Trajectories of Neighborhood Cohesion in Childhood, and Psychotic and Depressive Symptoms at Age 13 and 18 Years - 06/10/17
, Ian Colman, PhD b, Murray Weeks, PhD c, Glyn Lewis, PhD a, James B. Kirkbride, PhD aAbstract |
Objective |
Exposure to adverse social environments has been associated with psychotic and depressive symptoms in adolescence in cross-sectional studies, but the longitudinal relation is unclear. This study examined whether longitudinal trajectories of exposure to adverse social environments across childhood are associated with psychotic experiences and depressive symptoms in adolescence.
Method |
Data on participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to estimate longitudinal trajectories of childhood exposure to neighborhood cohesion (NC), discord (ND), and stress (NS) using latent class growth modeling. Logistic regression was used to examine the association between these trajectories and psychotic experiences and depressive symptoms at 13 and 18 years of age, adjusting for maternal psychopathology, participant sociodemographic and socioeconomic characteristics, and area-level deprivation.
Results |
A dose-response association was observed between higher NS and the odds of psychotic experiences at 13 years (medium NS, adjusted odds ratio [aOR] 1.25, 95% CI 1.05–1.49; high NS, aOR 1.77, 95% CI 1.30–2.40), whereas high levels of ND predicted psychotic experiences at 18 years (aOR 1.50, 95% CI 1.10–2.07). High levels of NC (aOR 1.43, 95% CI 1.02–1.71) and NS (aOR 1.55, 95% CI 1.07–2.26) were associated with increased odds of high depressive symptoms at 18 years in a dose-response fashion.
Conclusion |
Prolonged and more severe exposure to adverse social environments is associated with greater odds of developing psychotic and depressive symptoms in late adolescence.
Le texte complet de cet article est disponible en PDF.Key words : neighborhood social cohesion, psychotic experiences, depressive symptoms, Avon Longitudinal Study of Parents and Children (ALSPAC), cohort study
Plan
| The UK Medical Research Council and the Wellcome Trust (grant 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors who serve as guarantors for the contents of this article. This research was specifically funded by a Sir Henry Dale Fellowship to Dr. Kirkbride, jointly funded by the Wellcome Trust and the Royal Society (grant 101272/Z/13/Z). This research was supported in part by funding from the Canada Research Chairs program to Dr. Colman. |
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| Drs. Solmi, Weeks, and Kirkbride served as the statistical experts for this research. |
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| The authors are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the entire ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, and nurses. |
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| Disclosure: Dr. Solmi has received a small grant from The Challenge (UK registered charity number 1129239) to investigate the role of social integration in children’s mental health and has acted a consultant for a project funded by the UK Department of Health for the UCL Children Policy Research Unit (CPRU) on the cost of child disability in the United Kingdom. Prof. Colman has received funding from the Canadian Institutes of Health Research, the Canadian Institute for Military and Veterans Health Research, and the Consortium National de Formation en Santé. Prof. Lewis has received funding for studies based on ALSPAC from the Wellcome Trust, the Medical Research Council, and the Economic and Social Research Council. Dr. Kirkbride also has received a small grant from The Challenge as per the details described for Dr. Solmi. He has received further funding from the Wellcome Trust to develop population-based prediction models for first-episode psychosis (grant101272/Z/13/A). He is a coinvestigator on a grant to investigate the use of crisis care services in England funded by the National Institute of Health Research (grant NIHR-15-24-17). He has been awarded a PhD scholarship grant from Mental Health Research UK and the Schizophrenia Research Fund (John Grace QC PhD scholarship, October 2015). He also has received honoraria from the Danish National Research Foundation and Aix-Marseille University for peer-review activities and from the ARUP Consultancy (United Kingdom) for a keynote lecture. Dr. Weeks reports no biomedical financial interests or potential conflicts of interest. |
Vol 56 - N° 7
P. 570-577 - juillet 2017 Retour au numéro
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