Analysis of endogenous oxidative damage markers and association with pulmonary involvement severity in patients with SARS-CoV-2 pneumonia - 27/06/21
, Hamit Hakan Alp b, Selami Ekin a, Ahmet Arisoy a, Hulya Gunbatar a, Selvi Asker a, Buket Mermit Cilingir a, Aysel Sunnetcioglu a, Masuk Celikel a, Nevzat Esen a, Serhat Bedirhanoglu a, Nuruban Delal Baykal a, Mine Haylu a
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Highlights |
• | Serum levels of CoQ10, NOX4, MDA, and IMA - which can be used as biomarkers of endogenous oxidative damage - were significantly increased in patients with SARS-CoV-2 pneumonia. |
• | CoQ10H serum levels were also decreased in these patients, suggesting increased endogenous oxidative damage. |
• | We observed that CoQ10, NOX4, MDA, and IMA levels were significantly increased in patients with severe pulmonary involvement (severe SARS-CoV-2 pneumonia) compared to those without severe pulmonary involvement. Our findings support the association between the degree of endogenous oxidative damage and the degree of pulmonary involvement severity. |
Abstract |
Introduction |
The SARS-CoV-2 virus affects many organs, especially the lungs, with widespread inflammation. We aimed to compare the endogenous oxidative damage markers of coenzyme Q10, nicotinamide dinucleotide oxidase 4, malondialdehyde, and ischemia-modified albumin levels in patients with pneumonia caused by SARS-CoV-2 and in an healthy control group. We also aimed to compare these parameters between patients with severe and non-severe pulmonary involvement.
Methods |
The study included 58 adult patients with SARS-CoV-2 pneumonia and 30 healthy volunteers. CoQ10 and MDA levels were determined by high-pressure liquid chromatography. NOX4 and IMA levels were determined by ELISA assay and colorimetric method.
Results |
Higher levels of CoQ10, MDA, NOX4, and IMA and lower levels of COQ10H were observed in patients with SARS-CoV-2 pneumonia than in the control group. MDA, IMA, NOX4, and CoQ10 levels were significantly higher in patients with severe pulmonary involvement than in patients with non-severe pulmonary involvement, but no significant difference was observed in CoQ10H levels. CoQ10 levels were significantly and positively correlated with both ferritin and CRP levels.
Conclusion |
SARS-CoV-2 pneumonia is significantly associated with increased endogenous oxidative damage. Oxidative damage seems to be associated with pulmonary involvement severity.
Le texte complet de cet article est disponible en PDF.Keywords : COVID-19, Pneumonia, Oxidative damage, CoQ10, NOX4, SARS-CoV-2
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