Sommario

• • ·Introduction

    Pagina :S25

    Barbara A. Gilchrest, Lewis B. Holmes, From the aDepartment of Dermatology, Boston University School of Medicine; the bGenetics and Teratology Unit, Children's Service, Massachusetts General Hospital and bHarvard Medical School.

    
• • ·Treatment of photodamage with topical tretinoin: An overview

    Pagina :S27

    Barbara A. Gilchrest, From the Department of Dermatology, Boston University School of Medicine.

    Riassunto Riassunto Mappa Mappa  
• • ·The percutaneous absorption of topically applied tretinoin and its effect on endogenous concentrations of tretinoin and its metabolites after single doses or long-term use

    Pagina :S37

    Louise Latriano, Georg Tzimas, Frankie Wong, Robert J. Wills, From Johnson and Johnson Consumer Products Worldwide Research, Skin Research Center, Skillman, N.J.a; Tzimas-Dimolios, Co., Thessaloniki, Greeceb; The R.W. Johnson Research Institute, Raritan, N.J.c

    Riassunto Riassunto Mappa Mappa  
• • ·Tretinoin: A review of the nonclinical developmental toxicology experience

    Pagina :S47

    Devendra M. Kochhar, Mildred S. Christian, From the Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, and Argus Research Laboratories, Inc., Horsham.

    Riassunto Riassunto Mappa Mappa  
• • ·A developmental toxicity study of tretinoin administered topically and orally to pregnant Wistar rats

    Pagina :S60

    Robert E. Seegmiller, William H. Ford, Melvin W. Carter, Joseph J. Mitala, William J. Powers, From Brigham Young University, Provoa; Utah Biomedical Test Laboratory, Inc., Salt Lake Cityb; and the R.W. Johnson Pharmaceutical Research Institute, Raritan.c

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• • ·A developmental toxicity study of tretinoin emollient cream (Renova) applied topically to New Zealand white rabbits

    Pagina :S67

    Mildred S. Christian, Joseph J. Mitala, William J. Powers, Basil E. McKenzie, Louise Latriano, From Argus Research Laboratories, Inc., Horshama; and the R.W. Johnson Pharmaceutical Research Instituteb Johnson & Johnson Consumer Products Worldwide Research, Development and Engineering, Skillman.c

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• • ·A physiologically based pharmacokinetic model for retinoic acid and its metabolites

    Pagina :S77

    Harvey J. Clewell, Melvin E. Andersen, Robert J. Wills, Louise Latriano

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• • ·A risk assessment of topical tretinoin as a potential human developmental toxin based on animal and comparative human data

    Pagina :S86

    E.Marshall Johnson, From the Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia.

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