Deaths and major cardiovascular events in patients with lymphoma: Analysis from a French nationwide hospitalization database - 25/09/24
, Denis Caillot b, Alexandre Bodin d, Julien Herbert d, Bernard Bonnotte b, Marianne Zeller a, e, Yves Cottin a, Laurent Fauchier d
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Graphical abstract |
Highlights |
• | No hard data comparing risk of death in patients with/without lymphoma. |
• | No hard data comparing cardiovascular event risk in patients with/without lymphoma. |
• | Rates of all-cause death and major bleeding higher in lymphoma group. |
• | Rates of cardiovascular death, MI, ischaemic stroke and AF lower in lymphoma group. |
Abstract |
Background |
There are few data assessing the risk of death and cardiovascular events in patients with lymphoma.
Aim |
Using a nationwide hospitalization database, we aimed to address cardiovascular outcomes in patients with lymphoma.
Methods |
From 01 January to 31 December 2013, 3,381,472 adults were hospitalized in French hospitals; 22,544 of these patients had a lymphoma. The outcome analysis (all-cause or cardiovascular death, myocardial infarction, ischaemic stroke, bleedings, new-onset heart failure and new-onset atrial fibrillation) was performed over a 5-year follow-up period. Each patient with lymphoma was matched with a patient without a lymphoma or other cancer (1:1). A competing risk analysis was also performed.
Results |
After adjustment on all risk factors, cardiovascular and non-cardiovascular co-morbidities, the subdistribution hazard ratios for all-cause death, major bleeding, intracranial bleeding, new-onset heart failure and new-onset atrial fibrillation were higher in patients with lymphoma; conversely, the subdistribution hazard ratios for cardiovascular death, myocardial infarction and ischaemic stroke were lower in patients with lymphoma. In the matched analysis, the risk of all-cause death (subdistribution hazard ratio 1.936, 95% confidence interval 1.881–1.992) and major bleeding (subdistribution hazard ratio 1.117, 95% confidence interval 1.049–1.188) remained higher in patients with lymphoma.
Conclusion |
In this large nationwide cohort study, patients with lymphoma had a higher incidence of all-cause death and major bleeding.
Le texte complet de cet article est disponible en PDF.Keywords : Lymphoma, Myocardial infarction, Ischaemic stroke, Bleeding, Mortality
Plan
Vol 117 - N° 8-9
P. 497-504 - août 2024 Retour au numéro
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