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• • ·Table of Contents

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• • ·Editorial Board

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• • ·Information for Authors

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• • ·Information for Authors

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• • ·Information for Readers

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• • ·Correction

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• • ·Evaluation of a novel anti-ischemic agent in acute coronary syndromes: Design and rationale for the Metabolic Efficiency with Ranolazine for Less Ischemia in Non–ST-elevation acute coronary syndromes (MERLIN)-TIMI 36 trial

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    David A. Morrow, Benjamin M. Scirica, Ewa Karwatowska-Prokopczuk, Allan Skene, Carolyn H. McCabe, Eugene Braunwald, for the MERLIN-TIMI 36 Investigators

    Résumé Résumé Plan Plan  

• Editorial

  • ·The COX-2 inhibitors—An update

    Page :197-199

    Curt D. Furberg

    Plan Plan
  • ·Clopidogrel-statin interaction: A mountain or a mole hill?

    Page :200-203

    Steven R. Steinhubl, W. Scott Akers

    
  • ·In transition: From family history into the post-genomic era

    Page :204-206

    Heribert Schunkert, Björn Mayer

     

• Curriculum in Cardiology

  • ·Distal protection in cardiovascular medicine: Current status

    Page :207-216

    Onn Akbar Ali, Ravinay Bhindi, Aisling C. McMahon, David Brieger, Leonard Kritharides, Harry C. Lowe

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  • ·Meta-analysis: Inhibition of renin-angiotensin system prevents new-onset atrial fibrillation

    Page :217-222

    Kishlay Anand, Aryan N. Mooss, Tom T. Hee, Syed M. Mohiuddin

    Résumé Résumé Plan Plan  

• Trial Design

  • ·Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery

    Page :223-230

    The POISE Trial Investigators ?

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  • ·Rationale and design of a randomized clinical trial to assess the role of overdrive and triggered prevention pacing therapies in reducing atrial fibrillation: The Study of Atrial Fibrillation Reduction (SAFARI)

    Page :231-236

    Michael R. Gold, Ellen Hoffmann, for the SAFARI Investigators

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  • ·Clinical trial design and patient demographics of the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) Study Program: Cardiovascular outcomes with etoricoxib versus diclofenac in patients with osteoarthritis and rheumatoid arthritis

    Page :237-245

    Christopher P. Cannon, Sean P. Curtis, James A. Bolognese, Loren Laine, for the MEDAL Steering Committee

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  • ·Rationale and design: The VALsartan In Diastolic Dysfunction (VALIDD) Trial: Evolving the management of diastolic dysfunction in hypertension

    Page :246-252

    Rajesh Janardhanan, William L. Daley, Tasneem Z. Naqvi, Sharon L. Mulvagh, Gerard Aurigemma, Michael Zile, J. Malcolm O. Arnold, Eunice Artis, Das Purkayastha, James D. Thomas, Scott D. Solomon, for the VALIDD Investigators

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• Clinical Investigations

  • ·Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department

    Page :253-262

    Frank Peacock, Deborah L. Morris, Saif Anwaruddin, Robert H. Christenson, Paul O. Collinson, Steve W. Goodacre, James L. Januzzi, Robert L. Jesse, Juan C. Kaski, Michael C. Kontos, Guillaume Lefevre, Dave Mutrie, Manas K. Sinha, Denise Uettwiller-Geiger, Charles V. Pollack

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  • ·Correction

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  • ·A pharmacoepidemiology study of the interaction between atorvastatin and clopidogrel after percutaneous coronary intervention

    Page :263-269

    James M. Brophy, Mohan N. Babapulle, Vania Costa, Stephane Rinfret

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  • ·ST-segment depression in non–ST elevation acute coronary syndromes: Quantitative analysis may not provide incremental prognostic value beyond comprehensive risk stratification

    Page :270-276

    Andrew T. Yan, Raymond T. Yan, Mary Tan, Chi-Ming Chow, David H. Fitchett, Alina A. Georgescu, Quamrul Hassan, Janna Luchansky, Anatoly Langer, Shaun G. Goodman, for the Canadian ACS Registry Investigators

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  • ·The prognostic value of the admission and predischarge electrocardiogram in acute coronary syndromes: The GUSTO-IIb ECG Core Laboratory experience

    Page :277-284

    Shaun G. Goodman, Yuling Fu, Anatoly Langer, Aiala Barr, Mary Tan, Galen S. Wagner, Alejandro Barbagelata, Elena B. Sgarbossa, Yochai Birnbaum, Christopher B. Granger, Robert M. Califf, Frans Van de Werf, Eric J. Topol, Paul W. Armstrong, for the GUSTO-IIb Investigators i

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  • ·Antecedent left ventricular mass and infarct size in ST-elevation myocardial infarction

    Page :285-290

    Zaza Iakobishvili, Vladimir Danicek, Avital Porter, Shula Imbar, David Brosh, Alexander Battler, David Hasdai

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  • ·Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization

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    Shi Yin Foo, Brendan M. Everett, Robert W. Yeh, David Criss, Michael Laposata, Elizabeth M. Van Cott, Ik-Kyung Jang

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  • ·Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: A systematic overview

    Page :291-296

    Kenneth W. Mahaffey, Frans Van de Werf, Stanton K. Shernan, Christopher B. Granger, Edward D. Verrier, Thomas G. Filloon, Thomas G. Todaro, Peter X. Adams, Jerrold H. Levy, Vic Hasselblad, Paul W. Armstrong

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  • ·Maximum oxygen uptake at peak exercise in elderly patients with coronary artery disease and preserved left ventricular function : The role of inflammation on top of tissue Doppler–derived systolic and diastolic function

    Page :297.e1

    Nico R. Van de Veire, Olivier De Winter, Jan Philippé, Marc De Buyzere, Dirk Bernard, Michel Langlois, Thierry C. Gillebert, Johan De Sutter

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  • ·Prospective evaluation of the oxygen uptake efficiency slope as a submaximal predictor of peak oxygen uptake in aged patients with ischemic heart disease

    Page :297.e9

    Christophe Van Laethem, Nico Van De Veire, Johan De Sutter, Jozef Bartunek, Guy De Backer, Marc Goethals, Marc Vanderheyden

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  • ·Metabolic syndrome, C-reactive protein, and prognosis in patients with established coronary artery disease

    Page :298-304

    David Aguilar, Marian R. Fisher, Christopher M. O'Connor, Michael W. Dunne, Joseph B. Muhlestein, Louis Yao, Sandeep Gupta, Rebecca J. Benner, Thomas D. Cook, Dearborn Edwards, Marc A. Pfeffer, for the Investigators in the Weekly Intervention with Zithromax for Atherosclerosis and its Related Disorder (WIZARD) study

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  • ·Identification of excess clustering of coronary heart diseases among extended pedigrees in a genealogical population database

    Page :305-311

    Benjamin D. Horne, Nicola J. Camp, Joseph B. Muhlestein, Lisa A. Cannon-Albright

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  • ·Evaluation of AMPD1 C34T genotype as a predictor of mortality in heart failure and post–myocardial infarction patients

    Page :312-320

    Richard P. Collins, Barry R. Palmer, Anna P. Pilbrow, Chris M. Frampton, Richard W. Troughton, Tim G. Yandle, Lorraine Skelton, A. Mark Richards, Vicky A. Cameron

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  • ·Patterns and outcomes of drug-eluting coronary stent use in clinical practice

    Page :321-326

    Sunil V. Rao, Richard E. Shaw, Ralph G. Brindis, Lloyd W. Klein, William S. Weintraub, Ronald J. Krone, Eric D. Peterson

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  • ·Intravascular ultrasound assessment of fibrous cap remnants after coronary plaque rupture

    Page :327-332

    Lisette Okkels Jensen, Gary S. Mintz, Stéphane G. Carlier, Kenichi Fujii, Issam Moussa, George Dangas, Roxanna Mehran, Gregg W. Stone, Martin B. Leon, Jeffrey W. Moses

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  • ·The Extensive Lifestyle Management Intervention (ELMI) after cardiac rehabilitation: A 4-year randomized controlled trial

    Page :333-339

    Scott A. Lear, John J. Spinelli, Wolfgang Linden, Anka Brozic, Marla Kiess, Jiri J. Frohlich, Andrew Ignaszewski

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  • ·Predicting significant coronary artery disease in patients with left ventricular dysfunction

    Page :340-347

    David J. Whellan, Robert H. Tuttle, Eric J. Velazquez, Linda K. Shaw, James G. Jollis, Wendell Ellis, Christopher M. O'Connor, Robert M. Califf, Salvador Borges-Neto

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  • ·Racial variations in quality of care and outcomes in an ambulatory heart failure cohort

    Page :348-354

    Anita Deswal, Nancy J. Petersen, Diana L. Urbauer, Steven M. Wright, Rebecca Beyth

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  • ·Correction

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  • ·Low voltage on the electrocardiogram is a marker of disease severity and a risk factor for adverse outcomes in patients with heart failure due to systolic dysfunction

    Page :355-361

    Sandeep A. Kamath, Januario de P. Meo Neto, Russell M. Canham, Fatema Uddin, Kathleen H. Toto, Lauren L. Nelson, Patricia A. Kaiser, James A. de Lemos, Mark H. Drazner

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  • ·Persistence of iatrogenic atrial septal defect after pulmonary vein isolation—an underestimated risk?

    Page :362.e1

    Christoph Hammerstingl, Lars Lickfett, Kyung-Mi Jeong, Clemens Troatz, Jan-Arne Wedekind, Klaus Tiemann, Berndt Lüderitz, Thorsten Lewalter

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  • ·Risk stratification of patients with chronic kidney disease: Results of screening strategies incorporating clinical risk scoring and dobutamine stress echocardiography

    Page :363-370

    Dhrubo J. Rakhit, Kirsten A. Armstrong, Elaine Beller, Nicole M. Isbel, Thomas H. Marwick

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  • ·Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project

    Page :371-378

    Saif S. Rathore, Frederick A. Masoudi, Yongfei Wang, Jeptha P. Curtis, JoAnne M. Foody, Edward P. Havranek, Harlan M. Krumholz

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  • ·Implementation of a continuous quality improvement program for percutaneous coronary intervention and cardiac surgery at a large community hospital

    Page :379-385

    John E. Brush, Sharmini A. Balakrishnan, Joani Brough, Carl Hartman, Grace Hines, Deborah P. Liverman, John P. Parker, Jeffrey Rich, Nancy Tindall

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  • ·Risk factors for deaths occurring within 30 days and 1 year after hospital discharge for cardiac surgery among pediatric patients

    Page :386-393

    Ruey-Kang R. Chang, Sandra Rodriguez, Maggie Lee, Thomas S. Klitzner

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  • ·Racial differences are seen in blood pressure response to fosinopril in hypertensive children

    Page :394-399

    Sharad Menon, Katherine Y. Berezny, Rakhi Kilaru, Daniel K. Benjamin, Joseph D. Kay, Lydie Hazan, Ronald Portman, Ronald Hogg, David Deitchman, Robert M. Califf, Jennifer S. Li

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• Letters to the Editor

  • ·A perspective on antiarrhythmic drug therapy

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    O.M.P. Jolobe

    
  • ·Response to Letter to the Editor

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    Albert L. Waldo

    
  • ·Reduced CD34⁺, renal anemia, and adverse outcomes

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    Felicita Andreotti, Giulio Coluzzi, Silvia Cecchetti, Alberto Lavorgna, Francesca Marzo, Filippo Crea, Carlo Rumi