Risk factors and prognostic significance of infection of totally implantable vascular access port in solid tumor patients: A prospective cohort study - 15/11/23
Highlights |
• | Inserted in a dedicated expert platform, TIVAP is complicated by infection in less than 5% of patients. |
• | Chemotherapy administration through peripheral access in the month before placement is a risk factor for TIVAP-infection. |
• | Radiation therapy of the homolateral chest wall is an avoidable risk factor for TIVAP-infection. |
• | TIVAP-related infection is not associated with one-year mortality in solid tumor patients. |
Abstract |
Objectives |
Totally implantable venous access ports (TIVAP) are devices mainly used to deliver antineoplastic chemotherapies, of which the insertion may be complicated by TIVAP-related infection (TIVAP-RI). This study aims to provide data on the risk factors for TIVAP-RI and its influence on patient prognosis.
Patients and methods |
Prospective observational study including adult patients with solid tumors, in whom a TIVAP was inserted to deliver antineoplastic chemotherapy between January 2018 and October 2019. Factors associated with TIVAP-RI and one-year mortality were determined using multiple logistic regressions.
Results |
More than a thousand (1014) patients were included, among whom 48 (4.7%) presented with TIVAP-RI. Gram-positive cocci and Gram-negative bacilli represented 51% and 41% of the pathogens isolated, respectively. Young age (odds ratio [OR] 0.67; 95% Confidence Interval [0.53–0.83] per 10-year increase), WHO performance status ≥ 1 (OR 3.24 [1.52–7.79]), chemotherapy administration in the month before TIVAP placement (OR 2.26 [1.17–4.26]), and radiation therapy of the homolateral chest wall (OR 3.28 [1.51–6.67]) were independently associated with TIVAP-RI occurrence. During the year following TIVAP insertion, 287 (28%) patients died. TIVAP-RI was not associated with one-year mortality (OR 1.56 [0.75–3.19]).
Conclusion |
TIVAP insertion in adult patients with solid tumors is associated with a low infection rate, which did not influence one-year mortality. In addition to young age and impaired health status, TIVAP insertion in the month following initiation of the antineoplastic chemotherapy and TIVAP insertion in an irradiated area are two newly reported preventable TIVAP-RI risk factors.
Le texte complet de cet article est disponible en PDF.Keywords : Infection, Mortality, Risk factors, Solid tumor, Totally Implantable Vascular Access Port
Plan
Vol 53 - N° 8
Article 104766- octobre 2023 Retour au numéro
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