reply

    Pagina :803-804

    Sen Hee Tay, Amelia Santosa, Bernett Teck Kwong Lee, Paul Lorenz Bigliardi

    
  • ·HαT is associated with increased risk for severe Hymenoptera venom–triggered anaphylaxis

    Pagina :804-805

    Julij Šelb, Matija Rijavec, Peter Kopač, Jonathan J. Lyons, Peter Korošec

    
  • ·Reply

    Pagina :806

    Joshua A. Boyce

    

• Corrigenda

  • ·Corrigenda

    Pagina :807

    
  • ·Corrigendum

    Pagina :807