Hormone replacement therapy with GnRH agonist pretreatment improves pregnancy outcomes in patients with previous intrauterine adhesions - 15/09/22
Abstract |
Purpose |
To explore the optimal cycle regimen for frozen-thawed embryo transfer (FET) in women with previous intrauterine adhesions (IUAs).
Methods |
In this retrospective cohort study, a total of 1,002 FET cycles for patients with previous IUAs from January 2015 to December 2020 were included. Among them, 294 conventional hormone replacement therapy (HRT) cycles were matched with 155 HRT with gonadotropin releasing hormone agonist pretreatment (HRT+GnRH-a) cycles using propensity score matching. Multivariate logistic regression analysis was performed to further investigate the impact of cycle regimen on pregnancy outcomes.
Results |
After propensity score matching, baseline characteristics were consistent between HRT and HRT+GnRH-a group. Logistic regression analysis revealed that there was a significant superiority of HRT+GnRH-a over the conventional HRT group regarding the incidences of live birth (aOR=1.966, 95%CI: 1.212-3.188, P=0.006) and ongoing pregnancy (aOR=1.710, 95%CI: 1.057-2.767, P=0.029). HRT+GnRHa also had a higher odd of clinical pregnancy (aOR=1.414, 95%CI: 0.903-2.216, P=0.130), and lower odd of early miscarriage (aOR=0.511, 95%CI: 0.219-1.195, P=0.121) compared to HRT, yet not reached statistical significance.
Conclusion |
HRT with GnRH-a pretreatment improves pregnancy outcomes in women with previous IUAs. GnRH-a may restore the endometrial receptivity in the FET cycles of IUAs.
Synopsis |
: HRT with GnRH-a pretreatment may promote pregnancy prognosis of FET in women with history of IUAs by restoring endometrial receptivity.
Le texte complet de cet article est disponible en PDF.Keywords : Intrauterine adhesions, Frozen-thawed embryo transfer, Cycle regimen, GnRH agonist, Pregnancy outcomes
Plan
Vol 51 - N° 8
Article 102439- octobre 2022 Retour au numéro
Article précédent
- Second biopsy for embryos with inconclusive results after preimplantation genetic testing: Impact on pregnancy outcomes
- Manon Carles, Charlotte Sonigo, Olivier Binois, Laetitia Hesters, Julie Steffann, Serge Romana, Nelly Frydman, Anne Mayeur
- Success to reach 3cm of dilation with a Dinoprostone Vaginal Insert in primiparous women with a previous cesarean section versus nulliparous: A retrospective case-control study
- Aurélie Comptour, Amélie Delabaere, Camille Huret, Laurent Ouziel, Sylvie Ughetto, Bruno Pereira, Denis Gallot
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?