Sommario

• • ·Introduction

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    John S. Strauss

    

• Mechanism of Action of Retinoids

  • ·History of retinoids

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    Beverly A. Pawson

    Riassunto Riassunto
  • ·Discussion of article by Pawson

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  • ·Retinoid-binding proteins

    Pagina :583-588

    DeWitt S. Goodman

    Riassunto Riassunto
  • ·Discussion of article by Goodman

    Pagina :588-590

    
  • ·Effects of all-trans-retinoic acid (retinoic acid) and 4-hydroxyphenylretinamide on synovial cells and articular cartilage

    Pagina :591-602

    Constance E. Brinckerhoff, Hideaki Nagase, Jean E. Nagel, Edward D. Harris

    Riassunto Riassunto
  • ·Discussion of article by Brinckerhoff et al

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  • ·Inhibition of collagen degradative enzymes by retinoic acid in vitro

    Pagina :603-607

    Eugene A. Bauer, Jo Louise Seltzer, Arthur Z. Eisen

    Riassunto Riassunto
  • ·Discussion of article by Bauer et al

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  • ·General discussion of articles by Brinckerhoff et al and Bauer et al

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  • ·Studies on mannosyl carrier function of retinol and retinoic acid in epithelial and mesenchymal tissues

    Pagina :611-618

    Luigi M. De Luca

    Riassunto Riassunto
  • ·Discussion of article by De Luca

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  • ·The effects of retinoids on neutrophil functions in vitro

    Pagina :620-629

    Charles Camisa, Barrett Eisenstat, Anna Ragaz, Gerald Weissmann

    Riassunto Riassunto
  • ·The influence of retinoids on cultivated human keratinocytes

    Pagina :630-639

    Joseph McGuire, Neal Fedarko, Erik Johanssen, Jane LaVigne, Gary Lyons, Leonard Milstone, Michael Osber

    Riassunto Riassunto
  • ·General discussion of articles by Brinckerhoff et al, Bauer et al, De Luca, Camisa et al, and McGuire et al

    Pagina :640-642

    

• Pharmacology and Toxicology of Oral Retinoids

  • ·Pharmacokinetics of the retinoids isotretinoin and etretinate : A comparative review

    Pagina :643-651

    Romulus K. Brazzell, Wayne A. Colburn

    Riassunto Riassunto
  • ·Toxicology, carcinogenicity, and teratogenicity of some orally administered retinoids

    Pagina :652-659

    Jerome J. Kamm

    Riassunto Riassunto
  • ·General discussion of articles by Brazzell and Colburn Kamm

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  • ·Changes in lipid metabolism during retinoid administration

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    Leonard E. Gerber, John W. Erdman

    Riassunto Riassunto
  • ·Discussion of article by Gerber and Erdman

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  • ·General clinical toxicology of oral retinoids

    Pagina :675-682

    Dorothy B. Windhorst, Thomas Nigra

    Riassunto Riassunto
  • ·A study of potential hepatotoxicity of etretinate used in the treatment of psoriasis

    Pagina :683-687

    Scott D. Glazer, Henry H. Roenigk, H. Yokoo, Marshall Sparberg

    Riassunto Riassunto
  • ·Panel discussion: Toxicity of oral retinoid therapy

    Pagina :688-691

    

• Effect of Oral Synthetic Retinoids on Keratinizing Disorders

  • ·International studies of the efficacy of etretinate in the treatment of psoriasis

    Pagina :692-696

    Carl W. Ehmann, John J. Voorhees

    Riassunto Riassunto
  • ·Etretinate treatment for psoriasis inhibits epidermal ornithine decarboxylase

    Pagina :697-698

    Nicholas J. Lowe, Richard Kaplan, James Breeding

    Riassunto Riassunto
  • ·Etretinate therapy stimulates deposition of mucus-like material in epidermis of patients with psoriasis

    Pagina :699-704

    Charles N. Ellis, Robert C. Gold, Roy C. Grekin, Thomas F. Anderson, Neil A. Swanson, John J. Voorhees

    Riassunto Riassunto
  • ·Panel discussion: The efficacy of retinoids in the treatment of psoriasis

    Pagina :705-707

    
  • ·The use of isotretinoin in disorders of keratinization : An introduction

    Pagina :708-709

    Dorothy B. Windhorst

    Riassunto Riassunto
  • ·Pityriasis rubra pilaris response to 13-cis-retinoic acid (isotretinoin)

    Pagina :710-715

    Lowell A. Goldsmith, A. Elise Weinrich, Jerome Shupack

    Riassunto Riassunto
  • ·Treatment of ichthyosis with isotretinoin

    Pagina :716-720

    H.P. Baden, M.M. Buxman, G.D. Weinstein, F.W. Yoder

    Riassunto Riassunto
  • ·Isotretinoin treatment of Darier's disease

    Pagina :721-726

    Charles H. Dicken, Eugene A. Bauer, Paul G. Hazen, Gerald G. Krueger, James G. Marks, Joseph S. McGuire, Lawrence A. Schachner

    Riassunto Riassunto
  • ·The treatment of keratosis palmaris et plantaris with isotretinoin : A multicenter study

    Pagina :727-731

    Wilma F. Bergfeld, Vincent J. Derbes, Peter M. Elias, Phillip Frost, Kenneth E. Greer, Jerome L. Shupack

    Riassunto Riassunto
  • ·Short clinical reports

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• Effect of Oral Synthetic Retinoids on Sebaceous Glands and Acne

  • ·Isotretinoin versus placebo in the treatment of cystic acne : A randomized double-blind study

    Pagina :735-745

    Gary L. Peck, Thomas G. Olsen, Danute Butkus, Mangala Pandya, Jeanine Arnaud-Battandier, Earl G. Gross, Dorothy B. Windhorst, Joyce Cheripko

    Riassunto Riassunto
  • ·Actions of isotretinoin and etretinate on the pilosebaceous unit

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    Edward C. Gomez

    Riassunto Riassunto
  • ·Changes in long-term sebum production from isotretinoin therapy

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    John S. Strauss, Anna M. Stranieri

    Riassunto Riassunto
  • ·Discussion of article by Strauss and Stranieri

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  • ·General discussion of articles by Peck et al, Gomez, and Strauss and Stranieri

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  • ·Comparative effect of isotretinoin and etretinate on acne and sebaceous gland secretion

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    Jay A. Goldstein, Alicia Socha-Szott, Robert J. Thomsen, Peter E. Pochi, Alan R. Shalita, John S. Strauss

    Riassunto Riassunto
  • ·Action of isotretinoin in acne rosacea and gram-negative folliculitis

    Pagina :766-785

    Gerd Plewig, Jutta Nikolowski, Helmut H. Wolff

    Riassunto Riassunto
  • ·General discussion on the use of oral retinoids in nodulocystic acne

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• Risk/Benefits of Oral Retinoids

  • ·Panel discussion: Benefit/risk judgments for patients receiving retinoids on a short- and long-term basis

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• Tumor Prevention

  • ·Retinoids and inhibition of ornithine decarboxylase activity

    Pagina :796-798

    R.K. Boutwell

    Riassunto Riassunto
  • ·Discussion of article by Boutwell

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  • ·Perturbations of membrane glycosylation in retinoid-treated epidermis

    Pagina :801-808

    Michael K. Nemanic, Peter O. Fritsch, Peter M. Elias

    Riassunto Riassunto
  • ·Inhibition of chemical carcinogenesis by retinoids

    Pagina :809-814

    Richard C. Moon, David L. McCormick

    Riassunto Riassunto
  • ·Chemoprevention of basal cell carcinoma with isotretinoin

    Pagina :815-823

    Gary L. Peck, Earl G. Gross, Danute Butkus, John J. DiGiovanna

    Riassunto Riassunto
  • ·Studies of retinoids in the prevention and treatment of cancer

    Pagina :824-827

    Frank L. Meyskens

    Riassunto Riassunto
  • ·General discussion of articles by Moon and McCormick, Peck et al, and Meyskens

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• Summation

  • ·Closing comments

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    John S. Strauss