Routine biological tests in self-poisoning patients: results from an observational prospective multicenter study - 25/07/16
Abstract |
Context |
Routine biological tests are frequently ordered in self-poisoning patients, but their clinical relevance is poorly studied.
Materials and methods |
This is a prospective multicentric observational study conducted in the emergency departments and intensive care units of 5 university and nonuniversity French hospitals. Adult self-poisoning patients without severely altered vital status on admission were prospectively included.
Results |
Routine biological test (serum electrolytes and creatinine, liver enzymes, bilirubin, blood cell count, prothrombin time) ordering and results were analyzed. A total of 1027 patients were enrolled (age, 40.2 ± 14 years; women, 61.5%); no patient died during the hospital stay. Benzodiazepine was suspected in more than 70% of cases; 65% (range, 48%-80%) of patients had at least 1 routine biological test performed. At least 1 abnormal test was registered in 23% of these patients. Three factors were associated with abnormal test results: age older than 40 years, male sex, and poisoning with a drug known to alter routine tests (ie, acetaminophen, NSAIDs, metformine, lithium). Depending on these factors, abnormal results ranged from 14% to 48%. Unexpected severe life-threatening conditions were recorded in 6 patients. Only 3 patients were referred to the intensive care unit solely because of abnormal test results.
Conclusion |
Routine biological tests are commonly prescribed in nonsevere self-poisoning patients. Abnormal results are frequent but their relevance at bedside remains limited.
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| ☆ | This work was financially supported by institutional funding: Angers University, Angers and Angers University Hospital, Angers, France. |
| ☆☆ | All authors declare no conflict of interest. |
| ★ | The work was performed in 5 French centers: Angers University Hospital, Brest University Hospital, Cochin University Hospital (Paris), Le Mans Hospital, and Saint Malo Hospital, France. |
Vol 34 - N° 8
P. 1383-1388 - août 2016 Retour au numéro
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