Capsular contracture in the modern era: A multidisciplinary look at the incidence and risk factors after mastectomy and implant-based breast reconstruction - 04/05/21
Abstract |
Background |
Capsular contracture causes pain, poor cosmesis, and reoperations. This study analyzes its incidence and risk factors in a more modern treatment era.
Methods |
Patients undergoing mastectomy with implant reconstruction from 2010 to 18 were reviewed. Univariate and multivariate analysis evaluated rates and risk factors for capsular contracture.
Results |
Among 451 patients, the majority underwent nipple-sparing mastectomy (262, 58.1%) with one-stage reconstruction (283, 62.7%) utilizing subpectoral implants (353, 77.4%) and acellular dermal matrix (354, 78.5%). Overall capsular contracture incidence was 9.8%; the rate after post-mastectomy radiation therapy (PMRT) was 18.7%, and 7.5% for patients without PMRT. Significant factors included neoadjuvant chemotherapy (P = 0.006), hematoma (P = 0.047), and PMRT (P = 0.001). Multivariate analysis showed that PMRT increased risk of capsular contracture (OR = 3.12, 95% CI 1.55–6.26, P = 0.001), and adjuvant chemotherapy was protective (OR = 0.289, 95% CI 0.114–0.731, P = 0.01).
Conclusions |
Incidence of capsular contracture is lower than previously reported. Advancing therapeutic techniques may reduce the risk of this complication.
Le texte complet de cet article est disponible en PDF.Graphical abstract |
Highlights |
• | The incidence of capsular contracture is lower in the modern era. |
• | Radiation therapy remains a significant risk factor. |
• | New therapeutic techniques may reduce the risk for capsular contracture. |
Keywords : Capsular contracture, Mastectomy, Nipple-sparing, Breast reconstruction, Risk factors
Plan
Vol 221 - N° 5
P. 1005-1010 - mai 2021 Retour au numéro
Article précédent
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