Systematic Review and Meta-Analysis: Risks of Anxiety Disorders in Offspring of Parents With Mood Disorders - 26/03/24
Abstract |
Objective |
To examine the risk of anxiety disorders in offspring of parents with mood disorders.
Method |
We conducted a systematic review and meta-analysis. We searched 4 electronic databases (Medline, Embase, PsycINFO, and Web of Science [core collection]) to identify cross-sectional and cohort studies that examined the association between parental mood disorders (including bipolar disorder and unipolar depression) and risk of anxiety disorders in offspring. Pooled risk ratios (RRs) of overall and specific anxiety disorders were synthesized using a random effects model. Subgroup analyses and meta-regression were performed to identify moderation factors.
Results |
A total of 35 studies were included in the final analysis. Our results showed higher risks of all types of anxiety disorders in the offspring of parents with mood disorders (any anxiety disorder, RR = 1.82, 95% CI = 1.47-2.26), except for agoraphobia (RR = 1.08, 95% CI = 0.56-2.08), and with an especially elevated risk of panic disorder (RR = 3.07, 95% CI = 2.19-4.32). Subgroup analysis demonstrated no significant difference between the risks of anxiety disorders across the offspring of parents with bipolar disorder as opposed to unipolar depression. The absence of anxiety disorders in control parents, younger offspring age, and specific parent/offspring sex were associated with higher RRs for some anxiety disorders in offspring of parents with mood disorders.
Conclusion |
Our findings suggest a robust relationship between parental mood disorders and offspring anxiety disorders, and highlight the potential value of prevention and early intervention for anxiety disorders in this context.
Diversity & Inclusion Statement |
We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. While citing references scientifically relevant for this work, we also actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our reference list.
Study preregistration information |
Anxiety Disorders in Offspring of Parents with Mood Disorders: A Systematic Review; prospero/; CRD42021215058.
Le texte complet de cet article est disponible en PDF.Key words : affective, depressive, bipolar, parental, high-risk
Plan
| E.T. is supported by Chang Gung Memorial Hospital (CGMH), Keelung, Taiwan. H.M. and C.C. are funded by the National Institute for Health and Care Research (NIHR) Applied Research Collaboration Oxford and Thames Valley at Oxford Health NHS Foundation Trust. K.S. and C.C. are funded by the NIHR Oxford Health Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the Chang Gung Memorial Hospital, Keelung, the UK National Health Service, the NIHR, or the UK Department of Health. |
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| The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. |
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| This work has been prospectively registered: display_record.php?RecordID=215058. |
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| Edoardo Ostinelli, MD, of the University of Oxford, UK, Yun-Chun Wu, PhD and Chiao-Erh Chang, PhD, of the National Taiwan University, Taiwan, served as the statistical experts for this research. |
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| Author Contributions Conceptualization: Tu, Saunders, Creswell Data curation: Tu Formal analysis: Tu, Creswell Funding acquisition: Tu Investigation: Tu, Manley, Saunders Methodology: Tu, Manley, Saunders, Creswell Project administration: Tu, Creswell Resources: Tu, Creswell Software: Tu Supervision: Saunders, Creswell Validation: Manley, Saunders, Creswell Visualization: Tu Writing – original draft: Tu Writing – review and editing: Tu, Saunders, Creswell |
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| Disclosure: Drs. Tu and Saunders, Prof. Creswell, and Ms. Manley have reported no biomedical financial interests or potential conflicts of interest. |
Vol 63 - N° 4
P. 407-421 - avril 2024 Retour au numéro
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