Prevalence of digestive carriage of multi-drug resistant enterobacterales in hospitalized and community-based patients in Togo: a prospective study - 01/11/25

Doi : 10.1016/j.idnow.2025.105160

Rogatien Comlan Atoun ^a,^b,^⁎ , Iman Frédéric Youa ^a,^b, Lidaw Déassoua Bawe ^c, Isidore Tchaou ^d, Bodombossou Madera ^e, Awereou Kotosso ^d, Alexandre Bleibtreu ^f, Taïssiri Adedjouma ^a,^b, André Pouwedeou Bedekelabou ^g, Jules Tchédié ^h, Yvette Siliadin ⁱ, Eric Cardinale ^e, Laurence Armand Lefevre ^j,^k, Brücker Gilles ^l, Salou Mounerou ^m, Claver Anoumou Dagnra ⁿ, Didier Koumavi Ekouevi ^a,^b,^o, Dominique Salmon ^l,^p
^a University of Lomé, Faculty of Health Sciences, Department of Public Health, Lomé, Togo
^b African Center for Research in Epidemiology and Public Health (CARESP), Lomé, Togo
^c Department of Infectious Diseases, Sylvanus Olympio University Hospital, Lomé, Togo
^d Department of Health Sciences, University of Lomé, Togo
^e ASTRE Joint Research Unit, CIRAD, Montpellier, France
^f Department of Infectious and Tropical Diseases, AP-HP Pitié Salpêtrière University Hospital, Paris, France
^g Veterinary Inspector, Head of Animal Production and Veterinary Control Section, Savane, Togo
^h Sylvanus Olympio University Hospital Medical Bacteriology Laboratory, Lomé, Togo
ⁱ Campus University Hospital Medical Bacteriology Laboratory, Lomé, Togo
^j Bacteriology Department, Bichat Hospital, AP-HP, Paris, France
^k IAME INSERM UMR 1137, University Paris Cité, Paris, France
^l International Relations Department, AP-HP, Paris, France
^m Faculty of Health Sciences (FSS), Department of Pharmaceutical Sciences, Biology and Immunology Laboratory (BIOLIM), Department of Basic Sciences, University of Lomé, Togo
ⁿ Faculty of Health Sciences (FSS), Sylvanus Olympio University Hospital Medical Bacteriology Laboratory, Biology and Immunology Laboratory (BIOLIM), University of Lomé, Togo
^o University of Bordeaux, National Institute of Health and Medical Research (INSERM), Research Institute for Development (IRD), Bordeaux Population Health Center, UMR 1219, Bordeaux, France
^p Institut Fournier, Infectious Diseases Department, Paris, France

^⁎Corresponding author at: 89 Rue des Sarrasins, BP: 4089, Lomé, Togo.89 Rue des Sarrasins, BP: 4089LoméTogo

Highlights

•	This study assessed the prevalence of digestive carriage of ESBL and CPE in patients hospitalized in several departments of Lomé’s two university hospitals, in comparison with pregnant women attending the maternity hospital and representing community carriage.
•	The inclusion of hospitalized patients and community participants facilitated a comprehensive assessment of prevalence in different population categories.
•	To combat the emergence of MDRBs, it is crucial to maintain regular monitoring and to conduct nationwide (as well as regional) studies.
•	Educational and awareness programs are needed to promote good hygienic practices and the responsible use of antibiotics.

Le texte complet de cet article est disponible en PDF.

Abstract

Introduction

The aim of this study was to estimate the prevalence of digestive tract carriage of ESBL-E/CPE among patients having consulted or been hospitalized in two university hospitals in Lomé in 2023.

Methods

A cross-sectional study was conducted from January to June 2023. Rectal swabs were collected from 230 participants (100 in maternity, 50 in pediatrics, 50 in trauma-orthopedics, and 30 in intensive care).

Results

Median age was four years for children and 30 years for adults. Overall prevalence of ESBL-E carriage was 59.6 %, while that of CPB was 6.1 %. Carriage was more frequent in hospital settings than in the community (64.6 % vs. 53.0 %). The main isolated species were Escherichia coli (95.6 %) and Klebsiella pneumoniae (27.7 %). Hospitalization units were associated with multidrug-resistant bacteria carriage.

Conclusion

These findings highlight a high prevalence of digestive tract carriage in hospital as well as community settings.

Le texte complet de cet article est disponible en PDF.

Keywords : Multi-drug resistant bacteria, Enterobacteriaceae, Hospital, One Health, Togo

Plan

Introduction

Methods

Results

Sociodemographic participant characteristics

Overall prevalence of MDRB carriage

Acquisition of MDRB during hospitalization

Factors associated with MDRB carriage at admission

Discussion

Conclusion

Export

Vol 55 - N° 7

Article 105160- novembre 2025 Retour au numéro

Article précédent

Retrospective analysis of discharge antibiotic selection and 30-day readmission rate for community acquired pneumonia
Nick Hartwig, Eric Wombwell

| Article suivant

West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures
Pietro Ferrara

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Prevalence of digestive carriage of multi-drug resistant enterobacterales in hospitalized and community-based patients in Togo: a prospective study - 01/11/25

Highlights

Abstract

Introduction

Methods

Results

Conclusion

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL