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• • ·Table of Contents

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• • ·Information for readers

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• • ·Introduction to the Guest Editors of the American Journal of Obstetrics & Gynecology Supplement on Preeclampsia 2022

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    Roberto Romero

     
• • ·Preeclampsia and eclampsia: the conceptual evolution of a syndrome

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    Offer Erez, Roberto Romero, Eunjung Jung, Piya Chaemsaithong, Mariachiara Bosco, Manaphat Suksai, Dahiana M. Gallo, Francesca Gotsch

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• • ·The assessment of blood pressure in pregnant women: pitfalls and novel approaches

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    Alice Hurrell, Louise Webster, Lucy C. Chappell, Andrew H. Shennan

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• • ·Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance

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    Michal Fishel Bartal, Marshall D. Lindheimer, Baha M. Sibai

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• • ·The evolution of the diagnostic criteria of preeclampsia-eclampsia

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    Michael S. Tanner, Mary-Ann Davey, Ben W. Mol, Daniel L. Rolnik

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• • ·The etiology of preeclampsia

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    Eunjung Jung, Roberto Romero, Lami Yeo, Nardhy Gomez-Lopez, Piya Chaemsaithong, Adithep Jaovisidha, Francesca Gotsch, Offer Erez

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• • ·Progress in the understanding of the pathophysiology of immunologic maladaptation related to early-onset preeclampsia and metabolic syndrome related to late-onset preeclampsia

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    Pierre-Yves Robillard, Gustaaf Dekker, Marco Scioscia, Shigeru Saito

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• • ·Does race or ethnicity play a role in the origin, pathophysiology, and outcomes of preeclampsia? An expert review of the literature

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    Jasmine D. Johnson, Judette M. Louis

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• • ·Decidualization resistance in the origin of preeclampsia

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    Tamara Garrido-Gómez, Nerea Castillo-Marco, Teresa Cordero, Carlos Simón

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• • ·Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia

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    Anne Cathrine Staff, Heidi E. Fjeldstad, Ingrid Knutsdotter Fosheim, Kjartan Moe, Gitta Turowski, Guro Mørk Johnsen, Patji Alnaes-Katjavivi, Meryam Sugulle

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• • ·Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways

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    Christopher W.G. Redman, Anne Cathrine Staff, James M. Roberts

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• • ·Placental energy metabolism in health and disease—significance of development and implications for preeclampsia

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    Irving L.M.H. Aye, Catherine E. Aiken, D. Stephen Charnock-Jones, Gordon C.S. Smith

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• • ·Pregnancy-specific expression of protease-activated receptor 1: a therapeutic target for prevention and treatment of preeclampsia?

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    Scott W. Walsh, Jerome F. Strauss

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• • ·The placenta and preeclampsia: villain or victim?

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    Karen Melchiorre, Veronica Giorgione, Basky Thilaganathan

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• • ·An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array

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    Simcha Yagel, Sarah M. Cohen, Debra Goldman-Wohl

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• • ·Animal models of preeclampsia: investigating pathophysiology and therapeutic targets

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    Bhavisha A. Bakrania, Eric M. George, Joey P. Granger

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• • ·Hemodynamic pathways of gestational hypertension and preeclampsia

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    Wilfried Gyselaers

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• • ·Preeclampsia has two phenotypes which require different treatment strategies

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    Giulia Masini, Lin F. Foo, Jasmine Tay, Ian B. Wilkinson, Herbert Valensise, Wilfried Gyselaers, Christoph C. Lees

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• • ·Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

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    Sarosh Rana, Suzanne D. Burke, S. Ananth Karumanchi

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• • ·Discovery of antiangiogenic factors in the pathogenesis of preeclampsia

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    S. Ananth Karumanchi, Towia Libermann

     
• • ·Real-world data on the clinical use of angiogenic factors in pregnancies with placental dysfunction

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    Anne Dathan-Stumpf, Victoria Czarnowsky, Vicky Hein, Theresa Andraczek, Holger Stepan

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• • ·The diagnostic value of angiogenic and antiangiogenic factors in differential diagnosis of preeclampsia

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    Stefan Verlohren, Lisa-Antonia Dröge

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• • ·Complement activation and regulation in preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome

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    Richard M. Burwick, Bruce B. Feinberg

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• • ·First trimester preeclampsia screening and prediction

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    Piya Chaemsaithong, Daljit Singh Sahota, Liona C. Poon

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• • ·Ophthalmic artery Doppler in the prediction of preeclampsia

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    Kypros H. Nicolaides, Manoel Sarno, Alan Wright

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• • ·The prediction of preeclampsia: the way forward

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    Leslie Myatt

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• • ·Prevention of preeclampsia with aspirin

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    Daniel L. Rolnik, Kypros H. Nicolaides, Liona C. Poon

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• • ·When to give aspirin to prevent preeclampsia: application of Bayesian decision theory

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    David Wright, Alan Wright, Min Yi Tan, Kypros H. Nicolaides

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• • ·Low-molecular-weight heparin for prevention of preeclampsia and other placenta-mediated complications: a systematic review and meta-analysis

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    Monica Cruz-Lemini, Juan Carlos Vázquez, Johana Ullmo, Elisa Llurba

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• • ·Circulating maternal placental growth factor responses to low-molecular-weight heparin in pregnant patients at risk of placental dysfunction

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    Kelsey McLaughlin, Sebastian R. Hobson, Anjana Ravi Chandran, Swati Agrawal, Rory C. Windrim, W. Tony Parks, Adrian W. Bowman, Ulla Sovio, Gordon C. Smith, John C. Kingdom

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• • ·Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

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    Stephen Tong, Tu’uhevaha J. Kaitu’u-Lino, Roxanne Hastie, Fiona Brownfoot, Catherine Cluver, Natalie Hannan

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• • ·The role of statins in the prevention of preeclampsia

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    Devin D. Smith, Maged M. Costantine

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• • ·Chronic hypertension and superimposed preeclampsia: screening and diagnosis

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    Nikos A. Kametas, Diane Nzelu, Kypros H. Nicolaides

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• • ·Toward personalized management of chronic hypertension in pregnancy

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    Laura A. Magee, Asma Khalil, Nikos Kametas, Peter von Dadelszen

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• • ·Postpartum preeclampsia or eclampsia: defining its place and management among the hypertensive disorders of pregnancy

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    Alisse Hauspurg, Arun Jeyabalan

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• • ·Guidelines—similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension

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    Georgia Scott, Tessa E. Gillon, Anouk Pels, Peter von Dadelszen, Laura A. Magee

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• • ·Eclampsia in the 21st century

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    Michal Fishel Bartal, Baha M. Sibai

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• • ·The Preeclampsia Foundation: the voice and views of the patient and her family

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    Eleni Z. Tsigas

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