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• • ·Table of Contents

    Page :i

    
• • ·Editorial Board

    Page :iii

    
• • ·Information for Readers

    Page :iv

    

• Curriculum in Cardiology

  • ·Potential impact of the steroid hormone, vitamin D, on the vasculature

    Page :147-153

    Yin Tintut, Linda L. Demer

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• Trial Designs

  • ·A prospective multicenter validation study for a novel angiography-derived physiological assessment software: Rationale and design of the radiographic imaging validation and evaluation for Angio-iFR (ReVEAL iFR) study

    Page :19-26

    Masafumi Ono, Patrick W. Serruys, Manesh R. Patel, Javier Escaned, Takashi Akasaka, Martijn A. van Lavieren, Christian Haase, Michael Grass, Norihiro Kogame, Hironori Hara, Hideyuki Kawashima, Joanna J. Wykrzykowska, Jan J. Piek, Scot Garg, Neil O'Leary, Becky Inderbitzen, Yoshinobu Onuma

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  • ·Rationale and design of the intravenous iron for treatment of anemia before cardiac surgery trial

    Page :64-72

    Paul S. Myles, Toby Richards, Andrew Klein, Julian Smith, Erica M. Wood, Stephane Heritier, David McGiffin, Silva Zavarsek, Joel Symons, Zoe K. McQuilten, Robert A. Baker, Keyvan Karkouti, Sophia Wallace, the ANZCA Clinical Trials Network

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  • ·Batch enrollment for an artificial intelligence-guided intervention to lower neurologic events in patients with undiagnosed atrial fibrillation: rationale and design of a digital clinical trial

    Page :73-79

    Xiaoxi Yao, Zachi I. Attia, Emma M. Behnken, Kelli Walvatne, Rachel E. Giblon, Sijia Liu, Konstantinos C. Siontis, Bernard J. Gersh, Jonathan Graff-Radford, Alejandro A. Rabinstein, Paul A. Friedman, Peter A. Noseworthy

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  • ·Study design and rationale of VALOR-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy who are eligible for septal reduction therapy

    Page :80-89

    Milind Y. Desai, Kathy Wolski, Anjali Owens, Srihari S. Naidu, Jeffrey B. Geske, Nicholas G. Smedira, Hartzell Schaff, Kathy Lampl, Ellen McErlean, Christina Sewell, David Zhang, Jay M. Edelberg, Amy J. Sehnert, Steven E. Nissen

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  • ·Catheter-based alcohol-mediated renal denervation for the treatment of uncontrolled hypertension: design of two sham-controlled, randomized, blinded trials in the absence (TARGET BP OFF-MED) and presence (TARGET BP I) of antihypertensive medications

    Page :90-99

    Felix Mahfoud, Michael Weber, Roland E. Schmieder, Melvin D. Lobo, Peter J. Blankestijn, Alexandre Persu, Tim A. Fischell, Helen Parise, Atul Pathak, David E. Kandzari

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• Clinical Investigations

  • ·Sacubitril/valsartan versus enalapril on exercise capacity in patients with heart failure with reduced ejection fraction: A randomized, double-blind, active-controlled study

    Page :1-10

    Marcelo Rodrigues dos Santos, Maria-Janieire de Nazaré Nunes Alves, Camila Paixão Jordão, Caio Eduardo Novaes Pinto, Kelly Thayane Souza Correa, Francis Ribeiro de Souza, Guilherme Wesley Peixoto da Fonseca, Joaquim Tomaz Filho, Marcel Costa, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Antônio Carlos Pereira Barretto

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  • ·Advanced heart failure patients supported with ambulatory inotropic therapy: What defines success of therapy?

    Page :11-18

    Christopher S. Grubb, Lauren K. Truby, Veli K. Topkara, Michael S. Bohnen, Melana Yuzefpolskaya, Ersilia M. DeFilippis, Audrey Kleet, Shunichi Nakagawa, Jennifer H. Haythe, Kelly Axsom, Paolo Colombo, Koji Takeda, Nir Uriel, Gabriel Sayer, Hasan Garan, Yoshifumi Naka, Maryjane Farr

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  • ·Depressive hypertension: A proposed human endotype of brain/gut microbiome dysbiosis

    Article :100540

    Bruce R. Stevens, Carl J. Pepine, Elaine M. Richards, Seungbum Kim, Mohan K. Raizada

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  • ·The impact of a population-based prevention program on cardiovascular events: Findings from the heart of new Ulm project

    Page :38-51

    Abbey C. Sidebottom, Michael D. Miedema, Gretchen Benson, Marc Vacquier, Jeffrey J. VanWormer, Arthur Sillah, Rebecca Lindberg, Jackie L. Boucher, Steven M. Bradley

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  • ·Sarcopenia in cardiac surgery: Dual X-ray absorptiometry study from the McGill frailty registry

    Page :52-58

    Aayushi Joshi, Rita Mancini, Stephan Probst, Gad Abikhzer, Yves Langlois, Jean-Francois Morin, Lawrence G Rudski, Jonathan Afilalo

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  • ·Estimating the real-world performance of the PROMISE minimal-risk tool

    Page :100-109

    MG Nanna, TY Wang, K Chiswell, JL Sun, S Vemulapalli, U Hoffmann, MR Patel, JE Udelson, CB Fordyce, PS Douglas

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  • ·Early diuretic strategies and the association with In-hospital and Post-discharge outcomes in acute heart failure

    Page :110-119

    Marat Fudim, Toi Spates, Jie-Lena Sun, Veraprapas Kittipibul, Jeffrey M. Testani, Randall C. Starling, W.H. Wilson Tang, Adrian F. Hernandez, G. Michael Felker, Christopher M. O'Connor, Robert J. Mentz

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  • ·Pre-operative atrial fibrillation and early right ventricular failure after left ventricular assist device implantation: a systematic review and meta-analysis

    Page :120-128

    Veraprapas Kittipibul, Vanessa Blumer, Gabriel A. Hernandez, Marat Fudim, Robert Flowers, Sandra Chaparro, Richa Agarwal

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  • ·Simplifying the ISCHEMIA trial algorithm for clinical practice: Identifying left main coronary artery disease using coronary artery calcium scans

    Page :129-134

    Joel E. Money, Joseph B. Muhlestein, Steve Mason, Tami L. Bair, Kirk U. Knowlton, Benjamin D. Horne, Jeffrey L. Anderson

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  • ·The association of healthcare disparities and patient-specific factors on clinical outcomes in peripheral artery disease

    Page :135-146

    Dennis I. Narcisse, Cassie B. Ford, E. Hope Weissler, Steven J. Lippmann, Michelle M. Smerek, Melissa A. Greiner, N. Chantelle Hardy, Benjamin O'Brien, R. Casey Sullivan, Adam J. Brock, Chandler Long, Lesley H. Curtis, Manesh R. Patel, W. Schuyler Jones

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• Letter to the Editors

  • ·Effect of once-weekly exenatide on hospitalization for acute coronary syndrome or coronary revascularization in patients with type 2 diabetes mellitus

    Page :59-63

    Carlos E. Barbery, Anna Giczewska, Jennifer White, Yuliya Lokhnygina, Robert John Mentz, Rury R. Holman, Neha Pagidipati, Adrian F. Hernandez, W. Schuyler Jones

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