Legionella in the brain: First culture-confirmed post-surgical abscess case and its successful management - 11/12/25
, Fabrice Bartolomei c, d, Andreas Stein a, Romain Carron d, eHighlights |
• | First confirmed L. pneumophila brain abscess post-neurosurgery using culture and molecular methods. |
• | Only six Legionella brain abscess cases have been reported historically (including other species). |
• | Positive antigenuria in abscess fluid, although not validated diagnostically, guided effective therapy. |
• | This case underscores infection risks from electrode pathways and the need to monitor home water for contamination. |
Abstract |
Introduction |
Post-neurosurgical brain abscesses are documented in approximately 9% of cases, with causative pathogens often linked to polymicrobial or nosocomial origins.
Case report.
We report the first case of post-neurosurgical Legionella pneumophila brain abscess in a 55-year-old woman with drug-resistant epilepsy. The abscess developed following stereo-electroencephalography and thermocoagulation procedures, manifesting as hemiparesis and vomiting. Diagnosis was confirmed via 16S rRNA PCR, antigen testing, and Buffered Charcoal Yeast Extract (BCYE) culture. Treatment with targeted antibiotics, including levofloxacin and rifampicin, led to a complete recovery without sequelae. Investigation identified the patient’s home water system as the infection source.
Conclusion |
This case highlights the importance of molecular diagnostics and tailored therapy in managing rare brain abscesses.
Le texte complet de cet article est disponible en PDF.Keywords : Brain abscesses, Legionella pneumophila , Stereo-electroencephalography, Thermocoagulation procedures, Epilepsy
Plan
Vol 55 - N° 8
Article 105182- décembre 2025 Retour au numéro
Article précédent
- Evolution of the inappropriate use of broad-spectrum antibiotics for Pseudomonas aeruginosa infections following the 2022 CA-SFM guidelines
- C. Ourghanlian, D. Kharchenko, V. Fihman, A. Galy, P-L. Woerther, R. Lepeule
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?