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• • ·Table of Contents

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• • ·Editorial Board

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• • ·Information for Readers

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• Editorials

  • ·Prior bleeding, future bleeding and stroke risk with oral anticoagulation in atrial fibrillation: What new lessons can ARISTOTLE teach us?

    Page :168-171

    Shaun G. Goodman

    Plan Plan
  • ·Hospital triage of acute myocardial infarction: Is admission to the coronary care unit still necessary?

    Page :172-174

    Michael G. Silverman, David A. Morrow

    Plan Plan  

• Curriculum in Cardiology

  • ·The impact of drug shortages on patients with cardiovascular disease: causes, consequences, and a call to action

    Page :130-141

    Brent N. Reed, Erin R. Fox, Madeleine Konig, Cynthia A. Jackevicius, Frederick A. Masoudi, Alejandro A. Rabinstein, Robert L. Page

    Résumé Résumé Plan Plan   

• Progress in Cardiology

  • ·Utility of positron emission tomography for drug development for heart failure

    Page :142-152

    Lampros Papadimitriou, Peter M. Smith-Jones, Chaudhry M.S. Sarwar, Catherine N. Marti, Kavitha Yaddanapudi, Hal A. Skopicki, Mihai Gheorghiade, Ramin Parsey, Javed Butler

    Résumé Résumé Plan Plan  

• Trial Designs

  • ·Bivalirudin versus heparin in non-ST and ST-segment elevation myocardial infarction—a registry-based randomized clinical trial in the SWEDEHEART registry (the VALIDATE-SWEDEHEART trial)

    Page :36-46

    David Erlinge, Sasha Koul, Peter Eriksson, Fredrik Scherstén, Elmir Omerovic, Rikard Linder, Olof Petter Östlund, Lars Wallentin, Ole Fröbert, Stefan James

    Résumé Résumé Plan Plan  
  • ·Rationale and design of a home-based trial using wearable sensors to detect asymptomatic atrial fibrillation in a targeted population: The mHealth Screening To Prevent Strokes (mSToPS) trial

    Page :77-85

    Steven R. Steinhubl, Rajesh R. Mehta, Gail S. Ebner, Marissa M. Ballesteros, Jill Waalen, Gregory Steinberg, Percy Van Crocker, Elise Felicione, Chureen T. Carter, Shawn Edmonds, Joseph P. Honcz, Gines Diego Miralles, Dimitri Talantov, Troy C. Sarich, Eric J. Topol

    Résumé Résumé Plan Plan  
  • ·Design and rationale for the Effects of Ticagrelor and Clopidogrel in Patients with Peripheral Artery Disease (EUCLID) trial

    Page :86-93

    Jeffrey S. Berger, Brian G. Katona, W. Schuyler Jones, Manesh R. Patel, Lars Norgren, Iris Baumgartner, Juuso Blomster, Kenneth W. Mahaffey, Peter Held, Marcus Millegård, Gretchen Heizer, Craig Reist, F. Gerry Fowkes, William R. Hiatt

    Résumé Résumé Plan Plan   
  • ·The China Acute Myocardial Infarction (CAMI) Registry: A national long-term registry-research-education integrated platform for exploring acute myocardial infarction in China

    Page :193

    Haiyan Xu, Wei Li, Jingang Yang, Stephen D. Wiviott, Marc S. Sabatine, Eric D. Peterson, Ying Xian, Matthew T. Roe, Wei Zhao, Yang Wang, Xinran Tang, Xuan Jia, Yuan Wu, Runlin Gao, Yuejin Yang, CAMI Registry study group

    Résumé Résumé Plan Plan  

• Clinical Investigations

  • ·Comparison of performance on Hospital Compare process measures and patient outcomes between hospitals that do and do not participate in Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With The Guidelines

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    Robin Mathews, Gregg C. Fonarow, Shuang Li, Eric D. Peterson, John S. Rumsfeld, Paul A. Heidenreich, Matthew T. Roe, William J. Oetgen, James G. Jollis, Christopher P. Cannon, James A. de Lemos, Tracy Y. Wang, National Cardiovascular Data Registry

    Résumé Résumé Plan Plan   
  • ·Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation

    Page :9-17

    Jason D. Roberts, Thomas A. Dewland, David V. Glidden, Thomas J. Hoffmann, Dan E. Arking, Lin Y. Chen, Bruce M. Psaty, Jeffrey E. Olgin, Alvaro Alonso, Susan R. Heckbert, Gregory M. Marcus

    Résumé Résumé Plan Plan   
  • ·Ischemic cardiac outcomes and hospitalizations according to prior macrovascular disease status in patients with type 2 diabetes and recent acute coronary syndrome from the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care trial

    Page :18-27

    Yuichi J. Shimada, Christopher P. Cannon, Yuyin Liu, Craig Wilson, Stuart Kupfer, Venu Menon, William C. Cushman, Cyrus R. Mehta, George L. Bakris, Faeiz Zannad, William B. White, EXAMINE Investigators

    Résumé Résumé Plan Plan  
  • ·Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry

    Page :28-35

    Anna Gundlund, Emil Loldrup Fosbøl, Sunghee Kim, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, Elaine Hylek, Kenneth W. Mahaffey, Laine Thomas, Jonathan P. Piccini, Eric D. Peterson, ORBIT-AF Investigators

    Résumé Résumé Plan Plan  
  • ·Ten-year clinical outcomes after sirolimus-eluting stent implantation: Impact of an in-stent restenosis target lesion

    Page :47-55

    Katsuya Miura, Kazushige Kadota, Seiji Habara, Hiroshi Miyawaki, Takenobu Shimada, Masanobu Ohya, Hidewo Amano, Yu Izawa, Yusuke Hyodo, Suguru Otsuru, Daiji Hasegawa, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazuaki Mitsudo

    Résumé Résumé Plan Plan  
  • ·Risk and timing of recurrent ischemic events among patients with stable ischemic heart disease, non–ST-segment elevation acute coronary syndrome, and ST-segment elevation myocardial infarction

    Page :56-65

    Thomas Pilgrim, Pascal Vranckx, Marco Valgimigli, Giulio G. Stefanini, Raffaele Piccolo, Julie Rat, Martina Rothenbühler, Stefan Stortecky, Lorenz Räber, Stefan Blöchlinger, Lukas Hunziker, Sigmund Silber, Peter Jüni, Patrick W. Serruys, Stephan Windecker

    Résumé Résumé Plan Plan  
  • ·Changes in cardiovascular risk factors after 5 years of implementation of a population-based program to reduce cardiovascular disease: The Heart of New Ulm Project

    Page :66-76

    Abbey C. Sidebottom, Arthur Sillah, Michael D. Miedema, David M. Vock, Raquel Pereira, Gretchen Benson, Jackie L. Boucher, Thomas Knickelbine, Rebecca Lindberg, Jeffrey J. VanWormer

    Résumé Résumé Plan Plan
  • ·Patient and physician discordance in reporting symptoms of angina among stable coronary artery disease patients: Insights from the Angina Prevalence and Provider Evaluation of Angina Relief (APPEAR) study

    Page :94-100

    Ali Shafiq, Suzanne V. Arnold, Kensey Gosch, Faraz Kureshi, Tracie Breeding, Philip G. Jones, John Beltrame, John A. Spertus

    Résumé Résumé Plan Plan  
  • ·Sex-related differences in left ventricular remodeling in severe aortic stenosis and reverse remodeling after aortic valve replacement: A cardiovascular magnetic resonance study

    Page :101-111

    Laura E. Dobson, Timothy A. Fairbairn, Tarique A. Musa, Akhlaque Uddin, Cheryl A. Mundie, Peter P. Swoboda, David P. Ripley, Adam K. McDiarmid, Bara Erhayiem, Pankaj Garg, Christopher J. Malkin, Daniel J. Blackman, Linda D. Sharples, Sven Plein, John P. Greenwood

    Résumé Résumé Plan Plan   
  • ·Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studies

    Page :112-120

    Norrina B. Allen, Donald Lloyd-Jones, Shih-Jen Hwang, Laura Rasmussen-Torvik, Myriam Fornage, Alanna C. Morrison, Abigail S. Baldridge, Eric Boerwinkle, Daniel Levy, L. Adrienne Cupples, Caroline S. Fox, George Thanassoulis, Line Dufresne, Martha Daviglus, Andrew D. Johnson, Jared Reis, Jerome Rotter, Walter Palmas, Mathew Allison, James S. Pankow, Christopher J. O'Donnell

    Résumé Résumé Plan Plan   
  • ·Impact of severe lesion calcification on clinical outcome of patients with stable angina, treated with newer generation permanent polymer-coated drug-eluting stents : A patient-level pooled analysis from TWENTE and DUTCH PEERS (TWENTE II)

    Page :121-129

    Jennifer Huisman, Liefke C. van der Heijden, Marlies M. Kok, Peter W. Danse, Gillian A.J. Jessurun, Martin G. Stoel, K. Gert van Houwelingen, Marije M. Löwik, Raymond W.M. Hautvast, Maarten J. IJzerman, Carine J. Doggen, Clemens von Birgelen

    Résumé Résumé Plan Plan  
  • ·Association between publication of appropriate use criteria and the temporal trends in diagnostic angiography in stable coronary artery disease: A population-based study

    Page :153-159

    Yaron Arbel, Feng Qiu, Maria C. Bennell, Peter C. Austin, Idan Roifman, Mohammad R. Rezai, Jack V. Tu, Dennis T. Ko, Harindra C. Wijeysundera

    Résumé Résumé Plan Plan   
  • ·The optimal definition of contrast-induced acute kidney injury for prediction of inpatient mortality in patients undergoing percutaneous coronary interventions

    Page :160-167

    Jessica Parsh, Milan Seth, Carlo Briguori, Paul Grossman, Richard Solomon, Hitinder S. Gurm

    Résumé Résumé Plan Plan   
  • ·History of bleeding and outcomes with apixaban versus warfarin in patients with atrial fibrillation in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial

    Page :175-183

    Raffaele De Caterina, Ulrika Andersson, John H. Alexander, Sana M. Al-Khatib, M. Cecilia Bahit, Shinya Goto, Michael Hanna, Claes Held, Stefan Hohnloser, Elaine M. Hylek, Fernando Lanas, Renato D. Lopes, José López-Sendón, Giulia Renda, John Horowitz, Christopher B. Granger, Lars Wallentin, ARISTOTLE Investigators

    Résumé Résumé Plan Plan   
  • ·Do stable non–ST-segment elevation acute coronary syndromes require admission to coronary care units?

    Page :184-192

    Sean van Diepen, Meng Lin, Jeffrey A. Bakal, Finlay A. McAlister, Padma Kaul, Jason N. Katz, Christopher B. Fordyce, Danielle A. Southern, Michelle M. Graham, Stephen B. Wilton, L. Kristin Newby, Christopher B. Granger, Justin A. Ezekowitz

    Résumé Résumé Plan Plan   

• Letter to the Editors

  • ·Directions for future trials on blood glucose-lowering drugs to improve left ventricular function post–ST-segment elevation myocardial infarction

    Page :e1

    Peter Ruben van Dijk, Mohamed Mouden, Renicus Hermanides

    

• Corrigendum

  • ·Corrigendum to ’The Brazilian Cardioprotective Nutritional Program to reduce events and risk factors in secondary prevention for cardiovascular disease: study protocol (The BALANCE Program Trial)’ [American Heart Journal 171/1 (2016) 73–81]

    Page :202-203

    Bernardete Weber, Ângela C. Bersch-Ferreira, Camila R. Torreglosa, Maria B. Ross-Fernandes, Jacqueline T. da Silva, Andrea P. Galante, Enilda de Sousa Lara, Rosana P. Costa, Rafael M. Soares, Alexandre B. Cavalcanti, Emilio H. Moriguchi, Neide M. Bruscato, Josiele Kesties, Lilian Vivian, Marina Schumacher, Waldemar de Carli, Luciano M. Backes, Bruna R. Reolão, Milena P. Rodrigues, Dúnnia M.B. Baldissera, Glaucia S. Tres, Hugo R.K. Lisbôa, João B.J. Bem, Jose B.C. Reolão, Keyla L.A.L. Deucher, Maiara Cantarelli, Aline Lucion, Daniela Rampazzo, Vanessa Bertoni, Rosileide S. Torres, Adriana O.L. Verríssimo, Aldair S. Guterres, Andrea F.R. Cardos, Dalva B.S. Coutinho, Mayara G. Negrão, Mônica F.A. Alencar, Priscila M. Pinho, Socorro N.A.A. Barbosa, Ana P.P.F. Carvalho, Maria I.S. Taboada, Sheila A. Pereira, Raul V. Heyde, Francisca E.Z. Nagano, Rebecca Baumgartner, Fernanda P. Resende, Ranata Tabalipa, Ana C. Zanini, Michael J.R. Machado, Hevila Araujo, Maria L.V. Teixeira, Gabriela C. Souza, Priccila Zuchinali, Bianca M. Fracasso, Karen Ulliam, Marina Schumacher, Moara Pierotto, Thamires Hilário, Daniele M.O. Carlos, Cintia G.N.C. Cordeiro, Daniele A. Carvalho, Marília S. Gonçalves, Valdiana B. Vasconcelos, Rosa Bosquetti, Raira Pagano, Marcelo L.P. Romano, César A. Jardim, Bernardo N.A. de Abreu, Aline Marcadenti, Alessandra R. Schmitt, Angela M.V. Tavares, Christiane C. Faria, Flávia M. Silva, Jaqueline S. Fink, Raquel M. El Kik, Clarice F. Prates, Cristiane S. Vieira, Elaine F. Adorne, Ellen H. Magedanz, Fernanda L. Chieza, Ingrid S. Silva, Joise M. Teixeira, Eduardo P. Trescastro, Lívia A. Pellegrini, Jéssika C. Pinto, Cristina T. Telles, Antonio C.S. Sousa, Andreza S. Almeida, Ariane A. Costa, José A.C. Carmo, Juliana T. Silva, Luciana V.S. Alves, Saulo O.C. Sales, Maria E.M. Ramos, Marilia C.S. Lucas, Monica Damiani, Patricia C. Cardoso, Salvador S. Ramos, Clenise F. Dantas, Amanda G. Lopes, Ana M.P. Cabral, Ana C.A. Lucena, Auriene L. Medeiros, Bernardino B. Terceiro, Neuma M.F.S. Leda, Sandra R.D. Baía, Josilene M.F. Pinheiro, Alexandra N. Cassiano, Andressa N.L. Melo, Anny K.O. Cavalcanti, Camila V.S. Souza, Dayanna J.M. Queiroz, Hercilla N.C.F. Farias, Larissa C.F. Souza, Letícia S. Santos, Luana R.M. Lima, Meg S. Hoffmann, Átala S. Silva Ribeiro, Daniel F. Vasconcelos, Eliane S. Dutra, Marina K. Ito, José A.F. Neto, Alexsandro F. Santos, Rosângela M.L. Sousa, Luciana Pereira P. Dias, Maria T.M.A. Lima, Victor G. Modanesi, Adriana F. Teixeira, Luciana C.N.C.D. Estrada, Paulo V.G. Modanesi, Adriana B.L. Gomes, Bárbara R.S. Rocha, Cristina Teti, Marta M. David, Bruna M. Palácio, Délcio G.S. Junior, Érica H.S. Faria, Michelle C.F. Oliveira, Rose M. Uehara, Sandramara Sasso, Annie S.B. Moreira, Ana C.A.H. Cadinha, Carla W.M. Pinto, Mariana P. Castilhos, Mariana Costa, Cristiane Kovacs, Daniel Magnoni, Quênia Silva, Michele F.C.A. Germini, Renata A. da Silva, Aline S. Monteiro, Karina G. dos Santos, Priscila Moreira, Fernanda C. Amparo, Catharina C.J. Paiva, Soraia Poloni, Diana S. Russo, Izabele V. Silveira, Maria A. Moraes, Mirena Boklis, Quinto I. Cardoso, Annie S.B. Moreira, Aline M.S. Damaceno, Elisa M. Santos, Glauber M. Dias, Cláudia P.S. Pinho, Adrilene C. Cavalcanti, Amanda S. Bezerra, Andrey V. Queiroga, Isa G. Rodrigues, Tallita V. Leal, Viviane Sahade, Daniele A. Amaral, Diana S. Souza, Givaldo A. Araújo, Karine Curvello, Manuella Heine, Marília M.S. Barretto, Nailson A. Reis, Sandra M.L. Vasconcelos, Danielly C. Vieira, Francisco A. Costa, Jessica M.S. Fontes, Juvenal G.C. Neto, Laís N.P. Navarro, Raphaela C. Ferreira, Patrícia M. Marinho, Renata Torres Abib, Aline Longo, Eduardo G. Bertoldi, Lauren S. Ferreira, Lúcia R. Borges, Norlai A. Azevedo, Celma M. Martins, Juliana T. Kato, Maria C.O. Izar, Marina T. Asoo, Mariana D. de Capitani, Valéria A. Machado, Waléria T. Fonzar, Sônia L. Pinto, Kellen C. Silva, Lúcia H.A. Gratão, Sheila D. Machado, Susane R.U. de Oliveira, Josefina Bressan, Ana P.S. Caldas, Hatanne C.F.M. Lima, Helen H.M. Hermsdorff, Tânia M. Saldanha, Sílvia E. Priore, Naoel H. Feres, Adila de Queiroz Neves, Loanda M.G. Cheim, Nilma F. Silva, Silvia R.L. Reis, Andreza M. Penafort, Ana Paula O. de Queirós, Geysa M.N. Farias, Mônica L.P. de los Santos, Cíntia L. Ambrozio, Cirília N. Camejo, Cristiano P. dos Santos, Gabriela S. Schirmann, Jorge L. Boemo, Rosane E.C. Oliveira, Súsi M.B. Lima, Vera M.S. Bortolini, Cristina H. Matos, Claiza Barretta, Clarice M. Specht, Simone R. de Souza, Cristina S. Arruda, Priscila A. Rodrigues, Otávio Berwanger