This case report illustrates the treatment of a 17-year-old male patient characterized by an anterior open bite, skeletal Class III malocclusion, mandibular deviation, and severe temporomandibular joint symptoms. Given the complexity of the patient's condition, a strategic treatment approach was employed. Stabilization splint was used initially for a duration of 9 months to alleviate TMJ symptoms and repositioning the condyle. Through model analysis on the articulator pretreatment, we found a worsening of his V-shape open bite due to occlusal interference in molars. The patient refused the surgery, so the multiloop edgewise archwire treatment was provided to upright the molars and eliminate occlusal interference. After 26 months of treatment, a functional and aesthetic occlusion, and a relatively well-balanced facial profile were established. After a 6 years post-treatment follow-up, the results of this case have demonstrated long-term stability.