Using Kalman Filtering to Forecast Disease Trajectory for Patients With Normal Tension Glaucoma - 21/02/19
Abstract |
Purpose |
To determine whether a machine learning technique called Kalman filtering (KF) can accurately forecast future values of mean deviation (MD), pattern standard deviation, and intraocular pressure for patients with normal tension glaucoma (NTG).
Design |
Development and testing of a forecasting model for glaucoma progression.
Methods |
We parameterized and validated a KF (KF-NTG) to forecast MD, pattern standard deviation, and intraocular pressure at 24 months into the future using 263 eyes of 263 Japanese patients with NTG. We determined the proportion of patients with MD forecasts within 0.5, 1.0, and 2.5 dBs of the actual values and calculated the root mean squared error (RMSE) for each forecast. We compared KF-NTG with a previously published KF model calibrated using patients with high-tension open-angle glaucoma (KF-HTG) and to 3 conventional forecasting algorithms.
Results |
The 263 patients with NTG had mean ± standard deviation age of 63.4 ± 10.5 years. KF-NTG forecasted MD values 24 months ahead within 0.5, 1.0, and 2.5 dBs of the actual value for 78 eyes (32.2%), 122 eyes (50.4%), and 211 eyes (87.2%), respectively. The proportion of eyes with MD values forecasted within 2.5 dB of the actual value for the KF-NTG (87.2%) were similar to KF-HTG (86.0%) and the null model (86.4%), and much better than the 2 linear regression–based models (72.7-74.0%; P < .001). When forecasting MD, KF-NTG (RMSE = 2.71) and KF-HTG (RMSE = 2.68) achieved lower RMSE than the other 3 forecasting models (RMSE = 2.81-3.90), indicating better performance.
Conclusion |
As observed previously for patients with HTG, KF can also effectively forecast disease trajectory for many patients with NTG.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Kalman filtering, from machine learning, accurately predicts NTG disease trajectory. |
• | Kalman filtering outperformed standard forecasting methods like linear regression. |
• | Kalman filtering predicted MD within 1 dB of the actual value for >50% of patients. |
Plan
Vol 199
P. 111-119 - mars 2019 Retour au numéro
Article précédent
- Prevalence of Normal-Tension Glaucoma in the Chinese Population: A Systematic Review and Meta-Analysis
- Jing Zhao, Marisse Masis Solano, Catherine E. Oldenburg, Tianshu Liu, Yaxing Wang, Ningli Wang, Shan C. Lin
- Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma
- Huiyuan Hou, Sasan Moghimi, Linda M. Zangwill, Takuhei Shoji, Elham Ghahari, Rafaella C. Penteado, Tadamichi Akagi, Patricia Isabel C. Manalastas, Robert N. Weinreb
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