Efficacy of antimicrobial peripherally inserted central catheters in line-associated bloodstream infections: A systematic review and meta-analysis - 14/11/23
Résumé |
Background |
Several studies have investigated the safety and efficacy of antimicrobial peripherally inserted central catheters (PICCs), and the results are conflicting. Therefore, in this systematic review and meta-analysis, we aimed to summarize and identify the effect of antimicrobial PICCs on central line–associated bloodstream infection (CLABSI) risk.
Methods |
A systematic search of PubMed, Ovid MEDLINE, Ovid Embase, and Web of Science was performed to identify relevant studies up to December 2022.
Results |
A total of 9 studies were included for analysis. There were 7 retrospective/prospective cohort studies and 2 randomized controlled trials. The 9 studies involved 51,373 patients with PICCs. Among these patients, 6,563 (12.8%) antimicrobial-coated/impregnated PICCs and 44,810 (87.2%) nonantimicrobial-impregnated PICCs were inserted. The meta-analysis showed that antimicrobial PICCs had a nonsignificant association with lower CLABSI risk compared with noncoated PICCs (relative risk [RR] = 0.67; 95% CI, 0.43-1.05). In the subgroup analysis, minocycline-rifampin–(RR = 0.30; 95% CI, 0.19-0.49) or chlorhexidine-coated (RR = 0.61; 95% CI, 0.04-8.55) PICCs showed an association with reduced risk of CLABSI. In the adult population, antimicrobial PICCs had a nonsignificant association with lower CLABSI risk (RR = 0.50; 95% CI, 0.20-1.22).
Conclusions |
This systematic review and meta-analysis suggested that antimicrobial PICCs had a nonsignificant association with lower CLABSI risk compared with noncoated PICCs. Minocycline-rifampin–or chlorhexidine-coated PICCs showed an association with reduced risk of CLABSI.
Le texte complet de cet article est disponible en PDF.Highlights |
• | This systematic review and meta-analysis suggested that antimicrobial peripherally inserted central catheters (PICCs) had a nonsignificant association with lower central line–associated bloodstream infection (CLABSI) risk compared with noncoated PICCs. |
• | Minocycline-rifampin- or chlorhexidine-coated PICCs had a nonsignificant association with lower CLABSI risk. |
• | In the pediatric population, antimicrobial PICCs had a nonsignificant association with lower CLABSI risk compared with noncoated PICCs. |
Key Words : Central line–associated bloodstream infection, Minocycline, Rifampin, Chlorhexidine, Miconazole
Plan
| Conflicts of interest: None to report. |
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| Ethics approval: Ethics approval was obtained from the institutional review board of our hospital. |
Vol 51 - N° 12
P. 1425-1429 - décembre 2023 Retour au numéro
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