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• • ·Table of Contents

    Page :i

    
• • ·Editorial Board

    Page :iii

    
• • ·Information for Readers

    Page :v

    

• Trial Designs

  • ·Fractional flow reserve or 3D-quantitative-coronary-angiography based vessel-FFR guided revascularization. Rationale and study design of the prospective randomized fast III trial

    Page :1-8

    Alessandra Scoccia, Robert A. Byrne, Adrian P. Banning, Ulf Landmesser, Eric Van Belle, Ignacio J. Amat-Santos, Manel Sabaté, Jan G.P. Tijssen, Ernest Spitzer, Joost Daemen

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  • ·Rationale and design of the RESTORE trial: A multicenter, randomized, double-blinded, parallel-group, placebo-controlled trial to evaluate the effect of Shenfu injection on myocardial injury in STEMI patients after primary PCI

    Page :9-17

    Xiao Wang, Ruifeng Guo, Yingying Guo, Qian Guo, Yan Yan, Wei Gong, Wen Zheng, Hui Wang, Lei Xu, Hui Ai, Bin Que, Xiaoyan Yan, Xinliang Ma, Shaoping Nie

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  • ·Rationale and study design of the GOREISAN for heart failure (GOREISAN-HF) trial: A randomized clinical trial

    Page :18-25

    Hidenori Yaku, Takao Kato, Takeshi Morimoto, Kazuhisa Kaneda, Ryusuke Nishikawa, Takeshi Kitai, Yasutaka Inuzuka, Yodo Tamaki, Taketoshi Yamazaki, Jun Kitamura, Hirotaka Ezaki, Kazuya Nagao, Hiromi Yamamoto, Akihiro Isotani, Arita Takeshi, Chisato Izumi, Yukihito Sato, Yoshihisa Nakagawa, Satoaki Matoba, Yasushi Sakata, Koichiro Kuwahara, Takeshi Kimura, GOREISAN-HF trial Investigators

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  • ·Prospective randomized comparison between upgraded ‘2C3L’ vs. PVI approach for catheter ablation of persistent atrial fibrillation: PROMPT-AF trial design

    Page :34-43

    Xiao-Xia Liu, Qiang Liu, Yi-Wei Lai, Qi Guo, Rong Bai, De-Yong Long, Rong-Hui Yu, Ri-Bo Tang, Nian Liu, Chen-Xi Jiang, Wei Wang, Xue-Yuan Guo, Song-Nan Li, Xin Zhao, Song Zuo, Chang-Yi Li, Shang-Ming Song, Shuang-Lun Xie, Wei-Li Ge, Jian-Gang Zou, Xiao-Feng Hou, Ke Chen, Jin-Lin Zhang, He-Sheng Hu, Xin-Hua Wang, Zhao-Jun Wang, Xin Du, Chen-Yang Jiang, Cai-Hua Sang, Jian-Zeng Dong, Chang-Sheng Ma

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  • ·Nationwide Utilization of Danish Government Electronic letter system for increasing inFLUenza vaccine uptake (NUDGE-FLU): Study protocol for a nationwide randomized implementation trial

    Page :58-71

    Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Simin Gharib Lee, Daniel Modin, Brian L. Claggett, Erica L. Dueger, Sandrine Samson, Matthew M. Loiacono, Lars Køber, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Stæhr Jensen, Palle Valentiner-Branth, Tyra Grove Krause, Tor Biering-Sørensen

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  • ·A randomized controlled trial of gamification, financial incentives, or both to increase physical activity among patients with elevated risk for cardiovascular disease: rationale and design of the be active study

    Page :82-89

    Alexander C. Fanaroff, Mitesh S. Patel, Neel Chokshi, Samantha Coratti, David Farraday, Laurie Norton, Charles Rareshide, Jingsan Zhu, Julia E. Szymczak, Louise B. Russell, Dylan S. Small, Kevin G.M. Volpp

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  • ·The teammate trial: Study design and rationale tacrolimus and everolimus against tacrolimus and MMF in pediatric heart transplantation using the major adverse transplant event (MATE) score

    Page :100-112

    Christopher S. Almond, Lynn A. Sleeper, Joseph W. Rossano, Matthew J. Bock, Elfriede Pahl, Scott Auerbach, Ashwin Lal, Seth A. Hollander, Shelley D. Miyamoto, Chesney Castleberry, Joanne Lee, Lynsey M. Barkoff, Selena Gonzales, Gloria Klein, Kevin P. Daly

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  • ·Risk factor associations with individual myocardial infarction subtypes and acute non-ischemic myocardial injury in the Multi-Ethnic Study of Atherosclerosis (MESA): Design and rationale

    Page :151-173

    Andrew P. DeFilippis, Karita C.F. Lidani, Yunbi Nam, Patrick J. Trainor, W Craig Johnson, Susan R. Heckbert, Robyn L. McClelland, Michael J. Blaha, Khurram Nasir

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• Clinical Investigations

  • ·Perioperative bleeding and outcomes after noncardiac surgery

    Page :26-33

    Nathaniel R. Smilowitz, Kurt Ruetzler, Jeffrey S. Berger

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  • ·Variation in resource utilization and mortality among patients with varying MR type and severity

    Page :44-57

    Jennifer A. Rymer, Jie-Lena Sun, Karen Chiswell, David Cohen, Kate Vilain, Andrew Wang, Zainab Samad, Tracy Y. Wang, Pamela S. Douglas

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  • ·External validation of bleeding risk models for the prediction of long-term bleeding risk in patients with established cardiovascular disease

    Page :72-81

    Maria C. Castelijns, Steven H.J. Hageman, Martin Teraa, Manon G. van der Meer, Jan Westerink, Francesco Costa, Jurriën M. ten Berg, Frank L.J. Visseren, UCC-SMART study group

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  • ·The effect of tablet computer-based telemonitoring added to an established telephone disease management program on heart failure hospitalizations: The Specialized Primary and Networked Care in Heart Failure (SPAN-CHF) III Randomized Controlled Trial

    Page :90-99

    Jenica N. Upshaw, Susan Parker, Douglas Gregory, Benjamin Koethe, Amanda R. Vest, Ayan R. Patel, Michael S. Kiernan, David DeNofrio, Eric Davidson, Sharanya Mohanty, Patrick Arpin, Nicole Strauss, Crystal Sommer, Linda Brandon, Rita Butler, Henry Dwaah, Hilary Nadeau, Michael Cantor, Marvin A. Konstam

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  • ·Postoperative pericardial effusion, pericardiotomy, and atrial fibrillation: An explanatory analysis of the PALACS trial

    Page :113-123

    Lisa Q. Rong, Antonino Di Franco, Mohamed Rahouma, Arnaldo Dimagli, June Chan, Alexandra J. Lopes, Jiwon Kim, Tommaso Sanna, Richard B. Devereux, Victoria Delgado, Jonathan W. Weinsaft, Filippo Crea, John H. Alexander, Marc Gillinov, John Michael DiMaio, Kane O. Pryor, Leonard Girardi, Mario Gaudino

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  • ·Identifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method

    Page :124-140

    Che Ngufor, Xiaoxi Yao, Jonathan W. Inselman, Joseph S. Ross, Sanket S. Dhruva, David J. Graham, Joo-Yeon Lee, Konstantinos C. Siontis, Nihar R. Desai, Eric Polley, Nilay D. Shah, Peter A. Noseworthy

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  • ·P-wave terminal force in lead V1 and outcomes in patients with persistent atrial fibrillation undergoing catheter ablation

    Page :141-150

    Yuya Sudo, Takeshi Morimoto, Ryu Tsushima, Masahiro Sogo, Masatomo Ozaki, Masahiko Takahashi, Keisuke Okawa

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