Recommended gentamicin peak plasma levels rarely reached, even with recommended dosages - 29/05/25
Highlights |
• | This is the largest study on gentamycin peak concentration (601 samples). |
• | Only a small proportion (5.7 %) of values exceeded the minimal recommended value. |
• | Even with high gentamycin dose (>10 mg/kg), only 22.7 % of the values reached the target concentration. |
• | These results suggest that target concentration limits are unrealistic. |
Abstract |
Introduction |
The recommended gentamicin peak plasma concentration range is 32–40 mg/L; we aimed to determine how frequently it was reached, and for which gentamicin doses.
Patients and methods |
We retrospectively reviewed 601 gentamicin peak plasma concentrations in 501 patients aged ≥15 in our institution between 2013 and 2023.
Results |
Median gentamicin dose was 5.9 mg/kg [IQR 4.1–7.9]. Median peak plasma concentration was 16.5 mg/L [IQR 10.8–22.8] and was strongly correlated with dose (p < 0.0001). Only 5.7 % of values were ≥32 mg/L, including 22.8 % for dose ≥10 mg/kg.
Conclusion |
This suggests that existing recommendations regarding either dose or target concentration for gentamicin should be modified.
Le texte complet de cet article est disponible en PDF.Keywords : Gentamicin, Dose, Peak concentration, Plasma level
Plan
Vol 55 - N° 4
Article 105076- juin 2025 Retour au numéro
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