Ceftriaxone combination therapy versus respiratory fluoroquinolone monotherapy for community-acquired pneumonia: A meta-analysis - 18/09/18
, Shui-Lan Zou, MD b, Hua Zhao, MD a, Ming-Ming Zhang, MD a, Cai-Li Han, MD aAbstract |
Background |
The goal of this study was to investigate whether ceftriaxone combination therapy is associated with better clinical outcomes than respiratory fluoroquinolone monotherapy for adults with community-acquired pneumonia (CAP). We conducted a meta-analysis of published studies.
Methods |
Using the PubMed, EMBASE, and Cochrane Library databases, we performed a literature search of available randomized controlled trials (RCTs) published as original articles before September 2017.
Results |
Nine RCTs, involving 1520 patients, were included in the meta-analysis. The pooled relative risks (RRs) for the efficacy of ceftriaxone combination therapy versus respiratory fluoroquinolones monotherapy were 0.96 (95% CI: 0.92–1.01), based on clinically evaluable populations, and 0.93 (95% CI: 0.88–0.99) based on intention-to-treat (ITT) populations. No statistically significant differences were observed in microbiological treatment success (pooled RR=0.99, 95% CI: 0.90–1.09), although drug-related adverse events were significantly lower with ceftriaxone combination therapy than with respiratory fluoroquinolones monotherapy (pooled RR=1.27, 95% CI: 1.04–1.55).
Conclusions |
Current evidence showed that the efficacy of ceftriaxone combination therapy was similar to respiratory fluoroquinolone monotherapy for hospitalized CAP patients, and was associated with lower drug-related adverse events.
Le texte complet de cet article est disponible en PDF.Keywords : Ceftriaxone, Respiratory fluoroquinolones, Community-acquired pneumonia, Randomized controlled trials, Meta-analysis
Plan
Vol 36 - N° 10
P. 1759-1765 - octobre 2018 Retour au numéro
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