Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial - 21/08/25

Doi : 10.1016/S1473-3099(25)00093-3

RECOVERY Collaborative Group^†
The writing committee and data monitoring committee are listed at the end of this Article and a complete list of the members of the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial is in the Supplementary Material

O Abani, A Abbas, F Abbas, J Abbas, K Abbas, M Abbas, S Abbasi, H Abbass, A Abbott, N Abdallah, A Abdelaziz, M Abdelfattah, B Abdelqader, A Abdul, B Abdul, S Abdul, A Abdul Rasheed, A Abdulakeem, R Abdul-Kadir, A Abdullah, A Abdulmumeen, R Abdul-Raheem, N Abdulshukkoor, K Abdusamad, Y Abed El Khaleq, M Abedalla, A Abeer Ul Amna, L Abel, K Abernethy, M Abeywickrema, C Abhinaya, A Abidin, A Aboaba, A Aboagye-Odei, C Aboah, H Aboelela, H Abo-Leyah, K Abouelela, A Abou-Haggar, M Abouibrahim, A Abousamra, M Abouzaid, M Abraham, T Abraham, A Abraheem, J Abrams, R Abrams, HJ Abu, A Abu-Arafeh, SM Abubacker, A Abung, Y Abusamra, Y Aceampong, A Achara, D Acharya, F Acheampong, P Acheampong, S Acheampong, J Acheson, S Achieng, A Acosta, R Acquah, C Acton, J Adabie-Ankrah, P Adair, AS Adam, F Adam, M Adam, H Adamali, M Adamczyk, C Adams, D Adams, K Adams, L Adams, N Adams, R Adams, T Adams, L Adamu-Ikeme, K Adatia, K Adcock, L Addai-Boampong, A Addo, O Adeagbo, A Adebiyi, O Adedeji, Y Adegeye, K Adegoke, V Adell, S Adenwalla, FW Adeoye, OA Adesemoye, EO Adewunmi, A Adeyanju, J Adeyemi, T Adeyemo, B Adhikari, SA Adhikari, R Adhikary, A Aditya, P Adjepong, G Adkins, A Adnan, M Adriaanse, J Aeron-Thomas, D Affleck, C Afnan, M Afridi, P Afrim, FA Afriyie, ZA Aftab, A Afum-Adjei Awuah, M Agarwal, PN Agasiya, R Agbeko, C Agbo, S Aggarwal, A Aghababaie, L Aguilar Jimenez, JA Agyekum, K Agyen, EK Ahadome, S Ahamed Sadiq, MH Ahammed Nazeer, M Ahmad, S Ahmad, A Ahmed, BAR Ahmed, B Ahmed, F Ahmed, H Ahmed, I Ahmed, K Ahmed, L Ahmed, M Ahmed, MC Ahmed, MS Ahmed, N Ahmed, N Ahmed, O Ahmed, RA Ahmed, R Ahmed, R Ahmed, S Ahmed, SG Ahmed, SH Ahmed, R Ahmed Ali, B Ahmed Mohamud, S Ahmed, S Ahmer, A Ahonia, C Aidoo, C Aiken, D Ail, M Ainsworth, M Aissa, L Aitken, B Ajay, A Ajibode, A Ajmi, N Akhtar, S Akili, B Akinbiyi, O Akindolie, Y Akinfenwa, O Akinkugbe, I Akinpelu, M Akram, O Aktinade, U Akudi, ASAR Al Aaraj, A Al Balushi, M Al Dakhola, A Al Swaifi, E Al-Abadi, A Alabi, N Aladangady, M Alafifi, A Alam, S Alam, A Al-Asadi, K Alatzoglou, P Albert, A Albertus, L Albon, A Alcala, G Alcorn, S Alcorn, A Aldana, D Alderdice, A Aldesouki, R Aldouri, J Aldridge, N Aldridge, RM Ale, A Alegria, A Alexander, C Alexander, J Alexander, PDG Alexander, J Al-fori, L Alghazawi, O Alhabsha, B Al-Hakim, R Alhameed, M Al-Hayali, S Al-Hity, A Ali, FR Ali, J Ali, M Ali, MS Ali, N Ali, O Ali, R Ali, S Ali, E Aliberti, J Alin, A Alina, A Alipustain, B Alisjahbana, F Aliyuda, K Alizadeh, M Al-Jibury, S Al-Juboori, M Al-Khalil, A Alkhudhayri, M Alkhusheh, F Allan, N Allan, A Allanson, R Allcock, E Allen, J Allen, K Allen, L Allen, P Allen, R Allen, S Allen, T Allen, A Alli, K Allison, B Allman, HK Allsop, L Allsop, D Allsup, AFT Almahroos, H Al-Moasseb, M Al-Obaidi, L Alomari, A Al-Rabahi, B Al-Ramadhani, Z Al-Saadi, R Al-Sammarraie, I Alshaer, R Al-Shahi Salman, W Al-Shamkhani, F Alsheikh, B Al-Sheklly, S Altaf, A Alty, M Alvarez, M Alvarez Corral, E Alveyn, M Alzetani, S Amamou, N Amar, S Ambalavanan, R Ambrogetti, C Ambrose, A Ameen, A Amelia Ganefianty, K Ames, MR Amezaga, A Amin, A Amin, K Amin, S Amin, T Amin, B Amit, A Amjad, N Amjad, J Amoah-Dankwa, A Amoako-Adusei, V Amosun, M Amsal, K Amsha, J Amuasi, N Amutio Martin, P Amy, A Anada, A Anand, S Anandappa, SD Anantapatnaikuni, NKN Andari, E Anderson, J Anderson, L Anderson, M Anderson, N Anderson, R Anderson, S Anderson, W Anderson, P Andreou, A Andrews, J Andrews, K Aneke, A Ang, WW Ang, T Angel, A Angela, P Angelini, L Anguvaa, O Anichtchik, M Anim-Somuah, K Aniruddhan, J Annett, L Anning, M Ansah, PJ Anstey, R Anstey, A Anthony, A Anthony-Pillai, P Antill, Z Antonina, V Anu, M Anwar, S Anwar, E Apetri, A Apostolopoulos, S Appleby, D Appleyard, MF Aquino, B Araba, S Aransiola, M Araujo, A Archer, D Archer, S Archer, D Arcoria, C Ardley, G Arhin-Sam, A-M Arias, O Aribike, R Arimoto, NLPE Arisanti, C Arkley, C Armah, I Armata, J Armistead, A Armitage, C Armstrong, M Armstrong, S Armstrong, W Armstrong, P Armtrong, H Arndt, C Arnison-Newgass, D Arnold, R Arnold, A Arnott, D Arora, K Arora, P Arora, R Arora, A Arter, A Arthur, NM Artini, A Arumaithurai, A Arya, R Arya, D Aryal, D Asandei, GA Asare, A Asghar, M Asghar, A Ashab, C Ashbrook-Raby, H Ashby, J Ashcroft, S Ashcroft, G Asher, Z Ashfak, A Ashfaq, HA Asiamah, A Ashish, D Ashley, S Ashman-Flavell, S Ashok, A-E-A Ashour, MZ Ashraf, S Ashraf, MB Ashraq, D Ashton, S Ashton, A Ashworth, FJ Ashworth, R Ashworth, A Aslam, I Aslam, S Aslam, L Aslett, H Asogan, A Asrar, O Assaf, R Astin-Chamberlain, YE Atabudzi, P Athavale, D Athorne, B Atkins, C Atkins, S Atkins, J Atkinson, V Atkinson, A Atomode, B Atraskiewicz, AA Attia, E Attubato, M Attwood, P Aubrey, Z Auer, A Aujayeb, AT Aung, H Aung, HWW Aung, KK Aung, KT Aung, N Aung, Y Aung, ZM Aung, E Austin, K Austin, A Auwal, M Avari, M Avery, N Aveyard, J Avis, G Aviss, C Avram, P Avram, A Awadelkareem, G Awadzi, M Awaly, A Awan, S Awisi, A Aya, E Ayaz, JM Ayerh, A Ayers, J Azam, A Azeem, M Azharuddin, A Aziz, G Aziz, I Aziz, N Aziz, A Azkoul, A Azman Shah, G Azzopardi, H Azzoug, F Babatunde, M Babi, B Babiker, G Babington, M Babirecki, M Babores, AO Babs-Osibodu, T Bac, S Bacciarelli, R Bachar, M-E Bachour, A Bachti, G Bacon, J Bacon, B Badal, A Badat, M Bader, GR Badhan, S Badhrinarayanan, JP Bae, A Baggaley, A Baggott, G Bagley, D Bagmane, L Bagshaw, K Bahadori, Y Bahurupi, A Bailey, J Bailey, K Bailey, L Bailey, MA Bailey, M Bailey, P Bailey, S Bailey, H Baillie, JK Baillie, J Bain, V Bains, D Baird, E Baird, K Baird, S Baird, T Baird, Y Baird, A Bajandouh, M Bajracharya, DC Baker, E Baker, J Baker, K Baker, M Baker, R Baker, T-A Baker, V Baker, H Bakere, N Bakerly, M Baker-Moffatt, A Bakhai, N Bakhtiar, P Bakoulas, D Bakthavatsalam, N Balachandran, A Balan, P Balasingam, T Balaskas, M Balasubramaniam, N Balatoni, A Balcombe, A Baldwin, A Baldwin, C Baldwin, D Baldwin, F Baldwin, R Baldwin-Jones, N Bale, J Balfour, M Ball, Ro Ball, K Ballard, I Balluz, C Balmforth, E Balogh, A Baltmr, A Baluwala, G Bambridge, A Bamford, P Bamford, A Bamgboye, E Bancroft, H Bancroft, J Banda, K Bandaru, S Bandi, N Bandla, S Bandyopadhyam, A Banerjee, R Banerjee, P Bang, S Baniya, O Bani-Saad, H Banks, L Banks, P Banks, C Bann, H Bannister, O Bannister, L Banton, DG Bao, T Bao, M Baptist, T Baqai, AM Baral, SC Baral, D Baramova, R Barber, E Barbon, M Barbosa, J Barbour, A Barclay, C Barclay, G Bardsley, S Bareford, S Bari, M Barimbing, A Barker, D Barker, E Barker, H Barker, J Barker, L Barker, O Barker, K Barker-Williams, S Barkha, J Barla, G Barlow, R Barlow, V Barlow, J Barnacle, A Barnard, D Barnes, N Barnes, R Barnes, T Barnes, C Barnetson, A Barnett, A Barnett-Vanes, PG Barning, W Barnsley, A Barr, D Barr, J Barr, C Barr, N Barratt, S Barratt, M Barrera, A Barrett, Fi Barrett, J Barrett, S Barrett, E Barrow, J Bartholomew, MS Barthwal, C Bartlett, G Bartlett, J Bartlett, L Bartlett, S Bartley, S Bartolmeu-Pires, A Barton, G Barton, J Barton, L Barton, R Barton, R Baruah, S Baryschpolec, H Bashir, A Bashyal, B Basker, S Basnet, B Basnyat, A Basoglu, A Basran, J Bassett, G Bassett, C Bassford, B Bassoy, V Bastion, A Bastola, A Basumatary, P Basvi, JA Batac, VR Bataduwaarachchi, T Bate, HJ Bateman, K Bateman, V Bateman, E Bates, H Bates, M Bates, S Bates, S Batham, A Batista, A Batla, D Batra, H Batty, T Batty, A Batty, M Baum, R Baumber, C Bautista, F Bawa, T Bawa, FS Bawani, S Bax, M Baxter, N Baxter, Z Baxter, H Bayes, L-A Bayo, F Bazari, R Bazaz, A Bazli, L Beacham, W Beadles, K Beadon, P Beak, A Beale, K Beard, J Bearpark, A Beasley, S Beattie, K Beaumont, D Beaumont-Jewell, T Beaver, S Beavis, C Beazley, S Beck, V Beckett, R Beckitt, S Beckley, H Beddall, S Beddows, D Beeby, S Beeby, G Beech, M Beecroft, N Beer, Sa Beer, J Beety, G Bega, A Begg, S Begg, S Beghini, A Begum, S Begum, S Begum, T Behan, R Behrouzi, J Beishon, C Beith, J Belcher, H Belfield, K Belfield, A Belgaumkar, D Bell, G Bell, J Bell, L Bell, N Bell, P Bell, S Bell, J Bellamu, M Bellamy, T Bellamy, A Bellini, A Bellis, F Bellis, L Bendall, N Benesh, N Benetti, SA Bengu, L Benham, G Benison-Horner, S Benkenstein, T Benn, A Bennett, C Bennett, D Bennett, G Bennett, K Bennett, K Bennett, L Bennett, MR Bennett, S Bennett, K Bennion, G Benoy, V Benson, A Bentley, J Bentley, I Benton, E Beranova, M Beresford, C Bergin, M Bergstrom, J Bernatoniene, T Berriman, Z Berry, F Best, K Best, A-M Bester, Y Beuvink, E Bevan, S Bevins, T Bewick, A Bexley, S Beyatli, F Beynon, A Bhadi, S Bhagani, S Bhakta, R Bhalla, K Bhandal, K Bhandal, A Bhandari, L Bhandari, LN Bhandari, S Bhandari, J Bhanich Supapol, A Bhanot, R Bhanot, S Bhasin, A Bhat, P Bhat, R Bhatnagar, K Bhatt, J Bhayani, D Bhojwani, P Bhuie, MS Bhuiyan, S Bhuiyan, A Bibby, F Bibi, N Bibi, S Bibi, T Bicanic, S Bidgood, J Bigg, S Biggs, A Biju, A Bikov, S Billingham, J Billings, P Binh, A Binns, M BinRofaie, O Bintcliffe, C Birch, J Birch, K Birchall, S Bird, M Birt, C Bishop, K Bishop, L Bishop, K Bisnauthsing, N Biswas, M Bittaye, S Biuk, K Blachford, E Black, H Black, K Black, M Black, P Black, V Black, H Blackgrove, B Blackledge, J Blackler, S Blackley, H Blackman, C Blackstock, C Blair, F Blakemore, H Blamey, A Bland, S Blane, S Blankley, P Blaxill, K Blaylock, J Blazeby, N Blencowe, B Bloom, J Bloomfield, A Bloss, A Blowers, S Blows, H Bloxham, S Blrd, L Blundell, A Blunsum, M Blunt, T Blunt, I Blyth, K Blyth, A Blythe, K Blythe, KA Boahen, M Boampoaa, S Board, E Boatemah, B Bobie, K Bobruk, PN Bodalia, N Bodasing, M Boden, T Bodenham, G Boehmer, M Boffito, K Bohanan, K Bohmova, N Bohnacker, S Bokhandi, M Bokhar, S Bokhari, SO Bokhari, I Bokobza, A Boles, C Bolger, C Bonaconsa, C Bond, H Bond, S Bond, T Bond, A Bone, G Boniface, J Bonney, L Bonney, L Booker, S Boot, M Boothroyd, J Borbone, N Borman, S Bosence, K Bostock, N Botting, F Bottrill, H Bouattia, L Bough, H Boughton, Z Boult, T Boumrah, M Bourke, S Bourke, M Bourne, R Bousfield, L Boustred, A Bowes, P Bowker, T Bowker, H Bowler, L Bowman, S Bowman, R Bowmer, A Bowring, H Bowyer, A Boyd, J Boyd, L Boyd, N Boyer, N Boyle, P Boyle, R Boyle, L Boyles, L Brace, A Bracken, J Bradder, CJ Bradley, P Bradley, J Bradley-Potts, L Bradshaw, Z Bradshaw, C Brady, R Brady, S Brady, P Braga Sardo, D Braganza, M Braithwaite, S Brammer, M Branch, T Brankin-Frisby, J Brannigan, S Brattan, F Bray, N Bray, M Brazil, L Brear, Tr Brear, S Brearey, L Bremner, M Brend, C Bresges, C Bressington, G Bretland, C Brewer, M Bridgett, G Bridgwood, S Brigham, J Bright, C Brightling, T Brigstock, L Brimfield, P Brinksman, E Brinkworth, R Brittain-Long, V Britten, H Britton, L Broad, S Broadhead, R Broadhurst, A Broadley, M Broadway, C Brockelsby, M Brocken, T Brockley, M Brodsky, F Brogan, L Brohan, F Brokke, J Brolly, D Bromley, H Brooke-Ball, V Brooker, M Brookes, D Brooking, A Brooks, D Brooks, J Brooks, K Brooks, N Brooks, P Brooks, R Brooks, S Brooks, M Broom, N Broomhead, C Broughton, N Broughton, M Brouns, A Brown, C Brown, E Brown, H Brown, J Brown, L Brown, N Brown, P Brown, R Brown, S Brown, T Brown, B Browne, C Browne, D Browne, M Browne, S Brownlee, A Brraka, J Bruce, M Bruce, W Brudlo, A Brunchi, N Brunskill, A Brunton, M Brunton, M Bryant, E Bryden, H Brzezicki, A Buazon, MH Buch, R Buchan, R Buchanan, D Buche, A Buck, L Buck, M Buckland, C Buckley, L Buckley, P Buckley, S Buckley, C Buckman, A Budds, G Bugg, R Bujazia, M Bukhari, S Bukhari, R Bulbulia, A Bull, D Bull, K Bull, R Bull, Th Bull, E Bullock, S Bullock, N Bulteel, K Bumunarachchi, R Bungue-Tuble, O Burbidge, C Burchett, D Burda, C Burden, TG Burden, Mi Burgess, R Burgess, S Burgess, E Burhan, H Burhan, H Burke, K Burke, A Burman, S Burnard, C Burnett, S Burnett, A Burns, C Burns, J Burns, K Burns, D Burrage, K Burrows, C Burston, A Burton, B Burton, F Burton, H Burton, M Burton, M Butar butar, D Butcher, A Butler, E Butler, J Butler, P Butler, S Butler, J Butler, A-T Butt, M Butt, MM Butt, C Butterworth, N Butterworth-Cowin, R Buttery, T Buttle, H Button, D Buttress, H Bye, J Byrne, W Byrne, V Byrne-Watts, NK C, A Cabandugama, L Cabrero, S Caddy, R Cade, A Cadwgan, Z Cahilog, A Cahyareny, D Cairney, J Calderwood, D Caldow, E Cale, G Calisti, D Callaghan, J Callaghan, C Callens, D Callum, C Calver, M Cambell-Kelly, T Camburn, DR Cameron, E Cameron, F Cameron, S Cameron, C Camm, FD Cammack, A Campbell, B Campbell, D Campbell, H Campbell, J Campbell, K Campbell, M Campbell, R Campbell, W Campbell, Q Campbell Hewson, J Camsooksai, L Canclini, SM Candido, J Candlish, C Caneja, A Cann, J Cann, R Cannan, A Cannon, E Cannon, M Cannon, P Cannon, V Cannons, E Canonizado, J Cantliff, N Cap, NT Cap, B Caplin, S Capocci, N Caponi, A Capp, R Capstick, T Capstick, C Caraenache, A Card, M Cardwell, C Carey, R Carey, S Carley, F Carlin, T Carlin, S Carmichael, M Carmody, M Carnahan, C Caroline, J Carpenter, S Carr, A Carrasco, Z Carrington, A Carroll, P Carroll, R Carson, C Cart, E Carter, J Carter, M Carter, N Carter, P Carter, D Cartwright, J-A Cartwright, C Carty, L Carty, J Carungcong, C Carver, E Carver, R Carver, S Casey, A Cassells, T Castiello, G Castle, B Castles, M Caswell, AM Catana, H Cate, A Catelan Zborowski, S Cathcart, K Cathie, D Catibog, C Catley, L Catlow, M Caudwell, A Cavazza, A Cave, L Cave, S Cavinato, F Cawa, K Cawley, C Caws, K Cawthorne, H Cendl, H Century, J Cernova, M Cesay, E Cetti, S Chabane, M Chablani, C Chabo, J Chacko, D Chadwick, J Chadwick, R Chadwick, E Chakkarapani, A Chakraborty, M Chakraborty, M Chakravorty, P Chalakova, B Chalise, BS Chalise, J Chalmers, R Chalmers, G Chamberlain, S Chamberlain, E Chambers, J Chambers, L Chambers, N Chambers, A Chan, C Chan, E Chan, M Chan, K Chan, P Chan, R (P-C) Chan, XHS Chan, C Chandler, H Chandler, KJ Chandler, S Chandler, Z Chandler, S Chandra, N Chandran, B Chandrasekaran, Y Chang, HQ Chanh, G Chaplin, J Chaplin, G Chapman, J Chapman, K Chapman, L Chapman, M Chapman, P Chapman, T Chapman, L Chappell, A Charalambou, B Charles, D Charlton, S Charlton, K Chatar, C Chatha, D Chatterton, N Chau, R Chaube, A Chaudhary, MYN Chaudhary, B Chaudhary, I Chaudhry, Z Chaudhry, K Chaudhuri, N Chaudhuri, M Chaudhury, A Chauhan, RS Chauhan, L Chaulagain, A Chavasse, N Chavasse, V Chawla, L Cheater, J Cheaveau, C Cheeld, M Cheeseman, F Chen, HM Chen, T Chen, F Cheng, LY Cheng, Z Cheng, H Chenoweth, CH Cheong, JJ Cherian, S Cherian, M Cherrie, H Cheshire, CK Cheung, E Cheung, K Cheung, M Cheung, C Cheyne, S Chhabra, WL Chia, E Chiang, A Chiapparino, R Chicano, G Chikara, M Chikungwa, ZA Chikwanha, G Chilcott, S Chilcott, A Chilvers, P Chimbo, KW Chin, WJ Chin, R Chineka, A Chingale, E Chinonso, C Chin-Saad, M Chirgwin, H Chisem, C Chisenga, C Chisholm, B Chisnall, C Chiswick, S Chita, N Chitalia, M Chiu, L Chiverton, B Chivima, C Chmiel, S Choi, W Choon Kon Yune, M Chopra, V Choudhary, O Choudhury, S Choudhury, B-L Chow, M Chowdhury, S Chowdhury, A Chrisopoulou, V Christenssen, P Christian, A Christides, F Christie, D Christmas, G Christoforou, T Christopherson, A Christou, M Christy, P Chrysostomou, Y Chua, D Chudgar, R Chudleigh, S Chukkambotla, ME Chukwu, I Chukwulobelu, CY Chung, E Church, SR Church, D Churchill, N Cianci, P Cicconi, P Cinardo, Z Cipinova, B Cipriano, S Clamp, B Clancy, M Clapham, E Clare, S Clare, A Clark, C Clark, D Clark, E Clark, F Clark, G Clark, J Clark, K Clark, L Clark, M Clark, N Clark, P Clark, R Clark, T Clark, Z Clark, A Clarke, J Clarke, P Clarke, R Clarke, S Clarke, A Claxton, L Claxton, K Clay, C Clayton, E Clayton, O Clayton, J Clayton-Smith, B Clearyb, C Cleaver, R Cleeton, I Clement, C Clemente de la Torre, J Clements, S Clements, S Clenton, S Cliff, R Clifford, S Clifford, A Clive, J Clouston, V Clubb, S Clueit, L Clutterbuck, A Clyne, M Coakley, PGL Coakley, K Cobain, A Cochrane, P Cochrane, L Cockayne, M Cockerell, H Cockerill, S Cocks, R Codling, A Coe, S Coetzee, D Coey, D Cohen, J Cohen, O Cohen, M Cohn, L Coke, O Coker, N Colbeck, R Colbert, E Cole, J Cole, G Coleman, M Coleman, N Coleman, H Coles, M Colin, A Colino-Acevedo, J Colley, K Collie, A Collier, D Collier, H Collier, T Collingwood, P Collini, E Collins, J Collins, K Collins, M Collins, N Collins, S Collins, V Collins, A Collinson, B Collinson, J Collinson, M Collis, M Colmar, HE Colton, J Colton, K Colville, C Colvin, E Combes, D Comer, A Comerford, D Concannon, A Condliffe, R Condliffe, E Connell, L Connell, N Connell, K Connelly, G Connolly, E Connor, A Conroy, K Conroy, V Conteh, R Convery, F Conway, G Conway, R Conway, J-A Conyngham, A Cook, C Cook, E Cook, G Cook, H Cook, J Cook, M Cook, S Cook, D Cooke, G Cooke, H Cooke, J Cooke, K Cooke, T Cooke, V Cooke, A Cooper, C Cooper, D Cooper, H Cooper, J Cooper, L Cooper, N Cooper, R Cooper, S Cooray, T Cope, S Corbet, C Corbett, A Corbishley, J Corcoran, C Cordell, J Cordle, A Corfield, J Corless, A Corlett, J Cornwell, M Cornwell, D Corogeanu, A Corr, M Corredera, R Corrigan, P Corry, R Corser, J Cort, D Cosgrove, T Cosier, P Costa, T Costa, C Coston, S Cotgrove, Z Coton, L-J Cottam, R Cotter, D Cotterill, C Cotton, G Couch, M Coulding, A Coull, D Counsell, D Counter, C Coupland, E Courtney, J Courtney, R Cousins, AJ Coutts, A Cowan, E Cowan, R Cowan, R Cowell, L Cowen, S Cowman, A Cowton, E Cox, G Cox, H Cox, K Cox, M Cox, K Coy, A Cradduck-Bamford, H Craig, J Craig, V Craig, F Craighead, M Cramp, H Cranston, SS Crasta, J Crause, A Crawford, E Crawford, I Crawford, S Crawshaw, B Creagh-Brown, A Creamer, A Creaser-Myers, J Cremona, S Cremona, A Crepet, J Cresswell, M Cribb, C Crichton, D Crilly, L Crisp, N Crisp, D Crocombe, M Croft, J Crooks, H Crosby, E Cross, T Cross, A Crothers, S Crotty, S Crouch, M Crow, A Crowder, K Crowley, T Crowley, R Croysdill, C Cruickshank, I Cruickshank, J Cruise, C Cruz, T Cruz Cervera, D Cryans, G Cui, H Cui, L Cullen, G Cummings-Fosong, V Cunliffe, N Cunningham, J Cupitt, H Curgenven, G Curnow, D Curran, S Curran, C Currie, J Currie, S Currie, J Curtis, K Curtis, M Curtis, O Curtis, T Curtis, R Cuthbertson, J Cuthill, S Cutler, S Cutts, M Czekaj, P Czylok, S D’Souza, J da Rocha, GS Dadzie, M Dafalla, A Dagens, H Daggett, J Daglish, S Dahiya, A Dale, K Dale, M Dale, S Dale, J Dales, U D’Alessandro, H Dalgleish, H Dallow, C D’aloia, D Dalton, M Dalton, Z Daly, M Damani, E Damm, L Dan, A Danga, J Dangerfield, A Daniel, P Daniel, A Daniels, A Dann, KG Danso, S Danso-Bamfo, QT Dao, S Darby, A Darbyshire, J Darbyshire, P Dargan, P Dark, K Darlington, S Darnell, T Darton, G Darylile, A Das, M Das, S Das, M Daschel, J Dasgin, D Datta, A Daunt, V Dave, E Davenport, M Davey, M David, A Davidson, L Davidson, N Davidson, R Davidson, A Davies, B Davies, C Davies, D Davies, E Davies, F Davies, G Davies, H Davies, J Davies, K Davies, L Davies, M Davies, N Davies, O Davies, P Davies, R Davies, S Davies, A Davis, J-A Davis, K Davis, P Davis, A Davis-Cook, A Davison, C Dawe, H Dawe, M Dawkins, A Dawson, D Dawson, E Dawson, J Dawson, L Dawson, M Dawson, S Dawson, T Dawson, I Dawson, A Daxter, A Day, J Day, J D’Costa, P De, D de Fonseka, T de Freitas, P De Los Santos Dominguez, R De Pretto, F De Santana Miranda, E de Sausmarez, S de Silva, T de Silva, J De Sousa, P De Sousa, J de Souza, P De Souza, A De Soyza, N de Vere, J de Vos, B Deacon, S Dealing, A Dean, J Dean, K Dean, S Dean, T Dean, J Deane, J Dear, E Dearden, C Deas, S Debbie, G Debreceni, V Deelchand, M Deeley, J Deery, E Defever, M Del Forno, A Dela Rosa, G De-La-Cedra, A Dell, C Demetriou, D DeMets, J Democratis, J Denham, E Denis, L Denley, C Denmade, A Dent, K Dent, M Dent, E Denton, T Denwood, N Deole, D Depala, M Depante, S Dermody, A Desai, P Desai, S Deshpande, V Deshpande, S Devkota, U Devkota, D Devonport, M Devonport, P Dey, V Dey, R Deylami, K Dhaliwal, P Dhangar, S Dhani, A Dhanoa, M Dhar, A Dhariwal, D Dharmasena, D Dhasmana, E Dhillon, R Dhillon, S Dhillon, M Dhimal, D Dhiru, T Dhorajiwala, P Dias, S Diaz, K Diaz-Pratt, M Dibas, D Dickerson, P Dicks, M Dickson, S 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Thueux, NTH Thuong, P Thu-Ta, D Thuy, DTT Thuy, V Thwaiotes, C Thwaites, CL Thwaites, G Thwaites, S Tiberi, S Tieger, C Tierney, M Tighe, S Tilbey, C Till, A Tiller, H Tiller, J Timerick, E Timlick, A Timmins, A Timmis, H Timms, A-M Timoroksa, S Tinashe, S Tingley, N Tinker, H Tinkler, M Tinkler, J Tipper, A Tirumalai Adisesh, H Tivenan, K Tluchowska, H T-Michael, A Todd, J Todd, S Todd, O Toffoletti, M Tohfa, S Tohill, M Tolson, A Tomas, N Tomasova, S Tomlin, S Tomlins, J Tomlinson, K Tomlinson, J Tonkin, I Tonna, C Toohey, K Topham, M Topping, A Torokwa, C Torrance, O Touma, L Tous Sampol, R Tousis, M Tout, P Tovey, G Towersey, J Townley, R Tozer, DK Tran, H Tran, HB Tran, M Tran, NB Tran, VG Tran, VK Tran, NTH Trang, H Tranter, J Travers, C Travill, S Traynor, L Trethowan, E Treus Gude, M Trevelyan, NA Trewick, A Tridente, H Trieu, S Triggs, F Trim, A Trimmings, T Trinick, S Tripathy, K Trivedi, S Troedson, E Tropman, A Trotter, S Trous, H Trower, M Trowsdale Stannard, N Trudgill, R Truell, N Truman, M Truslove, S Trussell, T Trussell, K Tsakiridou, C Tsang, P Tsang, T Tsawayo, KK Tsilimpari, G Tsinaslanidis, M Tsitsi, S Tso, HTC Tu, N Tucker, S Tucker, S Tucker, DE Tudor, A Tufail, J Tuff, J Tuffney, R Tully, T Tulus Satriasih, G Tunesi, D Tung, DQ Tung, K Turbitt, R Turel, T Turgut, C Turley, A Turnbull, A Turner, C Turner, G Turner, K Turner, L Turner, LC Turner, M Turner, P Turner, S Turner, V Turner, I Turner-bone, S Turney, J Turvey, NTM Tuyen, C Tweed, D Tweed, R Twemlow, E Twohey, B Tyagi, V Tyagi, A Tyer, A Tyler, J Tyler, A Tyzack, P Tzavaras, I Tzinieris, AW Uddin, MS Uddin, R Uddin, J Ugoji, E Ukaegbu, M Ul Haq, W Ul Hassan, Z Ul-Haq, S Ullah, J Um, A Umaipalan, A Umate, J Umeadi, A Umeh, W Umeojiako, B Ummat, E Underhill, C Underwood, J Underwood, A Unsworth, V Uppal, VS Uppal, G Upson, M Ur Rasool, A Uriel, S Urruela, H Uru, J Usher, M Usher, R Usher, A Usher-Rea, A Ustianowski, E Usuf, FN Utomo, H Uzu, LC Vaccari, U Vaghela, A Vaidya, D Vail, B Valecka, J Valentine, B Valeria, P Vallabhaneni, T Valleri, N Vallotton, L Vamplew, E Vamvakiti, J Vamvakopoulos, CTC Van, S Van Blydenstein, L van Bruggen, M van de Venne, A van der Meer, N van der Stelt, R Van Doorn, L van Koutrik, A Van Loggerenberg, J Vance-Daniel, R Vancheeswaran, SI Vandeyoon, P Vankayalapati, P Vanmali, C Vansomeren, W Van’t Hoff, S Vara, SJ Vardy, A Varghese, M Varghese, W Varney, G Varnier, A-N Varouxaki, R Varquez, V Vasadi, O Vass, K Vassell, V Vasu, V Vasudevan, M Vatish, S Vaughan, H Vayalaman, D Vayapooree, C Vaz, N Veale, S Veerasamy, S Velankar, L Velauthar, N Veli, N Vella, A Velugupati, A Velusamy, I Venables, M Venditti, R Venkataramakrishnan, R Venn, M Venter, L Ventilacion, J Vere, M Veres, S Vergnano, W Verling, A Verma, R Vernall, B Vernon, M Vertue, L Verueco, J Verula, A Veterini, N Vethanayagam, S Vettikumaran, L Veys, C Vickers, S Victor, S Victoria, CP Vidaillac, J Vidler, B Vijayakumar, VW Vijayaraghavan Nalini, B Vilcinskaite, A Vileito, N Vilimiene, L Vinall, S Vinay, L Vinayakarao, O Vincent, R Vincent, NQ Vinh, P Virdee, E Virgilio, AM Virk, E Visentin, M Vitaglione, K Vithian, S Vittoria, S Vivekananthan, E Vlad, B Vlies, L von Oven, C Vooght, KT Vu Thai, K Vutipongsatorn, A Vuylsteke, E Vyras, R Wach, B Wadams, S Wadd, N Waddington, P Wade, J Wadsley, K Wadsworth, SEI Wafa, D Wagstaff, L Wagstaff, D Wahab, Z Wahbi, A Waheed Adigun, S Waidyanatha, A Waite, R Wake, A Wakefield, W Wakeford, F Wakinshaw, E Waldeck, A Walden, L Walding, A Waldron, J Waldron, E Wales, B Wali, D Walker, G Walker, H Walker, I Walker, K Walker, L Walker, O Walker, R Walker, S Walker, G Wallace, R Wallbutton, J Wallen, K Wallendszus, A Waller, R Waller, G Wallis, L Wallis, M Wallis, E Walmsley, D Walsh, E Walsh, L Walsh, D Walstow, D Walter, A Walters, H Walters, J Walters, E Walton, L Walton, M Walton, O Walton, S Walton, M Wan, J Wanda, M Wands, R Wane, F Wang, N Wang, R Wang, S Wang, D Warbrick, S Warburton, C Ward, D Ward, E Ward, H Ward, J Ward, L Ward, N Ward, R Ward, T Ward, SA Warden, G Wardere, S Wardle, H Wardy, G Waring, S Waring, J Warmington, B Warner, C Warner, L Warnock, S Warran, J Warren, L Warren, R Warren, Y Warren, D Warrender, H Warren-Miell, A Warris, G Warwick, H Wassall, S Wasserman, E Wasson, HJ Watchorn, H Waterfall, A Waters, D Waters, M Waterstone, A Watkin, C Watkins, E Watkins, K Watkins, L Watkins, A Watson, AJR Watson, E Watson, F Watson, JGR Watson, L Watson, P Watson, R Watson, K Watson, M Watters, D Watterson, K Wattimena, D Watts, J Watts, M Watts, V Waugh, E Wayman, M Wayman, A Wazir, M Weatherhead, N Weatherly, C Webb, H Webb, K Webb, S Webb, C Websdale, D Webster, I Webster, J Webster, T Webster, J Wedlin, L Wee, R Weerakoon, T Weerasinghe, J Weeratunga, M Weetman, S Wei, I Weichert, E Welch, H Welch, J Welch, L Welch, S Welch, B Welham, S Weller, L Wellings, B Wells, S Wellstead, B Welsh, R Welsh, I Welters, R Welton, V Wenn, L Wentworth, J Wesonga, K Wesseldine, J West, M West, R 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Williams, R Williams, S Williams, T Williams, S Williams, A Williamson, C Williamson, D Williamson, J Williamson, JD Williamson, R Williamson, C Williamson, H Williamson, E Willis, H Willis, J Willis, L Wills, L Willsher, C Willshire, F Willson, J Willson, A Wilson, B Wilson, D Wilson, I Wilson, J Wilson, K Wilson, K-A Wilson, L Wilson, M Wilson, S Wilson, T Wilson, J Wilson, KLY Win, M Win, T Win, TT Win, WYW Win, L Winckworth, L Winder, P Winder, S Winearl, H Winmill, S Winn, C Winpenny, H Winslow, H Winter, J Winter, B Winter-Goodwin, J Winterton, H Winwood, J Wischhusen, S Wisdom, M Wise, M Wiselka, R Wiseman, S Wiseman, S Wishart, T WIshlade, E Witele, N Withers, J Wittes, D Wixted, T Wodehouse, W Wolf, N Wolff, K Wolffsohn, R Wolf-Roberts, E Wolodimeroff, A Wolstencroft, A Wong, C Wong, C-H Wong, C-M Wong, E Wong, JSY Wong, KY Wong, MY Wong, N Wong, S Wong, T Wong, AA Wongkyezeng, A Wood, C Wood, D Wood, F Wood, G Wood, H Wood, J Wood, L Wood, M Wood, S Wood, T Wood, K Woodall, R Woodfield, C Woodford, E Woodford, J Woodford, L Woodhead, T Woodhead, P Woodland, M Woodman, S Woodmansey, C Woods, J Woods, K Woods, S Woods, Z Woodward, M Woolcock, G Wooldridge, R Woolf, C Woollard, L Woollen, E Woolley, J Woolley, D Woosey, D Wootton, J Wootton, D Worley, S Worton, J Wraight, M Wray, K Wren, L Wren, C Wrey Brown, C Wright, D Wright, F Wright, H Wright, I Wright, L Wright, R Wright, S Wright, T Wright, C Wroe, H Wroe, H Wu, P Wu, J Wubetu, F Wulandari, R Wulandari, S Wurie, C Wyatt, F Wyn-Griffiths, I Wynter, B Xavier, A Xhikola, BE Xia, Z Xia, E Yacoba, S Yadav, M Yakubi, M Yan, Y Yanagisawa, F Yang, Y Yang, M Yanney, WL Yap, N Yaqoob, S Yasmin, B Yates, D Yates, E Yates, H Yates, T Yates, M Yates, J Ye, C Yearwood Martin, K Yein, F Yelnoorkar, LM Yen, A Yeoh, CY Yeung, P Yew, D Yewatkar, L Ylquimiche Melly, I Ynter, H Yong, J Yorke, J Youens, A Younes Ibrahim, E Young, G Young, L Young, A Yousafzar, S Youssouf, A Yousuf, H Yovita, C Yu, JSJ Yuan, N Yufaniaputri, B Yung, D Yusef, S Yusef, I Yusuf, A-S Zafar, S Zagalo, S Zaher, A Zahoor, M Zainab, T Zak, K Zaki, N Zakir, K Zalewska, A Zamalloa, M Zaman, S Zaman, J Zamikula, L Zammit, M Zammit-Mangion, M Zawadzka, M Zayed, E Zebracki, D Zehnder, L Zeidan, D Zeinali, J Zhang, X Zhao, D Zheng, D Zhu, M Zia, O Zibdeh, R Zill-E-Huma, ET Zin, E Zincone, G Zindoga, E Zinkin, V Zinyemba, C Zipitis, L Zitter, A Zmierczak, G Zubikarai, A Zubir, N Zuhra, R Zulaikha, S Zulfikar, C Zullo, A Zuriaga-Alvaro

^*Correspondence to: Prof Peter W Horby and Prof Martin J Landray, RECOVERY Central Coordinating Office, Oxford OX3 7LF, UKRECOVERY Central Coordinating OfficeOxfordOX3 7LFUK

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Summary

Background

Molnupiravir and nirmatrelvir–ritonavir are oral antivirals that have shown efficacy in preventing disease progression in outpatients with COVID-19. We aimed to evaluate these treatments for patients hospitalised with COVID-19 pneumonia, for whom data on these antivirals are scarce.

Methods

The RECOVERY trial is a randomised, controlled, open-label, adaptive platform trial testing treatments for COVID-19. In this study we report the molnupiravir and nirmatrelvir–ritonavir comparisons from the RECOVERY trial. In each comparison, participants aged 18 years and older were randomly allocated (1:1) to the relevant antiviral (5 days of molnupiravir 800 mg twice daily or 300 mg nirmatrelvir and 100 mg ritonavir twice daily) in addition to usual care, or to usual care alone. The molnupiravir comparison was conducted at 75 hospitals in the UK, two in Nepal, and two in Indonesia; the nirmatrelvir–ritonavir comparison was conducted at 32 hospitals in the UK. Participants could take part in both comparisons. The primary outcome was 28-day mortality, and secondary outcomes were time to discharge alive from hospital and progression to invasive ventilation or death. Analysis was by intention to treat. Both comparisons were stopped because of low recruitment. This study is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.

Findings

From Jan 24, 2022, to May 24, 2023, 923 participants were recruited to the molnupiravir comparison (445 allocated to molnupiravir and 478 to usual care), and from March 31, 2022, to May 24, 2023, 137 participants were recruited to the nirmatrelvir–ritonavir comparison (68 allocated to nirmatrelvir–ritonavir and 69 to usual care). More than three-quarters of participants were vaccinated and had antispike antibodies at randomisation, and more than two-thirds were receiving other SARS-CoV-2 antivirals. In the molnupiravir comparison, 74 (17%) participants allocated to molnupiravir and 79 (17%) allocated to usual care died within 28 days (hazard ratio [HR] 0·93 [95% CI 0·68–1·28], p=0·66). In the nirmatrelvir–ritonavir comparison, 13 (19%) participants allocated to nirmatrelvir–ritonavir and 13 (19%) allocated to usual care died within 28 days (HR 1·02 [0·47–2·23], p=0·96). In neither comparison was there evidence of any difference in the duration of hospitalisation or the proportion of participants progressing to invasive ventilation or death.

Interpretation

Adding molnupiravir or nirmatrelvir–ritonavir to usual care was not associated with improvements in clinical outcomes. However, low recruitment meant a clinically meaningful benefit of treatment could not be ruled out, particularly for nirmatrelvir–ritonavir.

Funding

UK Research and Innovation (UK Medical Research Council), the National Institute for Health and Care Research, and the Wellcome Trust.

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Plan

Introduction

Methods

Study design and participants

Randomisation and masking

Procedures

Outcomes

Statistical analysis

Role of the funding source

Results

Discussion

Contributors

Writing committee (on behalf of the RECOVERY Collaborative Group)

Data monitoring committee

Data sharing

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Vol 25 - N° 9

P. 1000-1010 - septembre 2025 Retour au numéro

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Anant Mishra, Rahul Dwivedi, Kim Faure, Daniel J Morgan, Jennifer Cohn

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Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial - 21/08/25

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