Sommario

• • ·Cover 1

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• • ·Brief Overview of This Month's JACI

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• • ·Table of Contents

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• • ·Editorial Board

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• Reader services

  • ·Information for Readers

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  • ·News & Notes

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  • ·CME Calendar-AAAAI

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• Reviews and feature articles

  • ·Updated guidance regarding the risk of allergic reactions to COVID-19 vaccines and recommended evaluation and management: A GRADE assessment and international consensus approach

    Pagina :309-325

    Matthew Greenhawt, Timothy E. Dribin, Elissa M. Abrams, Marcus Shaker, Derek K. Chu, David B.K. Golden, Cem Akin, Akterini Anagnostou, Faisal ALMuhizi, Waleed Alqurashi, Peter Arkwright, James L. Baldwin, Aleena Banerji, Philippe Bégin, Moshe Ben-Shoshan, Jonathan Bernstein, Theresa A. Bingemann, Carsten Bindslev-Jensen, Kim Blumenthal, Aideen Byrne, Julia Cahill, Scott Cameron, Dianne Campbell, Ronna Campbell, Michael Cavender, Edmond S. Chan, Sharon Chinthrajah, Pasquale Comberiati, Jacqueline J. Eastman, Anne K. Ellis, David M. Fleischer, Adam Fox, Pamela A. Frischmeyer-Guerrerio, Remi Gagnon, Lene H. Garvey, Mitchell H. Grayson, Ghislaine Annie Clarisse Isabwe, Nicholas Hartog, David Hendron, Caroline C. Horner, Johnathan O'B Hourihane, Edward Iglesia, Manstein Kan, Blanka Kaplan, Constance H. Katelaris, Harold Kim, John M. Kelso, David A. Khan, David Lang, Dennis Ledford, Michael Levin, Jay A. Lieberman, Richard Loh, Douglas P. Mack, Bruce Mazer, Ketan Mody, Gisele Mosnaim, Daniel Munblit, S. Shahzad Mustafa, Anil Nanda, Richard Nathan, John Oppenheimer, Iris M. Otani, Miguel Park, Ruby Pawankar, Kirsten P. Perrett, Jonny Peter, Elizabeth J. Phillips, Matthieu Picard, Mitchell Pitlick, Allison Ramsey, Trine Holm Rasmussen, Melinda M. Rathkopf, Hari Reddy, Kara Robertson, Pablo Rodriguez del Rio, Stephen Sample, Ajay Sheshadri, Javed Sheik, Sayantani B. Sindher, Jonathan M. Spergel, Cosby A. Stone, David Stukus, Mimi L.K. Tang, James M. Tracy, Paul J. Turner, Timothy K. Vander Leek, Dana V. Wallace, Julie Wang, Susan Wasserman, David Weldon, Anna R. Wolfson, Margitta Worm, Mona-Rita Yacoub

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  • ·The regulatory landscape of macrophage interferon signaling in inflammation

    Pagina :326-337

    Ricky Siebeler, Menno P.J. de Winther, Marten A. Hoeksema

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• The Editors' choice

  • ·The Editors’ Choice

    Pagina :338-344

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• News beyond our pages

  • ·News beyond our pages

    Pagina :345-346

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• Paradigms and perspectives

  • ·Mechanisms underlying the efficacy and safety of IgG, antibody fragments, and design immune biologics

    Pagina :347-349

    Ario de Marco

     
  • ·Deep learning for detection of drug hypersensitivity reactions

    Pagina :350-352

    Suzanne V. Blackley, Abigail Salem, Li Zhou

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  • ·Extracellular vesicles as mediators of mast cell cross talk with immune cells: Possible druggable targets

    Pagina :353-355

    Irit Shefler, Pazit Salamon, Yoseph A. Mekori

     
  • ·The translation potential of harnessing the resolution of inflammation

    Pagina :356-358

    George Collins, Jhonatan de Souza Carvalho, Derek W. Gilroy

     

• Editorials

  • ·Dopamine primes T_H2 cells in the lungs

    Pagina :359-361

    Derek J. Bangs, Marion Pepper

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  • ·Moving forward with allergen immunotherapy: The significance of real-world studies

    Pagina :362-364

    Roy Gerth van Wijk, Paul van Daele

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  • ·Glimpses into treating GLILD

    Pagina :365-367

    Timi Martelius, Mikko R.J. Seppänen

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  • ·The pulmonary effects of STAT3 deficiency

    Pagina :368-370

    Elizabeth A. Gilje, Jordan K. Abbott

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  • ·“Where are they now?” Catching up with the 2018 AAAAI Faculty Development Awardees

    Pagina :371-373

    Zuhair K. Ballas

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• COVID-19

  • ·Does pollen exposure influence innate immunity to SARS-CoV-2 in allergy or asthma?

    Pagina :374-377

    Saeideh Hajighasemi, Kirsten Spann, Janet M. Davies

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• Asthma and lower airway disease

  • ·Neighborhood environmental vulnerability and pediatric asthma morbidity in US metropolitan areas

    Pagina :378

    Sneha Kannoth, Sarah E. Chung, Kelvin D. Tamakloe, Sandra S. Albrecht, Alexander Azan, Earle C. Chambers, Perry E. Sheffield, Azure Thompson, Jennifer A. Woo Baidal, Stephanie Lovinsky-Desir, Jeanette A. Stingone

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  • ·Lung dopaminergic nerves facilitate the establishment of T_H2 resident memory cells in early life

    Pagina :386-399

    Wei Wang, Carolyn Garcia, Fengzhi Shao, Jonathan A. Cohen, Yan Bai, Alan Fine, Xingbin Ai

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• Rhinitis, sinusitis, and ocular allergy

  • ·An eosinophil peroxidase activity assay accurately predicts eosinophilic chronic rhinosinusitis

    Pagina :400-407

    Kristine A. Smith, Amarbir S. Gill, Chelsea E. Pollard, Jorgen S. Sumsion, Hedieh Saffari, Shaelene Ashby, Benjamin L. Witt, Paige A. Shipman, David A. Gabrielsen, Michael T. Yim, Joshua M. Levy, Gretchen M. Oakley, Richard R. Orlandi, Gerald J. Gleich, Jeremiah A. Alt, Abigail Pulsipher

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• Atopic dermatitis and inflammatory skin disease

  • ·The neglected twin: Nummular eczema is a variant of atopic dermatitis with codominant T_H2/T_H17 immune response

    Pagina :408-419

    Alexander Böhner, Manja Jargosch, Nikola S. Müller, Natalie Garzorz-Stark, Caroline Pilz, Felix Lauffer, Rosi Wang, Sophie Roenneberg, Alexander Zink, Jenny Thomas, Fabian J. Theis, Tilo Biedermann, Stefanie Eyerich, Kilian Eyerich

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  • ·Single-cell RNA sequencing defines disease-specific differences between chronic nodular prurigo and atopic dermatitis

    Pagina :420-435

    Natalia Alkon, Frank P. Assen, Tamara Arnoldner, Wolfgang M. Bauer, Marco A. Medjimorec, Lisa E. Shaw, Katharina Rindler, Gregor Holzer, Philipp Weber, Wolfgang Weninger, Christian Freystätter, Sumanth Chennareddy, Tamar Kinaciyan, Matthias Farlik, Constanze Jonak, Johannes Griss, Christine Bangert, Patrick M. Brunner

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• Food allergy and gastrointestinal disease

  • ·IgE cross-inhibition between Ara h 1 and Ara h 2 is explained by complex formation of both major peanut allergens

    Pagina :436

    Hans J.M. Warmenhoven, Luuk Hulsbos, Stephen C. Dreskin, Jaap H. Akkerdaas, Serge A. Versteeg, Ronald van Ree

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• Biologics and immunotherapy

  • ·Real-world, long-term effectiveness of allergy immunotherapy in allergic rhinitis: Subgroup analyses of the REACT study

    Pagina :445

    Marco Contoli, Celeste Porsbjerg, Sarah Buchs, Julie Rask Larsen, Nick Freemantle, Benedikt Fritzsching

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• Mechanisms of allergy/immunology

  • ·IgG:FcγRIIb signals block effector programs of IgE:FcεRI-activated mast cells but spare survival pathways

    Pagina :453-468

    Cynthia Kanagaratham, Tahereh Derakhshan, Yasmeen S. El Ansari, Kameryn N. Furiness, Eleanor Hollers, Mats Keldsen, Hans C. Oettgen, Daniel F. Dwyer

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  • ·Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice

    Pagina :469

    William E. LeSuer, Melanie Kienzl, Sergei I. Ochkur, Rudolf Schicho, Alfred D. Doyle, Benjamin L. Wright, Matthew A. Rank, Alexander S. Krupnick, Hirohito Kita, Elizabeth A. Jacobsen

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  • ·Development of mouse models with restricted HLA-B∗57:01 presentation for the study of flucloxacillin-driven T-cell activation and tolerance in liver injury

    Pagina :486

    Suryatheja Ananthula, Kirthiram Krishnaveni Sivakumar, Marco Cardone, Shan Su, Gregory Roderiquez, Hanan Abuzeineh, David E. Kleiner, Michael A. Norcross, Montserrat Puig

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• Translational and clinical immunology

  • ·Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency

    Pagina :500-516

    Annaïse J. Jauch, Olivier Bignucolo, Sayuri Seki, Marie Ghraichy, Ottavia M. Delmonte, Valentin von Niederhäusern, Rebecca Higgins, Adhideb Ghosh, Masako Nishizawa, Mariko Tanaka, Adrian Baldrich, Julius Köppen, Julia R. Hirsiger, Robin Hupfer, Stephan Ehl, Anne Rensing-Ehl, Helmut Hopfer, Spasenija Savic Prince, Stephen R. Daley, Florian A. Marquardsen, Benedikt J. Meyer, Michael Tamm, Thomas D. Daikeler, Tamara Diesch, Thomas Kühne, Arthur Helbling, Caroline Berkemeier, Ingmar Heijnen, Alexander A. Navarini, Johannes Trück, Jean-Pierre de Villartay, Annette Oxenius, Christoph T. Berger, Christoph Hess, Luigi D. Notarangelo, Hiroyuki Yamamoto, Mike Recher

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  • ·Cohort-driven variant burden analysis and pathogenicity identification in monogenic autoinflammatory disorders

    Pagina :517-527

    Xiang Chen, Xiaomin Yu

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  • ·The efficacy and safety of systemic corticosteroids as first line treatment for granulomatous lymphocytic interstitial lung disease

    Pagina :528-537

    Bas Smits, Sigune Goldacker, Suranjith Seneviratne, Marion Malphettes, Hilary Longhurst, Omar E. Mohamed, Carla Witt-Rautenberg, Lucy Leeman, Eva Schwaneck, Isabelle Raymond, Kilifa Meghit, Annette Uhlmann, Christine Winterhalter, Joris van Montfrans, Marion Klima, Sarita Workman, Claire Fieschi, Lorena Lorenzo, Sonja Boyle, Shamin Onyango-Odera, Suzanne Price, Marc Schmalzing, Valerie Aurillac, Antje Prasse, Ieneke Hartmann, Jennifer J. Meerburg, Mariette Kemner-van de Corput, Harm Tiddens, Bodo Grimbacher, Peter Kelleher, Smita Y. Patel, Anne-Sophie Korganow, Jean-Francois Viallard, Hans-Peter Tony, Claire Bethune, Hendrik Schulze-Koops, Torsten Witte, Aarnoud Huissoon, Helen Baxendale, Sofia Grigoriadou, Eric Oksenhendler, Siobhan O. Burns, Klaus Warnatz

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  • ·STAT3 mutation-associated airway epithelial defects in Job syndrome

    Pagina :538-550

    Yihan Zhang, Tian Lin, Hui Min Leung, Cheng Zhang, Brittany Wilson-Mifsud, Michael B. Feldman, Anne Puel, Fanny Lanternier, Louis-Jean Couderc, Francois Danion, Emilie Catherinot, Hélène Salvator, Colas Tcherkian, Claire Givel, Jie Xu, Guillermo J. Tearney, Jatin M. Vyas, Hu Li, Bryan P. Hurley, Hongmei Mou

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