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• • ·Table of Contents

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• • ·Editorial Board

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• • ·Information for Readers

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• Editorials

  • ·The troponin decision-point dilemma: The 99th percentile solution “do the best you can [with cardiac troponin] until you know better. Then when you know better, do better.” Maya Angelou, poet, dancer, producer, playwright, director, author

    Page :132-134

    Robert H. Christenson, Christopher R. deFilippi

    

• Cardiac Safety Research Consortium

  • ·Use of endpoint adjudication to improve the quality and validity of endpoint assessment for medical device development and post marketing evaluation: Rationale and best practices. A report from the cardiac safety research consortium

    Page :76-85

    Jonathan H. Seltzer, Ted Heise, Peter Carson, Daniel Canos, Jo Carol Hiatt, Pascal Vranckx, Thomas Christen, Donald E. Cutlip

    Résumé Résumé Plan Plan  
  • ·Prevention of sudden cardiac death in the young: Developing a rational, reliable, and sustainable national health care resource. A report from the Cardiac Safety Research Consortium

    Page :123-131

    Salim F. Idriss, Stuart Berger, Kimberly G. Harmon, Allen Kindman, Robert Kleiman, Martha Lopez-Anderson, Silvana Molossi, Tess (Elizabeth) Saarel, Colette Strnadova, Thomas Todaro, Kaori Shinagawa, Valarie Morrow, Mitchell Krucoff, Victoria Vetter, Theressa J. Wright

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• Trial Designs

  • ·Probing oral anticoagulation in patients with atrial high rate episodes: Rationale and design of the Non–vitamin K antagonist Oral anticoagulants in patients with Atrial High rate episodes (NOAH–AFNET 6) trial

    Page :12-18

    Paulus Kirchhof, Benjamin F. Blank, Melanie Calvert, A. John Camm, Gregory Chlouverakis, Hans-Christoph Diener, Andreas Goette, Andrea Huening, Gregory Y.H. Lip, Emmanuel Simantirakis, Panos Vardas

    Résumé Résumé Plan Plan  
  • ·Stroke of Known Cause and Underlying Atrial Fibrillation (STROKE-AF) randomized trial: Design and rationale

    Page :19-24

    Richard A. Bernstein, Hooman Kamel, Christopher B. Granger, Robert C. Kowal, Paul D. Ziegler, Lee H. Schwamm

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  • ·A randomized trial of a 1-hour troponin T protocol in suspected acute coronary syndromes: Design of the Rapid Assessment of Possible ACS In the emergency Department with high sensitivity Troponin T (RAPID-TnT) study

    Page :25-33

    Cynthia Papendick, Andrew Blyth, Anil Seshadri, Michael J.R. Edmonds, Tom Briffa, Louise Cullen, Stephen Quinn, Jon Karnon, Anthony Chuang, Adam J. Nelson, Matthew Horsfall, Erin Morton, Derek P. Chew

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  • ·Implantable cardiac monitors in high-risk post-infarction patients with cardiac autonomic dysfunction and moderately reduced left ventricular ejection fraction: Design and rationale of the SMART-MI trial

    Page :34-39

    Wolfgang Hamm, Konstantinos D. Rizas, Lukas von Stülpnagel, Nikolay Vdovin, Steffen Massberg, Stefan Kääb, Axel Bauer

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  • ·Interventions Supporting Long-term Adherence aNd Decreasing cardiovascular events (ISLAND): Pragmatic randomized trial protocol

    Page :64-75

    Noah Ivers, J-D Schwalm, Holly O. Witteman, Justin Presseau, Monica Taljaard, Tara McCready, Beth Bosiak, Jennifer Cunningham, Shelley Smarz, Laura Desveaux, Jack V. Tu, Clare Atzema, Garth Oakes, Wanrudee Isaranuwatchai, Sherry L. Grace, R. Sacha Bhatia, Madhu Natarajan, Jeremy M. Grimshaw

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• Clinical Investigations

  • ·High-sensitivity C-reactive protein is an independent marker of abnormal coronary vasoreactivity in patients with non-obstructive coronary artery disease

    Page :1-11

    Jaskanwal D.S. Sara, Megha Prasad, Ming Zhang, Ryan J. Lennon, Joerg Herrmann, Lilach O. Lerman, Amir Lerman

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  • ·Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort

    Page :40-45

    Rong Jiang, Michael A. Babyak, Beverly H. Brummett, Elizabeth R. Hauser, Svati H. Shah, Richard C. Becker, Ilene C. Siegler, Abanish Singh, Carol Haynes, Megan Chryst-Ladd, Damian M. Craig, Redford B. Williams

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  • ·Retained cardiac implantable electronic device fragments are not associated with magnetic resonance imaging safety issues, morbidity, or mortality after orthotopic heart transplant

    Page :46-53

    Christopher O. Austin, Kevin Landolfo, Pragnesh P. Parikh, Parag C. Patel, K.L. Venkatachalam, Fred M. Kusumoto

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  • ·Clinical outcomes with percutaneous coronary revascularization vs coronary artery bypass grafting surgery in patients with unprotected left main coronary artery disease: A meta-analysis of 6 randomized trials and 4,686 patients

    Page :54-63

    Tullio Palmerini, Patrick Serruys, Arie Pieter Kappetein, Philippe Genereux, Diego Della Riva, Letizia Bacchi Reggiani, Evald Høj Christiansen, Niels R. Holm, Leif Thuesen, Timo Makikallio, Marie Claude Morice, Jung-Min Ahn, Seung-Jung Park, Holger Thiele, Enno Boudriot, Mario Sabatino, Mattia Romanello, Giuseppe Biondi-Zoccai, Raphael Cavalcante, Joseph F. Sabik, Gregg W. Stone

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  • ·Time in therapeutic range and major adverse outcomes in atrial fibrillation patients undergoing percutaneous coronary intervention: The Atrial Fibrillation Undergoing Coronary Artery Stenting (AFCAS) registry

    Page :86-93

    Marco Proietti, K.E. Juhani Airaksinen, Andrea Rubboli, Axel Schlitt, Tuomas Kiviniemi, Pasi P. Karjalainen, Gregory YH Lip, on behalf of the AFCAS Study Group

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  • ·Growth-differentiation factor 15 and risk of major bleeding in atrial fibrillation: Insights from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial

    Page :94-103

    Ziad Hijazi, Jonas Oldgren, Ulrika Andersson, Stuart J. Connolly, John W. Eikelboom, Michael D. Ezekowitz, Paul A. Reilly, Salim Yusuf, Agneta Siegbahn, Lars Wallentin

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  • ·County socioeconomic characteristics and heart transplant outcomes in the United States

    Page :104-112

    Dmitry Tumin, Jessica Horan, Emily A. Shrider, Sakima A. Smith, Joseph D. Tobias, Don Hayes, Randi E. Foraker

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  • ·Effects of serelaxin on the outcome of patients with or without substantial peripheral edema: A subgroup analysis from the RELAX-AHF trial

    Page :113-122

    Claudio Gimpelewicz, Marco Metra, John G.F Cleland, Peter Szecsödy, Chuan-Chuan Chang Wun, Leandro Boer-Martins, Gad Cotter, Beth A. Davison, Gary Michael Felker, Gerasimos Filippatos, Barry H. Greenberg, Peter Pang, Piotr Ponikowski, Thomas Severin, Adrian A. Voors, John R. Teerlink

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  • ·Use of troponin assay 99th percentile as the decision level for myocardial infarction diagnosis

    Page :135-139

    Akshay Bagai, Karen P. Alexander, Jeffrey S. Berger, Roxy Senior, Chakkanalil Sajeev, Radoslaw Pracon, Kreton Mavromatis, Jose Luis Lopez-Sendón, Gilbert Gosselin, Ariel Diaz, Gian Perna, Jarozlaw Drozdz, Dennis Humen, Birute Petrauskiene, Asim N. Cheema, Denis Phaneuf, Subhash Banerjee, Todd D. Miller, Sasko Kedev, Herwig Schuchlenz, Gregg W. Stone, Shaun G. Goodman, Kenneth W. Mahaffey, Allan S. Jaffe, Yves D. Rosenberg, Sripal Bangalore, L. Kristin Newby, David J. Maron, Judith S. Hochman, Bernard R. Chaitman

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