We provide critical considerations regarding the acceptance and commitment therapy (ACT) science. We discuss the reconsideration and potential dismissal of latent disease diagnoses in ACT science. We echo sentiments against employing standardized protocols. We identify concerns regarding the evidence of ACT process research. We also discuss measurement problems within the ACT literature and advocate for new and improved ACT measures. We conclude that there is considerable evidence for ACT, but that the underlying research has important growth areas. We also conclude that it is possible for ACT to demonstrate incremental and discriminant effects that are meaningful in real-world scenarios.