Snakes can be more challenging to anesthetize compared with other animals because of anatomic and physiologic differences, a wide range of patient sizes, and variable responses to anesthetic agents. Snakes have preferred optimal temperature zones, which, along with physiologic characteristics, such as the ability to shunt blood toward or away from the lungs, can have an impact on anesthesia. Injectable agents, including benzodiazepines, α₂-agonists, opioids, propofol, and alfaxalone, as well as inhalant anesthetics can be used to anesthetize snakes. Pain management must be incorporated to the anesthetic plan when performing procedures that are expected to produce nociception.