Chronologic order of appearance of immune-mediated inflammatory diseases relative to diagnosis of psoriasis - 09/11/19
Abstract |
Background |
Psoriasis is a common inflammatory skin disease associated with several immune-mediated inflammatory diseases (IMIDs); however, little is known of the chronology of disease development.
Objective |
To investigate the chronology of IMIDs relative to psoriasis.
Methods |
We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n = 10,923) and general population controls (n = 109,230).
Results |
Approximately 20% of patients with psoriasis developed ≥1 IMID, with a 5-fold increased risk compared with the general population. Most IMIDs were diagnosed before psoriasis, except for psoriatic arthritis. Psoriasis was significantly associated with having multiple IMIDs (odds ratio 15.2, 95% confidence interval 11.6-20.0). Human leukocyte antigen B27 positivity was significantly more frequent among psoriasis patients.
Limitations |
Clinical measurements were unavailable.
Conclusion |
IMIDs occur frequently in patients with psoriasis and most are diagnosed before psoriasis. The observed chronology might represent important mechanisms of disease development.
Le texte complet de cet article est disponible en PDF.Key words : autoimmune, comorbidity, epidemiology, HLA-B27, inflammation, psoriasis, psoriatic arthritis
Abbreviations used : CI, DNPR, ICD-10, IBD, IL, IMID, IQR, IRR, OR, PsA, SD
Plan
Funding sources: None. |
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Conflicts of interest: Dr Andersen has received research funding from the Lundbeck Foundation, the Aage Bang Foundation, and the A.P. Møller Foundation. Dr Wu is an investigator for AbbVie, Amgen, Eli Lilly, Janssen, and Novartis; a consultant for AbbVie, Almirall, Amgen, Bristol-Myers Squibb, Celgene, Dermira, Dr Reddy's Laboratories, Eli Lilly, Janssen, LEO Pharma, Novartis, Promius Pharma, Regeneron, Sun Pharmaceutical, UCB, and Valeant Pharmaceuticals North America LLC; and a speaker for AbbVie, Celgene, Novartis, Regeneron, Sun Pharmaceutical, UCB, and Valeant Pharmaceuticals North America LLC. Dr Thyssen is supported by an unrestricted research grant from the Lundbeck Foundation; has received speaker honoraria from Galderma, Sanofi-Genzyme, LEO Pharma, and MEDA; and attended advisory board meetings for Roche, Eli Lilly, and Sanofi-Genzyme. Dr Thyssen is also an investigator for LEO Pharma and Eli Lilly. Dr Egeberg has received research funding from Pfizer, Eli Lilly, the Danish National Psoriasis Foundation, and the Kgl Hofbundtmager Aage Bang Foundation and has received honoraria as a consultant or speaker from AbbVie, Almirall, Leo Pharma, Samsung Bioepis Co Ltd, Bristol-Myers Squibb, Dermavant, Pfizer, Eli Lilly, Novartis, Galderma, and Janssen Pharmaceuticals. |
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Reprints not available from the authors. |
Vol 81 - N° 6
P. 1283-1291 - décembre 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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