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• • ·Table of Contents

    Page :i

    
• • ·Editorial Board

    Page :iii

    
• • ·Information for Readers

    Page :iv

    

• Editorials

  • ·Democracy, healthcare, and the public good

    Page :121-127

    Richard C. Becker

    Plan Plan

• Trial Designs

  • ·Selective C-reactive protein apheresis in ST-elevation myocardial infarction: Design and rationale of the randomized CRP-STEMI trial

    Page :1-9

    Sebastian J. Reinstadler, Andreas Kronbichler, Martin Reindl, Christina Tiller, Magdalena Holzknecht, Fritz Oberhollenzer, Alex Kaser, Philipp Gauckler, Thomas Stiermaier, Hans-Josef Feistritzer, Agnes Mayr, Elke R. Gizewski, Richard Rezar, Heiko Bugger, Kathrin Eller, Ingo Eitel, Steffen Schneider, Gert Mayer, Holger Thiele, Axel Bauer, Bernhard Metzler, Ivan Lechner, CRP-STEMI Investigators

    Résumé Résumé Plan Plan  
  • ·A pragmatic individually randomized trial to evaluate bivalent RSV prefusion F protein–based vaccine effectiveness for preventing RSV hospitalizations in adults aged 60 years or above (DAN-RSV): Rationale and trial design

    Page :14-25

    Mats C. Højbjerg Lassen, Sine H. Christensen, Niklas D. Johansen, Negar Aliabadi, Kristoffer G. Skaarup, Daniel Modin, Brian L. Claggett, Carsten S. Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Matias G. Lindholm, Lars Køber, Scott D. Solomon, Jens Ulrik Stæhr Jensen, Cyril Jean-Marie Martel, Claudia Schwarz, Elisa Gonzalez, Mette Skovdal, Lawrence H. Moulton, Pingping Zhang, Bradford D. Gessner, Elizabeth Begier, Tor Biering-Sørensen

    Résumé Résumé Plan Plan   
  • ·PRevention of sudden cardiac death aFter myocardial infarction by defibrillator implantation: Design and rationale of the PROFID EHRA randomized clinical trial

    Page :37-43

    Nikolaos Dagres, Chris P Gale, Ramesh Nadarajah, Serge Boveda, Jose Luis Merino, Jens Cosedis Nielsen, Paulus Kirchhof, Valentina Kutyifa, Miloš Táborský, Holger Thiele, Jan G.P. Tijssen, Atul Verma, Tom De Potter, Frieder Braunschweig, Béla Merkely, Philipp Sommer, Kevin Vernooy, Mahmoud Suleiman, Helmut Pürerfellner, Gerhard Hindricks, PROFID EHRA trial investigators

    Résumé Résumé Plan Plan  
  • ·Distal versus conventional transradial artery access for coronary catheterization in patients with STEMI (DR-STEMI): Rationale and design of an international, multicenter, randomized trial

    Page :73-80

    Grigorios Tsigkas, Aikaterini Trigka-Vasilakopoulou, Anastasios Apostolos, Michael Papafaklis, Giuseppe Colletti, Antonio Mugnolo, Zoltán Ruzsa, Claudiu Ungureanu, Dimitrios Nikas, Panagiotis Xaplanteris, Gabriele L Gasparini, Alessandro Sciahbasi, Ioannis Tsiafoutis, Leonidas E. Poulimenos, Matthaios Didagelos, Loukas Pappas, Pavlos Stougiannos, Michalis Hamilos, Antonios Ziakas, Filippos Timpilis, Antonios Karanasos, Athanasios Moulias, Gregory A Sgueglia, Adel Aminian, Juan F. Iglesias, Lampros Michalis, Periklis Davlouros

    Résumé Résumé Plan Plan  
  • ·IMpact of therapY using coleSevelam treatment reducing bile acids in patients with fonTan cIrCulation (MYSTIC): Rationale and study design

    Page :81-88

    Ashish H. Shah, Heather K. Armstrong, Ishika Mittal, Aleisha Reimer, Setor K. Kunutsor, Robin A. Ducas, Keivan Alizadeh, James W. Tam, Amir Ravandi, Sanjiv Dhingra

    Résumé Résumé Plan Plan  
  • ·DAPAgliflozin for renal protection in heart transplant recipients. Rationale and design of the randomized controlled DAPARHT trial

    Page :128-135

    Stine Holmen, Olivier Manintveld, Kevin Damman, Oscar Braun, Ida Haugen Löfman, Mariusz Szymanski, Håvard Ravnestad, Einar Gude, Elisabeth Bjørkelund, Arne K. Andreassen, Lars Gullestad, Kaspar Broch

    Résumé Résumé Plan Plan  
  • ·Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry

    Page :136-143

    Masahiro Hada, Carlos Collet, Tatyana Storozhenko, Daniel Munhoz, Adriaan Wilgenhof, Alejandro Gutiérrez-Barrios, Annemiek de Vos, Branko Beleslin, Colin Berry, Divaka Perera, Fernando Rivero, Frederic Bouisset, Giovanni Luigi De Maria, Grigoris Karamasis, Jacob Lønborg, Javier Escaned, Kazumasa Ikeda, Kevin Carson, Klio Konstantinou, Mark Mariathas, Peter Damman, Ranil De Silva, Rasha Al-Lamee, Stephane Fournier, Thomas Engstrøm, Thomas R Keeble, Takuya Mizukami, Tommaso Gori, Tsunekazu Kakuta, Valeria Paradies, Nico H.J. Pijls, Danielle Keulards, Bernard De Bruyne

    Résumé Résumé Plan Plan  
  • ·Rationale and design of the comparative effectiveness of ICD vs non-ICD therapy in contemporary heart failure patients at a low risk for arrhythmic death (CONTEMP-ICD) trial

    Page :162-174

    Ilan Goldenberg, Wojciech Zareba, Justin A. Ezekowitz, Christine Albert, Jeffrey D. Alexis, Lisa Anderson, Elijah R Behr, James Daubert, Katherine E. Di Palo, Kenneth A. Ellenbogen, Dillon J. Dzikowicz, Joseph M. Harrington, Eileen Hsich, David T. Huang, James L. Januzzi, Anas Jawaid, Valentina Kutyifa, Anuradha Lala-Trindade, Alex Nakonechnyi, Anekwe Onwuanyi, Ileana L. Piña, Roopinder K. Sandhu, Samuel Sears, Jakub Sroubek, Tina Baykaner, Robert Strawderman, Christopher Beck, Javed Butler

    Résumé Résumé Plan Plan  
  • ·A pragmatic individually randomized trial to evaluate the effectiveness of high-dose vs standard-dose influenza vaccine in older adults: Rationale and design of the DANFLU-2 trial

    Page :186-198

    Niklas Dyrby Johansen, Daniel Modin, Matthew M. Loiacono, Rebecca C. Harris, Marine Dufournet, Carsten Schade Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Brian L. Claggett, Kristoffer Grundtvig Skaarup, Filip Søskov Davidovski, Scott D. Solomon, Martin J. Landray, Gunnar H. Gislason, Lars Køber, Pradeesh Sivapalan, Cyril Jean-Marie Martel, Jens Ulrik Stæhr Jensen, Tor Biering-Sørensen

    Résumé Résumé Plan Plan   
  • ·Design and rationale of a randomized clinical trial assessing the effect of inclisiran on atherosclerotic plaque in individuals without previous cardiovascular event and without flow- limiting lesions identified in an in-hospital screening: The VICTORION-PLAQUE primary prevention trial

    Page :199-212

    Pruthvi C. Revaiah, Patrick W. Serruys, Yoshinobu Onuma, Daniele Andreini, Matthew J. Budoff, Faisal Sharif, Ariel Chernofsky, Sheikh Vikarunnessa, Andrea J Wiethoff, Denise Yates, Assya Achouba

    Résumé Résumé Plan Plan   

• Special Articles

  • ·The low-risk TAVR trials—A critical appraisal of the current landscape

    Page :10-13

    Troels Højsgaard Jørgensen, Hans Gustav Hørsted Thyregod, Stefan Blankenberg, Martin Leon, Lars Sondergaard, Bernard Prendergast, Ole De Backer

    Résumé Résumé Plan Plan  

• Clinical Investigations

  • ·Relationship between industry payments to physicians and prescription patterns for PCSK9is, ARNis and DOACs: A report from the NCDR PINNACLE registry

    Page :26-36

    Amarnath R. Annapureddy, Karthik Murugiah, Luke Zheng, Karl E. Minges, Gowtham R. Grandhi, Joseph S. Ross, Tariq Ahmad, Benjamin A. Rodwin, Sanket S. Dhruva, Saket Girotra, Elias J. Dayoub, Jeptha P. Curtis, Nihar R. Desai

    Résumé Résumé Plan Plan   
  • ·Effect of cerebral embolic protection device on new cerebral embolism during transcatheter aortic valve replacement: A prospective sentinel registry

    Page :44-52

    Han-Su Park, Chong Hyun Suh, Jung-Min Ahn, Do-Yoon Kang, Soo-Yeon Ahn, Sung-Bong Wee, Seung-Han Lee, Kyeong-Won Seo, Min-Ju Kim, Seung-Jung Park, Duk-Woo Park

    Résumé Résumé Plan Plan   
  • ·Understanding gaps in guideline-recommended adult congenital heart disease care: Data from 12 US health care centers

    Page :53-62

    Joseph Bayne, Rong Duan, Lindsey Rudov, Rittal Mehta, Ruth Phillippi, Mark Roeder, Sneha Saraf, Jamie L. Jackson, Matthew Lewis, Arwa Saidi, Ronald Kanter, Satinder Sandhu, Thomas Young, Roni Jacobsen, Emily Ruckdeschel, Adam Lubert, Harsimran Singh, Ali Zaidi, Dan G. Halpern, Scott Leezer, Anitha S. John, Thomas Carton, Anushree Agarwal, Congenital Heart Initiative-Redefining Outcomes and Navigation to an Adult-centered Care (CHI-RON) Investigators

    Résumé Résumé Plan Plan   
  • ·Medicare coverage gap status, adherence to oral anticoagulation, and stroke rates in patients with atrial fibrillation

    Page :63-72

    Josephine Harrington, Rohin K. Reddy, Anthony Carnicelli, Lauren Wilson, Renato D. Lopes, Bernard J. Gersh, Lesley H. Curtis, Sean D. Pokorney, Chiara Melloni, Emily C. O’Brien, Christopher B. Granger

    Résumé Résumé Plan Plan   
  • ·Relationship between left atrial stiffness, pulmonary congestion, and impaired aerobic capacity in adults with repaired coarctation of aorta

    Page :89-100

    Alexander C. Egbe, Omar Abozied, Ahmed T. Abdelhalim, C. Charles Jain, William R. Miranda, Zeyad Kholeif, Heidi M. Connolly, Barry A. Borlaug

    Résumé Résumé Plan Plan  
  • ·Neonatal outcomes of pregnancy in women with congenital heart disease

    Page :101-110

    Sarah A. Goldstein, Lindsay A. Edwards, Ester K. Nilles, Karen Chiswell, Alfred D’Ottavio, Matthew R. Reeder, Kathleen Wood, Neeta Sethi, Cheryl L. Raskind-Hood, Wendy M. Book, Marcia L. Feldkamp, Jennifer S. Li, Lorenzo D. Botto

    Résumé Résumé Plan Plan  
  • ·Beta-blocker side-effects in clinical practice: A nationwide approach

    Page :111-120

    Peter Vibe Rasmussen, Jarl Emanuel Strange, Sebastian Kinnberg Nielsen, Rasmus Borup Hansen, Gunnar H. Gislason, Morten Lamberts, Morten Lock Hansen, Anders Holt

    Résumé Résumé Plan Plan   
  • ·Association between conversion from an initial shockable rhythm to pulseless electrical activity before extracorporeal cardiopulmonary resuscitation and outcome: A secondary analysis of the SAVE-J II study

    Page :144-152

    Shinichi Ijuin, Akihiko Inoue, Toru Hifumi, Takuya Taira, Taiki Moriyama, Masafumi Suga, Takeshi Nishimura, Tetsuya Sakamoto, Yasuhiro Kuroda, Satoshi Ishihara, SAVE-J II Study Group

    Résumé Résumé Plan Plan   
  • ·Artificial intelligence-enabled electrocardiogram guidance for pulmonary valve replacement timing in repaired tetralogy of Fallot

    Page :153-161

    Joshua Mayourian, Lynn A. Sleeper, Vedang Diwanji, Alon Geva, John K. Triedman, Rachel M. Wald, Anne Marie Valente, Tal Geva

    Résumé Résumé Plan Plan   
  • ·Extra-virgin olive oil and additional cardiovascular outcomes in the PREDIMED Trial: An outcome-wide perspective

    Page :175-185

    Javier Pérez de Rojas, Estefania Toledo, Ramón Estruch, Marta Guasch-Ferré, Jordi Salas-Salvadó, Enrique Gómez-Gracia, Emilio Ros, Montse Fitó, Fernando Arós, Miquel Fiol, José Lapetra, Lluis Serra-Majem, Xavier Pintó, José V. Sorlí, Nancy Babio, Olga Castañer, Ángel M. Alonso-Gómez, Miguel Ángel Martínez-González, José Juan Jiménez-Moleón

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• Letter to the Editors

  • ·Letter to the editor: Loop and thiazide diuretics and outcomes in heart failure with preserved ejection fraction

    Page :213

    Umaimah Naeem, Huda Abdul Qadir

    Plan Plan
  • ·Response to letter by Naeem regarding article, “Loop and thiazide diuretics and outcomes in heart failure with preserved ejection fraction”

    Page :214-215

    Barna Szabó-Söderberg, Lars H. Lund

    
  • ·Statistical methodological limitations and improvement suggestions in the study of vitamin D deficiency and cardiovascular mortality after heart transplantation

    Page :216-217

    Haiying Hu, Linjun Wang

    Résumé Résumé Plan Plan
  • ·Response to letter by Hu regarding article, “Statistical Methodological Limitations and Improvement Suggestions in the Study of Vitamin D Deficiency and Cardiovascular Mortality After Heart Transplantation.”

    Page :218-219

    Matthew Gold, Sarah Kulkarni, Arshed Quyyumi