Using a new plateau hyperbaric chamber to alleviate high altitude hypoxia: Rabbit and human studies - 28/09/17

Doi : 10.1016/j.ajem.2017.04.034

Liang Sun, MD ^a,^b,^{^⁎} , Meng-jiang Ding, MPH ^c, Tian-cai Cai, MPH ^d, Hao-jun Fan, MD ^e, Hong-mei Gao, MD ^f, Jian-peng Zhang, MD, PhD ^a,^f
^a Medical College of Chinese PLA, Chinese PLA General Hospital, 28#, Fu-Xing Road, Haidian District, Beijing 100853, China
^b Department of Respiratory and Critical Care Medicine of Ping Jin Hospital, Affiliated Hospital of Logistic University of Chinese People's Armed Police Force, China
^c Tianjin Municipal Corps Hospital of Chinese People's Armed Police Forces, China
^d Xia men sanatorium of Chinese people's Armed Police Forces, China
^e Institute of Disaster Medicine and Public Health, Affiliated Hospital of Logistic University of Chinese People's Armed Police Force, China
^f Department of Respiratory, General Hospital of Chinese People's Armed Police Force, China

^⁎Corresponding author at: Medical College of Chinese PLA, Chinese PLA General Hospital, 28#, Fu-Xing Road, Haidian District, Beijing 100853, China.Medical College of Chinese PLAChinese PLA General Hospital28#, Fu-Xing RoadBeijingHaidian District100853China

Abstract

Objectives

To validate the effects of the new plateau hyperbaric chamber on alleviating high altitude hypoxia on Mount Kun Lun.

Methods

A prospective, controlled study of rabbits and adult volunteers was conducted at altitudes of 355, 2880 and 4532m. We obtained arterial blood samples from rabbits and volunteers before and after hyperbaric treatment. The respiratory rate, heart rate, and blood pressure (BP) of adult volunteers were monitored during hyperbaric treatment.

Results

The mean PaO₂ levels of experimental group rabbits and volunteers increased significantly after 60min of hyperbaric treatment at 350, 2880 and 4532m. The mean PaCO₂ and pH levels of rabbits were not significant different before and after hyperbaric treatment at each altitude. The mean PaCO₂ and pH levels were not significant different at 355m in the human study. However, at 2880 and 4532m, pH fell with increasing PaCO₂ levels in humans before and after hyperbaric treatment.

Conclusions

The new multiplace plateau hyperbaric chamber may be used to alleviate plateau hypoxia by increasing patient PaO₂. However, its value in treating AMS must be confirmed in field conditions.

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Keywords : Acute mountain sickness, Hyperbaric chambers, Hypoxia, Test

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Results of animal experiments

Results of human experiments

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Vol 35 - N° 10

P. 1536-1541 - octobre 2017 Retour au numéro

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Using a new plateau hyperbaric chamber to alleviate high altitude hypoxia: Rabbit and human studies - 28/09/17

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