The Association Between Accelerated Biological Aging and Cardiovascular Outcomes in Older Adults with Hypertension - 11/02/25
, Sachin J. Shah, MD, MPH b, Garrett Fitzmaurice, ScD c, Colin Hubbard, PhD a, John C. Newman, MD, PhD d, e, Kenneth Covinsky, MD, MPH d, Margaret C. Fang, MD, MPH aAbstract |
Background |
Current hypertension treatments rely on chronological age, which may not reflect individual differences in aging and its impact on cardiovascular health. This study aimed to determine whether biological age can predict adverse outcomes in older adults with hypertension, independent of traditional risk factors including chronological age.
Methods |
An analysis of a prospective cohort was conducted using data from the Health and Retirement Study, a longitudinal survey of older adults in the United States. The Klemera-Doubal method was employed to calculate the biological age of the participants with hypertension at the time of enrollment in 2016. Discrete-time survival analysis was conducted to analyze the relationship between accelerated biological aging and the risk of mortality, heart disease, and stroke over four years of follow-up.
Results |
A total of 4,442 individuals were analyzed. Of these, 2,438 showed decelerated aging, whereas 2,004 experienced accelerated aging (biological age > chronological age). The median age of the patients in both groups was around 70 years. Both groups had similar racial and ethnic distributions and predominantly consisted of non-Hispanic whites. The accelerated aging group had a higher prevalence of chronic diseases, lower education levels, and less wealth than the decelerated aging group. After adjustment for these differences, accelerated aging was associated with a higher risk of a composite outcome of death, heart disease, and stroke, with an adjusted hazard ratio (a-HR) of 1.62 (95% confidence interval: 1.27-2.06, P = .001).
Conclusions |
Accelerated biological age is a predictor of cardiovascular outcomes and death in patients with hypertension.
Le texte complet de cet article est disponible en PDF.Keywords : Accelerated biological age, Geriatrics, Heart disease, Hypertension, Stroke
Plan
| Funding: Research reported in this publication was supported by the Clinical & Translational Science Institute (CTSI), Project ID: 137241F (Abugroun and Hubbard). Additionally, it was supported in part by (1) the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number K24HL141354 (Fang). (2) The National Institute on Aging/National Institutes of Health under award number K76AG074919 (Shah). (3) National Institute on Aging (Covinsky). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. |
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| Conflict of Interest: The authors declare that they have no conflicts of interest. |
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| Authorship: AA: Writing—review & editing, Writing—original draft, Visualization, Software, Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Conceptualization; SJS: Writing—review & editing, Supervision, Methodology, Conceptualization; GF: Writing—review & editing, Supervision, Methodology, Conceptualization; CH: Writing—review & editing, Visualization, Software, Formal analysis; JCN: Writing—review & editing, Methodology, Conceptualization; KC: Writing—review & editing, Supervision, Methodology, Conceptualization; MCF: Writing—review & editing, Supervision, Methodology, Conceptualization. All authors had access to the data and contributed to the writing of the manuscript. |
Vol 138 - N° 3
P. 487 - mars 2025 Retour au numéro
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