Translational Research: Precision Medicine, Personalized Medicine, Targeted Therapies: Marketing or Science? - 08/07/16
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participants of round table N°1 of Giens XXX:
Véronique Ameye 4, Pascale Augé 5, Béatrice Cazeneuve 6, Etienne Chatelut 7, Isabelle Diaz 8, 9, Marine Diviné 10, Philippe Froguel 11, 12, Sylvia Goni 13, François Gueyffier 14, Natalie Hoog-Labouret 15, Samia Mourah 16, 17, 18, Michèle Morin-Surroca 19, Olivier Perche 20, Florent Perin-Dureau 21, Martine Pigeon 22, Anne Tisseau 2, Céline Verstuyft 16, 23, †pages | 9 |
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Abstract |
Personalized medicine is based on: 1) improved clinical or non-clinical methods (including biomarkers) for a more discriminating and precise diagnosis of diseases; 2) targeted therapies of the choice or the best drug for each patient among those available; 3) dose adjustment methods to optimize the benefit-risk ratio of the drugs chosen; 4) biomarkers of efficacy, toxicity, treatment discontinuation, relapse, etc. Unfortunately, it is still too often a theoretical concept because of the lack of convenient diagnostic methods or treatments, particularly of drugs corresponding to each subtype of pathology, hence to each patient. Stratified medicine is a component of personalized medicine employing biomarkers and companion diagnostics to target the patients likely to present the best benefit-risk balance for a given active compound. The concept of targeted therapy, mostly used in cancer treatment, relies on the existence of a defined molecular target, involved or not in the pathological process, and/or on the existence of a biomarker able to identify the target population, which should logically be small as compared to the population presenting the disease considered. Targeted therapies and biomarkers represent important stakes for the pharmaceutical industry, in terms of market access, of return on investment and of image among the prescribers. At the same time, they probably represent only the first generation of products resulting from the combination of clinical, pathophysiological and molecular research, i.e. of translational research.
Le texte complet de cet article est disponible en PDF.Keywords : personalized medicine, stratified medicine, biomarkers, companion diagnostic, therapeutic drug monitoring, pharmacogenetics
Abbreviations : ACP, AVIESAN, CE, DNA, EMA, FDA, GBEA, HAS, HTA, INCa, INSERM, IQWIG, IVD, mTOR, NICE, NIH, PRA, RBACP, RNPGx, RCT, TDM
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Vol 70 - N° 1
P. 11-19 - janvier 2015 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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