Sommario

• • ·Cover 1

    Pagina :OFC

    
• • ·Brief Overview of This Month's JACI

    Pagina :A5

    
• • ·Table of Contents

    Pagina :A7

    
• • ·Editorial Board

    Pagina :A41

    

• Reader services

  • ·Information for Readers

    Pagina :A42

    
  • ·News & Notes

    Pagina :A50

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  • ·CME Calendar-AAAAI

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• Reviews and feature articles

  • ·Global warming and implications for epithelial barrier disruption and respiratory and dermatologic allergic diseases

    Pagina :1033-1046

    Zeynep Çelebi Sözener, Elsa R. Treffeisen, Betül Özdel Öztürk, Lynda C. Schneider

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  • ·Climate change is a health crisis with opportunities for health care action: A focus on health care providers, patients with asthma and allergic immune diseases, and their families and neighbors

    Pagina :1047-1052

    Nicholas J. Nassikas, Diane R. Gold

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  • ·Health-based strategies for overcoming barriers to climate change adaptation and mitigation

    Pagina :1053-1059

    Patrick L. Kinney, Beverly Ge, Vanitha Sampath, Kari Nadeau

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  • ·Climate change and epigenetic biomarkers in allergic and airway diseases

    Pagina :1060-1072

    Andres Cardenas, Raj Fadadu, Supinda Bunyavanich

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• The Editors' choice

  • ·The Editors’ Choice

    Pagina :1073-1078

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• News beyond our pages

  • ·News beyond our pages

    Pagina :1079-1080

    Marc E. Rothenberg, Jean Bousquet

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• Paradigms and perspectives

  • ·Increasing wildfire smoke from the climate crisis: Impacts on asthma and allergies

    Pagina :1081-1083

    John R. Balmes, Stephanie M. Holm

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  • ·Community- and neighborhood-level disparities in extreme climate exposure: Implications for asthma and atopic disease outcomes

    Pagina :1084-1086

    Allison J. Burbank, Andre E. Espaillat, Michelle L. Hernandez

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  • ·British Columbia, Canada, as a bellwether for climate-driven respiratory and allergic disorders

    Pagina :1087-1089

    Christopher Carlsten, Michael Brauer, Pat G. Camp, Lorien Nesbitt, Justin Turner

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• Editorials

  • ·Patient-reported outcome measures for urticaria and angioedema

    Pagina :1090-1091

    Pedro C. Avila

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  • ·Refashioning dexpramipexole: A new horizon in eosinophilic asthma?

    Pagina :1092-1094

    Ruth P. Cusack, Ibrahim Sulaiman, Gail M. Gauvreau

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• COVID-19

  • ·Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination: Results of the UCARE COVAC-CU study

    Pagina :1095-1106

    Emek Kocatürk, Pascale Salameh, Esra Sarac, Carolina E. Vera Ayala, Simon Francis Thomsen, Torsten Zuberbier, Luis Felipe Ensina, Todor A. Popov, Martijn B.A. van Doorn, Ana Maria Giménez-Arnau, Riccardo Asero, Paulo Ricardo Criado, Fernando M. Aarestrup, Zainab AbdulHameed Ansari, Salma Al Abri, Mona Al-Ahmad, Bushra Al Hinai, Anastasiia Allenova, Maryam Al-Nesf, Sabine Altrichter, Rand Arnaout, Joanna Bartosińska, Andrea Bauer, Jonathan A. Bernstein, Mojca Bizjak, Hanna Bonnekoh, Laurence Bouillet, Zenon Brzoza, Ana Caroline Calvalcanti Dela Bianca Melo, Fernanda L. Campinhos, Emily Carne, Saleema Cherichi Purayil, Ivan Cherrez-Ojeda, Herberto Jose Chong-Neto, George Christoff, Niall Conlon, Roberta Fachini Jardim Criado, Klara Cvenkel, Ebru Damadoglu, Inna Danilycheva, Cascia Day, Laurence de Montjoye, Semra Demir, Silvia Mariel Ferucci, Daria Fomina, Atsushi Fukunaga, Elizabeth Garcia, Asli Gelincik, Joe Hannah Göbel, Kiran Godse, Margarida Gonçalo, Maia Gotua, Clive Grattan, Agata Gugala, Carole Guillet, Ali Fuat Kalyoncu, Gul Karakaya, Alicja Kasperska-Zając, Constance H. Katelaris, Maryam Khoshkhui, Andreas Kleinheinz, Marta Kolacinska-Flont, Pavel Kolkhir, Mitja Košnik, Dorota Krasowska, Muthu Sendhil Kumaran, Izabela Kuprys-Lipinska, Marcin Kurowski, Elizaveta V. Kuznetsova, Désirée Larenas-Linnemann, Marina S. Lebedkina, Youngsoo Lee, Michael Makris, René Maximiliano Gómez, Iman Nasr, Sophia Neisinger, Yoshiko Oda, Rabia Öztaş Kara, Esther Bastos Palitot, Niki Papapostolou, Claudio Alberto Salvador Parisi, David Pesque, Jonathan Peter, Elena Petkova, Katie Ridge, Michael Rudenko, Krzysztof Rutkowski, Sarbjit S. Saini, Andac Salman, Jorge Sanchez, Bülent Şekerel, Sofia A. Serdotetskova, Faradiba S. Serpa, Bahar Sevimli Dikicier, Nikitas Sidiropoulos, Agnieszka Sikora, Jennifer Astrup Sørensen, Angele Soria, Ozlem Su Kucuk, Sherin Rahim Thalappil, Katarzyna Tomaszewska, Gulseren Tuncay, Derya Unal, Solange Valle, Esmee van Lindonk, Christian Vestergaard, Raisa Y. Meshkova, Aleksandr Vitchuk, Paraskevi Xepapadaki, Young-Min Ye, Anna Zalewska-Janowska, Mateusz Zamlynski, Marcus Maurer

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  • ·Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance

    Pagina :1107

    Timothy R. O'Meara, Etsuro Nanishi, Marisa E. McGrath, Soumik Barman, Danica Dong, Carly Dillen, Manisha Menon, Hyuk-Soo Seo, Sirano Dhe-Paganon, Robert K. Ernst, Ofer Levy, Matthew B. Frieman, David J. Dowling

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• Asthma and lower airway disease

  • ·Safety and Efficacy of Dexpramipexole in Eosinophilic Asthma (EXHALE): A randomized controlled trial

    Pagina :1121

    Salman Siddiqui, Sally E. Wenzel, Michael E. Bozik, Donald G. Archibald, Steven I. Dworetzky, James L. Mather, Randall Killingsworth, Natasha Ghearing, Justin T. Schwartz, Sergei I. Ochkur, Elizabeth A. Jacobsen, William W. Busse, Reynold A. Panettieri, Calman Prussin

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  • ·Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation

    Pagina :1131

    Thomas J.A. Maguire, Stephanie Yung, Elena Ortiz-Zapater, O. Stephanie Kayode, Stephen Till, Chris Corrigan, Leonard Q.C. Siew, Gregory A. Knock, Grzegorz Woszczek

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  • ·Complement C1q essential for aeroallergen sensitization via CSF1R⁺ conventional dendritic cells type 2

    Pagina :1141

    Hyung-Geun Moon, Jacob D. Eccles, Seung-jae Kim, Ki-Hyun Kim, Young-Mee Kim, Jalees Rehman, Hyun Lee, Pinal Kanabar, John W. Christman, Steven J. Ackerman, Christian Ascoli, Homan Kang, Hak Soo Choi, Minhyung Kim, Sungyong You, Gye Young Park

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• Rhinitis, sinusitis, and ocular allergy

  • ·Type 17 mucosal-associated invariant T cells contribute to neutrophilic inflammation in patients with nasal polyps

    Pagina :1153

    Xiaoyan Ye, Yachun Li, Bixing Fang, Yizhang Yuan, Danni Feng, Hexin Chen, Jian Li, Qingxiang Meng, Shaobing Xiong, Dongmei Ye, Linyi Jiao, Dehua Chen, Ruchong Chen, Wenbin Lei, Yifang Gao, Chunwei Li

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  • ·Nasal IL-13 production identifies patients with late-phase allergic responses

    Pagina :1167

    Nicholas J. Campion, Sergio Villazala-Merino, Ryan S. Thwaites, Victoria Stanek, Helen Killick, Eleftheria Pertsinidou, Mohammed Zghaebi, Josef Toth, Renate Fröschl, Thomas Perkmann, Katharina Gangl, Sven Schneider, Robin Ristl, Ian C. Scott, Emma Suzanne Cohen, Magnus Molin, Margit Focke-Tejkl, Guenther Regelsberger, Trevor T. Hansel, Rudolf Valenta, Verena Niederberger-Leppin, Julia Eckl-Dorna

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  • ·Rapid reduction in Staphylococcus aureus in atopic dermatitis subjects following dupilumab treatment

    Pagina :1179-1195

    Eric L. Simpson, Patrick M. Schlievert, Takeshi Yoshida, Stephanie Lussier, Mark Boguniewicz, Tissa Hata, Zelma Fuxench, Anna De Benedetto, Peck Y. Ong, Justin Ko, Agustin Calatroni, Amanda K. Rudman Spergel, Marshall Plaut, Sally A. Quataert, Samuel H. Kilgore, Liam Peterson, Ann L. Gill, Gloria David, Tim Mosmann, Steven R. Gill, Donald Y.M. Leung, Lisa A. Beck

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• Food allergy and gastrointestinal disease

  • ·Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children

    Pagina :1196-1209

    Sloan A. Lewis, Aaron Sutherland, Ferran Soldevila, Luise Westernberg, Minori Aoki, April Frazier, Synaida Maiche, Mich Erlewyn-Lajeunesse, Hasan Arshad, Stephanie Leonard, Susan Laubach, Jennifer A. Dantzer, Robert A. Wood, Alessandro Sette, Gregory Seumois, Pandurangan Vijayanand, Bjoern Peters

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• Anaphylaxis, drug allergy, urticaria, and angioedema

  • ·The 7-day recall period version of the Urticaria Control Test—UCT7

    Pagina :1210

    Thomas Buttgereit, Pascale Salameh, Olga Sydorenko, Torsten Zuberbier, Martin Metz, Karsten Weller, Marcus Maurer

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  • ·Restriction of C1-inhibitor activity in hereditary angioedema by dominant-negative effects of disease-associated SERPING1 gene variants

    Pagina :1218

    Laura Barrett Ryø, Didde Haslund, Anne Bruun Rovsing, Rasmus Pihl, Wariya Sanrattana, Steven de Maat, Yaseelan Palarasah, Coen Maas, Steffen Thiel, Jacob Giehm Mikkelsen

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• Biologics and immunotherapy

  • ·Integrated proteomics and genomics analysis of paradoxical eczema in psoriasis patients treated with biologics

    Pagina :1237-1246

    Ali Al-Janabi, Paul Martin, Adnan R. Khan, Amy C. Foulkes, Catherine H. Smith, Christopher E.M. Griffiths, Andrew P. Morris, Steve Eyre, Richard B. Warren, BSTOP Study Group and the BADBIR Study Group, Shehnaz Ahmed, Oras Alabas, Jonathan Barker, Gabrielle Becher, Anthony Bewley, Ian Evans, Philip Hampton, Brian Kirby, Elise Kleyn, Philip Laws, Linda Lawson, Teena Mackenzie, Kathleen McElhone, Tess McPherson, Simon Morrison, Caroline Owen, Eleanor Pearson, Amir Rashid, Nick Reynolds, Anja Strangfeld, Shernaz Walton, Zenas Yiu, Girish Gupta, Anja Strangfeld (chair), Richard Weller, Vera Zietemann, Nadia Aldoori, Mahmud Ali, Ahmed Al-Rusan, Caroline Angit, Alex Anstey, Fiona Antony, Charles Archer, Suzanna August, Periasamy Balasubramaniam, David Baudry, Kay Baxter, Anthony Bewley, Alexandra Bonsall, Sara Brown, Victoria Brown, David Burden, Ekaterina Burova, Aamir Butt, Mel Caswell, Anna Chapman, Sandeep Cliff, Mihaela Costache, Sharmela Darne, Claudia DeGiovanni, Trupti Desai, Victoria Diba, Eva Domanne, Michael Duckworth, Harvey Dymond, Caoimhe Fahy, Susanne Farwer, Leila Ferguson, Maria-Angeliki Gkini, Alison Godwin, Jon Goulding, Fiona Hammonds, Shaheen Haque, Caroline Higgins, Sue Hood, Teresa Joseph, Sarah Johnson, Manju Kalavala, Mohsen Khorshid, Liberta Labinoti, Ruth Lamb, Nicole Lawson, Alison Layton, Tara Lees, Nick Levell, Helen Lewis, Chris Lovell, Calum Lyon, Helen McAteer, Sandy McBride, Sally McCormack, Kevin McKenna, Serap Mellor, Fiona Meredith, Ruth Murphy, Paul Norris, Caroline Owen, Richard Parslew, Gay Perera, Nabil Ponnambath, Urvi Popli, James Powell, Raakhee Ramesh, Helen Ramsay, Aruni Ranasinghe, Saskia Reeken, Nick Reynolds, Rebecca Rose, Rada Rotarescu, Ingrid Salvary, Kathy Sands, Tapati Sinha, Julia Schofield, Alexa Shipman, Stefan Siebert, Simina Stefanescu, Kavitha Sundararaj, Kathy Taghipour, Michelle Taylor, Michelle Thomson, Joanne Topliffe, Roberto Verdolini, Rachel Wachsmuth, Martin Wade, Shymal Wahie, Sarah Walsh, Shernaz Walton, Louise Wilcox, Diane Williamson, Andrew Wright

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• Mechanisms of allergy/immunology

  • ·Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy

    Pagina :1247-1260

    Matthew C. Altman, R. Max Segnitz, David Larson, Naresh Doni Jayavelu, Malisa T. Smith, Sana Patel, Guy W. Scadding, Tielin Qin, Srinath Sanda, Esther Steveling, Aarif O. Eifan, Martin Penagos, Mikila R. Jacobson, Rebecca V. Parkin, Mohamed H. Shamji, Alkis Togias, Stephen R. Durham

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  • ·RelB-deficient autoinflammatory pathology presents as interferonopathy, but in mice is interferon-independent

    Pagina :1261-1272

    Héctor I. Navarro, Yi Liu, Anna Fraser, Diane Lefaudeux, Jennifer J. Chia, Linda Vong, Chaim M. Roifman, Alexander Hoffmann

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• Translational and clinical immunology

  • ·Comprehensive phenotypic analysis of diverse FOXN1 variants

    Pagina :1273

    Angela Moses, Pratibha Bhalla, Austin Thompson, Laijun Lai, Fatma S. Coskun, Christine M. Seroogy, Maria Teresa de la Morena, Christian A. Wysocki, Nicolai S.C. van Oers

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  • ·A gain-of-function variation in PLCG1 causes a new immune dysregulation disease

    Pagina :1292-1302

    Panfeng Tao, Xu Han, Qintao Wang, Shihao Wang, Jiahui Zhang, Lin Liu, Xiaorui Fan, Chenlu Liu, Meng Liu, Li Guo, Pui Y. Lee, Ivona Aksentijevich, Qing Zhou

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  • ·Pathogenic variants in the NLRP3 LRR domain at position 861 are responsible for a boost-dependent atypical CAPS phenotype

    Pagina :1303

    Antoine Fayand, Margaux Cescato, Laurent Le Corre, Alexandre Terré, Margaux Wacheux, Yixiang Y.J. Zhu, Armelle Melet, Thomas R.J. Moreau, Bahram Bodaghi, Fabrice Bonnet, Didier Bronnimann, Laurence Cuisset, Raquel Faria, Gilles Grateau, Pascal Pillet, Catharina M. Mulders-Manders, Benedicte Neven, Pierre Quartier, Olivier Richer, Léa Savey, Marie-Elise Truchetet, Bénédicte F. Py, Guilaine Boursier, Jean-Philippe Herbeuval, Sophie Georgin-Lavialle, Mathieu P. Rodero

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  • ·Monensin induces secretory granule-mediated cell death in eosinophils

    Pagina :1312

    Marianthi Vraila, Elin Asp, Fabio Rabelo Melo, Mirjana Grujic, Ola Rollman, Gunnar Pejler, Maria Lampinen

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• Environmental and occupational disease

  • ·Living in environmental justice areas worsens asthma severity and control: Differential interactions with disease duration, age at onset, and pollution

    Pagina :1321

    Brandy M. Byrwa-Hill, Tricia L. Morphew, Albert A. Presto, James P. Fabisiak, Sally E. Wenzel

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• Brief reports

  • ·Lower serum 15-HETE level predicts nasal ILC2 accumulation during COX-1 inhibition in AERD

    Pagina :1330

    Jana H. Badrani, Kellen Cavagnero, Jacqueline J. Eastman, Alex S. Kim, Allyssa Strohm, Carol Yan, Adam Deconde, Bruce L. Zuraw, Andrew A. White, Sandra C. Christiansen, Taylor A. Doherty

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  • ·Hemophagocytic lymphohistiocytosis–like hyperinflammation due to a de novo mutation in DPP9

    Pagina :1336

    Christine Wolf, Hannah Fischer, Jörn-Sven Kühl, Sarah Koss, Rami Abou Jamra, Sven Starke, Jurek Schultz, Stephan Ehl, Katrin Neumann, Catharina Schuetz, Robert Huber, Veit Hornung, Min Ae Lee-Kirsch

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  • ·Corrigendum

    Pagina :1345-1346