Association of genetic variants in the GPX1 and GPX4 genes with the activities of glutathione-dependent enzymes, their interaction with smoking and the risk of acute pancreatitis - 16/01/22
, Halina Milnerowicz bBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 15 |
| Iconographies | 2 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Genetic factors and tobacco smoke exposure can be associated with an increased risk of acute pancreatitis (AP). The pathogenesis of AP is associated with intensive oxidative stress. Glutathione peroxidase (GPx) is one of many enzymes involved in the neutralization of free radicals. This study aimed to investigate the impact of SNP rs1050450 in the GPX1 gene and rs713041 in the GPX4 gene on the activity of total GPx in a group of AP patients and healthy subjects. It was found that AP can contribute to decreased GPx activity (in plasma and erythrocyte lysate) accompanied by an increased glutathione reductase (GR) activity and decreased glutathione (GSH) concentration in two groups, non-smokers and smokers. A decreased GPx activity in erythrocyte lysate of AP patients compared to healthy subjects was associated with the occurrence of the CC genotype for SNP rs1050450. It was noted an increased GPx activity and decreased GR activity in erythrocytes of non-smoking AP patients with the TT genotype compared to subjects with the CC and TC genotype for SNP rs713041. However, in the group of smoking AP patients with this genotype, GR activity was elevated compared to non-smokers, which was accompanied by increased GSH concentration. These results can indicate that smoking in the course of AP can change the involvement of antioxidants in dependence on the genotype for the examined SNPs. The CC genotype for SNP rs1050450 and the TT genotype for rs713041 increases the risk of AP recurrence, which may be associated with increased MDA concentration.
Le texte complet de cet article est disponible en PDF.Graphical Abstract |
Highlights |
• | Acute pancreatitis (AP) is associated with the pro/antioxidative imbalance. |
• | AP can contribute to decreased GPx activity in plasma and erythrocytes. |
• | The CC genotype (rs1050450) and the TT genotype (rs713041) increases the risk of AP. |
• | Smoking in AP change the involvement of antioxidants in dependence on the genotype. |
Abbreviations : AP, GPx, GR, GSH, GST, MDA, SNP
Keywords : Pancreatitis, Glutathione peroxidase, Smoking, Single nucleotide polymorphism, rs1050450, rs713041
Plan
Vol 146
Article 112591- février 2022 Retour au numéro
Article précédent
- Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway
- Lingling Xie, Tianyi Wang, Shan Lin, Zhuqing Lu, Yilian Wang, Zhiqing Shen, Ying Cheng, Aling Shen, Jun Peng, Jianfeng Chu
- Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC)
- Jacek Pietrzak, Dagmara Szmajda-Krygier, Agnieszka Wosiak, Rafał Świechowski, Katarzyna Michalska, Marek Mirowski, Marta Żebrowska-Nawrocka, Mariusz Łochowski, Ewa Balcerczak
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?