Diagnostic accuracy of a rapid antigen triple test (SARS-CoV-2, respiratory syncytial virus, and influenza) using anterior nasal swabs versus multiplex RT-PCR in children in an emergency department - 15/10/23
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Highlights |
• | The performance of the triplex test (SARS-CoV-2, RSV and influenza) showed promising results. |
• | The triplex test was performed with an anterior nasal swab. |
• | For RT-PCR with Ct < 32, sensitivity increased (from 87.2% to 100%) for each virus. |
• | An accurate diagnosis was obtain for most cases of respiratory infection. |
Abstract |
Background |
In children, respiratory infections such as SARS-CoV-2, respiratory syncytial virus (RSV), and influenza share similar clinical signs and symptoms. Here we compared the performance of a rapid antigen diagnostic test using a self-collected anterior nasal swab (COVID-VIRO ALL IN TRIPLEX) and multiplex RT-PCR.
Methods |
From October to December 2022, in the emergency pediatrics unit of Orleans Hospital, France, we evaluated the diagnostic accuracy of the triplex test.
Results |
For the 263 children, sensitivity of the test was 88.9% (95%CI 51.8–99.7), 79.1% (95%CI 64.0–90.0), and 91.6% (95%CI 84.1–96.3), for SARS-CoV-2, RSV, and influenza, respectively. Specificity was 100% for each virus. For RT-PCR with cycle threshold < 32, sensitivity was 100.0% [95%CI 59.0–100.0], 87.2% [95%CI 72.6–95.7] and 92.3% [95%CI 84.896.9] for SARS-CoV-2, RSV, and influenza respectively.
Conclusions |
This easy-to-perform triplex test is a considerable advance, allowing clinicians to obtain an accurate diagnosis in most cases of respiratory infection. More data are needed to validate this test in different contexts and across several seasons.
Le texte complet de cet article est disponible en PDF.Keywords : Rapid antigen test, SARS-CoV-2, Respiratory syncytial virus, Influenza, Children
Plan
Vol 53 - N° 7
Article 104769- octobre 2023 Retour au numéro
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